{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:56:12Z","timestamp":1791996972412,"version":"4.4.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T00:00:00Z","timestamp":1383868800000},"content-version":"vor","delay-in-days":191,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM070808"],"award-info":[{"award-number":["GM070808"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM61390"],"award-info":[{"award-number":["GM61390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.ajhg.2013.03.022","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T11:25:08Z","timestamp":1367493908000},"page":"667-680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":240,"title":["Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS"],"prefix":"10.1016","volume":"92","author":[{"given":"Xin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris\u00a0K.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2013.03.022_bib1","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ajhg.2013.03.022_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Dunham","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","article-title":"Interactome networks and human disease","volume":"144","author":"Vidal","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2013.03.022_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11279","article-title":"The long-range interaction landscape of gene promoters","volume":"489","author":"Sanyal","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ng.77","article-title":"Regulatory changes underlying expression differences within and between Drosophila species","volume":"40","author":"Wittkopp","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib6","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1073\/pnas.0408709102","article-title":"The landscape of genetic complexity across 5,700 gene expression traits in yeast","volume":"102","author":"Brem","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ajhg.2013.03.022_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ng1222","article-title":"Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors","volume":"35","author":"Yvert","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib8","doi-asserted-by":"crossref","first-page":"e1000480","DOI":"10.1371\/journal.pbio.1000480","article-title":"Polymorphic cis- and trans-regulation of human gene expression","volume":"8","author":"Cheung","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrg2969","article-title":"From expression QTLs to personalized transcriptomics","volume":"12","author":"Montgomery","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib10","doi-asserted-by":"crossref","first-page":"e1000294","DOI":"10.1371\/journal.pgen.1000294","article-title":"Effects of cis and trans genetic ancestry on gene expression in African Americans","volume":"4","author":"Price","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib11","doi-asserted-by":"crossref","first-page":"e1000888","DOI":"10.1371\/journal.pgen.1000888","article-title":"Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS","volume":"6","author":"Nicolae","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ng1589","article-title":"An integrative genomics approach to infer causal associations between gene expression and disease","volume":"37","author":"Schadt","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib13","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.ajhg.2008.03.006","article-title":"Genetic architecture of transcript-level variation in humans","volume":"82","author":"Duan","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib14","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1371\/journal.pgen.0030114","article-title":"Imputation-based analysis of association studies: candidate regions and quantitative traits","volume":"3","author":"Servin","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib15","series-title":"Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids","author":"Durbin","year":"1998"},{"key":"10.1016\/j.ajhg.2013.03.022_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajhg.2010.06.009","article-title":"A versatile gene-based test for genome-wide association studies","volume":"87","author":"Liu","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrg2615","article-title":"Bayesian statistical methods for genetic association studies","volume":"10","author":"Stephens","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib18","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nature09410","article-title":"Hundreds of variants clustered in genomic loci and biological pathways affect human height","volume":"467","author":"Lango Allen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib19","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ajhg.2010.02.020","article-title":"Integrating pathway analysis and genetics of gene expression for genome-wide association studies","volume":"86","author":"Zhong","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib21","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gr.112821.110","article-title":"A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort","volume":"21","author":"Greenawalt","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.ajhg.2013.03.022_bib22","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1101\/gr.103341.109","article-title":"Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver","volume":"20","author":"Yang","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.ajhg.2013.03.022_bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature06758","article-title":"Genetics of gene expression and its effect on disease","volume":"452","author":"Emilsson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nature06757","article-title":"Variations in DNA elucidate molecular networks that cause disease","volume":"452","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib25","doi-asserted-by":"crossref","first-page":"e14319","DOI":"10.1371\/journal.pone.0014319","article-title":"Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross","volume":"5","author":"Derry","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2013.03.022_bib26","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/ije\/dym257","article-title":"Reporting and interpretation in genome-wide association studies","volume":"37","author":"Wakefield","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0Roy. Stat. Soc. B Met."},{"key":"10.1016\/j.ajhg.2013.03.022_bib29","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.175","article-title":"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn\u2019s disease","volume":"40","author":"Barrett","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrg2537","article-title":"Mapping complex disease traits with global gene expression","volume":"10","author":"Cookson","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib31","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"10.1016\/j.ajhg.2013.03.022_bib32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Abecasis","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib33","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"Lees","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.ajhg.2013.03.022_bib34","doi-asserted-by":"crossref","first-page":"e1002004","DOI":"10.1371\/journal.pgen.1002004","article-title":"Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci","volume":"7","author":"Zhernakova","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib35","doi-asserted-by":"crossref","first-page":"e1002254","DOI":"10.1371\/journal.pgen.1002254","article-title":"Pervasive sharing of genetic effects in autoimmune disease","volume":"7","author":"Cotsapas","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib36","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.4049\/jimmunol.169.12.6900","article-title":"Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin","volume":"169","author":"Donlin","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib37","doi-asserted-by":"crossref","first-page":"11035","DOI":"10.1128\/MCB.25.24.11035-11046.2005","article-title":"Deficiency in expression of the signaling protein Sin\/Efs leads to T-lymphocyte activation and mucosal inflammation","volume":"25","author":"Donlin","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib38","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1002\/art.22172","article-title":"IK cytokine ameliorates the progression of lupus nephritis in MRL\/lpr mice","volume":"54","author":"Muraoka","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ajhg.2013.03.022_bib39","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.lfs.2006.12.028","article-title":"Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands","volume":"80","author":"Moriwaki","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.ajhg.2013.03.022_bib40","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.4049\/jimmunol.1002711","article-title":"Cytokine-induced alterations of \u03b17 nicotinic receptor in colonic CD4 T\u00a0cells mediate dichotomous response to nicotine in murine models of Th1\/Th17- versus Th2-mediated colitis","volume":"187","author":"Galitovskiy","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib41","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1476-5381.2010.00699.x","article-title":"Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis","volume":"160","author":"Snoek","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib42","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/ddn388","article-title":"Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis","volume":"18","author":"Baranzini","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib44","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ng.120","article-title":"Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes","volume":"40","author":"Zeggini","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib45","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pbio.0060107","article-title":"Mapping the genetic architecture of gene expression in human liver","volume":"6","author":"Schadt","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ajhg.2013.03.022_bib46","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1096\/fj.11-190157","article-title":"Targeted deletion of one or two copies of the G protein \u03b2 subunit G\u03b25 gene has distinct effects on body weight and behavior in mice","volume":"25","author":"Wang","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.ajhg.2013.03.022_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jdiacomp.2006.12.005","article-title":"Association of insulin sensitivity and glucose tolerance with the c.825C>T variant of the G protein beta-3 subunit gene","volume":"22","author":"Kopf","year":"2008","journal-title":"J.\u00a0Diabetes Complications"},{"key":"10.1016\/j.ajhg.2013.03.022_bib48","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.609","article-title":"Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis","volume":"42","author":"Voight","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/jhg.2011.133","article-title":"Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study","volume":"57","author":"Langberg","year":"2012","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib50","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng.325","article-title":"Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks","volume":"41","author":"Yang","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib51","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cmet.2009.06.001","article-title":"Pigment epithelium-derived factor contributes to insulin resistance in obesity","volume":"10","author":"Crowe","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.ajhg.2013.03.022_bib52","doi-asserted-by":"crossref","first-page":"e34035","DOI":"10.1371\/journal.pone.0034035","article-title":"Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels","volume":"7","author":"B\u00f6hm","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2013.03.022_bib53","series-title":"Mendelian Inheritance in Man. A Catalog of Human Genes and Genetic Disorders","author":"McKusick","year":"1998"},{"key":"10.1016\/j.ajhg.2013.03.022_bib54","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00018-010-0258-1","article-title":"NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity","volume":"67","author":"Shen","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ajhg.2013.03.022_bib55","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.2337\/db06-0413","article-title":"Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth","volume":"55","author":"Miettinen","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ajhg.2013.03.022_bib56","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1086\/321272","article-title":"Are rare variants responsible for susceptibility to complex diseases?","volume":"69","author":"Pritchard","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib57","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/jhg.2010.19","article-title":"The pursuit of genome-wide association studies: where are we now?","volume":"55","author":"Ku","year":"2010","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib58","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng.2303","article-title":"Exome sequencing and the genetic basis of complex traits","volume":"44","author":"Kiezun","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature10354","article-title":"Human metabolic individuality in biomedical and pharmaceutical research","volume":"477","author":"Suhre","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib60","doi-asserted-by":"crossref","first-page":"e1000952","DOI":"10.1371\/journal.pgen.1000952","article-title":"Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain","volume":"6","author":"Gibbs","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib61","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature08454","article-title":"Molecular networks as sensors and drivers of common human diseases","volume":"461","author":"Schadt","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.03.022_bib62","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ajhg.2009.01.026","article-title":"Diverse genome-wide association studies associate the IL12\/IL23 pathway with Crohn disease","volume":"84","author":"Wang","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib63","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ng.2394","article-title":"Mapping cis- and trans-regulatory effects across multiple tissues in twins","volume":"44","author":"Grundberg","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib64","doi-asserted-by":"crossref","first-page":"e1002197","DOI":"10.1371\/journal.pgen.1002197","article-title":"Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA","volume":"7","author":"Fehrmann","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib65","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/ng1011-1040c","article-title":"Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes","volume":"43","author":"Small","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.03.022_bib66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000053370","article-title":"Case-control studies of genetic markers: power and sample size approximations for Armitage\u2019s test for trend","volume":"52","author":"Slager","year":"2001","journal-title":"Hum. Hered."}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929713001596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929713001596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:16:52Z","timestamp":1762078612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929713001596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0002929713001596"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2013.03.022","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2013.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}