{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:40:56Z","timestamp":1771472456853,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ajem.2023.02.012","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:22:05Z","timestamp":1676391725000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Clinical factors predicting return emergency department visits in chemotherapy-induced febrile neutropenia patients"],"prefix":"10.1016","volume":"67","author":[{"given":"Sejin","family":"Heo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongman","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boram","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoung-Eun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taerim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Yeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Gun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Chul","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Uk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2023.02.012_bb0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hon.2040","article-title":"Risk factors associated with complications in patients with chemotherapy-induced febrile neutropenia in emergency department","volume":"31","author":"Lynn","year":"2013","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.ajem.2023.02.012_bb0010","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.annemergmed.2013.07.006","article-title":"Can we safely discharge low-risk patients with febrile neutropenia from the emergency department?","volume":"63","author":"Mamtani","year":"2014","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0015","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.ajem.2019.09.016","article-title":"CISNE versus MASCC: identifying low risk febrile neutropenic patients","volume":"38","author":"Mohindra","year":"2020","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0020","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/bjc.2011.284","article-title":"Prognostic evaluation of febrile neutropenia in apparently stable adult cancer patients","volume":"105","author":"Carmona-Bayonas","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajem.2023.02.012_bb0025","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1200\/JCO.2000.18.16.3038","article-title":"The multinational association for supportive care in cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients","volume":"18","author":"Klastersky","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajem.2023.02.012_bb0030","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.annemergmed.2016.11.007","article-title":"Application of the MASCC and CISNE risk-stratification scores to identify low-risk febrile neutropenic patients in the emergency department","volume":"69","author":"Coyne","year":"2017","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.102922","volume":"149","author":"Zheng","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ajem.2023.02.012_bb0040","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/1078155219896396","article-title":"Guideline adherence for the management of emergency department patients with febrile neutropenia and no infection source: is there room for improvement?","volume":"26","author":"Jansma","year":"2020","journal-title":"J Oncol Pharm Pract"},{"key":"10.1016\/j.ajem.2023.02.012_bb0045","first-page":"659","article-title":"Assessment of initial febrile neutropenia management in hospitalized cancer patients at a community cancer center","volume":"9","author":"Goldsmith","year":"2018","journal-title":"J Adv Pract Oncol"},{"key":"10.1016\/j.ajem.2023.02.012_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajem.2021.07.008","article-title":"Emergency department management of chemotherapy related febrile neutropenia: an opportunity to improve care","volume":"50","author":"Pettit","year":"2021","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/acem.13079","article-title":"Emergency department management of patients with febrile neutropenia: guideline concordant or overly aggressive?","volume":"24","author":"Baugh","year":"2017","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216835","article-title":"Near-universal hospitalization of US emergency department patients with cancer and febrile neutropenia","volume":"14","author":"Baugh","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ajem.2023.02.012_bb0065","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/emermed-2020-210282","article-title":"COVID-19: resetting ED care","volume":"37","author":"Boyle","year":"2020","journal-title":"Emerg Med J"},{"key":"10.1016\/j.ajem.2023.02.012_bb0070","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jgo.2020.06.021","article-title":"Older patients with cancer and febrile neutropenia in the COVID-19 era: a new concern","volume":"11","author":"Tralongo","year":"2020","journal-title":"J Geriatr Oncol"},{"key":"10.1016\/j.ajem.2023.02.012_bb0075","first-page":"1129","article-title":"Emerging challenges in the evaluation of fever in cancer patients at risk of febrile neutropenia in the era of COVID-19: a MASCC position paper","volume":"29","author":"Cooksley","year":"2021","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ajem.2023.02.012_bb0080","doi-asserted-by":"crossref","first-page":"750","DOI":"10.7326\/M14-1616","article-title":"Revisit rates and associated costs after an emergency department encounter: a multistate analysis","volume":"162","author":"Duseja","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0085","first-page":"20","article-title":"The association between emergency department revisit and elderly patients","volume":"10","author":"Guo","year":"2020","journal-title":"J Acute Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0090","doi-asserted-by":"crossref","DOI":"10.1097\/MEJ.0000000000000650","article-title":"Emergency department revisits: a nation-wide database analysis on the same and different hospital revisits","volume":"27","author":"Lu","year":"2020","journal-title":"Eur J Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0095","doi-asserted-by":"crossref","first-page":"750","DOI":"10.7326\/M14-1616","article-title":"Revisit rates and associated costs after an emergency department encounter","volume":"162","author":"Duseja","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/MEJ.0000000000000851","article-title":"Factors associated with a high-risk return visit to the emergency department: a case-crossover study","volume":"28","author":"Sung","year":"2021","journal-title":"Eur J Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0105","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.eimc.2015.06.005","article-title":"Management of infection and febrile neutropenia in patients with solid cancer","volume":"35","author":"Aguado","year":"2017","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.ajem.2023.02.012_bb0110","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3855\/jidc.12520","article-title":"Evaluation of risk factors for mortality in febrile neutropenia","volume":"14","author":"Ceken","year":"2020","journal-title":"J Infect Dev Ctries"},{"key":"10.1016\/j.ajem.2023.02.012_bb0115","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/jpc.15330","article-title":"Managing low-risk febrile neutropenia in children in the time of COVID-19: what matters to parents and clinicians","volume":"57","author":"Haeusler","year":"2021","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.ajem.2023.02.012_bb0120","first-page":"1151","article-title":"Predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia","volume":"19","author":"Ahn","year":"2011","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ajem.2023.02.012_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210019","article-title":"Validation of the clinical index of stable febrile neutropenia (CISNE) model in febrile neutropenia patients visiting the emergency department. Can it guide emergency physicians to a reasonable decision on outpatient vs. inpatient treatment?","volume":"13","author":"Moon","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ajem.2023.02.012_bb0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ajem.2005.02.029","article-title":"Shock index in diagnosing early acute hypovolemia","volume":"23","author":"Birkhahn","year":"2005","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.7326\/0003-4819-92-2-227","article-title":"Lactate homeostasis and lactic acidosis","volume":"92","author":"Kreisberg","year":"1980","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0140","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jpainsymman.2007.10.007","article-title":"Evaluation and management of treatment-related diarrhea in patients with advanced cancer: a review","volume":"36","author":"Cherny","year":"2008","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.ajem.2023.02.012_bb0145","first-page":"13","article-title":"Clinical and economic consequences of mucositis induced by chemotherapy and\/or radiation therapy","volume":"5","author":"Murphy","year":"2007","journal-title":"J Support Oncol"},{"key":"10.1016\/j.ajem.2023.02.012_bb0150","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1188\/21.ONF.242-256","article-title":"Nurse-delivered telephone intervention to reduce oral mucositis and prevent dehydration","volume":"48","author":"Ruegg","year":"2021","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.ajem.2023.02.012_bb0155","doi-asserted-by":"crossref","DOI":"10.1097\/CCM.0000000000005357","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0160","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.38596","article-title":"Association between implementation of the severe sepsis and septic shock early management bundle performance measure and outcomes in patients with suspected sepsis in US hospitals","volume":"4","author":"Rhee","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ajem.2023.02.012_bb0165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jcrc.2020.01.024","article-title":"Abnormal shock index exposure and clinical outcomes among critically ill patients: a retrospective cohort analysis","volume":"57","author":"Maheshwari","year":"2020","journal-title":"J Crit Care"},{"key":"10.1016\/j.ajem.2023.02.012_bb0170","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3233\/CBM-160336","article-title":"Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: interplay between hematologic and solid neoplastic clones and their microenvironments","volume":"19","author":"Ding","year":"2017","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.ajem.2023.02.012_bb0175","doi-asserted-by":"crossref","first-page":"220","DOI":"10.21037\/atm.2019.02.32","article-title":"Lactate and cancer: a \u201clactatic\u201d perspective on spinal tumor metabolism (part 1)","volume":"7","author":"Goodwin","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.ajem.2023.02.012_bb0180","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1158\/0008-5472.CAN-11-1457","article-title":"Lactate: a metabolic key player in cancer","volume":"71","author":"Hirschhaeuser","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajem.2023.02.012_bb0185","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/scd.1.1996.5.407","article-title":"Thrombocytopenia after high-dose chemotherapy and autologous stem cell transplantation: an unresolved problem and possible approaches to resolve it","volume":"5","author":"Hassan","year":"1996","journal-title":"J Hematother"},{"key":"10.1016\/j.ajem.2023.02.012_bb0190","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-3-030-20315-3_9","article-title":"Management of thrombocytopenia in cancer patients","volume":"179","author":"Mones","year":"2019","journal-title":"Cancer Treat Res"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675723000815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675723000815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:04:36Z","timestamp":1760025876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675723000815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":38,"alternative-id":["S0735675723000815"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2023.02.012","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical factors predicting return emergency department visits in chemotherapy-induced febrile neutropenia patients","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2023.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}