{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:26:36Z","timestamp":1793316396374,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ajem.2017.06.057","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T21:46:58Z","timestamp":1499204818000},"page":"38-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Coagulopathy as a predictor of mortality after penetrating traumatic brain injury"],"prefix":"10.1016","volume":"36","author":[{"given":"Lindley E.","family":"Folkerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan A.","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Holcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Tomasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2017.06.057_bb0005","series-title":"Traumatic brain injury in the United States: emergency department visits, hospitalizations and deaths, 2002\u20132006","author":"Faul","year":"2010"},{"issue":"2","key":"10.1016\/j.ajem.2017.06.057_bb0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/HTR.0b013e3181ccc8b4","article-title":"The epidemiology of traumatic brain injury","volume":"25","author":"Corrigan","year":"2010","journal-title":"J Head Trauma Rehabil"},{"issue":"2","key":"10.1016\/j.ajem.2017.06.057_bb0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.HTR.0000314531.30401.39","article-title":"Incidence of long-term disability following traumatic brain injury hospitalization in the United States","volume":"23","author":"Selassie","year":"2008","journal-title":"J Head Trauma Rehabil"},{"key":"10.1016\/j.ajem.2017.06.057_bb0020","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1080\/02699050010025768","article-title":"Early predictors of mortality in penetrating compared with closed brain injury","volume":"15","author":"Peek-Asa","year":"2001","journal-title":"Brain Inj"},{"key":"10.1016\/j.ajem.2017.06.057_bb0025","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jamcollsurg.2004.02.030","article-title":"Mortality prediction of head abbreviated injury score and Glasgow Coma Scale: analysis of 7764 head injuries","volume":"199","author":"Demetriades","year":"2004","journal-title":"J Am Coll Surg"},{"issue":"2","key":"10.1016\/j.ajem.2017.06.057_bb0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/02699052.2011.635363","article-title":"A clinical comparison of penetrating and blunt traumatic brain injuries","volume":"26","author":"Santiago","year":"2012","journal-title":"Brain Inj"},{"key":"10.1016\/j.ajem.2017.06.057_bb0035","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3171\/2014.5.JNS131872","article-title":"Predictors of outcome in civilians with gunshot wounds to the head upon presentation","volume":"121","author":"Gressot","year":"2014","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ajem.2017.06.057_bb0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0090-3019(03)00302-1","article-title":"Prognostic factors and treatment of penetrating gunshot wounds to the head","volume":"60","author":"Martins","year":"2003","journal-title":"Surg Neurol"},{"issue":"2","key":"10.1016\/j.ajem.2017.06.057_bb0045","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1227\/00006123-199202000-00002","article-title":"Delayed brain injury after head trauma: significance of coagulopathy","volume":"30","author":"Stein","year":"1992","journal-title":"Neurosurgery"},{"issue":"5","key":"10.1016\/j.ajem.2017.06.057_bb0050","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/MBC.0b013e3283464f53","article-title":"The prognostic value of thrombelastography in identifying neurosurgical patients with worse prognosis","volume":"22","author":"Windelov","year":"2011","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"3","key":"10.1016\/j.ajem.2017.06.057_bb0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/SLA.0b013e3182658180","article-title":"Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients","volume":"256","author":"Holcomb","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajem.2017.06.057_bb0060","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.amjsurg.2011.12.011","article-title":"Thrombelastography-identified coagulopathy is associated with increased morbidity and mortality after traumatic brain injury","volume":"203","author":"Kunio","year":"2012","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.ajem.2017.06.057_bb0065","first-page":"55","article-title":"Coagulopathy in severe traumatic brain injury: a prospective study","volume":"66","author":"Talving","year":"2009","journal-title":"J Trauma"},{"issue":"3","key":"10.1016\/j.ajem.2017.06.057_bb0070","first-page":"158","article-title":"Mechanistic determinates of the acute coagulopathy of trauma (ACoT) in patients requiring emergency surgery","volume":"2","author":"Sixta","year":"2012","journal-title":"Int J Burns Trauma"},{"issue":"6","key":"10.1016\/j.ajem.2017.06.057_bb0075","first-page":"680","article-title":"Acute coagulopathy of trauma: mechanism, identification and effect","volume":"13","author":"Brohi","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.ajem.2017.06.057_bb0080","series-title":"ACS TQIP best practices in the management of traumatic brain injury","author":"The American College of Surgeons Trauma Quality Improvement Program","year":"2015"},{"issue":"1","key":"10.1016\/j.ajem.2017.06.057_bb0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jamcollsurg.2013.08.018","article-title":"Improving survival rates after civilian gunshot wounds to the brain","volume":"218","author":"Joseph","year":"2014","journal-title":"J Am Coll Surg"},{"issue":"5","key":"10.1016\/j.ajem.2017.06.057_bb0090","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1227\/00006123-199011000-00005","article-title":"Civilian gunshot wounds to the head: a prospective study","volume":"27","author":"Grahm","year":"1990","journal-title":"Neurosurgery"},{"issue":"5","key":"10.1016\/j.ajem.2017.06.057_bb0095","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1227\/00006123-198605000-00003","article-title":"Civilian gunshot wounds to the brain: prognosis and management","volume":"18","author":"Nagib","year":"1986","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.ajem.2017.06.057_bb0100","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00005373-200002000-00017","article-title":"Similarities between civilian gunshot wounds to the head and nongunshot head injuries","volume":"48","author":"Valadka","year":"2000","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2017.06.057_bb0105","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0090-3019(92)90109-Z","article-title":"Predictors of mortality in severely head-injured patients with civilian gunshot wounds: a report from the NIH traumatic coma data bank","volume":"38","author":"Aldrich","year":"1992","journal-title":"Surg Neurol"},{"issue":"1","key":"10.1016\/j.ajem.2017.06.057_bb0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/TA.0b013e3182a9cc95","article-title":"Acquired coagulopathy of traumatic brain injury defined by routine laboratory tests: which laboratory values matter?","volume":"76","author":"Joseph","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"issue":"6","key":"10.1016\/j.ajem.2017.06.057_bb0115","first-page":"1254","article-title":"Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway","volume":"63","author":"Cohen","year":"2007","journal-title":"J Trauma"},{"issue":"1","key":"10.1016\/j.ajem.2017.06.057_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/TA.0000000000000255","article-title":"Traumatic brain injury is not associated with coagulopathy out of proportion to injury in other body regions","volume":"77","author":"Lee","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"issue":"10","key":"10.1016\/j.ajem.2017.06.057_bb0125","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1001\/archsurg.139.10.1066","article-title":"Outcome and prognostic factors in head injuries with an admission Glasgow coma scale score of 3","volume":"139","author":"Demetriades","year":"2004","journal-title":"Arch Surg"},{"issue":"3","key":"10.1016\/j.ajem.2017.06.057_bb0130","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2006.08.086","article-title":"Severity level and injury track determine outcome following a penetrating ballistic-like brain injury in the rat","volume":"408","author":"Williams","year":"2006","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.ajem.2017.06.057_bb0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12028-014-0026-4","article-title":"Traumatic brain injury associated coagulopathy","volume":"22","author":"de Oliveira Manoe","year":"2015","journal-title":"Neurocrit Care"},{"issue":"1","key":"10.1016\/j.ajem.2017.06.057_bb0140","doi-asserted-by":"crossref","DOI":"10.1186\/cc9399","article-title":"Acute and delayed mild coagulopathy are related to outcome in patients with isolated traumatic brain injury","volume":"15","author":"Greuters","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2017.06.057_bb0145","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1757-7241-17-45","article-title":"Thrombelastography and thromboelastometry in assessing coagulopathy in trauma","volume":"17","author":"Johansson","year":"2009","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"12","key":"10.1016\/j.ajem.2017.06.057_bb0150","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1111\/trf.12214","article-title":"Low hemorrhage-related mortality in trauma patients in a level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets","volume":"53","author":"Johansson","year":"2013","journal-title":"Transfusion"},{"issue":"2","key":"10.1016\/j.ajem.2017.06.057_bb0155","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/TA.0b013e31827e20e0","article-title":"TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients","volume":"74","author":"Tapia","year":"2013","journal-title":"J Trauma Acute Care Surg"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675717305089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675717305089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:37:29Z","timestamp":1760024249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675717305089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0735675717305089"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2017.06.057","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coagulopathy as a predictor of mortality after penetrating traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2017.06.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}