{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:03:31Z","timestamp":1790525011303,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T00:00:00Z","timestamp":1478304000000},"content-version":"vor","delay-in-days":188,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajhg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ajhg.2016.03.008","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T13:29:55Z","timestamp":1462022995000},"page":"898-908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility"],"prefix":"10.1016","volume":"98","author":[{"given":"Hamdi","family":"Mbarek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale\u00a0R.","family":"Nyholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott\u00a0D.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0B.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan\u00a0F.","family":"McRae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke\u00a0Jan","family":"Hottenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix\u00a0R.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonneke","family":"Willemsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eco\u00a0J.","family":"de\u00a0Geus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth\u00a0E.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary\u00a0C.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda\u00a0W.","family":"Penninx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrie","family":"McAloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline\u00a0M.","family":"Vink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Kaprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Plomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim\u00a0D.","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik\u00a0K.","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reversade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.\u00a0Alan","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar\u00a0P.","family":"Kristjansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isleifur","family":"Olafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudmundur\u00a0Ingi","family":"Eyjolfsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Sigurdardottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William\u00a0G.","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis\u00a0B.","family":"Lambalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant\u00a0W.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"McGue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u00a0K.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0R.B.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas\u00a0G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hreinn","family":"Stef\u00e1nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Stef\u00e1nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorret\u00a0I.","family":"Boomsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2016.03.008_bib1","series-title":"The Biology of Twinning in Man","author":"Bulmer","year":"1970"},{"key":"10.1016\/j.ajhg.2016.03.008_bib2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(03)14237-7","article-title":"Twinning","volume":"362","author":"Hall","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2016.03.008_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/humupd\/dmm036","article-title":"Dizygotic twinning","volume":"14","author":"Hoekstra","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ajhg.2016.03.008_bib4","doi-asserted-by":"crossref","first-page":"e25239","DOI":"10.1371\/journal.pone.0025239","article-title":"Twinning across the developing world","volume":"6","author":"Smits","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2016.03.008_bib5","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1056\/NEJMoa1301467","article-title":"Fertility treatments and multiple births in the United States","volume":"369","author":"Kulkarni","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ajhg.2016.03.008_bib6","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(05)66478-1","article-title":"Multiple birth resulting from ovarian stimulation for subfertility treatment","volume":"365","author":"Fauser","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2016.03.008_bib7","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jamapediatrics.2014.1357","article-title":"Hospital costs of multiple-birth and singleton-birth children during the first 5\u00a0years of life and the role of assisted reproductive technology","volume":"168","author":"Chambers","year":"2014","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.ajhg.2016.03.008_bib8","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/humrep\/dev059","article-title":"Hospital costs during the first 5 years of life for multiples compared with singletons born after IVF or ICSI","volume":"30","author":"van Heesch","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ajhg.2016.03.008_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.fertnstert.2008.10.012","article-title":"Body composition, smoking, and spontaneous dizygotic twinning","volume":"93","author":"Hoekstra","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ajhg.2016.03.008_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1017\/S0001566000003871","article-title":"Twinning rate in Scandinavia, Germany and The Netherlands during years of privation","volume":"37","author":"Eriksson","year":"1988","journal-title":"Acta Genet. Med. Gemellol. (Roma)"},{"key":"10.1016\/j.ajhg.2016.03.008_bib11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1056\/NEJM196411052711908","article-title":"Inheritance in human dizygotic twinning","volume":"271","author":"White","year":"1964","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ajhg.2016.03.008_bib12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tem.2004.08.008","article-title":"Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals?","volume":"15","author":"Moore","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ajhg.2016.03.008_bib13","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/ng.3042","article-title":"The common marmoset genome provides insight into primate biology and evolution","volume":"46","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib14","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1073\/pnas.1316037111","article-title":"Evolutionary genetics and implications of small size and twinning in callitrichine primates","volume":"111","author":"Harris","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ajhg.2016.03.008_bib15","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(00)04178-7","article-title":"Is there a role for follicle-stimulating-hormone receptor in familial dizygotic twinning?","volume":"357","author":"Lambalk","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2016.03.008_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/91074","article-title":"IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers","volume":"28","author":"Duffy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/humrep\/deq084","article-title":"A genome wide linkage scan for dizygotic twinning in 525 families of mothers of dizygotic twins","volume":"25","author":"Painter","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ajhg.2016.03.008_bib18","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1210\/jc.2006-0970","article-title":"Novel variants in growth differentiation factor 9 in mothers of dizygotic twins","volume":"91","author":"Palmer","year":"2006","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ajhg.2016.03.008_bib19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1375\/twin.14.5.408","article-title":"Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinning","volume":"14","author":"Luong","year":"2011","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(96)10003-9","article-title":"Use of dizygotic to monozygotic twinning ratio as a measure of fertility","volume":"349","author":"Tong","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2016.03.008_bib21","doi-asserted-by":"crossref","first-page":"8842","DOI":"10.1038\/ncomms9842","article-title":"Shared genetic aetiology of puberty timing between sexes and with health-related outcomes","volume":"6","author":"Day","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2016.03.008_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13545","article-title":"Parent-of-origin-specific\u00a0allelic associations among 106 genomic loci for age at menarche","volume":"514","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2016.03.008_bib23","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1038\/ncomms9464","article-title":"Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome","volume":"6","author":"Day","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2016.03.008_bib24","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ng.3412","article-title":"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair","volume":"47","author":"Day","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1375\/twin.9.6.849","article-title":"Netherlands Twin Register: from twins to twin families","volume":"9","author":"Boomsma","year":"2006","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1375\/twin.13.3.231","article-title":"The Netherlands Twin Register biobank: a resource for genetic epidemiological studies","volume":"13","author":"Willemsen","year":"2010","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1017\/thg.2012.118","article-title":"The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children","volume":"16","author":"van Beijsterveldt","year":"2013","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/thg.2012.140","article-title":"The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection","volume":"16","author":"Willemsen","year":"2013","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mpr.256","article-title":"The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods","volume":"17","author":"Penninx","year":"2008","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"10.1016\/j.ajhg.2016.03.008_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1375\/twin.11.3.349","article-title":"Mode of conception of twin pregnancies: willingness to reply to survey items and comparison of survey data to hospital records","volume":"11","author":"van Beijsterveldt","year":"2008","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1017\/thg.2012.62","article-title":"The Minnesota Center for Twin and Family Research genome-wide association study","volume":"15","author":"Miller","year":"2012","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib32","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1017\/S0954579499002369","article-title":"Behavioral disinhibition and the development of substance-use disorders: findings from the Minnesota Twin Family Study","volume":"11","author":"Iacono","year":"1999","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.ajhg.2016.03.008_bib33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib34","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"Patterson","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib35","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/ejhg.2013.48","article-title":"Population structure, migration, and diversifying selection in the Netherlands","volume":"21","author":"Abdellaoui","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ajhg.2009.10.009","article-title":"Common variants in the trichohyalin gene are associated with straight hair in Europeans","volume":"85","author":"Medland","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib37","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neuropsychologia.2008.09.005","article-title":"Genetic influences on handedness: data from 25,732 Australian and Dutch twin families","volume":"47","author":"Medland","year":"2009","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.ajhg.2016.03.008_bib38","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ng.3097","article-title":"Defining the role of common variation in the genomic and biological architecture of adult human height","volume":"46","author":"Wood","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature12124","article-title":"Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits","volume":"497","author":"Styrkarsdottir","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2016.03.008_bib40","first-page":"19","article-title":"Regression standard errors in clustered samples","volume":"13","author":"Rogers","year":"1993","journal-title":"Stata Tech. Bull."},{"key":"10.1016\/j.ajhg.2016.03.008_bib41","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2016.03.008_bib42","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/ng.3247","article-title":"Large-scale whole-genome sequencing of the Icelandic population","volume":"47","author":"Gudbjartsson","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib43","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"10.1016\/j.ajhg.2016.03.008_bib44","series-title":"Statistical Methods for Research Workers","author":"Fisher","year":"1925"},{"key":"10.1016\/j.ajhg.2016.03.008_bib45","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib46","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ajhg.2016.03.008_bib47","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/bioinformatics\/btq330","article-title":"Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor","volume":"26","author":"McLaren","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2016.03.008_bib48","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ajhg.2012.08.004","article-title":"HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis","volume":"91","author":"Li","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib49","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ajhg.2011.01.019","article-title":"GATES: a rapid and powerful gene-based association test using extended Simes procedure","volume":"88","author":"Li","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib50","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ajhg.2015.09.001","article-title":"Modeling linkage disequilibrium increases accuracy of polygenic risk scores","volume":"97","author":"Vilhj\u00e1lmsson","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2016.03.008_bib52","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1038\/ncomms8756","article-title":"Rare coding variants and X-linked loci associated with age at menarche","volume":"6","author":"Lunetta","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2016.03.008_bib53","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/ng.1051","article-title":"Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways","volume":"44","author":"Stolk","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib54","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1038\/srep06412","article-title":"Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action","volume":"4","author":"Hagen","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ajhg.2016.03.008_bib55","first-page":"1557","article-title":"The control of ovulation in mothers of dizygotic twins","volume":"81","author":"Gilfillan","year":"1996","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ajhg.2016.03.008_bib56","first-page":"481","article-title":"Increased levels and pulsatility of follicle-stimulating hormone in mothers of hereditary dizygotic twins","volume":"83","author":"Lambalk","year":"1998","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ajhg.2016.03.008_bib57","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1017\/thg.2013.4","article-title":"Ovarian reserve and anti-Mullerian hormone (AMH) in mothers of dizygotic twins","volume":"16","author":"Van der Stroom","year":"2013","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib58","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0015-0282(01)01797-6","article-title":"Influence of the angiotensinogen gene on the ovulatory capacity of mice","volume":"75","author":"Hefler","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ajhg.2016.03.008_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/03009734.2013.782081","article-title":"Dynamic changes in glycosylation and glycan composition of serum FSH and LH during natural ovarian stimulation","volume":"118","author":"Wide","year":"2013","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.ajhg.2016.03.008_bib60","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/ejhg.2015.102","article-title":"Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes","volume":"24","author":"Ruth","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2016.03.008_bib61","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mbs.2013.09.006","article-title":"A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells","volume":"246","author":"Magill","year":"2013","journal-title":"Math. Biosci."},{"key":"10.1016\/j.ajhg.2016.03.008_bib62","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/molehr\/gap086","article-title":"Paracrine support of ovarian stimulation","volume":"15","author":"Hillier","year":"2009","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ajhg.2016.03.008_bib63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.rbmo.2015.05.001","article-title":"Genetic variants associated with female reproductive ageing--potential markers for assessing ovarian function and ovarian stimulation outcome","volume":"31","author":"Laisk-Podar","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ajhg.2016.03.008_bib64","doi-asserted-by":"crossref","first-page":"e0129025","DOI":"10.1371\/journal.pone.0129025","article-title":"A major gene for bovine ovulation rate","volume":"10","author":"Kirkpatrick","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2016.03.008_bib65","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1210\/me.2003-0264","article-title":"Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells","volume":"18","author":"Bernard","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ajhg.2016.03.008_bib66","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1095\/biolreprod.108.070086","article-title":"Smad3 is required for normal follicular follicle-stimulating hormone responsiveness in the mouse","volume":"81","author":"Gong","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ajhg.2016.03.008_bib67","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/iub.1280","article-title":"Effects of Smad3 on the proliferation and steroidogenesis in human ovarian luteinized granulosa cells","volume":"66","author":"Liu","year":"2014","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ajhg.2016.03.008_bib68","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(05)70326-3","article-title":"Twinning, cancer, and genetics","volume":"351","author":"Lambalk","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2016.03.008_bib69","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(97)05526-8","article-title":"Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology","volume":"350","author":"Swerdlow","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2016.03.008_bib70","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1210\/me.2006-0402","article-title":"Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery","volume":"21","author":"Looyenga","year":"2007","journal-title":"Mol. Endocrinol."}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292971630043X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292971630043X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T13:00:44Z","timestamp":1536757244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292971630043X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S000292971630043X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2016.03.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726325941.793518717","asserted-by":"object"}]},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2016.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Society of Human Genetics.","name":"copyright","label":"Copyright"}]}}