{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:50Z","timestamp":1791388790970,"version":"4.3.3"},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.ajem.2018.10.040","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T22:49:21Z","timestamp":1540075761000},"page":"376.e1-376.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Diabetic ketoacidosis induced by a single dose of pembrolizumab"],"prefix":"10.1016","volume":"37","author":[{"given":"Julian","family":"Maamari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Ching J.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Chaftari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2018.10.040_bb0005","series-title":"Keytruda (pembrolizumab) [prescribing information]","year":"2018"},{"issue":"7","key":"10.1016\/j.ajem.2018.10.040_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160221","article-title":"Adverse events associated with immune checkpoint blockade in patients with cancer: a systematic review of case reports","volume":"29;11","author":"Abdel-Wahab","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ajem.2018.10.040_bb0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/cen.13063","article-title":"Immune checkpoint inhibitor-related hypophysitis and endocrine dysfunction: clinical review","volume":"85","author":"Joshi","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"10.1016\/j.ajem.2018.10.040_bb0020","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.steroids.2011.02.026","article-title":"The reproductive endocrinology of the menopausal transition","volume":"76","author":"Butler","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.ajem.2018.10.040_bb0025","series-title":"Clinical physiology of acid-base and electrolyte disorders","first-page":"794","article-title":"Hyperosmolal states \u2013 hyperglycemia","author":"Rose","year":"2001"},{"issue":"1","key":"10.1016\/j.ajem.2018.10.040_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14740\/wjon1085w","article-title":"Autoimmune diabetes associated with pembrolizumab: a review of published case reports","volume":"9","author":"Cheema","year":"2018","journal-title":"World J Oncol"},{"key":"10.1016\/j.ajem.2018.10.040_bb0035","author":"US Food and Drug Administration"},{"key":"10.1016\/j.ajem.2018.10.040_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00561","article-title":"PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome","volume":"8","author":"Alsaab","year":"2017","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.ajem.2018.10.040_bb0045","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.2337\/dc14-2349","article-title":"Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy","volume":"38","author":"Hughes","year":"2015","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.ajem.2018.10.040_bb0050","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.2337\/dc15-1331","article-title":"Anti-PD1 pembrolizumab can induce exceptional fulminant type 1 diabetes","volume":"38","author":"Gaudy","year":"2015","journal-title":"Diabetes Care"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675718308544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675718308544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:43:49Z","timestamp":1760024629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675718308544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0735675718308544"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2018.10.040","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetic ketoacidosis induced by a single dose of pembrolizumab","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2018.10.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}