{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:42:21Z","timestamp":1791222141072,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009587","name":"School of Veterinary Science, Shiraz University","doi-asserted-by":"publisher","award":["97GRC1M83836"],"award-info":[{"award-number":["97GRC1M83836"]}],"id":[{"id":"10.13039\/100009587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ajem.2024.06.009","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T09:37:47Z","timestamp":1718271467000},"page":"107-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Evaluation of effects of Tempol on testicular ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"82","author":[{"given":"Vahid","family":"Ganjiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolhamid","family":"Meimandi-Parizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrollah","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Sharifiyazdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Reza","family":"Divar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2024.06.009_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104563","article-title":"Nitroglycerin ameliorates sperm parameters, oxidative stress and testicular injury following by testicular torsion\/detorsion in male rats","volume":"117","author":"Raisi","year":"2020","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.ajem.2024.06.009_bb0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.theriogenology.2019.08.021","article-title":"Beneficial effects of dapsone on ischemia\/reperfusion injury following torsion\/detorsion in ipsilateral and contralateral testes in rat","volume":"140","author":"Dejban","year":"2019","journal-title":"Theriogenology"},{"issue":"6","key":"10.1016\/j.ajem.2024.06.009_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/and.14049","article-title":"Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion\/detorsion on testicular tissue in rats","volume":"53","author":"Taheri","year":"2021","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.ajem.2024.06.009_bb0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/2394-8108.195279","article-title":"Targeting oxidative stress for the treatment of ischemic stroke: upstream and downstream therapeutic strategies","volume":"2","author":"Li","year":"2016","journal-title":"Brain Circulat"},{"issue":"6","key":"10.1016\/j.ajem.2024.06.009_bb0025","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.jpurol.2013.03.008","article-title":"The effects of glutathione on malondialdehyde expression and seminiferous tubule damage in experimental testicular torsion\u2013detorsion in Wistar rats","volume":"9","author":"Bilommi","year":"2013","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.ajem.2024.06.009_bb0030","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1007\/s12035-021-02494-8","article-title":"Mitochondrial quality control in cerebral ischemia\u2013reperfusion injury","volume":"58","author":"Wu","year":"2021","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0035","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.0767-3981.2003.00211.x","article-title":"Effect of tempol (4-hydroxy tempo) on gentamicin-induced nephrotoxicity in rats","volume":"18","author":"Karata\u015f","year":"2004","journal-title":"Fundam Clin Pharmacol"},{"issue":"42","key":"10.1016\/j.ajem.2024.06.009_bb0040","doi-asserted-by":"crossref","first-page":"26026","DOI":"10.1074\/jbc.271.42.26026","article-title":"Do nitroxide antioxidants act as scavengers of O 2\u2212 or as SOD mimics?","volume":"271","author":"Krishna","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajem.2024.06.009_bb0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11010-015-2572-2","article-title":"Experimental evidence for the therapeutic potential of tempol in the treatment of acute liver injury","volume":"411","author":"Abouzied","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ajem.2024.06.009_bb0050","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s10571-015-0274-7","article-title":"Intrathecal administration of tempol reduces chronic constriction injury-induced neuropathic pain in rats by increasing SOD activity and inhibiting NGF expression","volume":"36","author":"Zhao","year":"2016","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"10.1016\/j.ajem.2024.06.009_bb0055","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1046\/j.1523-1755.2000.00212.x","article-title":"Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat","volume":"58","author":"Chatterjee","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajem.2024.06.009_bb0060","series-title":"Transplantation proceedings","first-page":"849","article-title":"Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat","volume":"36","author":"Sepodes","year":"2004"},{"issue":"4","key":"10.1016\/j.ajem.2024.06.009_bb0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3171\/jns.2000.92.4.0646","article-title":"Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia","volume":"92","author":"Rak","year":"2000","journal-title":"J Neurosurg"},{"issue":"5\u20136","key":"10.1016\/j.ajem.2024.06.009_bb0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0891-5849(99)00100-8","article-title":"Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion","volume":"27","author":"McDonald","year":"1999","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"10.1016\/j.ajem.2024.06.009_bb0075","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1096\/fj.06-6188fje","article-title":"Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia\/reperfusion injury","volume":"20","author":"McCormick","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.ajem.2024.06.009_bb0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s13105-010-0021-y","article-title":"Tempol protects the gallbladder against ischemia\/reperfusion","volume":"66","author":"Gomez-Pinilla","year":"2010","journal-title":"J Physiol Biochem"},{"issue":"7","key":"10.1016\/j.ajem.2024.06.009_bb0085","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1139\/cjpp-2016-0309","article-title":"Protective effects of tempol in an experimental ovarian ischemia\u2013reperfusion injury model in female Wistar albino rats","volume":"95","author":"P\u0131nar","year":"2017","journal-title":"Can J Physiol Pharmacol"},{"issue":"5","key":"10.1016\/j.ajem.2024.06.009_bb0090","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/gut.42.5.623","article-title":"Nitroxide radical attenuates ischaemia\/reperfusion injury to the rat small intestine","volume":"42","author":"Udassin","year":"1998","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.ajem.2024.06.009_bb0095","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1248\/bpb.28.641","article-title":"Tempol protects against ischemic acute renal failure by inhibiting renal noradrenaline overflow and endothelin-1 overproduction","volume":"28","author":"Fujii","year":"2005","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"10.1016\/j.ajem.2024.06.009_bb0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000443414","article-title":"Protective effect of tempol on acute kidney injury through PI3K\/Akt\/Nrf2 signaling pathway","volume":"41","author":"Zhang","year":"2016","journal-title":"Kidney Blood Press Res"},{"issue":"2","key":"10.1016\/j.ajem.2024.06.009_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/and.13469","article-title":"Protective effects of Stevia rebaudiana aqueous extract on experimental unilateral testicular ischaemia\/reperfusion injury in rats","volume":"52","author":"Ganjiani","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.ajem.2024.06.009_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.theriogenology.2021.07.021","article-title":"Protective effects of crocin on testicular torsion\/detorsion in rats","volume":"173","author":"Ganjiani","year":"2021","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.ajem.2024.06.009_bb0115","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0012-1606(90)90254-G","article-title":"Structural and functional relationships between mouse and hamster zona pellucida glycoproteins","volume":"137","author":"Moller","year":"1990","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0120","first-page":"18","article-title":"Ferulago angulata: a complementary therapy in testicular torsion\u2013detorsion damage","volume":"18","author":"Ganjiani","year":"2023","journal-title":"Iran J Veterin Surg"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000178170","article-title":"Testicular biopsy score count\u2013a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.ajem.2024.06.009_bb0130","first-page":"e14605","article-title":"The evaluation of citral effects on experimental unilateral testicular ischemia\/reperfusion injury","author":"Rezakhaniha","year":"2022","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.ajem.2024.06.009_bb0135","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1\u20133","key":"10.1016\/j.ajem.2024.06.009_bb0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2008.11.057","article-title":"TEMPOL, a membrane-permeable radical scavenger, attenuates gastric mucosal damage induced by ischemia\/reperfusion: a key role for superoxide anion","volume":"603","author":"Abdallah","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ajem.2024.06.009_bb0145","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.biopha.2018.03.147","article-title":"Ameliorating effects of tempol on methotrexate-induced liver injury in rats","volume":"102","author":"P\u0131nar","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"10.1016\/j.ajem.2024.06.009_bb0150","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.bcp.2005.04.011","article-title":"Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson\u2019s disease","volume":"70","author":"Liang","year":"2005","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0155","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/15569543.2017.1313277","article-title":"Hepatoprotective effect of tempol on oxidative toxic stress in STZ-induced diabetic rats","volume":"37","author":"Ghadermazi","year":"2018","journal-title":"Toxin Rev"},{"key":"10.1016\/j.ajem.2024.06.009_bb0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.lfs.2019.02.016","article-title":"Tempol improves oxidant\/antioxidant parameters in testicular tissues of diabetic rats","volume":"221","author":"Shateri","year":"2019","journal-title":"Life Sci"},{"issue":"5","key":"10.1016\/j.ajem.2024.06.009_bb0165","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.urology.2014.07.022","article-title":"Beneficial effect of nifedipine on testicular torsion-detorsion injury in rats","volume":"84","author":"Me\u0161trovi\u0107","year":"2014","journal-title":"Urology"},{"issue":"4","key":"10.1016\/j.ajem.2024.06.009_bb0170","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/2305-0500.262831","article-title":"Effect of hydro\u2013alcoholic extract of Olea europaea on apoptosis\u2013related genes and oxidative stress in a rat model of torsion\/detorsion\u2013induced ovarian damage","volume":"8","author":"Shokoohi","year":"2019","journal-title":"Asian Pacific J Reprod"},{"issue":"5","key":"10.1016\/j.ajem.2024.06.009_bb0175","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1095\/biolreprod63.5.1465","article-title":"Molecular pathway of germ cell apoptosis following ischemia\/reperfusion of the rat testis","volume":"63","author":"Lysiak","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajem.2024.06.009_bb0180","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3389\/fphys.2019.00660","article-title":"Tempol protects against acetaminophen induced acute hepatotoxicity by inhibiting oxidative stress and apoptosis","volume":"10","author":"Ge","year":"2019","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.ajem.2024.06.009_bb0185","first-page":"701","article-title":"Myricetin induces cell death of human colon cancer cells via BAX\/BCL2-dependent pathway","volume":"34","author":"Kim","year":"2014","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0190","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.brainres.2006.07.021","article-title":"Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment","volume":"1112","author":"Rog\u00e9rio","year":"2006","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.ajem.2024.06.009_bb0195","first-page":"1","article-title":"TEMPOL has limited protective effects on renal oxygenation and hemodynamics but reduces kidney damage and inflammation in a rat model of renal ischemia\/reperfusion by aortic clamping","volume":"1","author":"Ergin","year":"2015","journal-title":"J Clin Translat Research"},{"issue":"6","key":"10.1016\/j.ajem.2024.06.009_bb0200","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1439-0272.2010.01044.x","article-title":"Protective effects of quercetin on testicular torsion\/detorsion-induced ischaemia-reperfusion injury in rats","volume":"42","author":"Aktoz","year":"2010","journal-title":"Andrologia"},{"issue":"11","key":"10.1016\/j.ajem.2024.06.009_bb0205","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.4103\/njcp.njcp_218_16","article-title":"Intermittent testicular torsion","volume":"20","author":"Obi","year":"2017","journal-title":"Niger J Clin Pract"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0210","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1097\/00003246-200301001-00011","article-title":"Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation","volume":"31","author":"Thiemermann","year":"2003","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.ajem.2024.06.009_bb0215","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5534\/wjmh.190037","article-title":"The impact of testicular torsion on testicular function","volume":"38","author":"Jacobsen","year":"2020","journal-title":"World J Men\u2019s Health"},{"key":"10.1016\/j.ajem.2024.06.009_bb0220","series-title":"The effect of lactobacillus Casei and Lactobacillus Acidophilus probiotic isolates on the expression of BCL2, BAX and CASPASE3 genes in Wistar breeding rat Albindor to evaluate gamma irradiation induced apoptosis","author":"Changizi","year":"2020"},{"key":"10.1016\/j.ajem.2024.06.009_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41936-020-00146-2","article-title":"Toxicological effects of the concurrent administration of cadmium and arsenic through the food chain on the liver and kidney of rats","volume":"81","author":"Ezedom","year":"2020","journal-title":"J Basic Appl Zool"},{"issue":"3","key":"10.1016\/j.ajem.2024.06.009_bb0230","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s12640-019-00119-6","article-title":"Folic acid protects rat cerebellum against oxidative damage caused by homocysteine: the expression of Bcl-2, Bax, and Caspase-3 apoptotic genes","volume":"37","author":"Koohpeyma","year":"2020","journal-title":"Neurotox Res"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0235","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3892\/mmr.2015.3423","article-title":"All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.ajem.2024.06.009_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227599","article-title":"Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps","volume":"15","author":"Perrault","year":"2020","journal-title":"PLoS One"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675724002742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675724002742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T16:05:17Z","timestamp":1737734717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675724002742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":48,"alternative-id":["S0735675724002742"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2024.06.009","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of effects of Tempol on testicular ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2024.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}