{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:32:41Z","timestamp":1783647161080,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54-GM104941"],"award-info":[{"award-number":["U54-GM104941"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ajem.2018.12.029","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:04:21Z","timestamp":1545102261000},"page":"1723-1728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of applying white blood cell cutoffs to non-diagnostic MRI and ultrasound studies for suspected pediatric appendicitis"],"prefix":"10.1016","volume":"37","author":[{"given":"Thomas M.","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabinda K.","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Caplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Schenker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"DePiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2018.12.029_bb0005","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/PEC.0000000000001049","article-title":"Current approach to the diagnosis and emergency department management of appendicitis in children","volume":"33","author":"Lipsett","year":"2017","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.ajem.2018.12.029_bb0010","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/acem.13181","article-title":"Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis","volume":"24","author":"Benabbas","year":"2017","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.ajem.2018.12.029_bb0015","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMra072149","article-title":"Computed tomography \u2013 an increasing source of radiation exposure","volume":"357","author":"Brenner","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ajem.2018.12.029_bb0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(12)60815-0","article-title":"Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study","volume":"380","author":"Pearce","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ajem.2018.12.029_bb0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/RUQ.0000000000000118","article-title":"ACR appropriateness criteria\u00ae right lower quadrant pain\u2013suspected appendicitis","volume":"31","author":"Smith","year":"2015","journal-title":"Ultrasound Q"},{"key":"10.1016\/j.ajem.2018.12.029_bb0030","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jpedsurg.2015.03.012","article-title":"The non-diagnostic ultrasound in appendicitis: is a non-visualized appendix the same as a negative study?","volume":"50","author":"Cohen","year":"2015","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ajem.2018.12.029_bb0035","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jamcollsurg.2015.01.039","article-title":"Use of white blood cell count and polymorphonuclear leukocyte differential to improve the predictive value of ultrasound for suspected appendicitis in children","volume":"220","author":"Anandalwar","year":"2015","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.ajem.2018.12.029_bb0040","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s00247-012-2412-4","article-title":"MRI for clinically suspected pediatric appendicitis: an implemented program","volume":"42","author":"Moore","year":"2012","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.ajem.2018.12.029_bb0045","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00261-014-0223-9","article-title":"Does abdominal pain duration affect the accuracy of first-line MRI for pediatric appendicitis?","volume":"40","author":"Koning","year":"2015","journal-title":"Abdom Imaging"},{"key":"10.1016\/j.ajem.2018.12.029_bb0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1148\/radiol.2015150468","article-title":"Accuracy of unenhanced MR imaging in the detection of acute appendicitis: single-institution clinical performance review","volume":"279","author":"Petkovska","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.ajem.2018.12.029_bb0055","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/acem.13180","article-title":"Magnetic resonance imaging versus ultrasound as the initial imaging modality for pediatric and young adult patients with suspected appendicitis","volume":"24","author":"Imler","year":"2017","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.ajem.2018.12.029_bb0060","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/acem.12374","article-title":"A simple clinical decision rule to rule out appendicitis in patients with nondiagnostic ultrasound results","volume":"21","author":"Leeuwenburgh","year":"2014","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.ajem.2018.12.029_bb0065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ajem.2017.07.005","article-title":"Predicting need for additional CT scan in children with a non-diagnostic ultrasound for appendicitis in the emergency department","volume":"36","author":"Nishizawa","year":"2018","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2018.12.029_bb0070","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.jpedsurg.2014.12.012","article-title":"An implemented MRI program to eliminate radiation from the evaluation of pediatric appendicitis","volume":"50","author":"Kulaylat","year":"2015","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ajem.2018.12.029_bb0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/acem.12873","article-title":"Accuracy of magnetic resonance imaging and ultrasound for appendicitis in diagnostic and nondiagnostic studies","volume":"23","author":"Kearl","year":"2016","journal-title":"Acad Emerg Med"},{"issue":"6","key":"10.1016\/j.ajem.2018.12.029_bb0080","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1053\/jpsu.2002.32893","article-title":"Pediatric appendicitis score","volume":"37","author":"Samuel","year":"2002","journal-title":"J Pediatr Surg"},{"issue":"4","key":"10.1016\/j.ajem.2018.12.029_bb0085","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jama.298.4.438","article-title":"Does this child have appendicitis?","volume":"298","author":"Bundy","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2018.12.029_bb0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ajem.2013.12.052","article-title":"Ultrasound evaluation of appendicitis: the importance of the 3\u202f\u00d7\u202f2 table for outcome reporting","volume":"32","author":"Fedko","year":"2014","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2018.12.029_bb0095","doi-asserted-by":"crossref","first-page":"e6717","DOI":"10.1136\/bmj.e6717","article-title":"Use of 3\u202f\u00d7\u202f2 tables with an intention to diagnose approach to assess clinical performance of diagnostic tests: meta-analytical evaluation of coronary CT angiography studies","volume":"345","author":"Schuetz","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.ajem.2018.12.029_bb0100","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1148\/radiol.2502080624","article-title":"Suspected appendicitis in children: diagnostic importance of normal abdominopelvic CT findings with nonvisualized appendix","volume":"250","author":"Garcia","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.ajem.2018.12.029_bb0105","doi-asserted-by":"crossref","first-page":"W543","DOI":"10.2214\/AJR.13.12093","article-title":"Value of gadolinium-enhanced MRI in detection of acute appendicitis in children and adolescents","volume":"203","author":"Rosines","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ajem.2018.12.029_bb0110","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2214\/AJR.15.14544","article-title":"A systematic review and meta-analysis of diagnostic performance of MRI for evaluation of acute appendicitis","volume":"206","author":"Duke","year":"2016","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ajem.2018.12.029_bb0115","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00247-016-3775-8","article-title":"Diagnostic utility of intravenous contrast for MR imaging in pediatric appendicitis","volume":"47","author":"Lyons","year":"2017","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.ajem.2018.12.029_bb0120","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s00247-016-3557-3","article-title":"Magnetic resonance imaging in pediatric appendicitis: a systematic review","volume":"46","author":"Moore","year":"2016","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.ajem.2018.12.029_bb0125","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.crad.2015.03.001","article-title":"Alternative diagnoses at paediatric appendicitis MRI","volume":"70","author":"Moore","year":"2015","journal-title":"Clin Radiol"},{"key":"10.1016\/j.ajem.2018.12.029_bb0130","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1542\/peds.2013-2128","article-title":"Ultrasonography\/MRI versus CT for diagnosing appendicitis","volume":"133","author":"Aspelund","year":"2014","journal-title":"Pediatrics"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675718309896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675718309896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:43:55Z","timestamp":1760024635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675718309896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0735675718309896"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2018.12.029","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utility of applying white blood cell cutoffs to non-diagnostic MRI and ultrasound studies for suspected pediatric appendicitis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2018.12.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}