{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:13:07Z","timestamp":1760026387575,"version":"build-2065373602"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.ajem.2021.01.029","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:03:15Z","timestamp":1610931795000},"page":"101-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chloride in targeted temperature management: Where is the data?"],"prefix":"10.1016","volume":"42","author":[{"given":"Elizabeth","family":"Gamboa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Cervera-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Varon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ajem.2021.01.029_bb0005","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.ajem.2021.01.029_bb0010","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.resuscitation.2009.08.021","article-title":"Therapeutic hypothermia in cardiac arrest: 206 years later!","volume":"80","author":"Varon","year":"2009","journal-title":"Resuscitation"},{"issue":"5","key":"10.1016\/j.ajem.2021.01.029_bb0015","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1378\/chest.07-2190","article-title":"Therapeutic hypothermia: past, present, and future","volume":"133","author":"Varon","year":"2008","journal-title":"Chest."},{"issue":"6","key":"10.1016\/j.ajem.2021.01.029_bb0020","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1186\/cc13139","article-title":"Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function","volume":"17","author":"Polderman","year":"2013","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.ajem.2021.01.029_bb0025","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3171\/jns.2001.94.5.0697","article-title":"Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury","volume":"94","author":"Polderman","year":"2001","journal-title":"J Neurosurg"},{"issue":"6","key":"10.1016\/j.ajem.2021.01.029_bb0030","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1097\/00003246-200006000-00057","article-title":"Hypomagnesemia and ypophosphatemia at admission in patients with severe head injury","volume":"28","author":"Polderman","year":"2000","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ajem.2021.01.029_bb0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40635-018-0174-5","article-title":"Serum chloride levels in critical illness-the hidden story","volume":"6","author":"Pfortmueller","year":"2018","journal-title":"Intensive Care Med Exp"},{"issue":"7","key":"10.1016\/j.ajem.2021.01.029_bb0040","first-page":"38","article-title":"Hospital-acquired serum chloride derangements and associated in-hospital mortality","volume":"7","author":"Thongprayoon","year":"2020","journal-title":"Medicines (Basel)"},{"issue":"4","key":"10.1016\/j.ajem.2021.01.029_bb0045","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/cc9052","article-title":"Bench-to-bedside review: chloride in critical illness","volume":"14","author":"Yunos","year":"2010","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.ajem.2021.01.029_bb0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejim.2011.11.013","article-title":"Chloride: the queen of electrolytes?","volume":"23","author":"Berend","year":"2012","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ajem.2021.01.029_bb0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ajem.2021.01.027","article-title":"Usefulness of chloride levels for fluid resuscitation in patients undergoing targeted temperature management after cardiac arrest","volume":"43","author":"You","year":"2021","journal-title":"Am J Emerg Med"},{"issue":"1","key":"10.1016\/j.ajem.2021.01.029_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.coph.2006.11.005","article-title":"Altered chloride homeostasis in neurological disorders: a new target","volume":"7","author":"De Koninck","year":"2007","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"10.1016\/j.ajem.2021.01.029_bb0065","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/CIRCULATIONAHA.114.012805","article-title":"Endovascular versus external targeted temperature management for patients with out-of-hospital cardiac arrest: a randomized, controlled study","volume":"132","author":"Deye","year":"2015","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.ajem.2021.01.029_bb0070","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1089\/ther.2018.0044","article-title":"Targeted temperature management: quantifying the extent of serum electrolyte and blood glucose shifts in postcardiac arrest patients","volume":"10","author":"Xie","year":"2020","journal-title":"Ther Hypothermia Temp Manag"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675721000322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675721000322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:52:15Z","timestamp":1760025135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675721000322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":14,"alternative-id":["S0735675721000322"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2021.01.029","relation":{},"ISSN":["0735-6757"],"issn-type":[{"type":"print","value":"0735-6757"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chloride in targeted temperature management: Where is the data?","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2021.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2021.01.027","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}