{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:17:32Z","timestamp":1788481052059,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ajg.2021.05.016","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T07:45:16Z","timestamp":1631519116000},"page":"224-228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Potentiation of anti-Helicobacter pylori activity of clarithromycin by Pelargonium graveolens oil"],"prefix":"10.1016","volume":"22","author":[{"given":"Mayar A.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar W.","family":"Sallem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam R.","family":"Abdelhassib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-0560","authenticated-orcid":false,"given":"Omayma A.","family":"Eldahshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ajg.2021.05.016_b0005","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/ptr.4853","article-title":"Chemical composition and biological activities of polar extracts and essential oil of rose-scented geranium, Pelargonium graveolens","volume":"27","author":"Boukhris","year":"2012","journal-title":"Phytother Res"},{"issue":"167","key":"10.1016\/j.ajg.2021.05.016_b0010","first-page":"1","article-title":"Phytochemical composition and antimicrobial activities of the essential oils and organic extracts from Pelargonium graveolens growing in Tunisia","volume":"11","author":"Ben Hsouna","year":"2012","journal-title":"Lipids Health Dis"},{"issue":"18","key":"10.1016\/j.ajg.2021.05.016_b0015","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1080\/14786419.2018.1547299","article-title":"Phytochemicals, antioxidant, anti-acetyl-cholinesterase, and antimicrobial activities of decoction and infusion of Pelargonium graveolens","volume":"34","author":"Ennaifer","year":"2020","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.ajg.2021.05.016_b0020","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/lam.13053","article-title":"Screening of antifungal activity of twelve essential oils against eight pathogenic fungi of vegetables and mushroom","volume":"67","author":"Dianez","year":"2018","journal-title":"Lett. App. Microbiol."},{"issue":"17","key":"10.1016\/j.ajg.2021.05.016_b0025","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1021\/jf400246a","article-title":"Bioactivity-guided investigation of geranium essential oils as natural tick repellents","volume":"61","author":"Tabanca","year":"2013","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.ajg.2021.05.016_b0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1472-765X.2009.02552.x","article-title":"Vapour-phase activities of essential oils against antibiotic sensitive and resistant bacteria including MRSA","volume":"48","author":"Doran","year":"2009","journal-title":"Lett App Microbiol"},{"key":"10.1016\/j.ajg.2021.05.016_b0035","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infections","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajg.2021.05.016_b0040","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of Helicobacter pylori infection, systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajg.2021.05.016_b0045","doi-asserted-by":"crossref","unstructured":"Singab AB, Mostafa NM, Edahshan OA, Ashour ML, Wink M. Profile of volatile components of hydrodistilled and extracted leaves of Jacaranda acutifolia and their antimicrobial activity against foodborne pathogens. Nat Prod Commun 2014;9(7):1007\u201310.","DOI":"10.1177\/1934578X1400900731"},{"key":"10.1016\/j.ajg.2021.05.016_b0050","doi-asserted-by":"crossref","unstructured":"Gisbert JP, Gonz\u00e1lez L, Calvet X, Garc\u00eda N, L\u00f3pez T, Roqu\u00e9 M, Gabriel R, Pajares JM. Proton pump inhibitor, clarithromycin and either amoxycillin or nitroimidazole: a meta-analysis of eradication of Helicobacter pylori, Aliment Pharmacol Ther 2000;14:1319\u201328.","DOI":"10.1046\/j.1365-2036.2000.00844.x"},{"key":"10.1016\/j.ajg.2021.05.016_b0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.micres.2016.12.003","article-title":"Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity","volume":"196","author":"Ramona","year":"2017","journal-title":"Microbiol Res"},{"key":"10.1016\/j.ajg.2021.05.016_b0060","doi-asserted-by":"crossref","unstructured":"Eldahshan OA, Halim AF. Comparison of the composition and antimicrobial activities of the essential oils of green branches and leaves of Egyptian navel orange (Citrus sinensis (L.) OSBECK var. malesy). Chem. Biodiver 2016;13:681\u201385.","DOI":"10.1002\/cbdv.201500139"},{"key":"10.1016\/j.ajg.2021.05.016_b0065","doi-asserted-by":"crossref","unstructured":"Taha AM, Eldahshan OA. Chemical characteristics, antimicrobial, and cytotoxic activities of the essential oil of Egyptian Cinnamomum glanduliferum Bark. Chem Biodiver 2017;14(5).","DOI":"10.1002\/cbdv.201600443"},{"key":"10.1016\/j.ajg.2021.05.016_b0070","series-title":"Identification of essential oil components by gas chromatography\/mass spectrometry","author":"Adams","year":"2007"},{"key":"10.1016\/j.ajg.2021.05.016_b0075","doi-asserted-by":"crossref","unstructured":"Bonacorsi C, Stella M, Raddi G, Carlos IZ, MSannomiya M, Vilegas W. Anti-Helicobacter pylori activity and immunostimulatory effect of extracts from Byrsonima crassa Nied. (Malpighiaceae). BMC Complement Altern Med 2009;9(1):2.","DOI":"10.1186\/1472-6882-9-2"},{"key":"10.1016\/j.ajg.2021.05.016_b0080","doi-asserted-by":"crossref","unstructured":"White RL, Burgess DS, Manduru M, Bosso JA. Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob Agents Chemother 1996; 40(8):1914\u201318.","DOI":"10.1128\/AAC.40.8.1914"},{"key":"10.1016\/j.ajg.2021.05.016_b0085","unstructured":"Eucast 2000"},{"issue":"97","key":"10.1016\/j.ajg.2021.05.016_b0090","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1365-2672.2004.02417.x","article-title":"Antifungal affects of herbal essential oils and in combination with ketoconazolo against Trichopyton spp.","volume":"2004","author":"Shin","year":"2004","journal-title":"J Appl Microbiol"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.016_b0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1472-765X.2003.01271.x","article-title":"Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole","volume":"36","author":"Shin","year":"2003","journal-title":"Lett Appl Microbiol"},{"issue":"3","key":"10.1016\/j.ajg.2021.05.016_b0100","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/molecules25030586","article-title":"The in vitro activity of essential oils against Helicobacter pylori growth and urease activity","volume":"25","author":"Korona-Glowniak","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ajg.2021.05.016_b0105","doi-asserted-by":"crossref","unstructured":"Ruiz-Rico M, Moreno Y, Barat JM. In vitro antimicrobial activity of immobilised essential oil components against Helicobacter pylori. World J Microbiol Biotechnol 2019;12;36(1):3.","DOI":"10.1007\/s11274-019-2782-y"},{"issue":"72","key":"10.1016\/j.ajg.2021.05.016_b0110","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.4315\/0362-028X-72.7.1468","article-title":"Food protective effect of geraniol and its congeners against stored food mites","volume":"2009","author":"Jeon","year":"2009","journal-title":"J Food Prot"},{"issue":"19","key":"10.1016\/j.ajg.2021.05.016_b0115","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1021\/jf0495340","article-title":"Antibacterial activities of plant essential oils and their components against Escherichia coli O157:H7 and Salmonella enterica in apple juice","volume":"52","author":"Friedman","year":"2004","journal-title":"J Agric Food Chem"},{"issue":"12","key":"10.1016\/j.ajg.2021.05.016_b0120","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.3390\/molecules13123107","article-title":"The effect of monoterpenes on swarming differentiation and haemolysin activity in Proteus mirabilis","volume":"13","author":"Echeverrigaray","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.ajg.2021.05.016_b0125","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/j.1365-2672.2007.03456.x","article-title":"Antimicrobial activity of flavoids extracted from bergamot (Citrus bergamia Risso) peel, a by-product from the essential industry","volume":"103","author":"Mandalari","year":"2007","journal-title":"J Appl Microbiol"},{"issue":"2-3","key":"10.1016\/j.ajg.2021.05.016_b0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"16","author":"Wagner","year":"2009","journal-title":"Phytomedicine"},{"issue":"82","key":"10.1016\/j.ajg.2021.05.016_b0135","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1046\/j.1365-2672.1997.00153.x","article-title":"Bioactivity of selected plant essential oils against Listeria monocytogenes","volume":"1997","author":"Lis-Balchim","year":"1997","journal-title":"J Appl Bacteriol"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:46:01Z","timestamp":1761659161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197921000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1687197921000381"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.016","relation":{},"ISSN":["1687-1979"],"issn-type":[{"value":"1687-1979","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potentiation of anti-Helicobacter pylori activity of clarithromycin by Pelargonium graveolens oil","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}