{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:59:42Z","timestamp":1770508782651,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Health and Family Planning Commission of PRC","award":["WKJ-ZJ-1601"],"award-info":[{"award-number":["WKJ-ZJ-1601"]}]},{"name":"Zhejiang medical and health science and technology plan project","award":["2017KY182"],"award-info":[{"award-number":["2017KY182"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.ajem.2017.03.027","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T22:40:38Z","timestamp":1489444838000},"page":"1136-1141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Persistent hyperlactatemia-high central venous-arterial carbon dioxide to arterial-venous oxygen content ratio is associated with poor outcomes in early resuscitation of septic shock"],"prefix":"10.1016","volume":"35","author":[{"given":"Juandi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-8441","authenticated-orcid":false,"given":"Jia","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-2867","authenticated-orcid":false,"given":"Shijin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2017.03.027_bb0005","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0010","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1097\/ALN.0b013e318273349d","article-title":"Prognostic significance of blood lactate and lactate clearance in trauma patients","volume":"117","author":"R\u00e9gnier","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ajem.2017.03.027_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/SHK.0b013e3181971d47","article-title":"Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis","volume":"32","author":"Arnold","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2017.03.027_bb0020","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1097\/CCM.0000000000000405","article-title":"Lactate clearance is a useful biomarker for the prediction of all-cause mortality in critically ill patients: a systematic review and meta-analysis","volume":"42","author":"Zhang","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","article-title":"Sepsis-associated hyperlactatemia","volume":"18","author":"Garcia-Alvarez","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2017.03.027_bb0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00134-003-1746-7","article-title":"Lactic acidosis","volume":"29","author":"De Backer","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0035","first-page":"E634","article-title":"Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver","volume":"250","author":"Vary","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajem.2017.03.027_bb0040","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1164\/ajrccm.157.4.9705037","article-title":"Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction","volume":"157","author":"Levraut","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0045","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00134-002-1215-8","article-title":"Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients","volume":"28","author":"Mekontso-Dessap","year":"2002","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0050","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"43","author":"Hanley","year":"1982","journal-title":"Radiology"},{"issue":"1 Supp","key":"10.1016\/j.ajem.2017.03.027_bb0065","first-page":"II14","article-title":"Gas exchange theory and the lactic acidosis (anaerobic) threshold","volume":"81","author":"Wasserman","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.ajem.2017.03.027_bb0070","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","article-title":"Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine","volume":"40","author":"Cecconi","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.resp.2004.11.008","article-title":"Comparison of two methods to assess blood CO2 equilibration curve in mechanically ventilated patients","volume":"146","author":"Cavaliere","year":"2005","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.ajem.2017.03.027_bb0080","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1097\/CCM.0b013e318275cece","article-title":"Lactate and venoarterial carbon dioxide difference\/arterial-venous oxygen difference ratio, but not central venous oxygen saturation, predict increase in oxygen consumption in fluid responders","volume":"41","author":"Monnet","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0085","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13054-015-0858-0","article-title":"Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock","volume":"19","author":"Mesquida","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2017.03.027_bb0090","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s00134-016-4233-7","article-title":"Understanding the venous\u2013arterial CO2 to arterial\u2013venous O2 content difference ratio","volume":"42","author":"Ospina-Tasc\u00f3n","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0095","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/0310057X1204000307","article-title":"Lactate\/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock","volume":"40","author":"Rimachi","year":"2012","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.ajem.2017.03.027_bb0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jcrc.2015.10.017","article-title":"High central venous-to-arterial CO2 difference\/arterial-central venous O2 difference ratio is associated with poor lactate clearance in septic patients after resuscitation","volume":"31","author":"He","year":"2016","journal-title":"J Crit Care"},{"key":"10.1016\/j.ajem.2017.03.027_bb0105","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00134-015-3720-6","article-title":"Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock","volume":"41","author":"Ospina-Tascon","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jcrc.2016.04.023","article-title":"The venous-arterial CO2 to arterial-venous O2 content difference ratio: easy to monitor?","volume":"35","author":"Danin","year":"2016","journal-title":"J Crit Care"},{"key":"10.1016\/j.ajem.2017.03.027_bb0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13613-016-0110-3","article-title":"Ratios of central venous-to-arterial carbon dioxide content or tension to arteriovenous oxygen content are better markers of global anaerobic metabolism than lactate in septic shock patients","volume":"6","author":"Mallat","year":"2016","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.ajem.2017.03.027_bb0120","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1056\/NEJMoa1404380","article-title":"Goal directed resuscitation for patients with early septic shock","volume":"371","author":"The ARISE Investigators","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0125","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa1500896","article-title":"Trial of early, goal-directed resuscitation for septic shock","volume":"372","author":"Mouncey","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2017.03.027_bb0130","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000\u20132012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2017.03.027_bb0135","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/01.TA.0000107182.43213.4B","article-title":"Intramucosal-arterial PCO2 gradient does not reflect intestinal dysoxia in anemic hypoxia","volume":"57","author":"Dubin","year":"2004","journal-title":"J Trauma"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675717301900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675717301900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:35:38Z","timestamp":1760024138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675717301900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0735675717301900"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2017.03.027","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent hyperlactatemia-high central venous-arterial carbon dioxide to arterial-venous oxygen content ratio is associated with poor outcomes in early resuscitation of septic shock","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2017.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}