{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T20:18:51Z","timestamp":1785615531039,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ajem.2022.05.026","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T13:42:42Z","timestamp":1652967762000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Oral Aspirin\/ketamine versus oral ketamine for emergency department patients with acute musculoskeletal pain"],"prefix":"10.1016","volume":"58","author":[{"given":"Louis","family":"Gerges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catsim","family":"Fassassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Barberan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Correa Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson","family":"Drapkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Likourezos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukhsana","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Niceforo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Gohel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Motov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2022.05.026_bb0005","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2147\/JPR.S137992","article-title":"Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department","volume":"10","author":"Mura","year":"2017","journal-title":"J Pain Res"},{"issue":"5","key":"10.1016\/j.ajem.2022.05.026_bb0010","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/pme.12668","article-title":"Pain management in the emergency chain: the use and effectiveness of pain management in patients with acute musculoskeletal pain","volume":"16","author":"Pierik","year":"2015","journal-title":"Pain Med"},{"issue":"9","key":"10.1016\/j.ajem.2022.05.026_bb0015","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.apmr.2008.04.009","article-title":"Standards of care for acute and chronic musculoskeletal pain: the bone and joint decade (2000\u22122010)","volume":"89","author":"Walsh","year":"2008","journal-title":"Arch Phys Med Rehabil"},{"issue":"5","key":"10.1016\/j.ajem.2022.05.026_bb0020","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1097\/BOT.0000000000001430","article-title":"Clinical practice guidelines for pain management in acute musculoskeletal injury","volume":"33","author":"Hsu","year":"2019","journal-title":"J Orthop Trauma"},{"issue":"5","key":"10.1016\/j.ajem.2022.05.026_bb0025","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jemermed.2018.01.020","article-title":"The treatment of acute pain in the emergency department: a white paper position statement prepared for the American Academy of emergency medicine","volume":"54","author":"Motov","year":"2018","journal-title":"J Emerg Med"},{"issue":"17","key":"10.1016\/j.ajem.2022.05.026_bb0030","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1001\/jama.2017.16190","article-title":"Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial","volume":"318","author":"Chang","year":"2017","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.annemergmed.2020.10.004","article-title":"A randomized trial comparing the efficacy of five oral analgesics for treatment of acute musculoskeletal extremity pain in the emergency department","volume":"77","author":"Bijur","year":"2021","journal-title":"Ann Emerg Med"},{"issue":"8","key":"10.1016\/j.ajem.2022.05.026_bb0040","article-title":"Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury","volume":"8","author":"Jones","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.ajem.2022.05.026_bb0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/0310057X9602400106","article-title":"Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine","volume":"24","author":"Gurnani","year":"1996","journal-title":"Anaesth Intensive Care"},{"issue":"2","key":"10.1016\/j.ajem.2022.05.026_bb0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.annemergmed.2018.03.027","article-title":"Feeling blocked? Another pain management tool in the emergency department","volume":"72","author":"Wilson","year":"2018","journal-title":"Ann Emerg Med"},{"issue":"2","key":"10.1016\/j.ajem.2022.05.026_bb0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ajem.2014.11.010","article-title":"The first 500: initial experience with widespread use of low-dose ketamine for acute pain management in the ED","volume":"33","author":"Ahern","year":"2015","journal-title":"Am J Emerg Med"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0060","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4103\/0259-1162.143110","article-title":"Ketamine: current applications in anesthesia, pain, and critical care","volume":"8","author":"Kurdi","year":"2014","journal-title":"Anesth Essays Res"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajem.2014.12.058","article-title":"Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial","volume":"33","author":"Miller","year":"2015","journal-title":"Am J Emerg Med"},{"issue":"11","key":"10.1016\/j.ajem.2022.05.026_bb0070","doi-asserted-by":"crossref","DOI":"10.1111\/acem.12510","article-title":"Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial","volume":"21","author":"Beaudoin","year":"2014","journal-title":"Acad Emerg Med"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.annemergmed.2015.03.004","article-title":"Intravenous subdissociative-dose ketamine versus morphine for analgesia in the emergency department: a randomized controlled trial","volume":"66","author":"Motov","year":"2015","journal-title":"Ann Emerg Med"},{"issue":"10","key":"10.1016\/j.ajem.2022.05.026_bb0080","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/acem.12229","article-title":"Intranasal ketamine for analgesia in the emergency department: a prospective observational series","volume":"20","author":"Andolfatto","year":"2013","journal-title":"Acad Emerg Med"},{"issue":"17","key":"10.1016\/j.ajem.2022.05.026_bb0085","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3390\/jcm10173978","article-title":"Efficacy and safety of intranasal ketamine for acute pain management in the emergency setting: a systematic review and meta-analysis","volume":"10","author":"Seak","year":"2021","journal-title":"J Clin Med"},{"issue":"6","key":"10.1016\/j.ajem.2022.05.026_bb0090","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.annemergmed.2021.04.031","article-title":"Comparison of nebulized ketamine at three different dosing regimens for treating painful conditions in the emergency department: a prospective, randomized, double-blind clinical trial","volume":"78","author":"Dove","year":"2021","journal-title":"Ann Emerg Med"},{"issue":"8","key":"10.1016\/j.ajem.2022.05.026_bb0095","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/bja\/53.8.805","article-title":"Pharmacokinetics and analgesic effects of i.m. and oral ketamine","volume":"53","author":"Grant","year":"1981","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/026921639601000309","article-title":"Ketamine injection used orally","volume":"10","author":"Broadley","year":"1996","journal-title":"Palliat Med"},{"issue":"5","key":"10.1016\/j.ajem.2022.05.026_bb0105","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ejpain.2009.09.005","article-title":"Use of oral ketamine in chronic pain management: a review","volume":"14","author":"Blonk","year":"2010","journal-title":"Eur J Pain"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0110","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/0897190019876497","article-title":"Oral administration of injectable ketamine during burn wound dressing changes","volume":"34","author":"Lintner","year":"2021","journal-title":"J Pharm Pract"},{"issue":"25","key":"10.1016\/j.ajem.2022.05.026_bb0115","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat New Biol"},{"key":"10.1016\/j.ajem.2022.05.026_bb0120","series-title":"Clinical pain management (acute pain)","first-page":"79","article-title":"Clinical pharmacology: traditional NSAIDs and selective COX-2 inhibitors","author":"Jones","year":"2008"},{"issue":"1","key":"10.1016\/j.ajem.2022.05.026_bb0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3940(03)00296-9","article-title":"Aspirin selectively augmented N-methyl-D-aspartate types of glutamate responses in cultured spiral ganglion neurons of mice","volume":"343","author":"Peng","year":"2003","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.ajem.2022.05.026_bb0130","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.ajem.2022.05.026_bb0135","first-page":"1","article-title":"Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat","volume":"103","author":"Bj\u00f6rkman","year":"1995","journal-title":"Acta Anaesthesiol Scand Suppl"},{"issue":"12 Suppl","key":"10.1016\/j.ajem.2022.05.026_bb0140","first-page":"20S","article-title":"Nonsteroidal antiinflammatory drug modulation of behavioral responses to intrathecal N-methyl-D-aspartate, but not to substance P and amino-methyl-isoxazole-propionic acid in the rat","volume":"36","author":"Bj\u00f6rkman","year":"1996","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.ajem.2022.05.026_bb0145","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41573-019-0019-2","article-title":"AMP-activated protein kinase: the current landscape for drug development","volume":"18","author":"Steinberg","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ajem.2022.05.026_bb0150","author":"Vitalis"},{"key":"10.1016\/j.ajem.2022.05.026_bb0155","author":"Schulz"},{"issue":"2","key":"10.1016\/j.ajem.2022.05.026_bb0160","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3959(94)00182-E","article-title":"Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia","volume":"61","author":"Eide Stubhaug","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.ajem.2022.05.026_bb0165","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1001\/jama.289.22.2983","article-title":"Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond agitation-sedation scale (RASS)","volume":"289","author":"Ely","year":"2003","journal-title":"JAMA"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675722003266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675722003266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:04:42Z","timestamp":1760025882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675722003266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":33,"alternative-id":["S0735675722003266"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2022.05.026","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral Aspirin\/ketamine versus oral ketamine for emergency department patients with acute musculoskeletal pain","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2022.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}