{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:13:04Z","timestamp":1780981984902,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007928","name":"Ningbo Municipal Bureau of Science and Technology","doi-asserted-by":"publisher","award":["2021Y46"],"award-info":[{"award-number":["2021Y46"]}],"id":[{"id":"10.13039\/501100007928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305334"],"award-info":[{"award-number":["82305334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074386"],"award-info":[{"award-number":["82074386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arab Journal of Gastroenterology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajg.2025.04.001","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T07:22:19Z","timestamp":1746429739000},"page":"262-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cinnamaldehyde attenuates CCL4-induced liver fibrosis by inhibiting the CYP2A6\/Notch3 pathway"],"prefix":"10.1016","volume":"26","author":[{"given":"Sicheng","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiye","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajg.2025.04.001_b0005","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jhep.2018.05.011","article-title":"Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies","volume":"69","author":"Pimpin","year":"2018","journal-title":"J Hepatol"},{"issue":"9930","key":"10.1016\/j.ajg.2025.04.001_b0010","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ajg.2025.04.001_b0015","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tacke","year":"2015","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.ajg.2025.04.001_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111339","article-title":"Mechanisms Underlying cell therapy in liver fibrosis: an overview","volume":"8","author":"Pinheiro","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ajg.2025.04.001_b0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/01480545.2017.1417995","article-title":"Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review","volume":"41","author":"Dorri","year":"2018","journal-title":"Drug Chem Toxicol"},{"key":"10.1016\/j.ajg.2025.04.001_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118893","article-title":"Acid-sensitive oxidative stress inducing and photoabsorbing polysaccharide nanoparticles for combinational anticancer therapy","volume":"574","author":"Hong","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajg.2025.04.001_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.570122","article-title":"Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19","volume":"11","author":"Mrityunjaya","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ajg.2025.04.001_b0040","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.taap.2009.12.030","article-title":"Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts","volume":"244","author":"Chao","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"11","key":"10.1016\/j.ajg.2025.04.001_b0045","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1248\/bpb.b20-00407","article-title":"trans-cinnamaldehyde prevents oxidative stress-induced apoptosis in V79-4 Chinese hamster lung fibroblasts through the Nrf2-mediated HO-1 activation","volume":"43","author":"Choi","year":"2020","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.ajg.2025.04.001_b0050","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2475047","article-title":"NRF2 activation inhibits both TGF-\u03b21- and IL-13-mediated periostin expression in fibroblasts: benefit of cinnamaldehyde for antifibrotic treatment","volume":"2018","author":"Mitamura","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajg.2025.04.001_b0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.biopha.2018.03.145","article-title":"Submicron emulsion of cinnamaldehyde ameliorates bleomycin-induced idiopathic pulmonary fibrosis via inhibition of inflammation, oxidative stress and epithelial-mesenchymal transition","volume":"102","author":"Yan","year":"2018","journal-title":"Biomed Pharmacotherapy = Biomed Pharmacotherapie"},{"key":"10.1016\/j.ajg.2025.04.001_b0060","article-title":"The methyltransferase METTL3-mediated fatty acid metabolism revealed the mechanism of cinnamaldehyde on alleviating steatosis","volume":"153","author":"Xu","year":"2022","journal-title":"Biomed Pharmacotherapy = Biomed Pharmacotherapie"},{"key":"10.1016\/j.ajg.2025.04.001_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","article-title":"P450 superfamily update on new sequences, gene mapping, accession numbers and nomenclature","volume":"6","author":"David","year":"1996","journal-title":"Pharmacogenetics"},{"issue":"2","key":"10.1016\/j.ajg.2025.04.001_b0070","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/hep.510270217","article-title":"Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma","volume":"27","author":"Raunio","year":"1998","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ajg.2025.04.001_b0075","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1124\/dmd.115.067942","article-title":"Inactivation of CYP2A6 by the dietary phenylpropanoid trans-cinnamic aldehyde (cinnamaldehyde) and estimation of interactions with nicotine and letrozole","volume":"44","author":"Chan","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.ajg.2025.04.001_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154466","article-title":"TKF, a mexicanolide-type limonoid derivative, suppressed hepatic stellate cells activation and liver fibrosis through inhibition of the YAP\/Notch3 pathway","volume":"107","author":"Yang","year":"2022","journal-title":"Phytomedicine"},{"issue":"7783","key":"10.1016\/j.ajg.2025.04.001_b0085","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ajg.2025.04.001_b0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s13205-022-03192-5","article-title":"Amelioration of high-fat diet (HFD)\u2009+\u2009CCl4 induced NASH\/NAFLD in CF-1 mice by activation of SIRT-1 using cinnamoyl sulfonamide hydroxamate derivatives: in-silico molecular modelling and in-vivo prediction","volume":"12","author":"Sodum","year":"2022","journal-title":"3 Biotech"},{"key":"10.1016\/j.ajg.2025.04.001_b0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biopha.2018.06.060","article-title":"Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway","volume":"106","author":"Sui","year":"2018","journal-title":"Biomed Pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"2","key":"10.1016\/j.ajg.2025.04.001_b0100","article-title":"Transforming growth factor \u03b2 latency: A mechanism of cytokine storage and signalling regulation in liver homeostasis and disease","volume":"4","author":"Li","year":"2022","journal-title":"JHEP Rep : Innov Hepatol"},{"issue":"14","key":"10.1016\/j.ajg.2025.04.001_b0105","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1074\/jbc.M113.545822","article-title":"Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein","volume":"289","author":"O'Reilly","year":"2014","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.ajg.2025.04.001_b0110","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00109-015-1308-9","article-title":"Gremlin is a key pro-fibrogenic factor in chronic pancreatitis","volume":"93","author":"Staloch","year":"2015","journal-title":"J Mol Med (Berl)"},{"issue":"41","key":"10.1016\/j.ajg.2025.04.001_b0115","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.2174\/0929867328666210419123200","article-title":"Regulatory roles of the notch signaling pathway in liver repair and regeneration: a novel therapeutic target","volume":"28","author":"Valizadeh","year":"2021","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.ajg.2025.04.001_b0120","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2018.02.051","article-title":"Novel insights on notch signaling pathways in liver fibrosis","volume":"826","author":"Ni","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.ajg.2025.04.001_b0125","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/bph.14873","article-title":"Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation","volume":"177","author":"Ge","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajg.2025.04.001_b0130","article-title":"MicroRNA-489-3p represses hepatic stellate cells activation by negatively regulating the JAG1\/Notch3 signaling pathway","author":"Li","year":"2020","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.ajg.2025.04.001_b0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00011-017-1114-7","article-title":"Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases","volume":"67","author":"Shehzad","year":"2018","journal-title":"Inflamm Res"},{"issue":"1\u20133","key":"10.1016\/j.ajg.2025.04.001_b0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0300-483X(99)00200-0","article-title":"CYP2A6: a human coumarin 7-hydroxylase","volume":"144","author":"Pelkonen","year":"2000","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.ajg.2025.04.001_b0145","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1124\/mol.65.6.1405","article-title":"Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene","volume":"65","author":"Christian","year":"2004","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.ajg.2025.04.001_b0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.taap.2004.01.010","article-title":"The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes","volume":"199","author":"Parkinson","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"issue":"6","key":"10.1016\/j.ajg.2025.04.001_b0155","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0168-8278(00)80120-8","article-title":"Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases","volume":"33","author":"Niemela","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajg.2025.04.001_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108321","article-title":"Treatment with cinnamaldehyde reduces the visceral adiposity and regulates lipid metabolism, autophagy and endoplasmic reticulum stress in the liver of a rat model of early obesity","volume":"77","author":"Neto","year":"2020","journal-title":"J Nutr Biochem"},{"issue":"3","key":"10.1016\/j.ajg.2025.04.001_b0165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3727\/096368915X686959","article-title":"The antisenescence effect of trans-cinnamaldehyde on adipose-derived stem cells","volume":"24","author":"Rajamani","year":"2015","journal-title":"Cell Transplant"},{"key":"10.1016\/j.ajg.2025.04.001_b0170","doi-asserted-by":"crossref","first-page":"27460","DOI":"10.1038\/srep27460","article-title":"Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4\/6-IRAK4\/1 signaling to suppress NLRP3 inflammasome activation","volume":"6","author":"Kang","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ajg.2025.04.001_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040929","article-title":"The endothelium as a driver of liver fibrosis and regeneration","volume":"9","author":"Lafoz","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ajg.2025.04.001_b0180","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI93562","article-title":"The balancing act of the liver: tissue regeneration versus fibrosis","volume":"128","author":"Cordero-Espinoza","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajg.2025.04.001_b0185","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2459212","article-title":"Protective effects of cinnamaldehyde on the oxidative stress, inflammatory response, and apoptosis in the hepatocytes of salmonella gallinarum-challenged young chicks","volume":"2022","author":"Yin","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"10.1016\/j.ajg.2025.04.001_b0190","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.lfs.2005.02.005","article-title":"Cinnamaldehyde-induced apoptosis in human PLC\/PRF\/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway","volume":"77","author":"Wu","year":"2005","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.ajg.2025.04.001_b0195","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ajg.2025.04.001_b0200","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/hep.27268","article-title":"Emerging roles of Notch signaling in liver disease","volume":"61","author":"Geisler","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ajg.2025.04.001_b0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxlet.2021.04.018","article-title":"The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways","volume":"347","author":"Esmail","year":"2021","journal-title":"Toxicol Lett"},{"issue":"12","key":"10.1016\/j.ajg.2025.04.001_b0210","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3748\/wjg.v18.i12.1397","article-title":"Notch3 regulates the activation of hepatic stellate cells","volume":"18","author":"Chen","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.ajg.2025.04.001_b0215","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41467-017-00204-4","article-title":"The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFbeta and Notch pathways","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"}],"container-title":["Arab Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197925000590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687197925000590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:51:34Z","timestamp":1762555894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687197925000590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1687197925000590"],"URL":"https:\/\/doi.org\/10.1016\/j.ajg.2025.04.001","relation":{},"ISSN":["1687-1979"],"issn-type":[{"value":"1687-1979","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cinnamaldehyde attenuates CCL4-induced liver fibrosis by inhibiting the CYP2A6\/Notch3 pathway","name":"articletitle","label":"Article Title"},{"value":"Arab Journal of Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajg.2025.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Pan-Arab Association of Gastroenterology.","name":"copyright","label":"Copyright"}]}}