{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:53:15Z","timestamp":1791805995941,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The Swedish Research Council"},{"name":"EU\/IMI project RTCure"},{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AFA"},{"DOI":"10.13039\/501100007949","name":"Swedish Rheumatism Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007857","name":"King Gustaf V's 80-year Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Swedish Research Council for Health, Working Life and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis, Musculoskeletal, and Skin Diseases","doi-asserted-by":"publisher","award":["1R01AR063759"],"award-info":[{"award-number":["1R01AR063759"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajhg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ajhg.2019.08.002","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T14:43:47Z","timestamp":1567089827000},"page":"616-624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-4095","authenticated-orcid":false,"given":"Chikashi","family":"Terao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boel","family":"Brynedal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Westerlind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Johan","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Skriner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Serre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"R\u00f6nnelid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Mathsson-Alm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Brink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solbritt Rantap\u00e4\u00e4","family":"Dahlqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Padyukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Alfredsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Klareskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Raychaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2019.08.002_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ajhg.2019.08.002_bib2","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1002\/art.23127","article-title":"Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles","volume":"56","author":"Verpoort","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ajhg.2019.08.002_bib3","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/art.39228","article-title":"Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis","volume":"67","author":"Kim","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ajhg.2014.02.013","article-title":"Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity","volume":"94","author":"Han","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2019.08.002_bib5","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/rheumatology\/kem265","article-title":"HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap","volume":"46","author":"Wedderburn","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ajhg.2019.08.002_bib6","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1002\/art.22205","article-title":"HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies","volume":"54","author":"O\u2019Hanlon","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ajhg.2019.08.002_bib7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/annrheumdis-2011-200182","article-title":"Interaction of HLA-DRB1\u221703 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study","volume":"71","author":"Chinoy","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib8","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.2337\/db11-0131","article-title":"Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct","volume":"60","author":"Howson","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.ajhg.2019.08.002_bib9","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1136\/annrheumdis-2011-200353","article-title":"A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects","volume":"70","author":"Terao","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/ard.2009.126821","article-title":"A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis","volume":"70","author":"Padyukov","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib11","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41588-018-0216-7","article-title":"Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes","volume":"50","author":"Westra","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2019.08.002_bib12","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1186\/ar4039","article-title":"Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides","volume":"14","author":"Hansson","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ajhg.2019.08.002_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/art.39827","article-title":"Differences in the Spectrum of Anti-Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis","volume":"69","author":"Too","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/annrheumdis-2017-211782","article-title":"Anticitrullinated protein\/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants","volume":"77","author":"R\u00f6nnelid","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1136\/annrheumdis-2012-201484","article-title":"Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein\/peptide antibody fine specificity profile","volume":"72","author":"Lundberg","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib16","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ng.2462","article-title":"High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis","volume":"44","author":"Eyre","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2019.08.002_bib17","doi-asserted-by":"crossref","first-page":"e64683","DOI":"10.1371\/journal.pone.0064683","article-title":"Imputing amino acid polymorphisms in human leukocyte antigens","volume":"8","author":"Jia","year":"2013","journal-title":"PLoS ONE"},{"issue":"Suppl 1","key":"10.1016\/j.ajhg.2019.08.002_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1463-1326.2008.00997.x","article-title":"Overview of the MHC fine mapping data","volume":"11","author":"Brown","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ajhg.2019.08.002_bib19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2019.08.002_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2019.08.002_bib21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s12016-007-8029-y","article-title":"Anti-CCP2 antibodies: an overview and perspective of the diagnostic abilities of this serological marker for early rheumatoid arthritis","volume":"34","author":"van Venrooij","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13075-015-0623-4","article-title":"Anti-citrullinated peptide\/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci\u00a0with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population","volume":"17","author":"Terao","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ajhg.2019.08.002_bib23","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1136\/annrheumdis-2011-201225","article-title":"Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients","volume":"71","author":"Viatte","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib24","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1093\/rheumatology\/keq273","article-title":"Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis","volume":"49","author":"Ohmura","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ajhg.2019.08.002_bib25","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/art.40587","article-title":"Affinity Maturation Drives Epitope Spreading and Generation of Proinflammatory Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis","volume":"70","author":"Elliott","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib26","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1136\/annrheumdis-2012-202868","article-title":"The fibrin-derived citrullinated peptide beta60-74Cit(6)(0),(7)(2),(7)(4) bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies","volume":"73","author":"Cornillet","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib27","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/art.40699","article-title":"Recognition of Amino Acid Motifs,\u00a0Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis","volume":"71","author":"Steen","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib28","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating\u00a0Single-cell Transcriptomics and Mass Cytometry","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib29","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1073\/pnas.79.11.3632","article-title":"Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis","volume":"79","author":"Klareskog","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ajhg.2019.08.002_bib30","doi-asserted-by":"crossref","first-page":"e36779","DOI":"10.1371\/journal.pone.0036779","article-title":"Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis","volume":"7","author":"Link","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajhg.2019.08.002_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ai.2018.09.001","article-title":"New Insights Into the Biology of CD8 Regulatory T Cells","volume":"140","author":"Nakagawa","year":"2018","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib32","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1002\/art.21302","article-title":"Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis","volume":"52","author":"Verpoort","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ajhg.2019.08.002_bib33","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/annrheumdis-2016-210873","article-title":"Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up","volume":"76","author":"Manivel","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ajhg.2019.08.002_bib34","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/art.39133","article-title":"An association between amino acid position 74 of HLA-DRB1 and anti-citrullinated protein antibody levels in Japanese patients with anti-citrullinated protein antibody-positive rheumatoid arthritis","volume":"67","author":"Terao","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ajhg.2019.08.002_bib35","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1093\/hmg\/ddu387","article-title":"Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations","volume":"23","author":"Okada","year":"2014","journal-title":"Hum. Mol. Genet."}],"updated-by":[{"DOI":"10.1016\/j.ajhg.2019.09.018","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000}}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929719303052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929719303052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T20:05:23Z","timestamp":1707336323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929719303052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0002929719303052"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2019.08.002","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ajhg.2019.09.018","asserted-by":"object"}]},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2019.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}