{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:24:54Z","timestamp":1787095494375,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["RDGS2023\\u201307"],"award-info":[{"award-number":["RDGS2023\\u201307"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015083","name":"Peking University People's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ajem.2026.01.022","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:32:25Z","timestamp":1768609945000},"page":"198-205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clinical profiles and mortality risk modeling in neurocritical care: A retrospective cohort study from high-altitude Xizang"],"prefix":"10.1016","volume":"102","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-lei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci-ren","family":"Zhuoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu-zhen","family":"Danzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-xue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0005","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41572-024-00583-1","article-title":"Neurological complications at high altitude beyond altitude illnesses","volume":"10","author":"Falla","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ajem.2026.01.022_bb0010","doi-asserted-by":"crossref","first-page":"1555910","DOI":"10.3389\/fimmu.2025.1555910","article-title":"Oxygen metabolism abnormalities and high-altitude cerebral edema","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12974-024-03101-y","article-title":"Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke","volume":"21","author":"Duan","year":"2024","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0020","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1186\/s12889-024-18896-x","article-title":"Cold waves and fine particulate matter in high-altitude Chinese cities: assessing their interactive impact on outpatient visits for respiratory disease","volume":"24","author":"Ning","year":"2024","journal-title":"BMC Public Health"},{"issue":"18","key":"10.1016\/j.ajem.2026.01.022_bb0025","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102463118","article-title":"Global and country-level estimates of human population at high altitude","volume":"118","author":"Tremblay","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"10.1016\/j.ajem.2026.01.022_bb0030","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000475","article-title":"2024 guideline for the primary prevention of stroke: a guideline from the American Heart Association\/American Stroke Association","volume":"55","author":"Bushnell","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.ajem.2026.01.022_bb0035","doi-asserted-by":"crossref","first-page":"1446076","DOI":"10.3389\/fnins.2024.1446076","article-title":"Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management","volume":"18","author":"Lipsky","year":"2024","journal-title":"Front Neurosci"},{"key":"10.1016\/j.ajem.2026.01.022_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.743535","article-title":"Prolonged sojourn at very high altitude decreases Sea-level anaerobic performance, anaerobic threshold, and fat mass","volume":"12","author":"Szymczak","year":"2021","journal-title":"Front Physiol"},{"issue":"22","key":"10.1016\/j.ajem.2026.01.022_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192214951","article-title":"Analysis of landscape characteristics and influencing factors of residential areas on the Qinghai-Tibet plateau: a case study of Tibet, China","volume":"19","author":"Niu","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12028-019-00858-6","article-title":"Neurocritical care: a growing international collaborative","volume":"32","author":"Kramer","year":"2020","journal-title":"Neurocrit Care"},{"issue":"6","key":"10.1016\/j.ajem.2026.01.022_bb0055","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.18036","article-title":"Partial pressure of arterial oxygen in healthy adults at high altitudes: a systematic review and meta-analysis","volume":"6","author":"Forrer","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0060","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12883-023-03277-5","article-title":"Secondary polycythaemia from chronic hypoxia is a risk for cerebral thrombosis: a case report","volume":"23","author":"Zhou","year":"2023","journal-title":"BMC Neurol"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0065","doi-asserted-by":"crossref","first-page":"18595","DOI":"10.1038\/s41598-023-44261-w","article-title":"Epidemiology and disease burden of patients requiring neurocritical care: a Brazilian multicentre cohort study","volume":"13","author":"Rea-Neto","year":"2023","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.ajem.2026.01.022_bb0070","doi-asserted-by":"crossref","first-page":"8198","DOI":"10.3390\/ijerph120708198","article-title":"Comparison of regional brain perfusion levels in chronically smoking and non-smoking adults","volume":"12","author":"Durazzo","year":"2015","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ajem.2026.01.022_bb0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2147\/JMDH.S436486","article-title":"Factors associated with elderly health-related quality of life in Tibet: a cross-sectional study from a health ecological perspective","volume":"17","author":"Pan","year":"2024","journal-title":"J Multidiscip Healthc"},{"issue":"6","key":"10.1016\/j.ajem.2026.01.022_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14060613","article-title":"The role of aging in intracerebral hemorrhage","volume":"14","author":"Huang","year":"2024","journal-title":"Brain Sci"},{"issue":"2","key":"10.1016\/j.ajem.2026.01.022_bb0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41380-021-01361-1","article-title":"Age-related immune alterations and cerebrovascular inflammation","volume":"27","author":"Finger","year":"2022","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0090","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12974-024-03236-y","article-title":"Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study","volume":"21","author":"Fang","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajem.2026.01.022_bb0095","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbi.2017.04.013","article-title":"Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice","volume":"64","author":"Zhou","year":"2017","journal-title":"Brain Behav Immun"},{"issue":"2","key":"10.1016\/j.ajem.2026.01.022_bb0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3233\/CH-221583","article-title":"Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID-19 patients: a prospective observational study","volume":"83","author":"Zlojutro","year":"2023","journal-title":"Clin Hemorheol Microcirc"},{"issue":"3","key":"10.1016\/j.ajem.2026.01.022_bb0105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0885066621996257","article-title":"Sepsis mortality is high in patients with connective tissue diseases admitted to the intensive care unit (ICU)","volume":"37","author":"Krasselt","year":"2022","journal-title":"J Intensive Care Med"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13049-021-00884-4","article-title":"Relationship between admission coagulopathy and prognosis in children with traumatic brain injury: a retrospective study","volume":"29","author":"You","year":"2021","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41419-025-07441-2","article-title":"Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the management of severe traumatic brain injury","volume":"80","author":"Carney","year":"2017","journal-title":"Fourth Edition Neurosurg"},{"issue":"3","key":"10.1016\/j.ajem.2026.01.022_bb0125","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s12028-020-00959-7","article-title":"Guidelines for the acute treatment of cerebral edema in neurocritical care patients","volume":"32","author":"Cook","year":"2020","journal-title":"Neurocrit Care"},{"issue":"7","key":"10.1016\/j.ajem.2026.01.022_bb0130","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1161\/STR.0000000000000407","article-title":"American Heart Association\/American Stroke Association. 2022 guideline for the Management of patients with Spontaneous Intracerebral Hemorrhage: a guideline from the American Heart Association\/American Stroke Association","volume":"53","author":"Greenberg","year":"2022","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ajem.2026.01.022_bb0135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13105-025-01069-8","article-title":"The impact of high altitude (hypobaric hypoxia) on insulin resistance in humans","volume":"81","author":"Adeva-Andany","year":"2025","journal-title":"J Physiol Biochem"},{"issue":"5","key":"10.1016\/j.ajem.2026.01.022_bb0140","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwaf071","article-title":"Closing the loop: autonomous intelligent control for hypoxia pre-acclimatization and high-altitude health management","volume":"12","author":"Shi","year":"2025","journal-title":"Natl Sci Rev"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073567572600029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073567572600029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:50:53Z","timestamp":1787093453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073567572600029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":28,"alternative-id":["S073567572600029X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2026.01.022","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical profiles and mortality risk modeling in neurocritical care: A retrospective cohort study from high-altitude Xizang","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2026.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}