{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:10:40Z","timestamp":1780524640811,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ajg.2021.05.018","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:32:46Z","timestamp":1631125966000},"page":"236-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exocrine pancreas functions in children with type 1 diabetes mellitus"],"prefix":"10.1016","volume":"22","author":[{"given":"Ahmet","family":"Basturk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Curek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasih","family":"Felek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Celmeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reha","family":"Artan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajg.2021.05.018_b0005","doi-asserted-by":"crossref","first-page":"812","DOI":"10.7326\/0003-4819-59-6-812","article-title":"External pancreatic secretion in diabetes mellitus","volume":"59","author":"Chey","year":"1963","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajg.2021.05.018_b0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7326\/0003-4819-61-2-242","article-title":"The exocrine pancreas in diabetes mellitus","volume":"61","author":"Vacca","year":"1964","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajg.2021.05.018_b0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF02997405","article-title":"The external secretion of the pancreas and diabetes mellitus","volume":"10","author":"Pollard","year":"1943","journal-title":"Am J Dig Dis."},{"key":"10.1016\/j.ajg.2021.05.018_b0020","first-page":"184","article-title":"Studies in pancreatic function. IV. The use of the secretin test in the diagnosis of tumors in and about the pancreas","volume":"18","author":"Dreilling","year":"1951","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajg.2021.05.018_b0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.17.9.685","article-title":"Exocrine pancreatic function in juvenile-onset diabetes mellitus","volume":"17","author":"Frier","year":"1976","journal-title":"Gut"},{"key":"10.1016\/j.ajg.2021.05.018_b0030","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000198833","article-title":"Exocrine pancreatic function in insulin-dependent diabetes mellitus","volume":"25","author":"Lankisch","year":"1982","journal-title":"Digestion"},{"key":"10.1016\/j.ajg.2021.05.018_b0035","first-page":"427","article-title":"Pankreatische Elasatase 1: Parameter f\u00fcr die chronische und akute Pankreatitis","volume":"16","author":"Scheefers-Borchel","year":"1992","journal-title":"Lab Med"},{"key":"10.1016\/j.ajg.2021.05.018_b0040","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/2047-783X-14-3-118","article-title":"Determinants of exocrine pancreatic function as measured by fecal elastase-1 concentration in patients with diabetes mellitus","volume":"14","author":"Ewald","year":"2009","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.ajg.2021.05.018_b0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s005920070011","article-title":"Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus","volume":"37","author":"Hardt","year":"2000","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.ajg.2021.05.018_b0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pan.2013.05.010","article-title":"Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus","volume":"13","author":"Vujasinovic","year":"2013","journal-title":"Pancreatology."},{"issue":"8","key":"10.1016\/j.ajg.2021.05.018_b0055","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1464-5491.2012.03597.x","article-title":"Article: Complications Pancreatic exocrine function in patients with diabetes","volume":"29","author":"Larger","year":"2012","journal-title":"Diabet Med."},{"issue":"11","key":"10.1016\/j.ajg.2021.05.018_b0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2318-11-4","article-title":"Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus","volume":"25","author":"Herzig","year":"2011","journal-title":"BMC Geriatr."},{"issue":"27","key":"10.1016\/j.ajg.2021.05.018_b0065","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/pedi.12698","article-title":"ISPAD Clinical Practice Consensus Guidelines 2018: Assessment and management of hypoglycemia in children and adolescents with diabetes","volume":"19","author":"Abraham","year":"2018","journal-title":"Pediatr Diabetes."},{"key":"10.1016\/j.ajg.2021.05.018_b0070","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.3748\/wjg.14.3149","article-title":"Pancreatic function testing: here to stay for the 21st century","volume":"14","author":"Lieb","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.05.018_b0075","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/MPA.0b013e3181656f8","article-title":"Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus","volume":"36","author":"Hahn","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.ajg.2021.05.018_b0080","doi-asserted-by":"crossref","unstructured":"Hardt PD. Comment on \u2018Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus (Pancreas 2008; 36: 274\u20138)\u2019.Pancreas 2009;38: 471\u20132 author reply 472\u20133.","DOI":"10.1097\/MPA.0b013e31818b0060"},{"key":"10.1016\/j.ajg.2021.05.018_b0085","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2337\/diacare.29.03.06.dc05-1389","article-title":"Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes?","volume":"29","author":"Cavalot","year":"2006","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.ajg.2021.05.018_b0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2337\/dc08-s244","article-title":"Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?","volume":"31","author":"Hardt","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajg.2021.05.018_b0095","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000073655","article-title":"High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients","volume":"3","author":"Hardt","year":"2003","journal-title":"Pancreatology"},{"key":"10.1016\/j.ajg.2021.05.018_b0100","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.2337\/diacare.27.8.2052","article-title":"Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects","volume":"27","author":"Cavalot","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajg.2021.05.018_b0105","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000198833","article-title":"Exocrine pancreatic function in insulin-dependent diabetes mellitus","volume":"25","author":"Lankisch","year":"1982","journal-title":"Digestion"},{"key":"10.1016\/j.ajg.2021.05.018_b0110","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1055\/s-2001-17867","article-title":"Low fecal elastase-1 in type I diabetes mellitus","volume":"39","author":"Icks","year":"2001","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.ajg.2021.05.018_b0115","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1111\/j.1572-0241.2003.08730.x","article-title":"Screening for pancreatic exocrine insufficiency in patients with diabetes mellitus","volume":"98","author":"Nunes","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.05.018_b0120","first-page":"75","article-title":"Investigation of fecal pancreatic elastase-1 levels in type 2 diabetic patients","volume":"16","author":"Yilmaztepe","year":"2005","journal-title":"Turk J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.05.018_b0125","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/761950","article-title":"Exocrine pancreatic insufficiency in diabetes mellitus: a complication of diabetic neuropathy or a different type of diabetes?","volume":"2011","author":"Hardt","year":"2011","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.ajg.2021.05.018_b0130","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/pedi.12030","article-title":"Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D exchange clinic registry","volume":"14","author":"Cengiz","year":"2013","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.ajg.2021.05.018_b0135","doi-asserted-by":"crossref","unstructured":"Ly TT, Maahs DM, Rewers A, Dunger D, Oduwole A, Jones TW, et al. ISPAD Clinical Practice Consensus Guidelines 2014. Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2014;15(20):180-92.","DOI":"10.1111\/pedi.12174"},{"key":"10.1016\/j.ajg.2021.05.018_b0140","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.2337\/dc11-0748","article-title":"Reducing rates of severe hypoglycemia in a population-based cohort of children and adolescents with type 1 diabetes over the decade 2000\u20132009","volume":"34","author":"O\u2019Connell","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajg.2021.05.018_b0145","doi-asserted-by":"crossref","unstructured":"Kaser S, Winhofer-St\u00f6ckl Y, Kazemi-Shirazi L, Hofer SE, Brath H, Sourij H, et al. Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2019). 2019;131(Suppl 1):S16\u201326.","DOI":"10.1007\/s00508-019-1454-0"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.018_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4158\/EP.17.1.143","article-title":"The D-batable Institute of Medicine report: a D-lightful perspective","volume":"17","author":"Holick","year":"2011","journal-title":"Endocr Pract. Jan-Feb"},{"key":"10.1016\/j.ajg.2021.05.018_b0155","unstructured":"Brink SJ. Vitamin D (hypovitaminosis D), osteopenia and associated future co-morbidity risks in children and adolescents. In: Velea I, Paul C, Brink SJ (eds). Clinical Issues in Pediatric Endocrinology 2012. Timisoara, Romania: Mirton, 123-146."},{"issue":"1","key":"10.1016\/j.ajg.2021.05.018_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-007-8062-y","article-title":"Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients","volume":"122","author":"Kazi","year":"2008","journal-title":"Biol Trace Elem Res"},{"issue":"10","key":"10.1016\/j.ajg.2021.05.018_b0165","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.metabol.2009.04.035","article-title":"Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus","volume":"58","author":"Viktor\u00ednov\u00e1","year":"2009","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.ajg.2021.05.018_b0170","first-page":"73","article-title":"Biochemical analysis of serum pancreatic amylase and lipase enzymes in patients with type 1 and type 2 diabetes mellitus","volume":"26","author":"Aughsteen","year":"2005","journal-title":"Saudi Med J"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S168719792100040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S168719792100040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:45:42Z","timestamp":1761659142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S168719792100040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S168719792100040X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.018","relation":{},"ISSN":["1687-1979"],"issn-type":[{"value":"1687-1979","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exocrine pancreas functions in children with type 1 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2021.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}