{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:47:06Z","timestamp":1790700426268,"version":"4.1.0"},"reference-count":8,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ajem.2021.12.006","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T02:28:07Z","timestamp":1639016887000},"page":"172-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Initial fluid resuscitation in patients with septic shock: Is fluid expansion achievement the real objective?"],"prefix":"10.1016","volume":"57","author":[{"given":"Romain","family":"Jouffroy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papa","family":"Gueye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2021.12.006_bb0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajem.2021.08.016","article-title":"Initial fluid resuscitation (30 mL\/kg) in patients with septic shock: more or less?","volume":"50","author":"Wang","year":"2021","journal-title":"Am J Emerg Med"},{"issue":"8","key":"10.1016\/j.ajem.2021.12.006_bb0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.ajem.2021.12.006_bb0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.ajem.2021.12.006_bb0020","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00134-018-5085-0","article-title":"The surviving sepsis campaign bundle: 2018 update","volume":"44","author":"Levy","year":"2018","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.ajem.2021.12.006_bb0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/SHK.0000000000000268","article-title":"Fluid overload in patients with severe sepsis and septic shock treated with early goal-directed therapy is associated with increased acute need for fluid-related medical interventions and hospital death","volume":"43","author":"Kelm","year":"2015","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.ajem.2021.12.006_bb0030","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/CCM.0000000000002189","article-title":"Higher fluid balance increases the risk of death from sepsis: results from a large international audit","volume":"45","author":"Sakr","year":"2017","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.ajem.2021.12.006_bb0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ajem.2014.11.016","article-title":"Fluid balance in sepsis and septic shock as a determining factor of mortality","volume":"33","author":"Sirvent","year":"2015","journal-title":"Am J Emerg Med"},{"issue":"14","key":"10.1016\/j.ajem.2021.12.006_bb0040","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1056\/NEJMclde1815472","article-title":"Sepsis guidelines","volume":"380","author":"Chen","year":"2019","journal-title":"N Engl J Med"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675721009773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675721009773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:01:31Z","timestamp":1760025691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675721009773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":8,"alternative-id":["S0735675721009773"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2021.12.006","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Initial fluid resuscitation in patients with septic shock: Is fluid expansion achievement the real objective?","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2021.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}