{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:38:34Z","timestamp":1778852314645,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01590"],"award-info":[{"award-number":["PI17\/01590"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010566","name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ajem.2023.09.003","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T01:20:54Z","timestamp":1694222454000},"page":"176-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effects of MIdazolam versus MOrphine in acute cardiogenic pulmonary edema and chronic obstructive pulmonary disease: An analysis of MIMO trial"],"prefix":"10.1016","volume":"73","author":[{"given":"Alberto","family":"Dom\u00ednguez-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hernandez-Vaquero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coral","family":"Suero-Mendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Burillo-PutzE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Calvo-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascual","family":"Pi\u00f1era-Salmeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Llorens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Mart\u00edn-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Abreu-Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2023.09.003_bb0005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.amjms.2019.09.011","article-title":"Cardiogenic Pulmonary Edema","volume":"358","author":"Dobbe","year":"2019","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.ajem.2023.09.003_bb0010","first-page":"85","article-title":"Current Spanish emergency department organization and clinical practices in caring for patients with acute heart failure","volume":"34","author":"Mir\u00f3","year":"2022","journal-title":"Emergencias."},{"key":"10.1016\/j.ajem.2023.09.003_bb0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","volume":"24","author":"Authors\/Task Force Members","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ajem.2023.09.003_bb0020","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/eurjhf\/hfn013","article-title":"Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiology","volume":"11","author":"Hawkins","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ajem.2023.09.003_bb0025","first-page":"171","article-title":"Chronic obstructive pulmonary disease and heart failure: a breathless conspiracy","volume":"40","author":"Pellicori","year":"2022","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.ajem.2023.09.003_bb0030","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccm.2019.02.006","article-title":"Clinical and physiologic implications of negative cardiopulmonary interactions in coexisting chronic obstructive pulmonary disease-heart failure","volume":"40","author":"Neder","year":"2019","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.ajem.2023.09.003_bb0035","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2147\/COPD.S242009","article-title":"Management of the COPD patient with comorbidities: An experts recommendation document","volume":"15","author":"Recio Iglesias","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.ajem.2023.09.003_bb0040","doi-asserted-by":"crossref","unstructured":"Dominguez-Rodriguez A, Burillo-Putze G, Garcia-Saiz MDM, Aldea-Perona A, Harmand MG, Mir\u00f2 O, Abreu-Gonzalez P; MIMO investigators. Study Design and Rationale of \u201cA Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema\u201d: MIMO Trial. Cardiovasc DrugsTher. 2017;31:209\u2013213.","DOI":"10.1007\/s10557-017-6722-5"},{"key":"10.1016\/j.ajem.2023.09.003_bb0045","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/ejhf.2602","article-title":"Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial","volume":"24","author":"Dom\u00ednguez-Rodr\u00edguez","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ajem.2023.09.003_bb0050","first-page":"25","article-title":"MIMO (MIdazolam versus MOrphine) Trial Investigators. Effects of midazolam versus morphine in patients with acute pulmonary edema with left ventricular systolic dysfunction: a secondary analysis of the MIMO trial","volume":"35","author":"Dom\u00ednguez-Rodr\u00edguez","year":"2023","journal-title":"Emergencias"},{"key":"10.1016\/j.ajem.2023.09.003_bb0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/bmj.2.5402.177","article-title":"Human experimentation code of ethics of the World Medical Association","volume":"2","author":"World Medical Association","year":"1964","journal-title":"Br Med J"},{"key":"10.1016\/j.ajem.2023.09.003_bb0060","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejim.2018.03.008","article-title":"Effects on short term outcome of non-invasive ventilation use in the emergency department to treat patients with acute heart failure: A propensity score-based analysis of the EAHFE Registry","volume":"53","author":"Mir\u00f3","year":"2018","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ajem.2023.09.003_bb0065","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00392-014-0708-0","article-title":"Differences in clinical characteristics, management and short-term outcome between acute heart failure patients chronic obstructive pulmonary disease and those without this co-morbidity","volume":"103","author":"Parissis","year":"2014","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.ajem.2023.09.003_bb0070","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ijcard.2016.11.013","article-title":"Impact of chronic obstructive pulmonary disease on clinical course after an episode of acute heart failure. EAHFE-COPD study","volume":"227","author":"Jacob","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ajem.2023.09.003_bb0075","first-page":"345","article-title":"Emergency department observation of patients with acute heart failure prior to hospital admission: impact on short-term prognosis","volume":"34","author":"L\u00f3pez D\u00edez","year":"2022","journal-title":"Emergencias."},{"key":"10.1016\/j.ajem.2023.09.003_bb0080","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00392-020-01710-0","article-title":"Factors associated with in-hospital mortality and adverse outcomes during the vulnerable post-discharge phase after the first episode of acute heart failure: results of the NOVICA-2 study","volume":"110","author":"Rizzi","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.ajem.2023.09.003_bb0085","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1378\/chest.14-0607","article-title":"Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study","volume":"147","author":"Fisher","year":"2015","journal-title":"Chest."},{"key":"10.1016\/j.ajem.2023.09.003_bb0090","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/emj.2007.050419","article-title":"Morphine and outcomes in acute decompensated heart failure: an ADHERE analysis","volume":"25","author":"Peacock","year":"2008","journal-title":"Emerg Med J"},{"key":"10.1016\/j.ajem.2023.09.003_bb0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/17482941.2011.575165","article-title":"Use of intravenous morphine for acute decompensated heart failure in patients with and without acute coronary syndromes","volume":"13","author":"Iakobishvili","year":"2011","journal-title":"Acute Card Care"},{"key":"10.1016\/j.ajem.2023.09.003_bb0100","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.chest.2017.03.037","article-title":"Morphine use in the ED and outcomes of patients with acute heart failure: a propensity score-matching analysis based on the EAHFE registry","volume":"152","author":"Mir\u00f3","year":"2017","journal-title":"Chest."},{"key":"10.1016\/j.ajem.2023.09.003_bb0105","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.medin.2016.05.007","article-title":"Influence of morphine treatment on in-hospital mortality among patients with acute heart failure","volume":"41","author":"Dominguez-Rodriguez","year":"2017","journal-title":"Med Intensiva"},{"key":"10.1016\/j.ajem.2023.09.003_bb0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijcard.2019.06.015","article-title":"Adverse dose-dependent effects of morphine therapy in acute heart failure","volume":"293","author":"Caspi","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ajem.2023.09.003_bb0115","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/clc.23691","article-title":"The safety of morphine in patients with acute heart failure: A systematic review and meta-analysis","volume":"44","author":"Zhang","year":"2021","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.ajem.2023.09.003_bb0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/FJC.0000000000000954","article-title":"the risk of mortality associated with opioid use in patients with acute heart failure: systematic review and meta-analysis","volume":"77","author":"Gao","year":"2021","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.ajem.2023.09.003_bb0125","doi-asserted-by":"crossref","DOI":"10.1177\/17539447221087587","article-title":"Impact of morphine use in acute cardiogenic pulmonary oedema on mortality outcomes: a systematic review and meta-analysis","volume":"16","author":"Witharana","year":"2022","journal-title":"Ther Adv Cardiovasc Dis"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675723004667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675723004667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:07:47Z","timestamp":1760026067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675723004667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":25,"alternative-id":["S0735675723004667"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2023.09.003","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of MIdazolam versus MOrphine in acute cardiogenic pulmonary edema and chronic obstructive pulmonary disease: An analysis of MIMO trial","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2023.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}