{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:13:51Z","timestamp":1790252031353,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ajg.2022.04.001","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T01:13:26Z","timestamp":1653095606000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The diagnostic utility of microRNA 222-3p, microRNA 21-5p, and microRNA 122-5p for HCV-related hepatocellular carcinoma and its relation to direct-acting antiviral therapy"],"prefix":"10.1016","volume":"23","author":[{"given":"Ahmed","family":"Khairy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa K.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"AbdElrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab","family":"Fouad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra","family":"Ayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Abdellatef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Yosry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajg.2022.04.001_b0005","first-page":"138","article-title":"Hepatocellular carcinoma","volume":"11","author":"Lichtenstein","year":"2015","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00261-017-1209-1","article-title":"Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis","volume":"43","author":"Tang","year":"2018","journal-title":"Abdom Radiol (NY)"},{"issue":"13","key":"10.1016\/j.ajg.2022.04.001_b0015","article-title":"Circulating biomarkers for early detection of hepatocellular carcinoma","volume":"13","author":"Beudeker","year":"2020","journal-title":"Ther Adv Gastroenterol"},{"issue":"12","key":"10.1016\/j.ajg.2022.04.001_b0020","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1158\/1055-9965.EPI-20-0005","article-title":"Biomarkers for the early detection of hepatocellular carcinoma","volume":"29","author":"Parikh","year":"2020","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"10.1016\/j.ajg.2022.04.001_b0025","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3390\/ijms19041007","article-title":"The role of circulating free DNA and microRNA in non-invasive diagnosis of HBV- and HCV-related hepatocellular carcinoma","volume":"19","author":"Pezzuto","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajg.2022.04.001_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.689992","article-title":"Role of lncRNA BANCR in human cancers: an updated review","volume":"9","author":"Hussen","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13148-018-0587-8","article-title":"The role and mechanisms of action of microRNAs in cancer drug resistance","volume":"11","author":"Si","year":"2019","journal-title":"Clin Epigenetics"},{"issue":"9","key":"10.1016\/j.ajg.2022.04.001_b0040","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers","volume":"101","author":"Calin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.ajg.2022.04.001_b0045","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ncb3227","article-title":"Distinct E-cadherin-based complexes regulate cell behaviour through microRNA processing or Src and p120 catenin activity","volume":"17","author":"Kourtidis","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.ajg.2022.04.001_b0050","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ijc.28068","article-title":"Concordant hypermethylation of intergenic microRNA genes in human hepatocellular carcinoma as new diagnostic and prognostic marker","volume":"133","author":"Anwar","year":"2013","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/ijms20010049","article-title":"Molecular mechanisms involved in HCC recurrence after direct-acting antiviral therapy","volume":"20","author":"Villani","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.ajg.2022.04.001_b0060","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.3390\/cancers11111773","article-title":"Serum microRNA are promising biomarkers for the detection of early hepatocellular carcinoma after treatment with direct-acting antivirals","volume":"11","author":"Pascut","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ajg.2022.04.001_b0065","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2011.13287","article-title":"The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis","volume":"141","author":"Haybaeck","year":"2011","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/hep.21672","article-title":"Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma","volume":"46","author":"Matsuzaki","year":"2007","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.ajg.2022.04.001_b0075","doi-asserted-by":"crossref","first-page":"e79655","DOI":"10.1371\/journal.pone.0079655","article-title":"miR-122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3","volume":"8","author":"Nassirpour","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajg.2022.04.001_b0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.virusres.2018.06.007","article-title":"microRNA-221 and microRNA-222 are promising biomarkers for progression of liver fibrosis in HCV Egyptian patients","volume":"253","author":"Abdel-Al","year":"2018","journal-title":"Virus Res"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0085","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1038\/s41598-019-46872-8","article-title":"Circulating microRNAs as potential diagnostic and prognostic biomarkers in hepatocellular carcinoma","volume":"9","author":"Jin","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajg.2022.04.001_b0090","unstructured":"European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatocellular carcinoma. J Hepatol 2018;69(1):182-236."},{"issue":"2","key":"10.1016\/j.ajg.2022.04.001_b0095","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1002\/lt.22365","article-title":"Milan criteria in liver transplantation for hepatocellular carcinoma: an evidence-based analysis of 15 years of experience","volume":"17","author":"Mazzaferro","year":"2011","journal-title":"Liver Transpl"},{"issue":"3","key":"10.1016\/j.ajg.2022.04.001_b0100","first-page":"71","article-title":"An improvement of the 2\u0302(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis","volume":"3","author":"Rao","year":"2013","journal-title":"Biostat Bioinforma Biomath"},{"key":"10.1016\/j.ajg.2022.04.001_b0105","first-page":"17","article-title":"Direct acting antivirals therapy and hepatocellular carcinoma risk in patients with hepatitis C virus","volume":"6","author":"Pazgan-Simon","year":"2020","journal-title":"Hepatoma Res"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12876-020-01345-5","article-title":"The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis","volume":"20","author":"Peng","year":"2020","journal-title":"BMC Gastroenterol"},{"issue":"3","key":"10.1016\/j.ajg.2022.04.001_b0115","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.gendis.2020.01.014","article-title":"Advances in the early diagnosis of hepatocellular carcinoma","volume":"7","author":"Wang","year":"2020","journal-title":"Genes Dis"},{"issue":"13","key":"10.1016\/j.ajg.2022.04.001_b0120","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/cncr.31406","article-title":"Risk factors for hepatocellular carcinoma by age, sex, and liver disorder status: A prospective cohort study in Korea","volume":"124","author":"Yi","year":"2018","journal-title":"Cancer"},{"issue":"1\u20132","key":"10.1016\/j.ajg.2022.04.001_b0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000505326","article-title":"Changing patterns of hepatocellular carcinoma after treatment with direct antiviral agents","volume":"7","author":"El Fayoumie","year":"2020","journal-title":"Gastrointest Tumors"},{"issue":"51","key":"10.1016\/j.ajg.2022.04.001_b0130","doi-asserted-by":"crossref","first-page":"88517","DOI":"10.18632\/oncotarget.19774","article-title":"MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis","volume":"8","author":"de Conti","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.ajg.2022.04.001_b0135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/ijo.2021.5200","article-title":"Emerging roles and mechanisms of microRNA\u2013222\u20133p in human cancer (Review) (Review)","volume":"58","author":"Wang","year":"2021","journal-title":"Int J Oncol"},{"issue":"3","key":"10.1016\/j.ajg.2022.04.001_b0140","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1158\/1078-0432.CCR-09-1840","article-title":"MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling","volume":"16","author":"Wong","year":"2010","journal-title":"Clin Cancer Res"},{"issue":"10","key":"10.1016\/j.ajg.2022.04.001_b0145","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1002\/ijc.33111","article-title":"The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein","volume":"147","author":"Ghosh","year":"2020","journal-title":"Int J Cancer"},{"issue":"27","key":"10.1016\/j.ajg.2022.04.001_b0150","doi-asserted-by":"crossref","first-page":"44050","DOI":"10.18632\/oncotarget.17211","article-title":"Circulating miR-21 serves as a serum biomarker for hepatocellular carcinoma and correlated with distant metastasis","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.001_b0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2011.04.026","article-title":"Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma","volume":"56","author":"Tomimaru","year":"2012","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.001_b0160","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jhep.2012.10.015","article-title":"Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis","volume":"58","author":"Trebicka","year":"2013","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.ajg.2022.04.001_b0165","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/hep.22806","article-title":"MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma","volume":"49","author":"Tsai","year":"2009","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.001_b0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/jvh.12470","article-title":"Serum miR-122 may serve as a biomarker for response to direct acting antivirals: effect of paritaprevir\/R with dasabuvir or ombitasvir on miR-122 in HCV-infected subjects","volume":"23","author":"Waring","year":"2016","journal-title":"J Viral Hepat"},{"issue":"4","key":"10.1016\/j.ajg.2022.04.001_b0175","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00535-014-0932-4","article-title":"Antitumor function of microRNA-122 against hepatocellular carcinoma","volume":"49","author":"Nakao","year":"2014","journal-title":"J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.001_b0180","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jhep.2014.10.004","article-title":"miR-122\u2013a key factor and therapeutic target in liver disease","volume":"62","author":"Bandiera","year":"2015","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.001_b0185","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/1566523214666141224095610","article-title":"miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as microRNA mimic and antimir","volume":"15","author":"Thakral","year":"2015","journal-title":"Curr Gene Ther"},{"issue":"6","key":"10.1016\/j.ajg.2022.04.001_b0190","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1007\/s13277-015-3128-5","article-title":"High serum microRNA-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients","volume":"36","author":"Xu","year":"2015","journal-title":"Tumour Biol"},{"issue":"5","key":"10.1016\/j.ajg.2022.04.001_b0195","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/hep.28679","article-title":"The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53\/mouse double minute 2 homolog circuitry","volume":"64","author":"Simerzin","year":"2016","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.ajg.2022.04.001_b0200","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1172\/JCI63455","article-title":"MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis","volume":"122","author":"Tsai","year":"2012","journal-title":"J Clin Invest"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197922000284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197922000284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:44:26Z","timestamp":1761659066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197922000284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1687197922000284"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2022.04.001","relation":{},"ISSN":["1687-1979"],"issn-type":[{"value":"1687-1979","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The diagnostic utility of microRNA 222-3p, microRNA 21-5p, and microRNA 122-5p for HCV-related hepatocellular carcinoma and its relation to direct-acting antiviral therapy","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2022.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V. on behalf of Pan-Arab Association of Gastroenterology.","name":"copyright","label":"Copyright"}]}}