{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:33:42Z","timestamp":1792100022836,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ajem.2019.04.015","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T10:41:11Z","timestamp":1554979271000},"page":"1139-1143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Factors associated with serious bacterial infections in infants \u226460\u202fdays with hypothermia in the emergency department"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-5726","authenticated-orcid":false,"given":"Sriram","family":"Ramgopal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne W.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Nowalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2019.04.015_bb0005","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2334-10-232","article-title":"Predicting sequelae and death after bacterial meningitis in childhood: a systematic review of prognostic studies","volume":"10","author":"de Jonge","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ajem.2019.04.015_bb0010","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-4381","article-title":"Validation of the \u201cstep-by-step\u201d approach in the management of young febrile infants","volume":"138","author":"Gomez","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajem.2019.04.015_bb0015","article-title":"A clinical prediction rule to identify febrile infants 60\u202fdays and younger at low risk for serious bacterial infections","author":"Kuppermann","year":"2019","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ajem.2019.04.015_bb0020","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/CCM.0000000000000940","article-title":"The presence of hypothermia within 24\u202fhours of sepsis diagnosis predicts persistent lymphopenia","volume":"43","author":"Drewry","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2019.04.015_bb0025","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2741\/1381","article-title":"Hypothermia in systemic inflammation: role of cytokines","volume":"9","author":"Leon","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.ajem.2019.04.015_bb0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.plefa.2005.10.004","article-title":"Inhibition of prostaglandins does not reduce the cardiovascular changes during endotoxemia in rats","volume":"74","author":"Azab","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.ajem.2019.04.015_bb0035","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s001340051237","article-title":"Hypothermia and cytokines in septic shock. Norasept II Study Investigators. North American study of the safety and efficacy of murine monoclonal antibody to tumor necrosis factor for the treatment of septic shock","volume":"26","author":"Marik","year":"2000","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2019.04.015_bb0040","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/archpedi.1984.02140430059015","article-title":"Infections in hypothermic infants younger than 3\u202fmonths old","volume":"138","author":"Dagan","year":"1984","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.ajem.2019.04.015_bb0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/bmj.1.5169.303","article-title":"Cold injury in the newborn. A study of 70 cases","volume":"1","author":"Bower","year":"1960","journal-title":"Br Med J"},{"key":"10.1016\/j.ajem.2019.04.015_bb0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/adc.58.2.143","article-title":"Infection in neonatal hypothermia","volume":"58","author":"El-Radhi","year":"1983","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ajem.2019.04.015_bb0055","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(63)90556-7","article-title":"Severe hypothermia in Glasgow infants in winter","volume":"2","author":"Arneil","year":"1963","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ajem.2019.04.015_bb0060","first-page":"1","article-title":"Hypothermia in young infants","author":"Perry","year":"2018","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.ajem.2019.04.015_bb0065","first-page":"1","article-title":"Hypothermia: a sign of sepsis in young infants in the emergency department?","author":"Kasmire","year":"2018","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.ajem.2019.04.015_bb0070","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1542\/hpeds.2017-0176","article-title":"Clinical characteristics and health outcomes of neonates reporting to the emergency department with hypothermia","volume":"8","author":"Wood","year":"2018","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.ajem.2019.04.015_bb0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International consensus conference on pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.ajem.2019.04.015_bb0080","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1442-200X.2012.03570.x","article-title":"Neonates presenting with temperature symptoms: role in the diagnosis of early onset sepsis","volume":"54","author":"Hofer","year":"2012","journal-title":"Pediatr Int"},{"key":"10.1016\/j.ajem.2019.04.015_bb0085","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jpeds.2013.09.049","article-title":"Hypothermia and early neonatal mortality in preterm infants","volume":"164","author":"de Almeida","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.ajem.2019.04.015_bb0090","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1542\/peds.2010-0479","article-title":"Febrile infants with urinary tract infections at very low risk for adverse events and bacteremia","volume":"126","author":"Schnadower","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajem.2019.04.015_bb0095","series-title":"Modern applied statistics with S","author":"Venebles","year":"2002"},{"key":"10.1016\/j.ajem.2019.04.015_bb0100","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1542\/peds.2014-1382","article-title":"Variation in care of the febrile young infant <90\u202fdays in US pediatric emergency departments","volume":"134","author":"Aronson","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajem.2019.04.015_bb0105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/INF.0000000000000225","article-title":"The changing epidemiology of serious bacterial infections in young infants","volume":"33","author":"Greenhow","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ajem.2019.04.015_bb0110","first-page":"52","article-title":"A clinical prediction rule for stratifying febrile infants 60\u202fdays and younger at risk for serious bacterial infections","volume":"297","author":"Kuppermann","year":"2019","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ajem.2019.04.015_bb0115","article-title":"Risk of serious bacterial infection in infants aged \u226460\u202fdays presenting to emergency departments with a history of fever only","author":"Ramgopal","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.ajem.2019.04.015_bb0120","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/INF.0000000000001632","article-title":"Serious bacterial infections in hospitalized febrile infants in the first and second months of life","volume":"36","author":"Carmon","year":"2017","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ajem.2019.04.015_bb0125","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/jp.2010.177","article-title":"Hypothermia in very low birth weight infants: distribution, risk factors and outcomes","volume":"31","author":"Miller","year":"2011","journal-title":"J Perinatol"},{"key":"10.1016\/j.ajem.2019.04.015_bb0130","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2017.2927","article-title":"Accuracy of complete blood cell counts to identify febrile infants 60\u202fdays or younger with invasive bacterial infections","volume":"171","author":"Cruz","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ajem.2019.04.015_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/2052-0492-1-9","article-title":"Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome","volume":"1","author":"Venkata","year":"2013","journal-title":"J Intensive Care"},{"key":"10.1016\/j.ajem.2019.04.015_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185581","article-title":"Thrombocytopenia in neonatal sepsis: incidence, severity and risk factors","volume":"12","author":"Ree","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ajem.2019.04.015_bb0145","series-title":"Nelson textbook of pediatrics","first-page":"629","article-title":"Infectious of the neonatal infant","author":"Stoll","year":"2011"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675719302359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675719302359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:43:23Z","timestamp":1760024603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675719302359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0735675719302359"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2019.04.015","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factors associated with serious bacterial infections in infants \u226460\u202fdays with hypothermia in the emergency department","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2019.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}