{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:38:14Z","timestamp":1792190294288,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.ajem.2016.05.019","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T17:56:56Z","timestamp":1463162216000},"page":"1743-1749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Does the infusion rate of fluid affect rapidity of mean arterial pressure restoration during controlled hemorrhage"],"prefix":"10.1016","volume":"34","author":[{"given":"Claire","family":"Roger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Louart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Louart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bobbia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Geraud","family":"Claret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-7783","authenticated-orcid":false,"given":"Antonia","family":"Perez-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Lefrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2016.05.019_bb0005","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMra1109343","article-title":"Injuries","volume":"368","author":"Norton","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00268-009-0266-1","article-title":"Epidemiology of traumatic deaths: comprehensive population-based assessment","volume":"34","author":"Evans","year":"2010","journal-title":"World J Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00423-013-1143-9","article-title":"Changes in the outcomes of severe trauma patients from 15-year experience in a Western European trauma ICU of Emilia Romagna region (1996-2010). A population cross-sectional survey study","volume":"399","author":"Di Saverio","year":"2014","journal-title":"Langenbeck's Arch Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0020","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ajem.2015.01.051","article-title":"Do not drown the patient: appropriate fluid management in critical illness","volume":"33","author":"Polderman","year":"2015","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0025","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2016.05.019_bb0030","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/cc9982","article-title":"Medical pre-hospital management reduces mortality in severe blunt trauma: a prospective epidemiological study","volume":"15","author":"Yeguiayan","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2016.05.019_bb0035","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0140-6736(12)61224-0","article-title":"Haemorrhage control in severely injured patients","volume":"380","author":"Gruen","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ajem.2016.05.019_bb0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/TA.0b013e3182987df3","article-title":"Diluting the benefits of hemostatic resuscitation: a multi-institutional analysis","volume":"75","author":"Duchesne","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0045","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1001\/jamasurg.2013.2911","article-title":"A paradigm shift in trauma resuscitation: evaluation of evolving massive transfusion practices","volume":"148","author":"Kutcher","year":"2013","journal-title":"JAMA Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0050","first-page":"307","article-title":"Damage control resuscitation: directly addressing the early coagulopathy of trauma","volume":"62","author":"Holcomb","year":"2007","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2016.05.019_bb0055","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/TA.0000000000000514","article-title":"Damage-control resuscitation increases successful nonoperative management rates and survival after severe blunt liver injury","volume":"78","author":"Shrestha","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0060","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ajem.2005.03.015","article-title":"Fluid resuscitation of trauma patients: how fast is the optimal rate?","volume":"23","author":"Mizushima","year":"2005","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0065","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1186\/cc12685","article-title":"Management of bleeding and coagulopathy following major trauma: an updated European guideline","volume":"17","author":"Spahn","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2016.05.019_bb0070","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00003643-199807000-00008","article-title":"Volume effect of Ringer's solution in the blood during general anaesthesia","volume":"15","author":"Hahn","year":"1998","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.ajem.2016.05.019_bb0075","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1399-6576.2007.01351.x","article-title":"The kinetics of Ringer's solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine","volume":"51","author":"Li","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ajem.2016.05.019_bb0080","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/ALN.0b013e3181dcd88f","article-title":"Volume kinetics for infusion fluids","volume":"113","author":"Hahn","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ajem.2016.05.019_bb0085","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/bja\/aem165","article-title":"Crystalloid infusion rate during fluid resuscitation from acute haemorrhage","volume":"99","author":"Tatara","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ajem.2016.05.019_bb0090","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/ALN.0b013e3181863117","article-title":"A rational approach to perioperative fluid management","volume":"109","author":"Chappell","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ajem.2016.05.019_bb0095","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/01.shk.0000168872.37660.d2","article-title":"Benefit of slow infusion of hypertonic saline\/dextran in swine with uncontrolled aortotomy hemorrhage","volume":"24","author":"Bruttig","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2016.05.019_bb0100","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00024382-200014060-00008","article-title":"Comparison of the effects of bolus vs. slow infusion of 7.5% NaCl\/6% dextran-70 in a model of near-lethal uncontrolled hemorrhage","volume":"14","author":"Stern","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2016.05.019_bb0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00005373-199901000-00005","article-title":"Do different rates of fluid resuscitation adversely or beneficially influence immune responses after trauma-hemorrhage?","volume":"46","author":"Knoferl","year":"1999","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2016.05.019_bb0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00000658-199208000-00007","article-title":"Saline resuscitation after fixed-volume hemorrhage. Role of resuscitation volume and rate of infusion","volume":"216","author":"Lilly","year":"1992","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0115","doi-asserted-by":"crossref","first-page":"f839","DOI":"10.1136\/bmj.f839","article-title":"Hydroxyethyl starch 130\/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis","volume":"346","author":"Haase","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.ajem.2016.05.019_bb0120","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jama.2013.430","article-title":"Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis","volume":"309","author":"Zarychanski","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2016.05.019_bb0125","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/bja\/aet375","article-title":"Does the type of fluid affect rapidity of shock reversal in an anaesthetized-piglet model of near-fatal controlled haemorrhage? A randomized study","volume":"112","author":"Roger","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ajem.2016.05.019_bb0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13054-015-0833-9","article-title":"Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-analysis of randomized controlled trials","volume":"19","author":"He","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2016.05.019_bb0135","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1001\/jama.2013.280502","article-title":"Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial","volume":"310","author":"Annane","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2016.05.019_bb0140","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/bja\/aer229","article-title":"Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)","volume":"107","author":"James","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ajem.2016.05.019_bb0145","first-page":"S159","article-title":"Effects of crystalloid and colloid resuscitation on hemorrhage-induced vascular hyporesponsiveness to norepinephrine in the rat","volume":"54","author":"Liu","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2016.05.019_bb0150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1399-6576.2004.00561.x","article-title":"Bolus injection of Ringer's solution and dextran 1 kDa during induction of spinal anesthesia","volume":"49","author":"Ewaldsson","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ajem.2016.05.019_bb0155","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/01.shk.0000239772.18151.18","article-title":"Post-traumatic hypotension: should systolic blood pressure of 90-109 mmHg be included?","volume":"27","author":"Edelman","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2016.05.019_bb0160","first-page":"291","article-title":"Hypotension begins at 110 mm Hg: redefining \"hypotension\" with data","volume":"63","author":"Eastridge","year":"2007","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2016.05.019_bb0165","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","article-title":"Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine","volume":"40","author":"Cecconi","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0170","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199410273311701","article-title":"Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries","volume":"331","author":"Bickell","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0175","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0196-0644(05)80195-7","article-title":"Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury","volume":"22","author":"Stern","year":"1993","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0180","first-page":"49","article-title":"Improved outcome with fluid restriction in treatment of uncontrolled hemorrhagic shock","volume":"180","author":"Capone","year":"1995","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.ajem.2016.05.019_bb0185","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.shk.0000135255.59817.8c","article-title":"Hypotensive resuscitation of multiple hemorrhages using crystalloid and colloids","volume":"22","author":"Rafie","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2016.05.019_bb0190","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/01.CCM.0000207341.78696.3A","article-title":"Normotensive and hypotensive closed-loop resuscitation using 3.0% NaCl to treat multiple hemorrhages in sheep","volume":"34","author":"Vaid","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0195","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1553-2712.2008.00202.x","article-title":"Eight hours of hypotensive versus normotensive resuscitation in a porcine model of controlled hemorrhagic shock","volume":"15","author":"Skarda","year":"2008","journal-title":"Acad Emerg Med Off J Soc Acad Emerg Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0200","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00005373-199902000-00003","article-title":"Controlled resuscitation for uncontrolled hemorrhagic shock","volume":"46","author":"Burris","year":"1999","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2016.05.019_bb0205","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/01.TA.0000062968.69867.6F","article-title":"Fluid resuscitation strategies: a systematic review of animal trials","volume":"55","author":"Mapstone","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2016.05.019_bb0210","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/00000542-200409000-00015","article-title":"Elimination rate constant describing clearance of infused fluid from plasma is independent of large infusion volumes of 0.9% saline in sheep","volume":"101","author":"Svensen","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ajem.2016.05.019_bb0215","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/00000542-200110000-00011","article-title":"Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy","volume":"95","author":"Rehm","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ajem.2016.05.019_bb0220","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/CCM.0b013e318274157e","article-title":"Importance of the infusion rate for the plasma expanding effect of 5% albumin, 6% HES 130\/0.4, 4% gelatin, and 0.9% NaCl in the septic rat","volume":"41","author":"Bark","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2016.05.019_bb0225","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/aas.12228","article-title":"Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig","volume":"58","author":"Bark","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ajem.2016.05.019_bb0230","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1399-6576.1987.tb02623.x","article-title":"A haemoglobin dilution method (HDM) for estimation of blood volume variations during transurethral prostatic surgery","volume":"31","author":"Hahn","year":"1987","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ajem.2016.05.019_bb0235","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/bja\/78.2.144","article-title":"Volume kinetics of Ringer's solution in female volunteers","volume":"78","author":"Hahn","year":"1997","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ajem.2016.05.019_bb0240","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00134-004-2481-4","article-title":"Plasma volume measurement in septic patients using an albumin dilution technique: comparison with the standard radio-labelled albumin method","volume":"31","author":"Margarson","year":"2005","journal-title":"Intensive Care Med"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675716301280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675716301280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:31:28Z","timestamp":1760023888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675716301280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0735675716301280"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2016.05.019","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does the infusion rate of fluid affect rapidity of mean arterial pressure restoration during controlled hemorrhage","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2016.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}