{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:29:06Z","timestamp":1791163746599,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:00:00Z","timestamp":1399420800000},"content-version":"vor","delay-in-days":187,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajhg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.ajhg.2013.10.009","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T17:16:55Z","timestamp":1383239815000},"page":"984-993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":182,"title":["Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region"],"prefix":"10.1016","volume":"93","author":[{"given":"William\u00a0T.","family":"Wissemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin\u00a0M.","family":"Hill-Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus\u00a0P.","family":"Zabetian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart\u00a0A.","family":"Factor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Patsopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Hoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie","family":"Holcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan\u00a0J.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenys","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Erlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haydeh","family":"Payami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2013.10.009_bib1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ng.642","article-title":"Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson\u2019s disease","volume":"42","author":"Hamza","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(10)62345-8","article-title":"Imputation of sequence variants for identification of genetic risks for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies","volume":"377","author":"Nalls","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2013.10.009_bib3","doi-asserted-by":"crossref","first-page":"e27109","DOI":"10.1371\/journal.pone.0027109","article-title":"Evidence for more than one Parkinson\u2019s disease-associated variant within the HLA region","volume":"6","author":"Hill-Burns","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2013.10.009_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/ana.22687","article-title":"Meta-analysis of Parkinson\u2019s disease: identification of a novel locus, RIT2","volume":"71","author":"Pankratz","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ajhg.2013.10.009_bib5","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/mds.25035","article-title":"Association between Parkinson\u2019s disease and the HLA-DRB1 locus","volume":"27","author":"Ahmed","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ajhg.2013.10.009_bib6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/ejhg.2010.254","article-title":"Genome-wide association study confirms extant PD risk loci among the Dutch","volume":"19","author":"Sim\u00f3n-S\u00e1nchez","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib7","doi-asserted-by":"crossref","first-page":"a009381","DOI":"10.1101\/cshperspect.a009381","article-title":"Inflammation and adaptive immunity in Parkinson\u2019s disease","volume":"2","author":"Mosley","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ajhg.2013.10.009_bib8","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/jnnp.2008.162883","article-title":"Association of the human leucocyte antigen region with susceptibility to Parkinson\u2019s disease","volume":"81","author":"Saiki","year":"2010","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ajhg.2013.10.009_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00439-008-0582-9","article-title":"Genomewide association study for susceptibility genes contributing to familial Parkinson disease","volume":"124","author":"Pankratz","year":"2009","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/brain\/awf080","article-title":"The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service","volume":"125","author":"Hughes","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.ajhg.2013.10.009_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1399-0039.2010.01606.x","article-title":"A multi-site study using high-resolution HLA genotyping by next generation sequencing","volume":"77","author":"Holcomb","year":"2011","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.ajhg.2013.10.009_bib12","doi-asserted-by":"crossref","first-page":"e64683","DOI":"10.1371\/journal.pone.0064683","article-title":"Imputing amino acid polymorphisms in human leukocyte antigens","volume":"8","author":"Jia","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2013.10.009_bib13","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/bioinformatics\/btr061","article-title":"HLA\u2217IMP\u2014an integrated framework for imputing classical HLA alleles from SNP genotypes","volume":"27","author":"Dilthey","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2013.10.009_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib15","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/521987","article-title":"Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering","volume":"81","author":"Browning","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2013.10.009_bib17","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib18","first-page":"541","article-title":"Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease","volume":"45","author":"Payami","year":"1989","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature09914","article-title":"Differential microRNA regulation of HLA-C expression and its association with HIV control","volume":"472","author":"Kulkarni","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.10.009_bib20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tig.2012.10.006","article-title":"Genomic modulators of the immune response","volume":"29","author":"Knight","year":"2013","journal-title":"Trends Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.1232685","article-title":"Influence of HLA-C expression level on HIV control","volume":"340","author":"Apps","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2013.10.009_bib22","doi-asserted-by":"crossref","first-page":"e1000888","DOI":"10.1371\/journal.pgen.1000888","article-title":"Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS","volume":"6","author":"Nicolae","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib23","doi-asserted-by":"crossref","first-page":"e1002003","DOI":"10.1371\/journal.pgen.1002003","article-title":"The architecture of gene regulatory variation across multiple human tissues: the MuTHER study","volume":"7","author":"Nica","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature08903","article-title":"Transcriptome genetics using second generation sequencing in a Caucasian population","volume":"464","author":"Montgomery","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2013.10.009_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/bioinformatics\/btp644","article-title":"SCAN:\u00a0SNP and copy number annotation","volume":"26","author":"Gamazon","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2013.10.009_bib26","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng2142","article-title":"Population genomics of human gene expression","volume":"39","author":"Stranger","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib27","doi-asserted-by":"crossref","first-page":"e10693","DOI":"10.1371\/journal.pone.0010693","article-title":"Genetics and beyond\u2014the transcriptome of human monocytes and disease susceptibility","volume":"5","author":"Zeller","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2013.10.009_bib28","doi-asserted-by":"crossref","first-page":"e1000214","DOI":"10.1371\/journal.pgen.1000214","article-title":"High-resolution mapping of expression-QTLs yields insight into human gene regulation","volume":"4","author":"Veyrieras","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib29","doi-asserted-by":"crossref","first-page":"e1002639","DOI":"10.1371\/journal.pgen.1002639","article-title":"Patterns of cis regulatory variation in diverse human populations","volume":"8","author":"Stranger","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2013.10.009_bib30","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1174148","article-title":"Common regulatory variation impacts gene expression in a cell type-dependent manner","volume":"325","author":"Dimas","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2013.10.009_bib31","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ng.2394","article-title":"Mapping cis- and trans-regulatory effects\u00a0across multiple tissues in twins","volume":"44","author":"Grundberg","year":"2012","journal-title":"Nat. Genet."}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929713004667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929713004667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T04:54:24Z","timestamp":1539233664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929713004667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0002929713004667"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2013.10.009","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2013.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}