{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:28:57Z","timestamp":1785234537142,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ajem.2023.10.054","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T12:52:32Z","timestamp":1699102352000},"page":"36-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Prognosis of patients with extreme acidosis on admission to the emergency department: A retrospective cohort study"],"prefix":"10.1016","volume":"76","author":[{"given":"Amichai","family":"Gutgold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaden","family":"Salameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeries","family":"Nashashibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan","family":"Gershinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ajem.2023.10.054_bb0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/102490791201900103","article-title":"The incidence and types of acid-base imbalance for critically ill patients in emergency","volume":"19","author":"Song","year":"2012","journal-title":"Hong Kong J Emerg Med"},{"key":"10.1016\/j.ajem.2023.10.054_bb0010","series-title":"Irwin and Rippe\u2019s intensive care medicine","first-page":"1918","article-title":"No title","author":"Irwin","year":"2017"},{"issue":"1","key":"10.1016\/j.ajem.2023.10.054_bb0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5152\/jaem.2014.27880","article-title":"Acid-Base disorders in the emergency department: incidence, etiologies and outcomes","volume":"13","author":"Kose","year":"2014","journal-title":"J Acad Emerg Med"},{"issue":"5","key":"10.1016\/j.ajem.2023.10.054_bb0020","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrneph.2010.33","article-title":"Metabolic acidosis: pathophysiology, diagnosis and management","volume":"6","author":"Kraut","year":"2010","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"10.1016\/j.ajem.2023.10.054_bb0025","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jcrc.2013.11.007","article-title":"Severe acidosis does not predict fatal outcomes in intensive care unit patients: a retrospective analysis","volume":"29","author":"Paz","year":"2014","journal-title":"J Crit Care"},{"issue":"1","key":"10.1016\/j.ajem.2023.10.054_bb0030","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jcrc.2015.09.025","article-title":"Prognosis of patients presenting extreme acidosis (pH < 7) on admission to intensive care unit","volume":"31","author":"Allyn","year":"2016","journal-title":"J Crit Care"},{"issue":"4","key":"10.1016\/j.ajem.2023.10.054_bb0035","doi-asserted-by":"crossref","first-page":"238","DOI":"10.20408\/jti.2019.029","article-title":"Resuscitation from a pH of 6.5: a case report and review of pathophysiology and Management of Extreme Acidosis from hypovolemic shock after trauma","volume":"32","author":"Balmaceda","year":"2019","journal-title":"J Trauma Inj"},{"issue":"5","key":"10.1016\/j.ajem.2023.10.054_bb0040","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF03017217","article-title":"Survival with extreme lactic acidosis following ethylene glycol poisoning?","volume":"55","author":"Castanares-Zapatero","year":"2008","journal-title":"Can J Anesth"},{"key":"10.1016\/j.ajem.2023.10.054_bb0045","first-page":"2012","article-title":"Survival from profound metabolic acidosis due to hypovolaemic shock. A world record?","author":"Di Rollo","year":"2013","journal-title":"BMJ Case Rep"},{"issue":"8","key":"10.1016\/j.ajem.2023.10.054_bb0050","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00003246-199708000-00035","article-title":"Survival put to the acid test","volume":"25","author":"Opdahl","year":"1997","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ajem.2023.10.054_bb0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/1751143719870102","article-title":"Recovery from profound acidosis (pH 6.685) in multi-organ dysfunction syndrome","volume":"22","author":"Davies","year":"2021","journal-title":"J Intensive Care Soc"},{"issue":"9596","key":"10.1016\/j.ajem.2023.10.054_bb0060","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ajem.2023.10.054_bb0065","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4103\/ijccm.IJCCM_129_18","article-title":"Early pH change predicts intensive care unit mortality","volume":"22","author":"Samanta","year":"2018","journal-title":"Indian J Crit Care Med"},{"issue":"4","key":"10.1016\/j.ajem.2023.10.054_bb0070","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/j.jemermed.2020.06.007","article-title":"Acidemia detected on venous blood gas after out-of-hospital cardiac arrest predicts likelihood to survive to hospital discharge","volume":"59","author":"Carr","year":"2020","journal-title":"J Emerg Med"},{"issue":"1","key":"10.1016\/j.ajem.2023.10.054_bb0075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13054-020-2762-5","article-title":"Prognostic value of venous blood analysis at the start of CPR in non-traumatic out-of-hospital cardiac arrest: association with ROSC and the neurological outcome","volume":"24","author":"Corral Torres","year":"2020","journal-title":"Crit Care"},{"issue":"2016","key":"10.1016\/j.ajem.2023.10.054_bb0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.resuscitation.2016.06.013","article-title":"Arterial blood gases during and their dynamic changes after cardiopulmonary resuscitation: a prospective clinical study","volume":"106","author":"Spindelboeck","year":"2016","journal-title":"Resuscitation"},{"issue":"6","key":"10.1016\/j.ajem.2023.10.054_bb0085","doi-asserted-by":"crossref","first-page":"R303","DOI":"10.1186\/cc13173","article-title":"Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study","volume":"17","author":"Stengl","year":"2013","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.ajem.2023.10.054_bb0090","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/bja\/aen148","article-title":"Physiological effects of hyperchloraemia and acidosis","volume":"101","author":"Handy","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ajem.2023.10.054_bb0095","series-title":"Seldin and Giebisch\u2019s the kidney: physiology and pathophysiology","first-page":"1773","article-title":"No title","author":"Bevensee","year":"2012"},{"issue":"12","key":"10.1016\/j.ajem.2023.10.054_bb0100","doi-asserted-by":"crossref","first-page":"R1413","DOI":"10.1152\/ajpregu.00154.2014","article-title":"Effects of metabolic acidosis on intracellular pH responses in multiple cell types","volume":"307","author":"Salameh","year":"2014","journal-title":"Am J Physiol Integr Comp Physiol"},{"issue":"8","key":"10.1016\/j.ajem.2023.10.054_bb0105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4330\/wjc.v7.i8.483","article-title":"Clinical significance of lactate in acute cardiac patients","volume":"7","author":"Lazzeri","year":"2015","journal-title":"World J Cardiol"},{"issue":"13","key":"10.1016\/j.ajem.2023.10.054_bb0110","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jacc.2020.12.065","article-title":"Therapeutic potential of ketone bodies for patients with cardiovascular disease: JACC state-of-the-art review","volume":"77","author":"Yurista","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.ajem.2023.10.054_bb0115","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1097\/01.CCM.0000181525.99295.8F","article-title":"Lactate and glucose metabolism in severe sepsis and cardiogenic shock","volume":"33","author":"Revelly","year":"2005","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.ajem.2023.10.054_bb0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.hrtlng.2019.10.007","article-title":"Bicarbonate use and mortality outcome among critically ill patients with metabolic acidosis: a meta analysis","volume":"49","author":"Lo","year":"2020","journal-title":"Heart Lung"},{"issue":"9","key":"10.1016\/j.ajem.2023.10.054_bb0125","doi-asserted-by":"crossref","first-page":"E139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics\u20142020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ajem.2023.10.054_bb0130","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.annemergmed.2019.01.017","article-title":"Derivation and validation of the SWAP score for very early prediction of neurologic outcome in patients with out-of-hospital cardiac arrest","volume":"73","author":"Shih","year":"2019","journal-title":"Ann Emerg Med"},{"issue":"42","key":"10.1016\/j.ajem.2023.10.054_bb0135","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1093\/eurheartj\/ehv556","article-title":"The CAHP (cardiac arrest hospital prognosis) score: a tool for risk stratification after out-of-hospital cardiac arrest","volume":"37","author":"Maupain","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajem.2023.10.054_bb0140","article-title":"The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis","volume":"14","author":"K. F. and L. J.-D","year":"2013","journal-title":"BMC Pharmacol Toxicol"},{"issue":"3","key":"10.1016\/j.ajem.2023.10.054_bb0145","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3803\/EnM.2016.31.3.424","article-title":"Prognostic factors in patients hospitalized with diabetic ketoacidosis","volume":"31","author":"Agarwal","year":"2016","journal-title":"Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.ajem.2023.10.054_bb0150","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2265.2002.01636.x","article-title":"A mortality prediction model in diabetic ketoacidosis","volume":"57","author":"Efstathiou","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ajem.2023.10.054_bb0155","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/emj.2006.035915","article-title":"Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate","volume":"23","author":"Middleton","year":"2006","journal-title":"Emerg Med J"},{"issue":"8","key":"10.1016\/j.ajem.2023.10.054_bb0160","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/emj.2007.046979","article-title":"Comparison of arterial and venous pH, bicarbonate, PCO2 and PO2 in initial emergency department assessment","volume":"24","author":"Malatesha","year":"2007","journal-title":"Emerg Med J"},{"issue":"2","key":"10.1016\/j.ajem.2023.10.054_bb0165","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/resp.12225","article-title":"Peripheral venous and arterial blood gas analysis in adults: are they comparable? A systematic review and meta-analysis","volume":"19","author":"Byrne","year":"2014","journal-title":"Respirology"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073567572300606X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073567572300606X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:06:43Z","timestamp":1760026003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073567572300606X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":33,"alternative-id":["S073567572300606X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2023.10.054","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognosis of patients with extreme acidosis on admission to the emergency department: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2023.10.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}