{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:35:38Z","timestamp":1754159738066,"version":"3.41.2"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajg.2025.01.010","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T15:23:49Z","timestamp":1747063429000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy and safety of venous thromboembolism prophylaxis among hospitalized cirrhotic patients: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"26","author":[{"given":"Abdel-Naser","family":"Elzouki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Nabil","family":"Elshafei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam","family":"Elzouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munir","family":"Abu-Ageila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Aamir","family":"Waheed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmukhtar","family":"Habas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed I.","family":"Danjuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajg.2025.01.010_b0005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1053\/j.seminhematol.2013.06.003","article-title":"Hematologic manifestations of liver disease","volume":"50","author":"Marks","year":"2013","journal-title":"Semin Hematol"},{"issue":"6","key":"10.1016\/j.ajg.2025.01.010_b0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cgh.2009.02.021","article-title":"Portal Hypertension Collaborative Group. Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis","volume":"7","author":"Qamar","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.ajg.2025.01.010_b0015","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2008.03.009","article-title":"Thrombocytopenia associated with chronic liver disease","volume":"48","author":"Afdhal","year":"2008","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.ajg.2025.01.010_b0020","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/jth.14011","article-title":"Increased factor VIII plays a significant role in plasma hypercoagulability phenotype of patients with cirrhosis","volume":"16","author":"Sinegre","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.ajg.2025.01.010_b0025","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/jth.14020","article-title":"Mechanisms of enhanced thrombin-generating capacity in patients with cirrhosis","volume":"16","author":"Lisman","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"8","key":"10.1016\/j.ajg.2025.01.010_b0030","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1055\/s-0038-1661393","article-title":"Major Changes of von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Stable Disease or Acute Decompensation","volume":"118","author":"Palyu","year":"2018","journal-title":"Thromb Haemost"},{"issue":"5","key":"10.1016\/j.ajg.2025.01.010_b0035","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1600-6143.2009.02621.x","article-title":"Development of a severe von Willebrand factor\/ADAMTS13 dysbalance during orthotopic liver transplantation","volume":"9","author":"Pereboom","year":"2009","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajg.2025.01.010_b0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ajg.2025.01.010_b0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000442877","article-title":"The Complex Role of Anticoagulation in Cirrhosis: An Updated Review of Where We Are and Where We Are Going","volume":"93","author":"Khoury","year":"2016","journal-title":"Digestion"},{"issue":"1","key":"10.1016\/j.ajg.2025.01.010_b0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1160\/TH16-06-0450","article-title":"The risk of venous thromboembolism in patients with cirrhosis. A systematic review and meta-analysis","volume":"117","author":"Ambrosino","year":"2017","journal-title":"Thromb Haemost"},{"issue":"5","key":"10.1016\/j.ajg.2025.01.010_b0055","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1378\/chest.09-2177","article-title":"Coagulopathy does not protect against venous thromboembolism in hospitalized patients with chronic liver disease","volume":"137","author":"Dabbagh","year":"2010","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ajg.2025.01.010_b0060","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D'Amico","year":"2006","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.ajg.2025.01.010_b0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1478-3231.2011.02517.x","article-title":"All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study","volume":"32","author":"Fleming","year":"2012","journal-title":"Liver Int"},{"issue":"7","key":"10.1016\/j.ajg.2025.01.010_b0070","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1007\/s10620-011-1582-5","article-title":"Deep Vein Thrombosis and Pulmonary Embolism in Hospitalized Patients with Cirrhosis: A Nationwide Analysis","volume":"56","author":"Ali","year":"2011","journal-title":"Dig Dis Sci"},{"issue":"1","key":"10.1016\/j.ajg.2025.01.010_b0075","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ajg.2008.34","article-title":"Risk of venous thromboembolism in patients with liver disease: a nationwide population-based case-control study","volume":"104","author":"S\u00f8gaard","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ajg.2025.01.010_b0080","doi-asserted-by":"crossref","unstructured":"Wu H, Nguyen GC. Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study [published correction appears in Clin Gastroenterol Hepatol. 2011 Apr;9(4):366]. Clin Gastroenterol Hepatol. 2010;8(9):800-805. doi:10.1016\/j.cgh.2010.05.014.","DOI":"10.1016\/j.cgh.2010.05.014"},{"issue":"3","key":"10.1016\/j.ajg.2025.01.010_b0085","first-page":"e123","article-title":"PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement","volume":"3","author":"Moher","year":"2009","journal-title":"Open Med"},{"key":"10.1016\/j.ajg.2025.01.010_b0090","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jclinepi.2021.01.012","article-title":"The MethodologicAl STandards for Epidemiological Research (MASTER) scale demonstrated a unified framework for bias assessment","volume":"134","author":"Stone","year":"2021","journal-title":"J Clin Epidemiol"},{"issue":"8","key":"10.1016\/j.ajg.2025.01.010_b0095","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jval.2021.02.011","article-title":"Bias Assessment in Outcomes Research: The Role of Relative Versus Absolute Approaches","volume":"24","author":"Stone","year":"2021","journal-title":"Value Health"},{"key":"10.1016\/j.ajg.2025.01.010_b0100","article-title":"Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice","author":"Doi","year":"2022142271","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ajg.2025.01.010_b0105","article-title":"Selecting the best meta-analytic estimator for evidence-based practice: a simulation study","author":"Doi","year":"202018186","journal-title":"Int J Evid Based Healthc"},{"key":"10.1016\/j.ajg.2025.01.010_b0110","doi-asserted-by":"crossref","unstructured":"Doi SA, Barendregt JJ, Khan S, Thalib L, Williams GM. Advances in the meta-analysis of heterogeneous clinical trials I: The inverse variance heterogeneity model. Contemp Clin Trials. 2015;45(Pt A):130-138. doi:10.1016\/j.cct.2015.05.009.","DOI":"10.1016\/j.cct.2015.05.009"},{"issue":"4","key":"10.1016\/j.ajg.2025.01.010_b0115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4254\/wjh.v11.i4.379","article-title":"Effectiveness of venous thromboembolism prophylaxis in patients with liver disease","volume":"11","author":"Yerke","year":"2019","journal-title":"World J Hepatol"},{"issue":"3","key":"10.1016\/j.ajg.2025.01.010_b0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/ejh.13363","article-title":"Overuse of venous thromboembolism prophylaxis among hospitalized patients with liver disease","volume":"104","author":"Davis","year":"2020","journal-title":"Eur J Haematol"},{"issue":"1","key":"10.1016\/j.ajg.2025.01.010_b0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0897190015611570","article-title":"A Retrospective Cohort Analysis of Pharmacologic VTE Prophylaxis and Padua Prediction Score in Hospitalized Patients With Chronic Liver Disease","volume":"30","author":"Moorehead","year":"2017","journal-title":"J Pharm Pract"},{"issue":"4","key":"10.1016\/j.ajg.2025.01.010_b0130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/phar.1218","article-title":"Evaluation of pharmacologic prophylaxis for venous thromboembolism in patients with chronic liver disease","volume":"33","author":"Barclay","year":"2013","journal-title":"Pharmacotherapy"},{"issue":"10","key":"10.1016\/j.ajg.2025.01.010_b0135","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/phar.1464","article-title":"Risk of hemorrhage in patients with chronic liver disease and coagulopathy receiving pharmacologic venous thromboembolism prophylaxis","volume":"34","author":"Reichert","year":"2014","journal-title":"Pharmacotherapy"},{"issue":"2","key":"10.1016\/j.ajg.2025.01.010_b0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.14740\/gr1493","article-title":"The Incidence of Venous Thromboembolism and Practice of Deep Venous Thrombosis Prophylaxis Among Hospitalized Cirrhotic Patients","volume":"15","author":"Alsheikh","year":"2022","journal-title":"Gastroenterology Res"},{"issue":"7","key":"10.1016\/j.ajg.2025.01.010_b0145","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/jth.13000","article-title":"Safety and efficacy of pharmacological thromboprophylaxis for hospitalized patients with cirrhosis: a single-center retrospective cohort study","volume":"13","author":"Shatzel","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ajg.2025.01.010_b0150","doi-asserted-by":"crossref","unstructured":"Aldawood A, Arabi Y, Aljumah A, et al. The incidence of venous thromboembolism and practice of deep venous thrombosis prophylaxis in hospitalized cirrhotic patients. Thromb J. 2011;9(1):1. Published 2011 Jan 18. doi:10.1186\/1477-9560-9-1.","DOI":"10.1186\/1477-9560-9-1"},{"key":"10.1016\/j.ajg.2025.01.010_b0155","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/807526","article-title":"Venous thromboembolism in critically ill cirrhotic patients: practices of prophylaxis and incidence","volume":"2013","author":"Al-Dorzi","year":"2013","journal-title":"Thrombosis"},{"issue":"2","key":"10.1016\/j.ajg.2025.01.010_b0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.ajg.2025.01.010_b0165","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.3748\/wjg.v20.i19.5737","article-title":"Deep vein thrombosis and pulmonary embolism in cirrhotic patients: systematic review","volume":"20","author":"Aggarwal","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.ajg.2025.01.010_b0170","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1053\/j.gastro.2009.08.045","article-title":"An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis","volume":"137","author":"Tripodi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajg.2025.01.010_b0175","doi-asserted-by":"crossref","unstructured":"Chang WH, Mueller SH, Tan YY, Lai AG. Antithrombotic therapy in patients with liver disease: population-based insights on variations in prescribing trends, adherence, persistence and impact on stroke and bleeding. Lancet Reg Health Eur. 2021;10:100222. Published 2021 Sep 8. doi:10.1016\/j.lanepe.2021.100222.","DOI":"10.1016\/j.lanepe.2021.100222"},{"key":"10.1016\/j.ajg.2025.01.010_b0180","doi-asserted-by":"crossref","unstructured":"Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S-453S. doi:10.1378\/chest.08-0656.","DOI":"10.1378\/chest.08-0656"},{"issue":"37","key":"10.1016\/j.ajg.2025.01.010_b0185","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000030551","article-title":"Recurrent thromboembolism, bleeding, and mortality in Asian patients with venous thromboembolism receiving different oral anticoagulants: A nationwide analysis","volume":"101","author":"Lee","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ajg.2025.01.010_b0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.thromres.2022.05.004","article-title":"Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis","volume":"215","author":"Subhani","year":"2022","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.ajg.2025.01.010_b0195","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.thromres.2013.08.001","article-title":"Efficacy and safety of the use of heparin as thromboprophylaxis in patients with liver cirrhosis: a systematic review and meta-analysis","volume":"132","author":"Cuervo","year":"2013","journal-title":"Thromb Res"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197925000103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197925000103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T19:46:13Z","timestamp":1753472773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197925000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1687197925000103"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2025.01.010","relation":{},"ISSN":["1687-1979"],"issn-type":[{"type":"print","value":"1687-1979"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The efficacy and safety of venous thromboembolism prophylaxis among hospitalized cirrhotic patients: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2025.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}