{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:54:17Z","timestamp":1775282057828,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ajem.2016.05.045","type":"journal-article","created":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T15:49:13Z","timestamp":1463932153000},"page":"1556-1560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcome of nonsurgical intervention in patients with perforated peptic ulcers"],"prefix":"10.1016","volume":"34","author":[{"given":"Ping-Lien","family":"Lay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Hung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Kuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Yuan","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien-Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan-Hwai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2016.05.045_bb0005","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1056\/NEJM197508212930802","article-title":"Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer","volume":"293","author":"Henn","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2016.05.045_bb0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/290159a0","article-title":"Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase","volume":"290","author":"Fellenius","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.ajem.2016.05.045_bb0015","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","article-title":"Peptic ulcer disease","volume":"374","author":"Malfertheiner","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ajem.2016.05.045_bb0020","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Marshall","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.ajem.2016.05.045_bb0025","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1056\/NEJM199302043280503","article-title":"Effect of ranitidine and amoxicillin plus metronidazole on the eradication of helicobacter pylori and the recurrence of duodenal ulcer","volume":"328","author":"Hentschel","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2016.05.045_bb0030","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/j.1365-2036.2009.04131.x","article-title":"Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005","volume":"30","author":"Cai","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ajem.2016.05.045_bb0035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1440-1746.2006.04500.x","article-title":"Factors affecting mortality and morbidity in patients with peptic ulcer perforation","volume":"22","author":"Kocer","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajem.2016.05.045_bb0040","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s002689910045","article-title":"Trends in perforated peptic ulcer: incidence, etiology, treatment, and prognosis","volume":"24","author":"Svanes","year":"2000","journal-title":"World J Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0045","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1136\/gut.34.12.1666","article-title":"Perforated peptic ulcer over 56years. Time trends in patients and disease characteristics","volume":"34","author":"Svanes","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.ajem.2016.05.045_bb0050","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/gut.50.4.460","article-title":"Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects","volume":"50","author":"Higham","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.ajem.2016.05.045_bb0055","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.dld.2003.10.011","article-title":"Helicobacter pylori and perforated peptic ulcer prevalence of the infection and role of non-steroidal anti-inflammatory drugs","volume":"36","author":"Gisbert","year":"2004","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.ajem.2016.05.045_bb0060","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/archsurg.140.2.201","article-title":"Management of complicated peptic ulcer disease","volume":"140","author":"Behrman","year":"2005","journal-title":"Arch Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00268-008-9796-1","article-title":"Perforated peptic ulcer: clinical presentation, surgical outcomes, and the accuracy of the Boey scoring system in predicting postoperative morbidity and mortality","volume":"33","author":"Lohsiriwat","year":"2009","journal-title":"World J Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0070","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/00365520802307997","article-title":"Perforated peptic ulcer: how to improve outcome?","volume":"44","author":"Moller","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.ajem.2016.05.045_bb0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000264653","article-title":"Perforated peptic ulcer disease: a review of history and treatment","volume":"27","author":"Bertleff","year":"2010","journal-title":"Dig Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0080","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/bmj.2.4485.941-a","article-title":"Conservative treatment of acute perforated peptic ulcer","volume":"2","author":"Visick","year":"1946","journal-title":"Br Med J"},{"key":"10.1016\/j.ajem.2016.05.045_bb0085","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF02944352","article-title":"Non-operative management of perforated duodenal ulcer","volume":"168","author":"Gul","year":"1999","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.ajem.2016.05.045_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2482-4-1","article-title":"Non-operative treatment for perforated gastro-duodenal peptic ulcer in Duchenne muscular dystrophy: a case report","volume":"4","author":"Brinkman","year":"2004","journal-title":"BMC Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4414\/smw.2007.11796","article-title":"Results of conservative treatment for perforated gastroduodenal ulcers in patients not eligible for surgical repair","volume":"137","author":"Bucher","year":"2007","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.ajem.2016.05.045_bb0100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(46)90971-3","article-title":"Perforated peptic ulcer; treated without operation","volume":"2","author":"Taylor","year":"1946","journal-title":"Lancet"},{"key":"10.1016\/j.ajem.2016.05.045_bb0105","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1056\/NEJM198904133201504","article-title":"A randomized trial of nonoperative treatment for perforated peptic ulcer","volume":"320","author":"Crofts","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2016.05.045_bb0110","first-page":"263","article-title":"Treatment and mortality of perforated peptic ulcer: a survey of 852 cases","volume":"105","author":"Cohen","year":"1971","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.ajem.2016.05.045_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00000658-198701000-00005","article-title":"Risk stratification in perforated duodenal ulcers. A prospective validation of predictive factors","volume":"205","author":"Boey","year":"1987","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0120","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11845-010-0515-1","article-title":"Mortality in perforated duodenal ulcer depends upon pre-operative risk: a retrospective 10-year study","volume":"179","author":"Larkin","year":"2010","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.ajem.2016.05.045_bb0125","first-page":"47","article-title":"Simplify the technique of nasoenteric feeding tube placement with a modified suture tie","volume":"39","author":"Chang","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.ajem.2016.05.045_bb0130","first-page":"52","article-title":"Transpyloric tube feeding for 506 consecutive patients with delayed gastric emptying","volume":"17","author":"Lin","year":"2006","journal-title":"J Intern Med Taiwan"},{"key":"10.1016\/j.ajem.2016.05.045_bb0135","series-title":"Clinical gastrointestinal endoscopy","author":"Ginsberg","year":"2011"},{"key":"10.1016\/j.ajem.2016.05.045_bb0140","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1001\/archsurg.133.11.1166","article-title":"Perforated duodenal ulcer: an alternative therapeutic plan","volume":"133","author":"Donovan","year":"1998","journal-title":"Arch Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0145","first-page":"519","article-title":"Perforated peptic ulcer","volume":"96","author":"Devitt","year":"1967","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.ajem.2016.05.045_bb0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/1947-2714.92902","article-title":"Perforated duodenal ulcer in high risk patients: is percutaneous drainage justified?","volume":"4","author":"Saber","year":"2012","journal-title":"N Am J Med Sci"},{"key":"10.1016\/j.ajem.2016.05.045_bb0155","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/2141-9248.126604","article-title":"An overview of history, pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults","volume":"4","author":"Prabhu","year":"2014","journal-title":"Ann Med Health Sci Res"},{"key":"10.1016\/j.ajem.2016.05.045_bb0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jcu.10125","article-title":"Sonographic diagnosis and successful nonoperative management of sealed perforated duodenal ulcer","volume":"31","author":"Fujii","year":"2003","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.ajem.2016.05.045_bb0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s004230050250","article-title":"Surgical management of peptic ulcer disease today\u2014indication, technique and outcome","volume":"385","author":"Zittel","year":"2000","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0170","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.amjsurg.2003.09.005","article-title":"A two institution experience with 226 endoscopically placed jejunal feeding tubes in critically ill surgical patients","volume":"186","author":"Nicholas","year":"2003","journal-title":"Am J Surg"},{"key":"10.1016\/j.ajem.2016.05.045_bb0175","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1097\/00003246-200112000-00005","article-title":"Early enteral nutrition in acutely ill patients: a systematic review","volume":"29","author":"Marik","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2016.05.045_bb0180","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00101-010-1800-0","article-title":"Enteral feeding tubes for critically ill patients","volume":"60","author":"Braun","year":"2011","journal-title":"Anaesthesist"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675716301784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675716301784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:33:21Z","timestamp":1760024001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675716301784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0735675716301784"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2016.05.045","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcome of nonsurgical intervention in patients with perforated peptic ulcers","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2016.05.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}