{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:39:19Z","timestamp":1759883959318,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260385"],"award-info":[{"award-number":["82260385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["2023580"],"award-info":[{"award-number":["2023580"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"crossref","award":["gzwkj2022\\u2013103"],"award-info":[{"award-number":["gzwkj2022\\u2013103"]}],"id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Eagle Talent Project of Chongqing Emergency Medical Center","award":["SYRCCY20230312"],"award-info":[{"award-number":["SYRCCY20230312"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0873"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0873"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Project of Guizhou"},{"name":"Chongqing Key Laboratory of Emergency Medicine","award":["2023-KFKT-03"],"award-info":[{"award-number":["2023-KFKT-03"]}]},{"DOI":"10.13039\/100017501","name":"Science Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["2024ZDXM024"],"award-info":[{"award-number":["2024ZDXM024"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"General Project of the Chongqing Province Natural Science Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ajem.2025.06.010","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:58:40Z","timestamp":1749038320000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Age-leukocyte-international normalized ratio score (ALIS): A bedside triparametric tool for neurological prognostication in heat stroke emergencies"],"prefix":"10.1016","volume":"96","author":[{"given":"Fating","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haizhen","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanshu","family":"Que","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmu","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ajem.2025.06.010_bb0005","first-page":"482","article-title":"Heat-related illnesses","volume":"99","author":"Gauer","year":"2019","journal-title":"Am Fam Physician"},{"issue":"25","key":"10.1016\/j.ajem.2025.06.010_bb0010","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1056\/NEJMra011089","article-title":"Heat stroke","volume":"346","author":"Bouchama","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0015","first-page":"1","article-title":"Expert consensus on the diagnosis and treatment of heat stroke in China","volume":"7","author":"Liu","year":"2020","journal-title":"Mil Med Res"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0020","first-page":"5","article-title":"Research progress of heat stroke during 1989-2019: a bibliometric analysis","volume":"8","author":"Xia","year":"2021","journal-title":"Mil Med Res"},{"key":"10.1016\/j.ajem.2025.06.010_bb0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.resuscitation.2020.01.007","article-title":"First aid cooling techniques for heat stroke and exertional hyperthermia: a systematic review and meta-analysis","volume":"148","author":"Douma","year":"2020","journal-title":"Resuscitation"},{"key":"10.1016\/j.ajem.2025.06.010_bb0030","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2147\/JMDH.S428617","article-title":"Risk factor analysis and nomogram for predicting in-hospital mortality in ICU patients with heat stroke: a National Multicenter Study","volume":"16","author":"Wang","year":"2023","journal-title":"J Multidiscip Healthc"},{"issue":"8","key":"10.1016\/j.ajem.2025.06.010_bb0035","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.2215\/CJN.13841215","article-title":"Climate change and the emergent epidemic of CKD from heat stress in rural communities: the case for heat stress nephropathy","volume":"11","author":"Glaser","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"issue":"20","key":"10.1016\/j.ajem.2025.06.010_bb0040","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1001\/archinte.167.20.ioi70147","article-title":"Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon","volume":"167","author":"Argaud","year":"2007","journal-title":"France Arch Intern Med"},{"issue":"4","key":"10.1016\/j.ajem.2025.06.010_bb0045","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/01.CCM.0000206469.33615.02","article-title":"Mortality of patients with heatstroke admitted to intensive care units during the 2003 heat wave in France: a national multiple-center risk-factor study","volume":"34","author":"Misset","year":"2006","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.annemergmed.2024.07.013","article-title":"Heat stroke management updates: a description of the development of a novel in-emergency department cold-water immersion protocol and guide for implementation","volume":"85","author":"Comp","year":"2025","journal-title":"Ann Emerg Med"},{"issue":"8","key":"10.1016\/j.ajem.2025.06.010_bb0055","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.4103\/jfmpc.jfmpc_690_20","article-title":"Heat-related illness-clinical profile and predictors of outcome from a healthcare center in South India","volume":"9","author":"Ninan","year":"2020","journal-title":"J Family Med Prim Care"},{"issue":"4","key":"10.1016\/j.ajem.2025.06.010_bb0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.15441\/ceem.18.081","article-title":"Predictors of poor prognosis in patients with heat stroke","volume":"6","author":"Chun","year":"2019","journal-title":"Clin Exp Emerg Med"},{"issue":"2","key":"10.1016\/j.ajem.2025.06.010_bb0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1871530321666210122153249","article-title":"The relationship between 24-hour indicators and mortality in patients with exertional heat stroke","volume":"22","author":"Liu","year":"2022","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.ajem.2025.06.010_bb0070","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajem.2020.04.062","article-title":"The prognostic value of routine coagulation tests for patients with heat stroke","volume":"44","author":"Xing","year":"2021","journal-title":"Am J Emerg Med"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0075","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/SHK.0000000000001589","article-title":"Risk factors for the 90-day prognosis of severe heat stroke: a case-control study","volume":"55","author":"Zhong","year":"2021","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2025.06.010_bb0080","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ajem.2021.08.036","article-title":"The value of the exertional heat stroke score for the prognosis of patients with exertional heat stroke","volume":"50","author":"Li","year":"2021","journal-title":"Am J Emerg Med"},{"issue":"6","key":"10.1016\/j.ajem.2025.06.010_bb0085","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/ATVBAHA.107.158709","article-title":"Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model","volume":"28","author":"Roberts","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"10.1016\/j.ajem.2025.06.010_bb0090","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"2 Suppl","key":"10.1016\/j.ajem.2025.06.010_bb0095","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2025.06.010_bb0100","article-title":"Evaluation of a novel scoring system based on thrombosis and inflammation for predicting stroke-associated pneumonia: a retrospective cohort study","volume":"15","author":"Li","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-021-00334-6","article-title":"Classic and exertional heatstroke","volume":"8","author":"Bouchama","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0110","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2023.2294151","article-title":"Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study","volume":"46","author":"Chen","year":"2024","journal-title":"Ren Fail"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0115","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2022-000239","article-title":"Exertional heat stroke: pathophysiology and risk factors","volume":"1","author":"Garcia","year":"2022","journal-title":"BMJ Med"},{"issue":"2","key":"10.1016\/j.ajem.2025.06.010_bb0120","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/1742-6723.12990","article-title":"Review article: environmental heatstroke and long-term clinical neurological outcomes: a literature review of case reports and case series 2000-2016","volume":"31","author":"Lawton","year":"2019","journal-title":"Emerg Med Austral"},{"issue":"44","key":"10.1016\/j.ajem.2025.06.010_bb0125","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000008417","article-title":"Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke","volume":"96","author":"Yang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ajem.2025.06.010_bb0130","article-title":"Analysis of clinical characteristics and risk factors for patients with heat stroke in western China in 2022: a multicenter retrospective study","volume":"12","author":"Zheng","year":"2025","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"10.1016\/j.ajem.2025.06.010_bb0135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5847\/wjem.j.1920-8642.2022.047","article-title":"Severe acute liver injury in patients with exertional heat stroke associated with poor short-term prognosis","volume":"13","author":"Li","year":"2022","journal-title":"World J Emerg Med"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0140","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s13054-022-04273-w","article-title":"The pathogenesis and therapeutic strategies of heat stroke-induced liver injury","volume":"26","author":"Wang","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2025.06.010_bb0145","first-page":"1","article-title":"People's liberation Army professional Committee of Critical Care M. Expert consensus on standardized diagnosis and treatment for heat stroke","volume":"3","year":"2016","journal-title":"Mil Med Res"},{"issue":"3","key":"10.1016\/j.ajem.2025.06.010_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/emj.2003.009365","article-title":"Predictors of multi-organ dysfunction in heatstroke","volume":"22","author":"Varghese","year":"2005","journal-title":"Emerg Med J"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.516","article-title":"Clinical characteristics, prognostic factors, and outcomes of heat-related illness (heatstroke study 2017-2018)","volume":"7","author":"Shimazaki","year":"2020","journal-title":"Acute Med Surg"},{"issue":"10","key":"10.1016\/j.ajem.2025.06.010_bb0160","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1113\/EP090686","article-title":"Exertional heat stroke in sport and the military: epidemiology and mitigation","volume":"107","author":"Periard","year":"2022","journal-title":"Exp Physiol"},{"issue":"1","key":"10.1016\/j.ajem.2025.06.010_bb0165","article-title":"Development and validation of a prognostic model of survival for classic heatstroke patients: a multicenter study","volume":"13","author":"Wang","year":"2023","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.ajem.2025.06.010_bb0170","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/EDE.0000000000001661","article-title":"High summer temperatures and heat stroke mortality in Spain","volume":"34","author":"Tobias","year":"2023","journal-title":"Epidemiology"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675725003912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675725003912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T21:25:06Z","timestamp":1759872306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675725003912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":34,"alternative-id":["S0735675725003912"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2025.06.010","relation":{},"ISSN":["0735-6757"],"issn-type":[{"type":"print","value":"0735-6757"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-leukocyte-international normalized ratio score (ALIS): A bedside triparametric tool for neurological prognostication in heat stroke emergencies","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2025.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}