{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:22:12Z","timestamp":1780392132665,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010847","name":"Health and Family Planning Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202130635"],"award-info":[{"award-number":["202130635"]}],"id":[{"id":"10.13039\/501100010847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ajg.2022.04.002","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T16:40:59Z","timestamp":1651509659000},"page":"188-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Forkhead box A2 transcriptionally activates hsa-let-7\u00a0g to inhibit hypoxia-induced epithelial-mesenchymal transition by targeting c14orf28 in colorectal cancer"],"prefix":"10.1016","volume":"23","author":[{"given":"Canhui","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qubo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajg.2022.04.002_b0005","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/nu11010164","article-title":"Colorectal cancer and nutrition","volume":"11","author":"Thanikachalam","year":"2019","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.ajg.2022.04.002_b0010","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ajg.2022.04.002_b0015","doi-asserted-by":"crossref","first-page":"11767","DOI":"10.3748\/wjg.v21.i41.11767","article-title":"Colorectal cancer: Metastases to a single organ","volume":"21","author":"Vatandoust","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajg.2022.04.002_b0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1067\/j.cpsurg.2018.08.004","article-title":"Cytoreduction for colorectal metastases: Liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?","volume":"55","author":"Stewart","year":"2018","journal-title":"Curr Probl Surg"},{"key":"10.1016\/j.ajg.2022.04.002_b0025","doi-asserted-by":"crossref","first-page":"iv61","DOI":"10.1093\/annonc\/mdp130","article-title":"Advanced colorectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up","volume":"20","author":"Van Cutsem","year":"2009","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.ajg.2022.04.002_b0030","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2017.06.118","article-title":"Regulation of testicular steroidogenesis by Foxa3 via transcriptional modulation of ER\u03b1 signaling in type 2 diabetes mellitus (T2DM)","volume":"490","author":"Zhao","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0035","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1186\/1471-2164-14-680","article-title":"A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer","volume":"14","author":"Wang","year":"2013","journal-title":"BMC Genomics"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.002_b0040","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.canlet.2015.03.008","article-title":"FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer","volume":"361","author":"Zhang","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajg.2022.04.002_b0045","doi-asserted-by":"crossref","unstructured":"Cernilogar FM, Hasen\u00f6der S, Wang Z, Scheibner K, Burtscher I, Sterr M, et al. Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2. Nucleic Acids Res 2019;47: 9069-86.","DOI":"10.1093\/nar\/gkz627"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0050","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-019-0810-5","article-title":"PGC-1\u03b2 cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells","volume":"19","author":"Cao","year":"2019","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.ajg.2022.04.002_b0055","first-page":"2","article-title":"LINC00261 and the adjacent gene FOXA2 are epithelial markers and are suppressed during lung cancer tumorigenesis and progression","volume":"5","author":"Dhamija","year":"2018","journal-title":"Noncoding RNA"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10620-014-3290-4","article-title":"The transcription factor FOXA2 suppresses gastric tumorigenesis in vitro and in vivo","volume":"60","author":"Zhu","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ajg.2022.04.002_b0065","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.928763","article-title":"Correlation between high expression of FOXA2 and improved overall survival in ovarian cancer patients","volume":"27","author":"Shang","year":"2021","journal-title":"Med Sci Monit"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41422-019-0259-z","article-title":"Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer","volume":"30","author":"Teng","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.ajg.2022.04.002_b0075","first-page":"133","article-title":"FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer","volume":"16","author":"Wang","year":"2018","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bib\/bbs075","article-title":"Identifying miRNAs, targets and functions","volume":"15","author":"Liu","year":"2014","journal-title":"Brief Bioinform"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.002_b0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/cbic.201402449","article-title":"miRNA and methylation: A multifaceted liaison","volume":"16","author":"Chhabra","year":"2015","journal-title":"ChemBioChem"},{"issue":"5","key":"10.1016\/j.ajg.2022.04.002_b0090","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: Biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajg.2022.04.002_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbior.2014.09.013","article-title":"MicroRNA and cancer\u2013A brief overview","volume":"57","author":"Acunzo","year":"2015","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.ajg.2022.04.002_b0100","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biopha.2015.08.006","article-title":"miRNA-144 suppresses proliferation and migration of colorectal cancer cells through GSPT1","volume":"74","author":"Xiao","year":"2015","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0105","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-017-0445-8","article-title":"Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer","volume":"10","author":"Sun","year":"2017","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.ajg.2022.04.002_b0110","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.3390\/cells10092415","article-title":"The roles of the Let-7 family of microRNAs in the regulation of cancer stemness","volume":"10","author":"Ma","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ajg.2022.04.002_b0115","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/jcmm.12997","article-title":"MicroRNA let-7g possesses a therapeutic potential for peripheral artery disease","volume":"21","author":"Hsu","year":"2017","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/YPG.0000000000000303","article-title":"Evaluation of hsa-let-7d-5p, hsa-let-7g-5p and hsa-miR-15b-5p plasma levels in patients with Alzheimer\u2019s disease","volume":"32","author":"Poursaei","year":"2022","journal-title":"Psychiatr Genet"},{"issue":"2","key":"10.1016\/j.ajg.2022.04.002_b0125","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/j.gastro.2017.04.017","article-title":"Antagonistic effects of p53 and HIF1A on microRNA-34a regulation of PPP1R11 and STAT3 and hypoxia-induced epithelial to mesenchymal transition in colorectal cancer cells","volume":"153","author":"Li","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajg.2022.04.002_b0130","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3389\/fonc.2019.01255","article-title":"RAS, cellular plasticity, and tumor budding in colorectal cancer","volume":"9","author":"Maffeis","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.ajg.2022.04.002_b0135","first-page":"384","article-title":"2-Amino-4-(1-piperidine) pyridine exhibits inhibitory effect on colon cancer through suppression of FOXA2 expression. 3","volume":"9","author":"Wang","year":"2019","journal-title":"Biotech"},{"issue":"4","key":"10.1016\/j.ajg.2022.04.002_b0140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/cancers11040489","article-title":"Functional effects of let-7g expression in colon cancer metastasis","volume":"11","author":"Chang","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"1-2","key":"10.1016\/j.ajg.2022.04.002_b0145","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11010-017-3049-2","article-title":"C14orf28 downregulated by miR-519d contributes to oncogenicity and regulates apoptosis and EMT in colorectal cancer","volume":"434","author":"Yang","year":"2017","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"10.1016\/j.ajg.2022.04.002_b0150","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/ijc.29519","article-title":"HIF-1 at the crossroads of hypoxia, inflammation, and cancer","volume":"138","author":"Balamurugan","year":"2016","journal-title":"Int J Cancer"},{"issue":"6","key":"10.1016\/j.ajg.2022.04.002_b0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2174\/1566524018666181109121849","article-title":"Role of HIF-1 in cancer progression: Novel insights","volume":"18","author":"Pezzuto","year":"2019","journal-title":"A review. Curr Mol Med"},{"key":"10.1016\/j.ajg.2022.04.002_b0160","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1478-3231.2010.02205.x","article-title":"Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms","volume":"30","author":"Copple","year":"2010","journal-title":"Liver Int"},{"key":"10.1016\/j.ajg.2022.04.002_b0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2014.02.011","article-title":"The dual PI3K\/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-\u03b21","volume":"729","author":"Lin","year":"2014","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2010.05.024","article-title":"Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors","volume":"18","author":"Qi","year":"2010","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.ajg.2022.04.002_b0175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccr.2004.06.009","article-title":"Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway","volume":"6","author":"Kung","year":"2004","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.ajg.2022.04.002_b0180","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1158\/0008-5472.CAN-05-1235","article-title":"Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity","volume":"65","author":"Kong","year":"2005","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.ajg.2022.04.002_b0185","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ajg.2022.04.002_b0190","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.3892\/ol.2016.5369","article-title":"Biomarkers for EMT and MET in breast cancer: An update","volume":"12","author":"Liu","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ajg.2022.04.002_b0195","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcancer.2019.08.003","article-title":"Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator","volume":"62","author":"Karamanou","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ajg.2022.04.002_b0200","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.3748\/wjg.v22.i30.6764","article-title":"Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancer","volume":"22","author":"Gurzu","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajg.2022.04.002_b0205","first-page":"349","article-title":"The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas","volume":"48","author":"Gurzu","year":"2007","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.ajg.2022.04.002_b0210","first-page":"149","article-title":"The angiogenesis in colorectal carcinomas with and without lymph node metastases","volume":"49","author":"Gurzu","year":"2008","journal-title":"Rom J Morphol Embryol"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197922000296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197922000296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:46:54Z","timestamp":1761659214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197922000296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1687197922000296"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2022.04.002","relation":{},"ISSN":["1687-1979"],"issn-type":[{"value":"1687-1979","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Forkhead box A2 transcriptionally activates hsa-let-7\u00a0g to inhibit hypoxia-induced epithelial-mesenchymal transition by targeting c14orf28 in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2022.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}