{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:26:58Z","timestamp":1787678818808,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003007","name":"Ministry of Scientific Research, Egypt","doi-asserted-by":"publisher","award":["17-2-120"],"award-info":[{"award-number":["17-2-120"]}],"id":[{"id":"10.13039\/501100003007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ajg.2021.06.002","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:32:26Z","timestamp":1631125946000},"page":"278-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis and characterization of amoxicillin-loaded polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori"],"prefix":"10.1016","volume":"22","author":[{"given":"Aya","family":"Abdelghany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"El-Desouky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Shemis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajg.2021.06.002_b0005","first-page":"8979","article-title":"Helicobacter pylori: friend or foe?","volume":"20","author":"Malnick","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.06.002_b0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5897\/AJMR2015.7693","article-title":"Helicobacter pylori vacA genotyping in relation to cagA status, ultra-structure of gastric mucosa and clinical outcomes in Egyptian patients","volume":"10","author":"Manal","year":"2016","journal-title":"Afr J Microbiol Res"},{"key":"10.1016\/j.ajg.2021.06.002_b0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ejmhg.2018.06.003","article-title":"Helicobacter pylori Western cagA genotype in Egyptian patients with upper gastrointestinal disease","volume":"19","author":"Diab","year":"2018","journal-title":"Egyptian J Med Hum Genet"},{"key":"10.1016\/j.ajg.2021.06.002_b0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","article-title":"Helicobacter pylori -induced gastric inflammation and gastric cancer","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajg.2021.06.002_b0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro3016","article-title":"Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori","volume":"11","author":"Salama","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ajg.2021.06.002_b0030","first-page":"43","article-title":"Helicobacter pylori cag Pathogenicity Island Genes Among Dyspeptic Patients with Chronic Gastritis","volume":"18","author":"Diab","year":"2009","journal-title":"Egypt J Med Microbiol"},{"key":"10.1016\/j.ajg.2021.06.002_b0035","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejmhg.2017.04.003","article-title":"Detection of Helicobacter pylori vacA, cagA and iceA1 virulence genes associated with gastric diseases in Egyptian patients","volume":"18","author":"El-Shenawy","year":"2017","journal-title":"Egyptian Journal of Medical Human Genetics"},{"key":"10.1016\/j.ajg.2021.06.002_b0040","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/apt.13497","article-title":"Review article: the global emergence of Helicobacter pylori antibiotic resistance","volume":"43","author":"Thung","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ajg.2021.06.002_b0045","first-page":"8971","article-title":"Natural products and food components with anti- Helicobacter pylori activities","volume":"20","author":"Takeuchi","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajg.2021.06.002_b0050","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11938-020-00300-3","article-title":"Update on the Management of Helicobacter pylori Infection","volume":"18","author":"Saleem","year":"2020","journal-title":"Curr Treat Options Gastroenterol"},{"key":"10.1016\/j.ajg.2021.06.002_b0055","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jemermed.2011.05.035","article-title":"The use of cephalosporins in penicillin-allergic patients: A literature review","volume":"42","author":"Campagna","year":"2012","journal-title":"J Emerg Med"},{"key":"10.1016\/j.ajg.2021.06.002_b0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/nano7060122","article-title":"A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs","volume":"7","author":"Li","year":"2017","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ajg.2021.06.002_b0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"Management of Helicobacter pylori infection\u2014the Maastricht IV\/ Florence Consensus Report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.ajg.2021.06.002_b0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.clay.2019.02.024","article-title":"Bionanocomposites based on cationic and anionic layered clays as controlled release devices of amoxicillin","volume":"173","author":"Rebitski","year":"2019","journal-title":"Appl Clay Sci"},{"key":"10.1016\/j.ajg.2021.06.002_b0075","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/02652040802373012","article-title":"Formulation and evaluation of stomach-specific microspheres for anti- Helicobacter pylori therapy","volume":"26","author":"Patel","year":"2009","journal-title":"J Microencapsul"},{"key":"10.1016\/j.ajg.2021.06.002_b0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12876-017-0589-6","article-title":"Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?","volume":"17","author":"Branquinho","year":"2017","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.ajg.2021.06.002_b0085","first-page":"139","volume":"21","author":"Santos","year":"2015","journal-title":"Pharmacological therapy used in the elimination of Helicobacter pylori infection : A review"},{"key":"10.1016\/j.ajg.2021.06.002_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2014.06.020","article-title":"Eradication of Helicobacter pylori: Past, present and future","author":"Lopes","year":"2014","journal-title":"J Control Release"},{"key":"10.1016\/j.ajg.2021.06.002_b0095","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.msec.2017.08.038","article-title":"Development of novel pH-sensitive thiolated chitosan\/PMLA nanoparticles for amoxicillin delivery to treat Helicobacter pylori","volume":"83","author":"Arif","year":"2018","journal-title":"Mater Sci Eng, C"},{"key":"10.1016\/j.ajg.2021.06.002_b0100","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ijbiomac.2016.05.027","article-title":"Floating mucoadhesive alginate beads of amoxicillin trihydrate: A facile approach for H. pylori eradication","volume":"89","author":"Dey","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.ajg.2021.06.002_b0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1517\/17425247.2012.673278","article-title":"Lipid nanoparticles: State of the art, new preparation methods and challenges in drug delivery","volume":"9","author":"Battaglia","year":"2012","journal-title":"Expert Opinion on Drug Delivery"},{"key":"10.1016\/j.ajg.2021.06.002_b0110","unstructured":"Singh DY, Prasad NK. Double liposomes mediated dual drug targeting for treatment of Helicobacter pylori infections 2011;66. https:\/\/doi.org\/10.1691\/ph.2011.0271."},{"key":"10.1016\/j.ajg.2021.06.002_b0115","first-page":"506","article-title":"A review on : Liposomes","volume":"5","author":"Deshmukh","year":"2016","journal-title":"World J Pharmacy Pharmaceutical Sci"},{"key":"10.1016\/j.ajg.2021.06.002_b0120","first-page":"1629","article-title":"Biopolymer-Based Nanoparticles for Drug \/ Gene Delivery and Tissue","author":"Nitta","year":"2013","journal-title":"Engineering"},{"key":"10.1016\/j.ajg.2021.06.002_b0125","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4161\/hv.26796","article-title":"Polymeric nanoparticles Potent vectors for vaccine delivery targeting cancer and infectious diseases","volume":"10","author":"Bolhassani","year":"2014","journal-title":"Human Vaccines Immunother"},{"key":"10.1016\/j.ajg.2021.06.002_b0130","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.biomaterials.2010.01.065","article-title":"Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles","volume":"31","author":"He","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ajg.2021.06.002_b0135","first-page":"47","article-title":"Polymers as Biomaterials for Tissue Engineering and Controlled","author":"Nair","year":"2006","journal-title":"Drug Delivery"},{"key":"10.1016\/j.ajg.2021.06.002_b0140","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jconrel.2011.07.031","article-title":"Albumin-based nanoparticles as potential controlled release drug delivery systems","volume":"157","author":"Elzoghby","year":"2012","journal-title":"J Control Release"},{"key":"10.1016\/j.ajg.2021.06.002_b0145","doi-asserted-by":"crossref","unstructured":"Pohlmann AR, Fonseca FN, Paese K, Detoni CB, Coradini K, Beck RCR, et al. Poly (e -caprolactone) microcapsules and nanocapsules in drug delivery 2013:623\u201338.","DOI":"10.1517\/17425247.2013.769956"},{"key":"10.1016\/j.ajg.2021.06.002_b0150","doi-asserted-by":"crossref","unstructured":"Ma Z, Haddadi A, Molavi O, Lavasanifar A, Lai R, Samuel J. Micelles of poly (ethylene oxide) - b -poly (e -caprolactone) as vehicles for the solubilization , stabilization , and controlled delivery of curcumin 2007. https:\/\/doi.org\/10.1002\/jbm.a.31584.","DOI":"10.1002\/jbm.a.31584"},{"key":"10.1016\/j.ajg.2021.06.002_b0155","unstructured":"Kumari A, Singla R, Guliani A, Yadav SK. Review article\u00a0: Nanoencapsulation for drug delivery 2014:265\u201386."},{"key":"10.1016\/j.ajg.2021.06.002_b0160","first-page":"280","article-title":"Pharmaceutical nanoencapsulation strategies: a mechanistic review","volume":"2","author":"Pattnaik","year":"2012","journal-title":"Int J Pharmacy Biol Sci"},{"key":"10.1016\/j.ajg.2021.06.002_b0165","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijpharm.2015.10.057","article-title":"Double emulsion solvent evaporation techniques used for drug encapsulation","volume":"496","author":"Iqbal","year":"2015","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajg.2021.06.002_b0170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jcis.2013.03.066","article-title":"Production of W\/O\/W (water-in-oil-in-water) multiple emulsions: Droplet breakup and release of water","volume":"402","author":"Schuch","year":"2013","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.ajg.2021.06.002_b0175","doi-asserted-by":"crossref","unstructured":"Katata L, Tshweu L. Design and formulation of nano-sized spray dried efavirenz-part I\u00a0: influence of formulation parameters 2012. https:\/\/doi.org\/10.1007\/s11051-012-1247-0.","DOI":"10.1007\/s11051-012-1247-0"},{"key":"10.1016\/j.ajg.2021.06.002_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-013-2040-4","article-title":"Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment","volume":"15","author":"Tshweu","year":"2013","journal-title":"J Nanopart Res"},{"key":"10.1016\/j.ajg.2021.06.002_b0185","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2147\/DDDT.S39956","article-title":"Pharmaceutical suspension containing both immediate\/sustained-release amoxicillin-loaded gelatin nanoparticles: Preparation and in vitro characterization","volume":"7","author":"Harsha","year":"2013","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.ajg.2021.06.002_b0190","doi-asserted-by":"crossref","unstructured":"Tshweu L, Katata L, Swai H. Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly (epsilon-caprolactone) nanoparticles by a spray-drying method 2013. https:\/\/doi.org\/10.2217\/NNM.13.167.","DOI":"10.2217\/nnm.13.167"},{"key":"10.1016\/j.ajg.2021.06.002_b0205","doi-asserted-by":"crossref","unstructured":"Mora-huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery 2010;385:113\u201342. https:\/\/doi.org\/10.1016\/j.ijpharm.2009.10.018.","DOI":"10.1016\/j.ijpharm.2009.10.018"},{"key":"10.1016\/j.ajg.2021.06.002_b0210","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3797\/scipharm.1011-05","article-title":"Amoxicillin loaded chitosan-alginate polyelectrolyte complex nanoparticles as mucopenetrating delivery system for H. pylori","volume":"79","author":"Arora","year":"2011","journal-title":"Sci Pharm"},{"key":"10.1016\/j.ajg.2021.06.002_b0215","doi-asserted-by":"crossref","unstructured":"Bardonnet P, Faivre V, Boullanger P, Piffaretti J. Pre-formulation of liposomes against Helicobacter pylori\u00a0: Characterization and interaction with the bacteria 2008;69:908\u201322. https:\/\/doi.org\/10.1016\/j.ejpb.2008.01.018.","DOI":"10.1016\/j.ejpb.2008.01.018"},{"key":"10.1016\/j.ajg.2021.06.002_b0220","first-page":"1","article-title":"Protocols for screening chemical agents and natural products against animal tumors and other biological systems \u2013 ScienceOpen","volume":"3","author":"Geran","year":"1972","journal-title":"Cancer Chemother Rep"},{"key":"10.1016\/j.ajg.2021.06.002_b0225","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s11418-012-0628-0","article-title":"Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L","volume":"66","author":"Susanti","year":"2012","journal-title":"J Nat Med"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197921000447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:44:38Z","timestamp":1761659078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197921000447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1687197921000447"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2021.06.002","relation":{},"ISSN":["1687-1979"],"issn-type":[{"value":"1687-1979","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and characterization of amoxicillin-loaded polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2021.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}