{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:54:24Z","timestamp":1780412064086,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.ajem.2021.11.020","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T15:10:35Z","timestamp":1637334635000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Choice of intravenous thrombolysis therapy in patients with mild stroke complaining of acute dizziness"],"prefix":"10.1016","volume":"52","author":[{"given":"Tianming","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huadong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ajem.2021.11.020_bb0005","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4065\/83.7.765","article-title":"Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample","volume":"83","author":"Newman-Toker","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ajem.2021.11.020_bb0010","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3389\/fneur.2020.00822","article-title":"A prospective analysis of lesion-symptom relationships in acute vestibular and ocular motor stroke","volume":"11","author":"Zwergal","year":"2020","journal-title":"Front Neurol"},{"issue":"15","key":"10.1016\/j.ajem.2021.11.020_bb0015","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1212\/WNL.0000000000003814","article-title":"ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging: A meta-analysis","volume":"88","author":"Tarnutzer","year":"2017","journal-title":"Neurology."},{"issue":"5","key":"10.1016\/j.ajem.2021.11.020_bb0020","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000331046","article-title":"Dizziness in the emergency room: diagnoses and misdiagnoses","volume":"66","author":"Royl","year":"2011","journal-title":"Eur Neurol"},{"issue":"3","key":"10.1016\/j.ajem.2021.11.020_bb0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0733-8627(02)00012-3","article-title":"Stroke mimics and chameleons","volume":"20","author":"Huff","year":"2002","journal-title":"Emerg Med Clin North Am"},{"issue":"9558","key":"10.1016\/j.ajem.2021.11.020_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(07)60151-2","article-title":"Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison","volume":"369","author":"Chalela","year":"2007","journal-title":"Lancet."},{"issue":"3","key":"10.1016\/j.ajem.2021.11.020_bb0035","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/STROKEAHA.117.016979","article-title":"Diagnosing Stroke in Acute Dizziness and Vertigo: Pitfalls and Pearls","volume":"49","author":"Saber","year":"2018","journal-title":"Stroke."},{"key":"10.1016\/j.ajem.2021.11.020_bb0040","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/B978-0-444-53486-6.00046-6","article-title":"Vertigo and hearing loss","volume":"136","author":"Newman-Toker","year":"2016","journal-title":"Handb Clin Neurol"},{"issue":"2","key":"10.1016\/j.ajem.2021.11.020_bb0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1212\/WNL.0000000000000573","article-title":"Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms","volume":"83","author":"Saber","year":"2014","journal-title":"Neurology."},{"issue":"1","key":"10.1016\/j.ajem.2021.11.020_bb0050","doi-asserted-by":"crossref","DOI":"10.1177\/2396987321989865","article-title":"European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke","volume":"6","author":"Berge","year":"2021","journal-title":"Eur Stroke J"},{"issue":"12","key":"10.1016\/j.ajem.2021.11.020_bb0055","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1161\/STROKEAHA.119.027708","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke","volume":"50","author":"Warner","year":"2019","journal-title":"Stroke."},{"issue":"2","key":"10.1016\/j.ajem.2021.11.020_bb0060","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2018.8496","article-title":"Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits: The PRISMS randomized clinical trial","volume":"320","author":"Khatri","year":"2018","journal-title":"JAMA."},{"issue":"11","key":"10.1016\/j.ajem.2021.11.020_bb0065","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1161\/STROKEAHA.109.551234","article-title":"HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging","volume":"40","author":"Kattah","year":"2009","journal-title":"Stroke."},{"issue":"15","key":"10.1016\/j.ajem.2021.11.020_bb0070","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1212\/WNL.0000000000003198","article-title":"Why are acute ischemic stroke patients not receiving IV tPA? Results from a national registry","volume":"87","author":"Mess\u00e9","year":"2016","journal-title":"Neurology."},{"issue":"9","key":"10.1016\/j.ajem.2021.11.020_bb0075","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1161\/STROKEAHA.116.013644","article-title":"Effects of alteplase for acute stroke on the distribution of functional outcomes: A pooled analysis of 9 trials","volume":"47","author":"Lees","year":"2016","journal-title":"Stroke."},{"issue":"3","key":"10.1016\/j.ajem.2021.11.020_bb0080","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1001\/archneurol.2011.2083","article-title":"Symptoms and signs of posterior circulation ischemia in the new England medical center posterior circulation registry","volume":"69","author":"Searls","year":"2012","journal-title":"Arch Neurol"},{"issue":"2","key":"10.1016\/j.ajem.2021.11.020_bb0085","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1515\/dx-2013-0038","article-title":"Missed diagnosis of stroke in the emergency department: a cross-sectional analysis of a large population-based sample","volume":"1","author":"Newman-Toker","year":"2014","journal-title":"Diagnosis (Berl)"},{"issue":"4","key":"10.1016\/j.ajem.2021.11.020_bb0090","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/svn-2018-000160","article-title":"Use of HINTS in the acute vestibular syndrome. An overview","volume":"3","author":"Kattah","year":"2018","journal-title":"Stroke Vasc Neurol"},{"issue":"24 Pt 2","key":"10.1016\/j.ajem.2021.11.020_bb0095","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1212\/01.wnl.0000314685.01433.0d","article-title":"Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis","volume":"70","author":"Newman-Toker","year":"2008","journal-title":"Neurology."},{"issue":"4","key":"10.1016\/j.ajem.2021.11.020_bb0100","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/STROKEAHA.111.000033","article-title":"Quantitative video-oculography to help diagnose stroke in acute vertigo and dizziness: toward an ECG for the eyes","volume":"44","author":"Newman-Toker","year":"2013","journal-title":"Stroke."},{"issue":"6","key":"10.1016\/j.ajem.2021.11.020_bb0105","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1161\/STROKEAHA.120.032488","article-title":"Transient vestibular symptoms preceding posterior circulation stroke: a prospective multicenter study","volume":"52","author":"Kim","year":"2021","journal-title":"Stroke."},{"issue":"11","key":"10.1016\/j.ajem.2021.11.020_bb0110","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1161\/STROKEAHA.117.018132","article-title":"Association between onset-to-door time and clinical outcomes after ischemic stroke","volume":"48","author":"Matsuo","year":"2017","journal-title":"Stroke."}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675721009244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675721009244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:56:03Z","timestamp":1760025363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675721009244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":22,"alternative-id":["S0735675721009244"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2021.11.020","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Choice of intravenous thrombolysis therapy in patients with mild stroke complaining of acute dizziness","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2021.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}