{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:56:52Z","timestamp":1765486612474,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017249","name":"Universit\u00e9 Monastir","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ajg.2021.05.006","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T01:07:39Z","timestamp":1622682459000},"page":"316-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti-gp210 and anti-Sp100 antibodies in primary biliary cholangitis"],"prefix":"10.1016","volume":"22","author":[{"given":"Zeineb","family":"Ben Lamine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhem","family":"Ben Jazia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariem","family":"Ben Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayda","family":"Ben Slama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza","family":"Baccouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foued","family":"Slama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Jemaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtissem","family":"Ghedira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amani","family":"Manka\u00ef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ajg.2021.05.006_b0005","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41575-019-0226-7","article-title":"Primary biliary cholangitis: pathogenesis and therapeutic opportunities","volume":"17","author":"Gulamhusein","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajg.2021.05.006_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9251879","article-title":"Meta-analysis of antinuclear antibodies in the diagnosis of antimitochondrial antibody-negative primary biliary cholangitis","volume":"2019","author":"Zhang","year":"2019","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.ajg.2021.05.006_b0015","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver Diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"issue":"03","key":"10.1016\/j.ajg.2021.05.006_b0020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1055\/s-0034-1383732","article-title":"Clinical significance of autoantibodies in primary biliary cirrhosis","volume":"34","author":"Nakamura","year":"2014","journal-title":"Semin Liver Dis"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.006_b0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrm.2016.147","article-title":"The nuclear pore complex: understanding its function through structural insight","volume":"18","author":"Beck","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.006_b0030","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1365-3083.1992.tb03224.x","article-title":"Autoantibodies to the nuclear Sp100 protein in primary biliary cirrhosis and associated diseases: epitope specificity and immunoglobulin class distribution","volume":"36","author":"Szostecki","year":"1992","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.006_b0035","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/hep.30604","article-title":"Genome wide association studies of specific antinuclear autoantibody sub-phenotypes in primary biliary cholangitis","volume":"70","author":"Wang","year":"2019","journal-title":"Hepatology"},{"issue":"21","key":"10.1016\/j.ajg.2021.05.006_b0040","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJM199611213352107","article-title":"Primary biliary cirrhosis","volume":"335","author":"Kaplan","year":"1996","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.006_b0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.patbio.2007.05.001","article-title":"Detection of M2 antimitochondrial antibodies by dot blot assay is more specific than by enzyme linked immunosorbent assay","volume":"56","author":"Bargou","year":"2008","journal-title":"Pathol Biol"},{"issue":"05","key":"10.1016\/j.ajg.2021.05.006_b0050","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9899.1000564","article-title":"Primary biliary cholangitis in elderly: about 12 Tunisian cases","volume":"09","author":"Ben Lamine","year":"2018","journal-title":"J Clin Cell Immunol"},{"issue":"5","key":"10.1016\/j.ajg.2021.05.006_b0055","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1053\/sarh.2001.20266","article-title":"Anti-nuclear envelope antibodies: clinical associations","volume":"30","author":"Nesher","year":"2001","journal-title":"Semin Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.006_b0060","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cld.2008.02.009","article-title":"Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value","volume":"12","author":"Muratori","year":"2008","journal-title":"Clin Liver Dis"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.006_b0065","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jaut.2010.09.005","article-title":"PBC screen: an IgG\/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis","volume":"35","author":"Liu","year":"2010","journal-title":"J Autoimmun"},{"issue":"7","key":"10.1016\/j.ajg.2021.05.006_b0070","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/08916934.2013.801461","article-title":"Clinical significance of the fluctuation of primary biliary cirrhosis-related autoantibodies during the course of the disease","volume":"46","author":"Gatselis","year":"2013","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ajg.2021.05.006_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cca.2016.11.021","article-title":"Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis","volume":"464","author":"Han","year":"2017","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ajg.2021.05.006_b0080","doi-asserted-by":"crossref","unstructured":"Stinton LM, Swain M, Myers RP, et al. Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis. Clin Exp Immunol. 2011;163:147-156.","DOI":"10.1111\/j.1365-2249.2010.04288.x"},{"issue":"15-16","key":"10.1016\/j.ajg.2021.05.006_b0085","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.cca.2012.03.020","article-title":"Diagnostic and clinicalutility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis","volume":"413","author":"Mytilinaiou","year":"2012","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.006_b0090","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5387\/fms.58.107","article-title":"Autoantibodies by line immunoassay in patients with primary biliary cirrhosis","volume":"58","author":"Saito","year":"2012","journal-title":"Fukushima J Med Sci"},{"key":"10.1016\/j.ajg.2021.05.006_b0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cca.2014.08.024","article-title":"Autoantibody profiling of patients with primary biliary cirrhosis using a multiplexed line-blot assay","volume":"438","author":"Villalta","year":"2015","journal-title":"Clin Chim Acta"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.006_b0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/19401736.2013.879649","article-title":"Phylogeny and genetic structure of Tunisians and their position within Mediterranean populations","volume":"26","author":"Kefi","year":"2015","journal-title":"Mitochondrial DNA"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.006_b0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hep.21472","article-title":"Anti-gp210 and Anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis","volume":"45","author":"Nakamura","year":"2007","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.006_b0110","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1665-2681(19)30838-5","article-title":"Predicting outcome in primary biliary cirrhosis","volume":"13","author":"Lammers","year":"2014","journal-title":"Ann Hepatol"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.006_b0115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.molmed.2015.02.006","article-title":"Autoimmune host-microbiota interactions at barrier sites and beyond","volume":"21","author":"Ruff","year":"2015","journal-title":"Trends Mol Med"},{"issue":"3","key":"10.1016\/j.ajg.2021.05.006_b0120","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gutjnl-2016-313332","article-title":"Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy","volume":"67","author":"Tang","year":"2018","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.ajg.2021.05.006_b0125","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ncpgasthep0259","article-title":"Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases","volume":"2","author":"Fasano","year":"2005","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.006_b0130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrgastro.2014.188","article-title":"Mycobiota in gastrointestinal diseases","volume":"12","author":"Mukherjee","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajg.2021.05.006_b0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jaut.2018.09.010","article-title":"Gut microbiota translocation promotes autoimmune cholangitis","volume":"95","author":"Ma","year":"2018","journal-title":"J Autoimmun"},{"issue":"6","key":"10.1016\/j.ajg.2021.05.006_b0140","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1155\/2010\/752314","article-title":"Infectious agents and xenobiotics in the etiology of primary biliary cirrhosis","volume":"29","author":"Selmi","year":"2010","journal-title":"Dis Markers"},{"issue":"7697","key":"10.1016\/j.ajg.2021.05.006_b0145","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature26003","article-title":"Integrative structure and functional anatomy of a nuclear pore complex","volume":"555","author":"Kim","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.006_b0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/hep.1840040102","article-title":"Complement components and activation in primary biliary cirrhosis","volume":"4","author":"Lindgren","year":"1984","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.006_b0155","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jaut.2005.10.007","article-title":"Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis","volume":"26","author":"Nakamura","year":"2006","journal-title":"J Autoimmun"},{"issue":"8","key":"10.1016\/j.ajg.2021.05.006_b0160","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.dld.2013.01.005","article-title":"Apotopes and innate immune system: novel players in the primary biliary cirrhosis scenario","volume":"45","author":"Lleo","year":"2013","journal-title":"Dig Liver Dis"},{"issue":"9","key":"10.1016\/j.ajg.2021.05.006_b0165","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s10620-006-9544-z","article-title":"Abnormal intestinal permeability in primary biliary cirrhosis","volume":"51","author":"Feld","year":"2006","journal-title":"Dig Dis Sci"},{"issue":"7","key":"10.1016\/j.ajg.2021.05.006_b0170","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s10620-007-0092-y","article-title":"Anti-saccharomyces cerevisiae antibodies in primary biliary cirrhosis","volume":"53","author":"Sakly","year":"2008","journal-title":"Dig Dis Sci"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.006_b0175","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10238-012-0207-4","article-title":"Clinical significance and prevalence of anti-Saccharomyces cerevisiae antibody in Chinese patients with primary biliary cirrhosis","volume":"13","author":"Hu","year":"2013","journal-title":"Clin Exp Med"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:44:57Z","timestamp":1761659097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197921000289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1687197921000289"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.006","relation":{},"ISSN":["1687-1979"],"issn-type":[{"type":"print","value":"1687-1979"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-gp210 and anti-Sp100 antibodies in primary biliary cholangitis","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}