{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:35:23Z","timestamp":1789868123655,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":187,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ajhg.2019.10.003","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T21:35:14Z","timestamp":1572557714000},"page":"1102-1111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Genome Sequencing Explores Complexity of Chromosomal Abnormalities in Recurrent Miscarriage"],"prefix":"10.1016","volume":"105","author":[{"given":"Zirui","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi Gin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne K.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber N.","family":"Pursley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline P.W.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul E.","family":"Pi\u00f1a-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Yeung","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sau Wai","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia C.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong Wai","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2019.10.003_bib1","first-page":"76","article-title":"Recurrent pregnancy loss: etiology, diagnosis, and therapy","volume":"2","author":"Ford","year":"2009","journal-title":"Rev. Obstet. Gynecol."},{"key":"10.1016\/j.ajhg.2019.10.003_bib2","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.fertnstert.2012.06.048","article-title":"Evaluation and treatment of recurrent pregnancy loss: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ajhg.2019.10.003_bib3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/AOG.0000000000000325","article-title":"Genomic imbalance in products of conception: single-nucleotide polymorphism chromosomal microarray analysis","volume":"124","author":"Levy","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ajhg.2019.10.003_bib4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/humrep\/dey021","article-title":"Recurrent pregnancy loss evaluation combined with 24-chromosome microarray of miscarriage tissue provides a probable or definite cause of pregnancy loss in over 90% of patients","volume":"33","author":"Popescu","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ajhg.2019.10.003_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0301-2115(98)00185-7","article-title":"Structural chromosome rearrangements in couples with recurrent fetal wastage","volume":"81","author":"Fryns","year":"1998","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ajhg.2019.10.003_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng.3720","article-title":"The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies","volume":"49","author":"Redin","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/humupd\/dmr011","article-title":"Reproductive outcome after PGD in couples with recurrent miscarriage carrying a structural chromosome abnormality: a systematic review","volume":"17","author":"Franssen","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ajhg.2019.10.003_bib8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-2605.2004.00490.x","article-title":"Meiotic segregation of translocations during male gametogenesis","volume":"27","author":"Morel","year":"2004","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.ajhg.2019.10.003_bib9","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1056\/NEJMoa1208594","article-title":"Clinical diagnosis by whole-genome sequencing of a prenatal sample","volume":"367","author":"Talkowski","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/humu.23146","article-title":"Whole-genome sequencing of cytogenetically balanced chromosome translocations identifies potentially pathological gene disruptions and highlights the importance of microhomology in the mechanism of formation","volume":"38","author":"Nilsson","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ajhg.2019.10.003_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/ng.2202","article-title":"Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration","volume":"44","author":"Chiang","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib12","article-title":"Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis","author":"Wang","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.fertnstert.2012.09.023","article-title":"Definitions of infertility and recurrent pregnancy loss: a committee opinion","volume":"99","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ajhg.2019.10.003_bib14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/humu.22541","article-title":"A robust approach for blind detection of balanced chromosomal rearrangements with whole-genome low-coverage sequencing","volume":"35","author":"Dong","year":"2014","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ajhg.2019.10.003_bib15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/gim.2015.199","article-title":"Low-pass whole-genome sequencing in clinical cytogenetics: a validated approach","volume":"18","author":"Dong","year":"2016","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.1181498","article-title":"Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays","volume":"327","author":"Drmanac","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2019.10.003_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/cmb.2011.0201","article-title":"Computational techniques for human genome resequencing using mated gapped reads","volume":"19","author":"Carnevali","year":"2012","journal-title":"J.\u00a0Comput. Biol."},{"key":"10.1016\/j.ajhg.2019.10.003_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000356142","article-title":"Inverted segment size and the presence of recombination hot spot clusters matter in sperm segregation analysis","volume":"142","author":"Bhatt","year":"2014","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.ajhg.2019.10.003_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/GIM.0b013e3182217a3a","article-title":"American College of Medical Genetics standards and guidelines for interpretation and reporting of postnatal constitutional copy number variants","volume":"13","author":"Kearney","year":"2011","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/gim.2013.129","article-title":"ACMG Standards and Guidelines for constitutional cytogenomic microarray analysis, including postnatal and prenatal applications: revision 2013","volume":"15","author":"South","year":"2013","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/gim.2017.170","article-title":"Identification of balanced chromosomal rearrangements previously unknown among participants in the 1000 Genomes Project: implications for interpretation of structural variation in genomes and the future of clinical cytogenetics","volume":"20","author":"Dong","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.cell.2011.07.042","article-title":"Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements","volume":"146","author":"Liu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2019.10.003_bib23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ajhg.2019.02.024","article-title":"The Iceberg under Water: Unexplored Complexity of Chromoanagenesis in Congenital Disorders","volume":"104","author":"Zepeda-Mendoza","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/humrep\/dey367","article-title":"Interaction of acrocentric chromosome involved in translocation and sex of the carrier influences the proportion of alternate segregation in autosomal reciprocal translocations","volume":"34","author":"Zhang","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ajhg.2019.10.003_bib25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/oxfordjournals.humrep.a137135","article-title":"Cytogenetic studies in couples experiencing repeated pregnancy losses","volume":"5","author":"De Braekeleer","year":"1990","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ajhg.2019.10.003_bib26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1471-0528.2010.02566.x","article-title":"Is karyotyping couples experiencing recurrent miscarriage worth the cost?","volume":"117","author":"Barber","year":"2010","journal-title":"BJOG"},{"key":"10.1016\/j.ajhg.2019.10.003_bib27","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1530\/rep.1.01063","article-title":"The importance of aneuploidy screening in reciprocal translocation carriers","volume":"131","author":"Pujol","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.ajhg.2019.10.003_bib28","doi-asserted-by":"crossref","first-page":"e1005601","DOI":"10.1371\/journal.pgen.1005601","article-title":"Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development","volume":"11","author":"McCoy","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib29","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ajmg.a.33941","article-title":"Pregnancy outcome in carriers of Robertsonian translocations","volume":"155A","author":"Keymolen","year":"2011","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.ajhg.2019.10.003_bib30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ajhg.2015.02.005","article-title":"Chromothripsis in healthy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring","volume":"96","author":"de Pagter","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib31","first-page":"960","article-title":"Molecular cytogenetic characterization of 17 rob(13q14q) Robertsonian translocations by FISH, narrowing the region containing the breakpoints","volume":"55","author":"Han","year":"1994","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1399-0004.2010.01445.x","article-title":"The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements","volume":"78","author":"Kurahashi","year":"2010","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10577-014-9439-3","article-title":"Narrowing the localization of the region breakpoint in most frequent Robertsonian translocations","volume":"22","author":"Jarmuz-Szymczak","year":"2014","journal-title":"Chromosome Res."},{"key":"10.1016\/j.ajhg.2019.10.003_bib34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ejhg.2014.120","article-title":"An exome sequencing strategy to diagnose lethal autosomal recessive disorders","volume":"23","author":"Ellard","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib35","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/molehr\/gaw008","article-title":"Whole exome sequencing in recurrent early pregnancy loss","volume":"22","author":"Qiao","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ajhg.2019.10.003_bib36","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0140-6736(18)32042-7","article-title":"Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study","volume":"393","author":"Petrovski","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2019.10.003_bib37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3389\/fgene.2019.00761","article-title":"Prenatal Diagnosis of Fetuses With Increased Nuchal Translucency by Genome Sequencing Analysis","volume":"10","author":"Choy","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.ajhg.2019.10.003_bib38","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1056\/NEJMoa1000641","article-title":"Aspirin plus heparin or aspirin alone in women with recurrent miscarriage","volume":"362","author":"Kaandorp","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib39","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1056\/NEJMoa1504927","article-title":"A Randomized Trial of Progesterone in Women with Recurrent Miscarriages","volume":"373","author":"Coomarasamy","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib40","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.rbmo.2017.09.001","article-title":"Preimplantation genetic screening: results of a worldwide web-based survey","volume":"35","author":"Weissman","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ajhg.2019.10.003_bib41","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.fertnstert.2017.03.011","article-title":"In\u00a0vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study","volume":"107","author":"Rubio","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ajhg.2019.10.003_bib42","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.rbmo.2018.12.043","article-title":"Evaluation of preimplantation genetic testing based on next-generation sequencing for balanced reciprocal translocation carriers","volume":"38","author":"Cai","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ajhg.2019.10.003_bib43","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jcma.2015.03.010","article-title":"Improved assay performance of single nucleotide polymorphism array over conventional karyotyping in analyzing products of conception","volume":"78","author":"Lin","year":"2015","journal-title":"J.\u00a0Chin. Med. Assoc."},{"key":"10.1016\/j.ajhg.2019.10.003_bib44","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMc1500421","article-title":"Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts","volume":"373","author":"Greco","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ajhg.2019.10.003_bib45","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.fertnstert.2018.10.019","article-title":"One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies","volume":"111","author":"Victor","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ajhg.2019.10.003_bib46","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.rbmo.2018.01.005","article-title":"An evidence-based scoring system for prioritizing mosaic aneuploid embryos following preimplantation genetic screening","volume":"36","author":"Grati","year":"2018","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ajhg.2019.10.003_bib47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/molehr\/gau104","article-title":"Human embryonic stem\u00a0cells carrying an unbalanced translocation demonstrate\u00a0impaired differentiation into trophoblasts: an in\u00a0vitro model of human implantation failure","volume":"21","author":"Shpiz","year":"2015","journal-title":"Mol. Hum. Reprod."}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292971930391X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292971930391X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:17:51Z","timestamp":1757575071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292971930391X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S000292971930391X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2019.10.003","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome Sequencing Explores Complexity of Chromosomal Abnormalities in Recurrent Miscarriage","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2019.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society of Human Genetics.","name":"copyright","label":"Copyright"}]}}