{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:34:02Z","timestamp":1784543642514,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ajem.2025.10.041","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:35:09Z","timestamp":1761183309000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Comparative efficacy and safety of urapidil and nitroglycerin for blood pressure control in acute cardiogenic pulmonary edema"],"prefix":"10.1016","volume":"99","author":[{"given":"Furkan","family":"Yakin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Altun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Kudu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Altunbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkman","family":"Sanri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Karacabey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ajem.2025.10.041_bb0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/arm91050034","article-title":"Cardiogenic pulmonary edema in emergency medicine","volume":"91","author":"Zanza","year":"2023","journal-title":"Adv Respir Med"},{"issue":"26","key":"10.1016\/j.ajem.2025.10.041_bb0010","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1056\/NEJMcp052699","article-title":"Clinical practice. Acute pulmonary edema","volume":"353","author":"Ware","year":"2005","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ajem.2025.10.041_bb0015","first-page":"e38","article-title":"Heart disease and stroke statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.ajem.2025.10.041_bb0020","first-page":"e240","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ajem.2025.10.041_bb0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajem.2024.12.061","article-title":"Emergency medicine updates: sympathetic crashing acute pulmonary edema","volume":"90","author":"Long","year":"2025","journal-title":"Am J Emerg Med"},{"issue":"2","key":"10.1016\/j.ajem.2025.10.041_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00134-008-1281-7","article-title":"Mortality in acute cardiogenic pulmonary edema treated with continuous positive airway pressure","volume":"35","author":"Cosentini","year":"2009","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.ajem.2025.10.041_bb0035","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/cc8889","article-title":"The role of noninvasive ventilation in acute cardiogenic pulmonary edema","volume":"14","author":"Salman","year":"2010","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.ajem.2025.10.041_bb0040","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ijcard.2012.09.128","article-title":"Long-term survival after hospitalization for acute heart failure\u2013differences in prognosis of acutely decompensated chronic and new-onset acute heart failure","volume":"168","author":"Lassus","year":"2013","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.ajem.2025.10.041_bb0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10554-017-1241-9","article-title":"Predictive value of SYNTAX score II for clinical outcomes in cardiogenic shock underwent primary percutaneous coronary intervention; a pilot study","volume":"34","author":"Hay\u0131ro\u011flu","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.ajem.2025.10.041_bb0050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.hlc.2017.10.023","article-title":"Predictors of in-hospital mortality in patients with ST-segment elevation myocardial infarction complicated with cardiogenic shock","volume":"28","author":"Hay\u0131ro\u011flu","year":"2019","journal-title":"Heart Lung Circ"},{"issue":"1","key":"10.1016\/j.ajem.2025.10.041_bb0055","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ajem.2019.06.046","article-title":"Role of high-dose intravenous nitrates in hypertensive acute heart failure","volume":"38","author":"Wang","year":"2020","journal-title":"Am J Emerg Med"},{"issue":"1","key":"10.1016\/j.ajem.2025.10.041_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM200101043440103","article-title":"The pathogenesis of acute pulmonary edema associated with hypertension","volume":"344","author":"Gandhi","year":"2001","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ajem.2025.10.041_bb0065","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jemermed.2021.05.011","article-title":"High-dose nitroglycerin bolus for sympathetic crashing acute pulmonary edema: a prospective observational pilot study","volume":"61","author":"Mathew","year":"2021","journal-title":"J Emerg Med"},{"key":"10.1016\/j.ajem.2025.10.041_bb0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ajem.2022.10.018","article-title":"High-dose nitroglycerin infusion description of safety and efficacy in sympathetic crashing acute pulmonary edema: the HI-DOSE SCAPE study","volume":"63","author":"Houseman","year":"2023","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2025.10.041_bb0075","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/OAEM.S340513","article-title":"Nitroglycerin use in the emergency department: current perspectives","volume":"14","author":"Twiner","year":"2022","journal-title":"Open Access Emerg Med"},{"key":"10.1016\/j.ajem.2025.10.041_bb0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2147\/DDDT.S185972","article-title":"Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis","volume":"13","author":"Shi","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.ajem.2025.10.041_bb0085","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ajem.2025.01.076","article-title":"Expanding perspectives on SCAPE management","volume":"89","author":"Unal","year":"2025","journal-title":"Am J Emerg Med"},{"issue":"7","key":"10.1016\/j.ajem.2025.10.041_bb0090","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s12325-010-0039-0","article-title":"Urapidil, a dual-acting antihypertensive agent: current usage considerations","volume":"27","author":"Buch","year":"2010","journal-title":"Adv Ther"},{"issue":"1","key":"10.1016\/j.ajem.2025.10.041_bb0095","article-title":"Clinical review of hypertensive acute heart failure","volume":"60","author":"Lasica","year":"2024","journal-title":"Medicina (Kaunas)"},{"issue":"10","key":"10.1016\/j.ajem.2025.10.041_bb0100","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ejim.2015.10.005","article-title":"The association between admission systolic blood pressure of heart failure patients with preserved systolic function and mortality outcomes","volume":"26","author":"Rosman","year":"2015","journal-title":"Eur J Intern Med"},{"issue":"38","key":"10.1016\/j.ajem.2025.10.041_bb0105","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","article-title":"2024 ESC guidelines for the management of elevated blood pressure and hypertension","volume":"45","author":"McEvoy","year":"2024","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.ajem.2025.10.041_bb0110","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.recesp.2021.11.027","volume":"75","author":"McDonagh","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"41","key":"10.1016\/j.ajem.2025.10.041_bb0115","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017352","article-title":"Efficacy of urapidil for the treatment of patients with senile hypertension and acute heart failure","volume":"98","author":"Xie","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.ajem.2025.10.041_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"issue":"1","key":"10.1016\/j.ajem.2025.10.041_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3349\/ymj.2017.58.1.105","article-title":"Efficacy and safety of intravenous urapidil for older hypertensive patients with acute heart failure: a multicenter randomized controlled trial","volume":"58","author":"Yang","year":"2017","journal-title":"Yonsei Med J"},{"issue":"3","key":"10.1016\/j.ajem.2025.10.041_bb0130","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/cpt.3509","article-title":"Oxygenation effects of antihypertensive agents in intensive care: a prospective comparative study of nicardipine and urapidil","volume":"117","author":"Suard","year":"2025","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.ajem.2025.10.041_bb0135","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0735-6757(93)90026-8","article-title":"Intravenous urapidil versus sublingual nifedipine in the treatment of hypertensive urgencies","volume":"11","author":"Hirschl","year":"1993","journal-title":"Am J Emerg Med"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073567572500703X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073567572500703X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:42:10Z","timestamp":1770154930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073567572500703X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"alternative-id":["S073567572500703X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2025.10.041","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative efficacy and safety of urapidil and nitroglycerin for blood pressure control in acute cardiogenic pulmonary edema","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2025.10.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}