{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:47:24Z","timestamp":1761659244741,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ajg.2020.08.001","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T03:28:45Z","timestamp":1601609325000},"page":"246-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["QT interval abnormalities and heart rate variability in patients with cirrhosis"],"prefix":"10.1016","volume":"21","author":[{"given":"Elloumi","family":"H\u00e9la","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamoun","family":"Sofien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ltaief","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouakaa","family":"Asma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gargouri","family":"Dalila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kraiem","family":"Sondos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kharrat","family":"Jamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajg.2020.08.001_b0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ancard.2011.07.004","article-title":"Cirrhotic cardiomyopathy: a specific entity","volume":"61","author":"Brondex","year":"2012","journal-title":"Ann Cardiol Ang\u00e9iol"},{"key":"10.1016\/j.ajg.2020.08.001_b0010","first-page":"132","article-title":"Cirrhotic cardiomyopathy","volume":"5","author":"Lee","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ajg.2020.08.001_b0015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/hep.510270106","article-title":"Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors","volume":"27","author":"Bernardi","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.ajg.2020.08.001_b0020","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jhep.2007.03.013","article-title":"Diurnal variation and dispersion in QT interval in cirrhosis: relation to haemodynamic changes","volume":"47","author":"Hansen","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajg.2020.08.001_b0025","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/hep.510230529","article-title":"Effect of liver transplantation on QT interval prolongation and autonomic dysfunction in end-stage liver disease","volume":"23","author":"Mohamed","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.ajg.2020.08.001_b0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.dld.2007.12.084","article-title":"Acute gastrointestinal bleeding prolongs QT interval in cirrhosis","volume":"40","author":"Zambruni","year":"2008","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.ajg.2020.08.001_b0035","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/jhep.2003.50447","article-title":"Systemic, renal, and hepatic hemodynamic derangement in cirrhotic patients with spontaneous bacterial peritonitis","volume":"38","author":"Ruiz-del-ArbolL","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ajg.2020.08.001_b0040","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1053\/jhep.2003.50489","article-title":"Cardiac dysfunction in spontaneous bacterial peritonitis: a manifestation of cirrhotic cardiomyopathy?","volume":"38","author":"Lee","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ajg.2020.08.001_b0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1665-2681(19)31940-4","article-title":"Does autonomic dysfunction in cirrhosis liver influence variceal bleed?","volume":"6","author":"Joye Varghese","year":"2007","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.ajg.2020.08.001_b0050","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4097\/kjae.2010.59.3.144","article-title":"Recent advance in patient monitoring","volume":"59","author":"Nishiyama","year":"2010","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.ajg.2020.08.001_b0055","unstructured":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996;93:1043-65."},{"issue":"6","key":"10.1016\/j.ajg.2020.08.001_b0060","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/HYPERTENSIONAHA.114.03782","article-title":"Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart ratenovelty and significance","volume":"64","author":"Monfredi","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.ajg.2020.08.001_b0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding esophageal varicies","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"10.1016\/j.ajg.2020.08.001_b0070","first-page":"353","article-title":"An analysis of the time-relations of electrocardiograms","volume":"7","author":"Bazett","year":"1920","journal-title":"Heart"},{"key":"10.1016\/j.ajg.2020.08.001_b0075","series-title":"La cardiomyopathie cirrhotique [Th\u00e8se]","first-page":"98","author":"Fourti","year":"2006"},{"key":"10.1016\/j.ajg.2020.08.001_b0085","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.jhep.2005.10.034","article-title":"Cardiac electrophysiological abnormalities in patients with cirrhosis","volume":"44","author":"Zambruni","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajg.2020.08.001_b0090","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/0140-6736(93)90879-L","article-title":"QT prolongation and sudden cardiac death in patients with alcoholic liver disease","volume":"341","author":"Day","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ajg.2020.08.001_b0095","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0168-8278(03)00057-6","article-title":"QT interval in patients with non-cirrhotic portal hypertension and in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt","volume":"38","author":"Trevisani","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajg.2020.08.001_b0100","doi-asserted-by":"crossref","unstructured":"Vibe G, Fr\u00f8kj\u00e6rGitte I, Strauss Jesper Mehlsen Gitte M, Knudsen Verner Rasmussen Fin S. Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis. Clin Auton Res 2006;16:208-16.","DOI":"10.1007\/s10286-006-0337-4"},{"key":"10.1016\/j.ajg.2020.08.001_b0105","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1023\/A:1005468711494","article-title":"Heart rate variability as a predictor of autonomic dysfunction in patients awaiting liver transplantation","volume":"45","author":"Fleisher","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ajg.2020.08.001_b0110","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1572-0241.2002.05551.x","article-title":"Prevalence of autonomic dysfunction in cirrhotic and noncirrhotic portal hypertension","volume":"97","author":"Rangari","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ajg.2020.08.001_b0115","first-page":"1544","article-title":"Autonomic function in cirrhosis assessed by cardiovascular reflex test and 24-hour heart variability","volume":"89","author":"Dillon","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ajg.2020.08.001_b0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.dld.2009.05.009","article-title":"Long-term effect of liver transplantation on cirrhotic autonomic cardiac dysfunction","volume":"42","author":"Baratta","year":"2010","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.ajg.2020.08.001_b0125","first-page":"2717","article-title":"Clinical investigation of Q-T prolongation in hepatic cirrhosis","volume":"87","author":"Li","year":"2007","journal-title":"J Chin Med Assoc"},{"key":"10.1016\/j.ajg.2020.08.001_b0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1034\/j.1600-0676.2003.00833.x","article-title":"Prolongation of QTc Interval: Relationship with etiology and severity of liver disease, mortality and liver transplantation","volume":"23","author":"Bal","year":"2003","journal-title":"Liver Int"},{"key":"10.1016\/j.ajg.2020.08.001_b0135","first-page":"247","article-title":"The heart matters when the liver shatters! Cirrhotic cardiomyopathy: frequency, comparaison, and correlation with severity of disease","volume":"11","author":"Naqvi","year":"2016","journal-title":"Prz Gastroenterol."},{"key":"10.1016\/j.ajg.2020.08.001_b0140","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4254\/wjh.v8.i3.200","article-title":"Cirrhotic cardiomyopathy: Isn\u2019t stress evaluation always required for the diagnosis?","volume":"8","author":"Barbosa","year":"2016","journal-title":"World J Hepatol"},{"key":"10.1016\/j.ajg.2020.08.001_b0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4236\/ojim.2014.41006","article-title":"Prolonged QTc interval is an electrophysiological hallmark of cirrhotic cardiomyopathy","volume":"4","author":"Bhatti","year":"2014","journal-title":"OJIM"},{"key":"10.1016\/j.ajg.2020.08.001_b0150","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1042\/CS20080325","article-title":"QT interval prolongation and decreased heart rate variability in cirrhotic patients: relevance of hepatic venous pressure gradient and serum calcium","volume":"116","author":"Genovesi","year":"2009","journal-title":"Clin Sci"},{"key":"10.1016\/j.ajg.2020.08.001_b0155","first-page":"44","article-title":"Cardiovascular complications of cirrhosis","volume":"85","author":"Moller","year":"2009","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.ajg.2020.08.001_b0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1665-2681(19)31940-4","article-title":"Does autonomic dysfunction in cirrhosis liver influence variceal bleed?","volume":"6","author":"JoyeVarghese","year":"2007","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.ajg.2020.08.001_b0165","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00004836-200401000-00015","article-title":"Autonomic dysfunction and gastroparesis in cirrhosis","volume":"38","author":"Verne","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.ajg.2020.08.001_b0170","doi-asserted-by":"crossref","unstructured":"Bajaj BK, Agarwal MP, Ram BK. Autonomic neuropathy in patients with hepatic cirrhosis. Postgrad Med J2003; 79: 408-11.","DOI":"10.1136\/pmj.79.933.408"},{"key":"10.1016\/j.ajg.2020.08.001_b0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bpg.2006.06.003","article-title":"Cardiac dysfunction in cirrhosis","volume":"21","author":"Lee","year":"2007","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.ajg.2020.08.001_b0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2008-1040321","article-title":"Cirrhotic cardiomyopathy","volume":"28","author":"Alqahtani","year":"2008","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.ajg.2020.08.001_b0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.dld.2013.10.013","article-title":"Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study","volume":"46","author":"Hobolth","year":"2014","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.ajg.2020.08.001_b0190","doi-asserted-by":"crossref","unstructured":"Amaral JATD, Salatini R, Arab C, Abreu LC, Valenti VE, et al. Non-Alcoholic Cirrhosis and Heart Rate Variability: A Systematic Mini-Review.Medicina (Kaunas). 2020 Mar 5;56(3):E116.","DOI":"10.3390\/medicina56030116"},{"issue":"5","key":"10.1016\/j.ajg.2020.08.001_b0195","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/apt.15365","article-title":"Significant reduction in heart rate variability is a feature of acute decompensation of cirrhosis and predicts 90-day mortality","volume":"50","author":"Jansen","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ajg.2020.08.001_b0200","article-title":"The effect of oxidative stress on the autonomic nervous system in patients with liver cirrhosis","author":"Abrahamovych","year":"202029894","journal-title":"Georgian Med News"},{"issue":"5","key":"10.1016\/j.ajg.2020.08.001_b0205","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.dld.2018.09.011","article-title":"Which heart rate variability index is an independent predictor of mortality in cirrhosis?","volume":"51","author":"Bhogal","year":"2019","journal-title":"Dig Liver Dis"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197920300836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197920300836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:43:54Z","timestamp":1761659034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197920300836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1687197920300836"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2020.08.001","relation":{},"ISSN":["1687-1979"],"issn-type":[{"type":"print","value":"1687-1979"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"QT interval abnormalities and heart rate variability in patients with cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2020.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}