{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:18:20Z","timestamp":1766902700264,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ajg.2021.05.017","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T02:16:08Z","timestamp":1623377768000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genotyping Helicobacter pylori antibiotic resistance and virulence-associated genes in patients with gastric cancer in Wenzhou, China"],"prefix":"10.1016","volume":"22","author":[{"given":"Yonglin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rixu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-7728","authenticated-orcid":false,"given":"Bicheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ajg.2021.05.017_b0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of helicobacter pylori infection-the maastricht V\/florence consensus report","volume":"66","author":"Malfertheiner","year":"2017","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.017_b0010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/apm.13034","article-title":"Epidemiology and role of Helicobacter pylori virulence factors in gastric cancer carcinogenesis","volume":"128","author":"Sukri","year":"2020","journal-title":"APMIS"},{"key":"10.1016\/j.ajg.2021.05.017_b0015","doi-asserted-by":"crossref","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018;68:394-424.","DOI":"10.3322\/caac.21492"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.017_b0020","doi-asserted-by":"crossref","DOI":"10.1186\/s13099-017-0167-z","article-title":"Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico","volume":"9","author":"Rom\u00e1n-Rom\u00e1n","year":"2017","journal-title":"Gut pathogens"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.017_b0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ajg.2020.07.011","article-title":"Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer","volume":"21","author":"Li","year":"2020","journal-title":"Arab J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.05.017_b0030","first-page":"330","article-title":"Helicobacter pylori vacA d1\/-i1 genotypes and geographic differentiation between high and low incidence areas of gastric cancer in Iran","volume":"16","author":"Latifi-Navid","year":"2013","journal-title":"Archiv Iran Med"},{"key":"10.1016\/j.ajg.2021.05.017_b0035","doi-asserted-by":"crossref","first-page":"e12580","DOI":"10.1111\/hel.12580","article-title":"Impact factors that modulate gastric cancer risk in Helicobacter pylori-infected rodent models","author":"Peng","year":"2019","journal-title":"Helicobacter"},{"issue":"8","key":"10.1016\/j.ajg.2021.05.017_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13150","article-title":"Helicobacter pylori pathogenicity and primary antimicrobial resistance in Northern Spain","volume":"49","author":"Fern\u00e1ndez\u2010Reyes","year":"2019","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.017_b0045","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-019-0986-0","article-title":"Detection of Helicobacter pylori and its virulence genes (cagA, dupA, and vacA) among patients with gastroduodenal diseases in Chris Hani Baragwanath Academic Hospital, South Africa","volume":"19","author":"Idowu","year":"2019","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.017_b0050","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-015-0111-0","article-title":"Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways","volume":"13","author":"Yong","year":"2015","journal-title":"Cell Commun Signal"},{"issue":"6","key":"10.1016\/j.ajg.2021.05.017_b0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/toxins8060182","article-title":"Relationship between vacA types and development of gastroduodenal diseases","volume":"8","author":"Thi Huyen Trang","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.ajg.2021.05.017_b0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.micpath.2018.02.016","article-title":"Influence of Helicobacter pylori virulence factors CagA and VacA on pathogenesis of gastrointestinal disorders","volume":"117","author":"Nejati","year":"2018","journal-title":"Microb Pathog"},{"issue":"5","key":"10.1016\/j.ajg.2021.05.017_b0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/QCO.0000000000000396","article-title":"Antibiotic resistance in Helicobacter pylori","volume":"30","author":"Alba","year":"2017","journal-title":"Curr Opin Infect Dis"},{"issue":"7","key":"10.1016\/j.ajg.2021.05.017_b0070","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01834-18","article-title":"Helicobacter pylori mutations detected by next-generation sequencing in formalin-fixed, paraffin-embedded gastric biopsy specimens are associated with treatment failure","volume":"57","author":"Nezami","year":"2019","journal-title":"J Clin Microbiol"},{"issue":"7","key":"10.1016\/j.ajg.2021.05.017_b0075","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/jcm8071071","article-title":"Antibiotic resistance and genotypes of Helicobacter pylori strains in patients with gastroduodenal disease in southeast Poland","volume":"8","author":"Korona-Glowniak","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.ajg.2021.05.017_b0080","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.3748\/wjg.v21.i40.11221","article-title":"Diagnosis of Helicobacter pylori infection: Current options and developments","volume":"21","author":"Wang","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.017_b0085","doi-asserted-by":"crossref","DOI":"10.23736\/S1120-4826.20.02665-8","article-title":"Molecular methods for the detection of Helicobacter pylori","volume":"32","author":"Isaeva","year":"2020","journal-title":"Minerva Biotecnologica"},{"issue":"Suppl 7","key":"10.1016\/j.ajg.2021.05.017_b0090","first-page":"71","article-title":"Can gastric cancer be prevented?","volume":"60","author":"Tepes","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.ajg.2021.05.017_b0095","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.3748\/wjg.v19.i34.5685","article-title":"Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders","volume":"19","author":"Vaziri","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.1016\/j.ajg.2021.05.017_b0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/1097-0215(20000801)87:3<322::AID-IJC3>3.0.CO;2-M","article-title":"The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany","volume":"87","author":"Miehlke","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajg.2021.05.017_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/753710","article-title":"Prevalence of Helicobacter pylori vacA, cagA, and iceA genotypes in cuban patients with upper gastrointestinal diseases","volume":"2015","author":"Feliciano","year":"2015","journal-title":"Biomed Res Int"},{"issue":"3","key":"10.1016\/j.ajg.2021.05.017_b0110","doi-asserted-by":"crossref","first-page":"e9645","DOI":"10.1371\/journal.pone.0009645","article-title":"Ethnic and geographic differentiation of Helicobacter pylori within Iran","volume":"5","author":"Latifi-Navid","year":"2010","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.ajg.2021.05.017_b0115","doi-asserted-by":"crossref","first-page":"e750","DOI":"10.1016\/j.ijid.2013.03.004","article-title":"Genotyping of Helicobacter pylori virulence-associated genes shows high diversity of strains infecting patients in western Venezuela","volume":"17","author":"Chiurillo","year":"2013","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ajg.2021.05.017_b0120","first-page":"304","article-title":"A 2016 panorama of Helicobacter pylori infection: key messages for clinicians","volume":"58","author":"Pellicano","year":"2016","journal-title":"Panminerva Med"},{"issue":"5","key":"10.1016\/j.ajg.2021.05.017_b0125","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1053\/j.gastro.2018.07.007","article-title":"Prevalence of Antibiotic Resistance in Helicobacter pylori: A Systematic Review and Meta-analysis in World Health Organization Regions","volume":"155","author":"Savoldi","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajg.2021.05.017_b0130","doi-asserted-by":"crossref","unstructured":"Liu DS, Wang YH, Zeng ZR, et al. Primary antibiotic resistance of Helicobacter pylori in Chinese patients: a multiregion prospective 7-year study. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2018;24:780.e785-780.e788.","DOI":"10.1016\/j.cmi.2017.11.010"},{"issue":"4","key":"10.1016\/j.ajg.2021.05.017_b0135","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/hel.12046","article-title":"Antibiotic resistance of Helicobacter pylori isolated in the Southeast Coastal Region of China","volume":"18","author":"Su","year":"2013","journal-title":"Helicobacter"},{"key":"10.1016\/j.ajg.2021.05.017_b0140","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.3748\/wjg.v21.i9.2786","article-title":"Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: a prospective serial study","volume":"21","author":"Zhang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.05.017_b0145","doi-asserted-by":"crossref","first-page":"9912","DOI":"10.3748\/wjg.v20.i29.9912","article-title":"Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance","volume":"20","author":"Smith","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.017_b0150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1128\/AAC.40.2.477","article-title":"Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori","volume":"40","author":"Versalovic","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.ajg.2021.05.017_b0155","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1128\/AAC.41.12.2724","article-title":"Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes","volume":"41","author":"Occhialini","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.ajg.2021.05.017_b0160","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1128\/AAC.41.12.2621","article-title":"Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations","volume":"41","author":"Taylor","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajg.2021.05.017_b0165","first-page":"351","article-title":"Occurrence of Mutations in the Antimicrobial Target Genes Related to Levofloxacin, Clarithromycin, and Amoxicillin Resistance in Helicobacter pylori Isolates from Buenos Aires City. Microbial drug resistance (Larchmont","volume":"23","author":"Zerbetto De Palma","year":"2017","journal-title":"NY)"},{"key":"10.1016\/j.ajg.2021.05.017_b0170","doi-asserted-by":"crossref","unstructured":"Bachir M, Allem R, Benejat L, et al. Molecular detection of mutations involved in Helicobacter pylori antibiotic resistance in Algeria. The Journal of antimicrobial chemotherapy. 2018;73:2034-2038.","DOI":"10.1093\/jac\/dky167"},{"issue":"10","key":"10.1016\/j.ajg.2021.05.017_b0175","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1348-0421.2007.tb03990.x","article-title":"Correlation between substitutions in penicillin-binding protein 1 and amoxicillin resistance in Helicobacter pylori","volume":"51","author":"Rimbara","year":"2007","journal-title":"Microbiol Immunol"},{"issue":"8","key":"10.1016\/j.ajg.2021.05.017_b0180","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/jgh.14980","article-title":"Application of gene chip technology in the diagnostic and drug resistance detection of Helicobacter pylori in children","volume":"35","author":"Yin","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.ajg.2021.05.017_b0185","first-page":"399","article-title":"Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. A short review","volume":"51","author":"Fagoonee","year":"2019","journal-title":"Infect Dis (London, England)"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:45:03Z","timestamp":1761659103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197921000393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1687197921000393"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.017","relation":{},"ISSN":["1687-1979"],"issn-type":[{"type":"print","value":"1687-1979"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotyping Helicobacter pylori antibiotic resistance and virulence-associated genes in patients with gastric cancer in Wenzhou, China","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}