{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:34:57Z","timestamp":1792128897755,"version":"4.4.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC013817"],"award-info":[{"award-number":["R01DC013817"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC019370"],"award-info":[{"award-number":["R01DC019370"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS017950"],"award-info":[{"award-number":["R01 NS017950"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["UH2 NS100605"],"award-info":[{"award-number":["UH2 NS100605"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016990","name":"Beneficentia Stiftung","doi-asserted-by":"publisher","award":["D70-RESRICGIROTTO"],"award-info":[{"award-number":["D70-RESRICGIROTTO"]}],"id":[{"id":"10.13039\/100016990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011721","name":"Chronic Disease Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016873","name":"Framingham Heart Study","doi-asserted-by":"publisher","award":["75N92019D00031"],"award-info":[{"award-number":["75N92019D00031"]}],"id":[{"id":"10.13039\/100016873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016873","name":"Framingham Heart Study","doi-asserted-by":"publisher","award":["HHSN268201500001I"],"award-info":[{"award-number":["HHSN268201500001I"]}],"id":[{"id":"10.13039\/100016873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016873","name":"Framingham Heart Study","doi-asserted-by":"publisher","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}],"id":[{"id":"10.13039\/100016873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["GNP-182"],"award-info":[{"award-number":["GNP-182"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["503"],"award-info":[{"award-number":["503"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS-779681"],"award-info":[{"award-number":["SLS-779681"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["722046"],"award-info":[{"award-number":["722046"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["848261"],"award-info":[{"award-number":["848261"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001646","name":"Robert Bosch Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["312073"],"award-info":[{"award-number":["312073"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["P30 AG066546"],"award-info":[{"award-number":["P30 AG066546"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["R01 AG059727"],"award-info":[{"award-number":["R01 AG059727"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["UF1 NS125513"],"award-info":[{"award-number":["UF1 NS125513"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG049607"],"award-info":[{"award-number":["R01 AG049607"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG054076"],"award-info":[{"award-number":["R01 AG054076"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG059421"],"award-info":[{"award-number":["R01 AG059421"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG063507"],"award-info":[{"award-number":["RF1 AG063507"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG066524"],"award-info":[{"award-number":["RF1 AG066524"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG052409"],"award-info":[{"award-number":["U01 AG052409"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG058589"],"award-info":[{"award-number":["U01 AG058589"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0578"],"award-info":[{"award-number":["W81XWH-21-1-0578"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ajhg.2022.04.010","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:33:21Z","timestamp":1652697201000},"page":"1077-1091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss"],"prefix":"10.1016","volume":"109","author":[{"given":"Natalia","family":"Trpchevska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim B.","family":"Freidin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Broer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthe C.","family":"Oosterloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyro","family":"Bizaki-Vallaskangas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Canlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Castellana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Chasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Cherny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pina","family":"Concas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Elkon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Metspalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Nelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reedik","family":"M\u00e4gi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00f5nu","family":"Esko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Mengel-From","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.S.","family":"Giersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Girotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gudjonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Heard-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronna","family":"Hertzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob v.B.","family":"Hjelmborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Hjerling-Leffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Kaprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kettunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"K\u00e4hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Lallemend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hampton","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Lowenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik K.E.","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"van Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia C.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike A.","family":"Nalls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Giovanni","family":"Nardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Nygaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Palviainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Quaranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"R\u00e4m\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmo","family":"Saarentaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Sardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia L.","family":"Satizabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Schweinfurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Shiroma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Simonsick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Spankovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Tropitzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker M.","family":"Lauschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Goedegebure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Cederroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.K.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries Paul","family":"Nagtegaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2022.04.010_bib1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0140-6736(21)00516-X","article-title":"Hearing loss prevalence and years lived with disability, 1990-2019: findings from the Global Burden of Disease Study 2019","volume":"397","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2022.04.010_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/14992027.2021.1883197","article-title":"Estimating the global costs of hearing loss","volume":"60","author":"McDaid","year":"2021","journal-title":"Int. J. Audiol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jamaoto.2014.42","article-title":"Hearing impairment associated with depression in US adults, national Health and nutrition examination survey 2005-2010","volume":"140","author":"Li","year":"2014","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.ajhg.2022.04.010_bib4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nbt.2736","article-title":"Hearing loss and tinnitus--are funders and industry listening?","volume":"31","author":"Cederroth","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000368399","article-title":"The mouse as a model for age-related hearing loss - a mini-review","volume":"61","author":"Bowl","year":"2014","journal-title":"Gerontology"},{"key":"10.1016\/j.ajhg.2022.04.010_bib6","doi-asserted-by":"crossref","first-page":"107906","DOI":"10.1016\/j.heares.2020.107906","article-title":"Small fish, big prospects: using zebrafish to unravel the mechanisms of hereditary hearing loss","volume":"397","author":"Vona","year":"2020","journal-title":"Hearing Res."},{"key":"10.1016\/j.ajhg.2022.04.010_bib7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/EDE.0b013e318245996e","article-title":"Heritability of hearing loss","volume":"23","author":"Kvestad","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajhg.2022.04.010_bib8","doi-asserted-by":"crossref","first-page":"e35500","DOI":"10.1371\/journal.pone.0035500","article-title":"Hearing ability with age in northern European women: a new web-based approach to genetic studies","volume":"7","author":"Wolber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajhg.2022.04.010_bib9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ajhg.2019.09.008","article-title":"GWAS identifies 44 independent associated genomic loci for self-reported adult hearing difficulty in UK biobank","volume":"105","author":"Wells","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib10","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s42003-021-02224-9","article-title":"The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis","volume":"4","author":"Ivarsdottir","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41588-017-0009-4","article-title":"Multi-trait analysis of genome-wide association summary statistics using MTAG","volume":"50","author":"Turley","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib12","doi-asserted-by":"crossref","first-page":"e1009025","DOI":"10.1371\/journal.pgen.1009025","article-title":"Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty","volume":"16","author":"Kalra","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib13","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41431-018-0126-2","article-title":"Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection","volume":"26","author":"Vuckovic","year":"2018","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib14","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41431-020-0603-2","article-title":"Self-reported hearing loss questions provide a good measure for genetic studies: a polygenic risk score analysis from UK Biobank","volume":"28","author":"Cherny","year":"2020","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"Winkler","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ajhg.2022.04.010_bib16","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2022.04.010_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib20","doi-asserted-by":"crossref","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput. Biol"},{"key":"10.1016\/j.ajhg.2022.04.010_bib21","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2022.04.010_bib22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1017\/thg.2014.79","article-title":"VEGAS2: software for more flexible gene-based testing","volume":"18","author":"Mishra","year":"2015","journal-title":"Twin Res. Human Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nature19356","article-title":"High-throughput discovery of novel developmental phenotypes","volume":"537","author":"Dickinson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2022.04.010_bib24","doi-asserted-by":"crossref","first-page":"bav071","DOI":"10.1093\/database\/bav071","article-title":"SHIELD: an integrative gene expression database for inner ear research","volume":"2015","author":"Shen","year":"2015","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.ajhg.2022.04.010_bib25","doi-asserted-by":"crossref","first-page":"11085","DOI":"10.1523\/JNEUROSCI.1690-14.2014","article-title":"Characterization of transcriptomes of cochlear inner and outer hair cells","volume":"34","author":"Liu","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ajhg.2022.04.010_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/thg.2016.100","article-title":"A novel approach for pathway analysis of GWAS data highlights role of BMP signaling and muscle cell differentiation in colorectal cancer susceptibility","volume":"20","author":"Mishra","year":"2017","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib27","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ajhg.2018.08.006","article-title":"Genomic landscape and mutational signatures of deafness-associated genes","volume":"103","author":"Azaiez","year":"2018","journal-title":"Am. journal Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ajhg.2022.04.010_bib29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/bioinformatics\/btu703","article-title":"DANN: a deep learning approach for annotating the pathogenicity of genetic variants","volume":"31","author":"Quang","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2022.04.010_bib30","doi-asserted-by":"crossref","first-page":"e46688","DOI":"10.1371\/journal.pone.0046688","article-title":"Predicting the functional effect of amino acid substitutions and indels","volume":"7","author":"Choi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajhg.2022.04.010_bib31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib32","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2164-14-S3-S3","article-title":"Identifying Mendelian disease genes with the variant effect scoring tool","volume":"14","author":"Carter","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ajhg.2022.04.010_bib33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ng.3477","article-title":"A spectral approach integrating functional genomic annotations for coding and noncoding variants","volume":"48","author":"Ionita-Laza","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/bioinformatics\/btw613","article-title":"LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis","volume":"33","author":"Zheng","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2022.04.010_bib35","doi-asserted-by":"crossref","unstructured":"GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)\u2014Analysis Working Group, Statistical Methods groups-Analysis Working Group, Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH\/NCI; NIH\/NHGRI; NIH\/NIMH; NIH\/NIDA; Biospecimen Collection Source Site\u2014NDRI; et\u00a0al. (2017). Genetic effects on gene expression across human tissues. Nature 550, 204-213, https:\/\/doi.org\/10.1038\/nature24277.","DOI":"10.1038\/nature24277"},{"key":"10.1016\/j.ajhg.2022.04.010_bib36","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41588-020-0610-9","article-title":"Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease","volume":"52","author":"Bryois","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib37","doi-asserted-by":"crossref","first-page":"109758","DOI":"10.1016\/j.celrep.2021.109758","article-title":"A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma","volume":"36","author":"Milon","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ajhg.2022.04.010_bib38","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1016\/j.celrep.2019.02.053","article-title":"Insights into the biology of hearing and deafness revealed by single-cell RNA sequencing","volume":"26","author":"Ranum","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ajhg.2022.04.010_bib39","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular architecture of the mouse nervous system","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2022.04.010_bib40","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.3404","article-title":"Partitioning heritability by functional annotation using genome-wide association summary statistics","volume":"47","author":"Finucane","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib41","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2307\/2529826","article-title":"400: a method for combining non-independent,\u00a0one-sided tests of significance","volume":"31","author":"Brown","year":"1975","journal-title":"Biometrics"},{"key":"10.1016\/j.ajhg.2022.04.010_bib42","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41588-018-0231-8","article-title":"Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations","volume":"50","author":"Gazal","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib43","unstructured":"Van Camp, G., and Smith, R.J.H. Hereditary Hearing Loss Homepage: hereditaryhearingloss.Org."},{"key":"10.1016\/j.ajhg.2022.04.010_bib44","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.1541-10.2010","article-title":"The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA\/2J mice","volume":"30","author":"Shin","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ajhg.2022.04.010_bib45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ajmg.a.36165","article-title":"Autosomal recessive Stickler syndrome due to a loss of function mutation in the COL9A3 gene","volume":"164","author":"Faletra","year":"2014","journal-title":"Am. journal Med. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-013-1358-4","article-title":"The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine","volume":"133","author":"Stenson","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib47","doi-asserted-by":"crossref","first-page":"18100","DOI":"10.1038\/s41598-020-75238-8","article-title":"Characterization of rare spindle and root cell transcriptional profiles in the stria vascularis of the adult mouse cochlea","volume":"10","author":"Gu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ajhg.2022.04.010_bib48","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41588-018-0129-5","article-title":"Genetic identification of brain cell types underlying schizophrenia","volume":"50","author":"Skene","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib49","series-title":"The Primary Auditory Neurons of the Mammalian Cochlea","article-title":"Loss, degeneration, and preservation of the spiral ganglion neurons and their processes","author":"Lang","year":"2016"},{"key":"10.1016\/j.ajhg.2022.04.010_bib50","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/adc.72.5.386","article-title":"The Landau-Kleffner syndrome","volume":"72","author":"Appleton","year":"1995","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ajhg.2022.04.010_bib51","series-title":"GeneReviews((R))","article-title":"Pyruvate carboxylase deficiency","author":"Wang","year":"1993"},{"key":"10.1016\/j.ajhg.2022.04.010_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson disease","volume":"4","author":"Czlonkowska","year":"2018","journal-title":"Nat. Rev. Dis. primers"},{"key":"10.1016\/j.ajhg.2022.04.010_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0022-510X(90)90239-J","article-title":"Brainstem auditory evoked potentials in Wilson's disease","volume":"95","author":"Butinar","year":"1990","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.ajhg.2022.04.010_bib54","series-title":"GeneReviews((R))","article-title":"Xia-gibbs syndrome","author":"Chander","year":"1993"},{"key":"10.1016\/j.ajhg.2022.04.010_bib55","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/jnr.24549","article-title":"Genetics of age-related hearing loss","volume":"98","author":"Wells","year":"2020","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.ajhg.2022.04.010_bib56","doi-asserted-by":"crossref","first-page":"e1005137","DOI":"10.1371\/journal.pgen.1005137","article-title":"HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice","volume":"11","author":"Azaiez","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2022.04.010_bib57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biocel.2014.12.024","article-title":"Identification of stage-specific markers during differentiation of hair cells from mouse inner ear stem cells or progenitor cells in\u00a0vitro","volume":"60","author":"Liu","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib58","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.devcel.2021.04.017","article-title":"Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing","volume":"56","author":"Chen","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ajhg.2022.04.010_bib59","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.1002\/lary.24332","article-title":"GJB2-associated hearing loss: systematic review of worldwide prevalence, genotype, and auditory phenotype","volume":"124","author":"Chan","year":"2014","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.ajhg.2022.04.010_bib60","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1152\/jn.00372.2016","article-title":"Evidence of degraded representation of speech in noise, in the aging midbrain and cortex","volume":"116","author":"Presacco","year":"2016","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1001\/jamaoto.2017.2513","article-title":"Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis","volume":"144","author":"Loughrey","year":"2018","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.ajhg.2022.04.010_bib62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.heares.2011.12.003","article-title":"Actin in hair cells and hearing loss","volume":"288","author":"Drummond","year":"2012","journal-title":"Hearing Res."},{"key":"10.1016\/j.ajhg.2022.04.010_bib63","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12916-021-02169-0","article-title":"A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens","volume":"19","author":"Liu","year":"2021","journal-title":"BMC Med."},{"key":"10.1016\/j.ajhg.2022.04.010_bib64","doi-asserted-by":"crossref","first-page":"eaav7803","DOI":"10.1126\/sciadv.aav7803","article-title":"Critical role of spectrin in hearing development and deafness","volume":"5","author":"Liu","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ajhg.2022.04.010_bib65","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/jn.00164.2013","article-title":"Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates","volume":"110","author":"Furman","year":"2013","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib66","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \"temporary\" noise-induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ajhg.2022.04.010_bib67","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.cub.2019.06.057","article-title":"Circadian regulation of cochlear sensitivity to noise by circulating glucocorticoids","volume":"29","author":"Cederroth","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib68","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cub.2014.01.047","article-title":"TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea","volume":"24","author":"Meltser","year":"2014","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.ajhg.2022.04.010_bib69","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1016\/j.cub.2020.09.046","article-title":"Hidden hearing loss impacts the neural representation of speech in background noise","volume":"30","author":"Monaghan","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib70","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","article-title":"Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model","volume":"31","author":"Schaette","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ajhg.2022.04.010_bib71","doi-asserted-by":"crossref","first-page":"e507","DOI":"10.1097\/MAO.0000000000002535","article-title":"Histology of the cochlear outer sulcus cells in normal human ears, presbycusis, and meniere's disease","volume":"41","author":"Christov","year":"2020","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.ajhg.2022.04.010_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2012.10.010","article-title":"The enigmatic root cell - emerging roles contributing to fluid homeostasis within the cochlear outer sulcus","volume":"303","author":"Jagger","year":"2013","journal-title":"Hearing Res."},{"key":"10.1016\/j.ajhg.2022.04.010_bib73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00441-012-1456-y","article-title":"Co-localisation of K(ir)4.1 and AQP4 in rat and human cochleae reveals a gap in water channel expression at the transduction sites of endocochlear K(+) recycling routes","volume":"350","author":"Eckhard","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ajhg.2022.04.010_bib74","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-5955(03)00338-1","article-title":"Expression patterns of claudins, tight junction adhesion molecules, in the inner ear","volume":"187","author":"Kitajiri","year":"2004","journal-title":"Hearing Res."},{"key":"10.1016\/j.ajhg.2022.04.010_bib75","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1523\/JNEUROSCI.0937-20.2020","article-title":"Age-related hearing loss is dominated by damage to inner ear sensory cells, not the cellular battery that powers them","volume":"40","author":"Wu","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ajhg.2022.04.010_bib76","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41467-021-21173-9","article-title":"Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice","volume":"12","author":"Wu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2022.04.010_bib77","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41586-019-1900-1","article-title":"The emergence of transcriptional identity in somatosensory neurons","volume":"577","author":"Sharma","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2022.04.010_bib78","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.otohns.2004.05.022","article-title":"Age-related histopathologic changes in the human cochlea: a temporal bone study","volume":"131","author":"Kusunoki","year":"2004","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.ajhg.2022.04.010_bib79","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.neuroscience.2009.05.036","article-title":"Quantitative analysis of the expression of the glutamate-aspartate transporter and identification of functional glutamate uptake reveal a role for cochlear fibrocytes in glutamate homeostasis","volume":"162","author":"Furness","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ajhg.2022.04.010_bib80","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1121\/1.4789933","article-title":"The digits-in-noise test: assessing auditory speech recognition abilities in noise","volume":"133","author":"Smits","year":"2013","journal-title":"J.\u00a0Acoust. Soc. America"},{"key":"10.1016\/j.ajhg.2022.04.010_bib81","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1038\/s41467-020-15707-w","article-title":"Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia","volume":"11","author":"Halvorsen","year":"2020","journal-title":"Nat. Commun."}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929722001586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929722001586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:21:32Z","timestamp":1762078892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929722001586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0002929722001586"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2022.04.010","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742154727.793593316","asserted-by":"object"}]},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2022.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}]}}