{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:59:56Z","timestamp":1790405996279,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ajem.2026.06.027","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:01:34Z","timestamp":1781827294000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["First-line vasopressor therapy in neonates with fluid-refractory septic shock: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"109","author":[{"given":"Rand","family":"Yahya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Hassoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hamodat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrar","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10063","key":"10.1016\/j.ajem.2026.06.027_bb0005","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of under-5 mortality in 2000\u20132015, with projections to inform post-2015 priorities","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ajem.2026.06.027_bb0010","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1164\/rccm.201412-2323OC","article-title":"Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study","volume":"191","author":"Schlapbach","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.ajem.2026.06.027_bb0015","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jpeds.2009.12.026","article-title":"Hemodynamics in preterm infants with late-onset sepsis","volume":"156","author":"De Waal","year":"2010","journal-title":"J Pediatr"},{"issue":"6","key":"10.1016\/j.ajem.2026.06.027_bb0020","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/CCM.0000000000002425","article-title":"American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock","volume":"45","author":"Davis","year":"2017","journal-title":"Crit Care Med"},{"issue":"Suppl. 1","key":"10.1016\/j.ajem.2026.06.027_bb0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00134-019-05878-6","article-title":"Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children","volume":"46","author":"Weiss","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2026.06.027_bb0030","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/s41372-025-02407-w","article-title":"Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line","volume":"45","author":"H\u00e9bert","year":"2025","journal-title":"J Perinatol"},{"issue":"3","key":"10.1016\/j.ajem.2026.06.027_bb0035","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-3476(95)70445-0","article-title":"Cardiovascular, renal, and endocrine actions of dopamine in neonates and children","volume":"126","author":"Seri","year":"1995","journal-title":"J Pediatr"},{"issue":"9","key":"10.1016\/j.ajem.2026.06.027_bb0040","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1056\/NEJMoa0907118","article-title":"Comparison of dopamine and norepinephrine in the treatment of shock","volume":"362","author":"De Backer","year":"2010","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ajem.2026.06.027_bb0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.clp.2011.12.010","article-title":"Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents","volume":"39","author":"Noori","year":"2012","journal-title":"Clin Perinatol"},{"issue":"3","key":"10.1016\/j.ajem.2026.06.027_bb0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpeds.2008.03.007","article-title":"Pulmonary circulatory effects of norepinephrine in newborn infants with persistent pulmonary hypertension","volume":"153","author":"Tourneux","year":"2008","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.ajem.2026.06.027_bb0055","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.ajem.2026.06.027_bb0060","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.clp.2010.04.002","article-title":"Pathophysiology and treatment of septic shock in neonates","volume":"37","author":"Wynn","year":"2010","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajem.2026.06.027_bb0065","series-title":"Cochrane Handbook for Systematic Reviews of Interventions (Version 6.3)","year":"2022"},{"key":"10.1016\/j.ajem.2026.06.027_bb0070","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"issue":"7414","key":"10.1016\/j.ajem.2026.06.027_bb0075","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.ajem.2026.06.027_bb0080","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1097\/CCM.0000000000001260","article-title":"Double-blind prospective randomized controlled trial of dopamine versus epinephrine as first-line vasoactive drugs in pediatric septic shock","volume":"43","author":"Ventura","year":"2015","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.ajem.2026.06.027_bb0085","doi-asserted-by":"crossref","first-page":"e502","DOI":"10.1097\/PCC.0000000000000954","article-title":"Dopamine versus epinephrine in pediatric fluid-refractory septic shock","volume":"17","author":"Ramaswamy","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.ajem.2026.06.027_bb0090","author":"UAE Ministry of Health and Prevention"},{"issue":"9","key":"10.1016\/j.ajem.2026.06.027_bb0095","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00431-018-3195-x","article-title":"Epinephrine versus dopamine in neonatal septic shock: a randomized controlled trial","volume":"177","author":"Baske","year":"2018","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.ajem.2026.06.027_bb0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13052-019-0768-x","article-title":"Dopamine versus epinephrine in pediatric or neonatal septic shock: a meta-analysis","volume":"46","author":"Wen","year":"2020","journal-title":"Ital J Pediatr"},{"issue":"6","key":"10.1016\/j.ajem.2026.06.027_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/tropej\/fmaf045","article-title":"Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial","volume":"71","author":"Singh","year":"2025","journal-title":"J Trop Pediatr"},{"issue":"5","key":"10.1016\/j.ajem.2026.06.027_bb0110","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/SHK.0000000000002427","article-title":"Outcomes of pediatric fluid-refractory septic shock according to vasoactive strategies: a systematic review and meta-analysis","volume":"62","author":"Marchetto","year":"2024","journal-title":"Shock"},{"issue":"11","key":"10.1016\/j.ajem.2026.06.027_bb0115","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.ajem.2026.06.027_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2025.114599","article-title":"Norepinephrine versus dopamine for septic shock in neonates: a randomized controlled trial","volume":"282","author":"Mazhari","year":"2025","journal-title":"J Pediatr"},{"issue":"10","key":"10.1016\/j.ajem.2026.06.027_bb0125","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/s41372-025-02399-7","article-title":"Dopamine versus epinephrine for neonatal septic shock: an open labeled, randomized controlled trial","volume":"45","author":"Singh","year":"2025","journal-title":"J Perinatol: official journal of the California Perinatal Association"},{"issue":"6","key":"10.1016\/j.ajem.2026.06.027_bib126","doi-asserted-by":"crossref","first-page":"fmaf045","DOI":"10.1093\/tropej\/fmaf045","article-title":"Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial","volume":"71","author":"Singh","year":"2025","journal-title":"Journal of Tropical Pediatrics"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675726003013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675726003013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:34:07Z","timestamp":1790404447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675726003013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":26,"alternative-id":["S0735675726003013"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2026.06.027","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First-line vasopressor therapy in neonates with fluid-refractory septic shock: A systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2026.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}