{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:28:19Z","timestamp":1787002099598,"version":"build-2736575974"},"reference-count":78,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,6]],"date-time":"2027-02-06T00:00:00Z","timestamp":1801872000000},"content-version":"am","delay-in-days":189,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100017192","name":"University of Southern California Norris Comprehensive Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society Inc","doi-asserted-by":"publisher","award":["IRG-22-144-60"],"award-info":[{"award-number":["IRG-22-144-60"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA262263"],"award-info":[{"award-number":["R01CA262263"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Blood Cancer United","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajhg.2026.06.008","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:41:10Z","timestamp":1782916870000},"page":"1646-1664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns"],"prefix":"10.1016","volume":"113","author":[{"given":"Yunqi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Alonzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan E.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalen","family":"Langie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swe Swe","family":"Myint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Ince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charleston W.K.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Mancuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Kachuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-7543","authenticated-orcid":false,"given":"Adam J.","family":"de Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2026.06.008_bib1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/jhg.2012.2","article-title":"Common genetic factors for hematological traits in humans","volume":"57","author":"Okada","year":"2012","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/ajcp\/aqy165","article-title":"The Top 25 Laboratory Tests by Volume and Revenue in Five Different Countries","volume":"151","author":"Horton","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714461","article-title":"Application of Genetic Studies to Flow Cytometry Data and Its Impact on Therapeutic Intervention for Autoimmune Disease","volume":"12","author":"Orr\u00f9","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib4","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.celrep.2016.10.053","article-title":"Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits","volume":"17","author":"Aguirre-Gamboa","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ajhg.2026.06.008_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2014.12.020","article-title":"Variation in the human immune system is largely driven by non-heritable influences","volume":"160","author":"Brodin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib6","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/s41590-021-01058-1","article-title":"Human immune diversity: from evolution to modernity","volume":"22","author":"Liston","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib7","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","article-title":"Complex genetic signatures in immune cells underlie autoimmunity and inform therapy","volume":"52","author":"Orr\u00f9","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2015.02.046","article-title":"The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis","volume":"161","author":"Roederer","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.celrep.2018.09.048","article-title":"Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators","volume":"25","author":"Lagou","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ajhg.2026.06.008_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41590-018-0049-7","article-title":"Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors","volume":"19","author":"Patin","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib11","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1182\/blood.2021013220","article-title":"Genome-wide association study on 13 167 individuals identifies regulators of blood CD34+cell levels","volume":"139","author":"Lopez de Lapuente Portilla","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.ajhg.2026.06.008_bib12","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2016.10.042","article-title":"The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease","volume":"167","author":"Astle","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib13","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.cell.2020.08.008","article-title":"The Polygenic and Monogenic Basis of Blood Traits and Diseases","volume":"182","author":"Vuckovic","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006760","article-title":"Genome-wide association study of red blood cell traits in Hispanics\/Latinos: The Hispanic Community Health Study\/Study of Latinos","volume":"13","author":"Hodonsky","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib15","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/hmg\/dds534","article-title":"GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children","volume":"22","author":"Li","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib16","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2020.06.045","article-title":"Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/ng.3607","article-title":"Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits","volume":"48","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ajhg.2016.05.003","article-title":"Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases","volume":"99","author":"Tajuddin","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41586-020-2786-7","article-title":"Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells","volume":"586","author":"Bao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2026.06.008_bib20","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.ajhg.2021.08.004","article-title":"Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia","volume":"108","author":"Kachuri","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib21","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41577-023-00874-w","article-title":"Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease","volume":"23","author":"Donald","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib22","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"Simon","year":"2015","journal-title":"Proc. R. Soc. A B."},{"key":"10.1016\/j.ajhg.2026.06.008_bib23","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","article-title":"Immune responses in neonates","volume":"10","author":"Basha","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ajhg.2015.12.001","article-title":"Genetic Diversity and Association Studies in US Hispanic\/Latino Populations: Applications in the Hispanic Community Health Study\/Study of Latinos","volume":"98","author":"Conomos","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ajhg.2014.11.010","article-title":"The genetic ancestry of African Americans, Latinos, and European Americans across the United States","volume":"96","author":"Bryc","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1299355","article-title":"The genetic risk of acute lymphoblastic leukemia and its implications for children of Latin American origin","volume":"13","author":"de Smith","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/thorax-2022-218755","article-title":"Admixture mapping of severe asthma exacerbations in Hispanic\/Latino children and youth","volume":"78","author":"Herrera-Luis","year":"2023","journal-title":"Thorax"},{"key":"10.1016\/j.ajhg.2026.06.008_bib28","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jaci.2014.07.053","article-title":"Genetic ancestry influences asthma susceptibility and lung function among Latinos","volume":"135","author":"Pino-Yanes","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2023.101894","article-title":"Reframing health disparities in SLE: A critical reassessment of racial and ethnic differences in lupus disease outcomes","volume":"37","author":"Parodis","year":"2023","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib30","article-title":"The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus","volume":"56","author":"Lewis","year":"2016","journal-title":"Rheumatology"},{"key":"10.1016\/j.ajhg.2026.06.008_bib31","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1537-2995.2005.04429.x","article-title":"Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report","volume":"45","author":"Cairo","year":"2005","journal-title":"Transfusion"},{"key":"10.1016\/j.ajhg.2026.06.008_bib32","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1537-2995.2005.04428.x","article-title":"Results of the cord blood transplantation (COBLT) study unrelated donor banking program","volume":"45","author":"Kurtzberg","year":"2005","journal-title":"Transfusion"},{"key":"10.1016\/j.ajhg.2026.06.008_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.ajhg.2026.06.008_bib34","series-title":"gtc2vcf","author":"Genovese","year":"2025"},{"key":"10.1016\/j.ajhg.2026.06.008_bib35","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib36","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib37","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1093\/bioinformatics\/btz567","article-title":"Genetic association testing using the GENESIS R\/Bioconductor package","volume":"35","author":"Gogarten","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajhg.2026.06.008_bib38","first-page":"1521","article-title":"Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations","volume":"30","author":"Luo","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng.608","article-title":"Common SNPs explain a large proportion of the heritability for human height","volume":"42","author":"Yang","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib40","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/rssb.12388","article-title":"A simple new approach to variable selection in regression, with application to genetic fine mapping","volume":"82","author":"Wang","year":"2020","journal-title":"J. R. Stat. Soc., Ser. B Stat. Methodol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib41","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2026.06.008_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ajhg.2026.06.008_bib43","doi-asserted-by":"crossref","first-page":"D998","DOI":"10.1093\/nar\/gkae1070","article-title":"The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity","volume":"53","author":"Cerezo","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ajhg.2026.06.008_bib44","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression","volume":"175","author":"Schmiedel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib45","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib46","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2026.06.008_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf3041","article-title":"Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease","volume":"376","author":"Yazar","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2026.06.008_bib48","article-title":"Efficient count-based models improve power and robustness for large-scale single-cell eQTL mapping","author":"Zhang","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.ajhg.2026.06.008_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz082","article-title":"PRSice-2: Polygenic Risk Score software for biobank-scale data","volume":"8","author":"Choi","year":"2019","journal-title":"GigaScience"},{"key":"10.1016\/j.ajhg.2026.06.008_bib51","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajhg.2013.06.020","article-title":"RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference","volume":"93","author":"Maples","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib52","article-title":"The impact of Indigenous American-like ancestry on the risk of acute lymphoblastic leukemia in Hispanic\/Latino children","volume":"7","author":"Langie","year":"2026","journal-title":"HGG Adv."},{"key":"10.1016\/j.ajhg.2026.06.008_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010388","article-title":"Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children","volume":"18","author":"Li","year":"2022","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib54","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3679","article-title":"Reference-based phasing using the Haplotype Reference Consortium panel","volume":"48","author":"Loh","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib55","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajhg.2015.12.003","article-title":"Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic\/Latino Americans","volume":"98","author":"Schick","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib56","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2026.06.008_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41588-020-00757-z","article-title":"Genetics of 35 blood and urine biomarkers in the UK Biobank","volume":"53","author":"Sinnott-Armstrong","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib58","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009440","article-title":"A more accurate method for colocalisation analysis allowing for multiple causal variants","volume":"17","author":"Wallace","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ajhg.2026.06.008_bib60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10875-016-0323-0","article-title":"Protein Kinase C delta: a Gatekeeper of Immune Homeostasis","volume":"36","author":"Salzer","year":"2016","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib61","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fimmu.2016.00186","article-title":"Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation","volume":"7","author":"Porciello","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming","volume":"166","author":"Buck","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib63","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.cell.2020.08.030","article-title":"Unraveling Hematopoiesis through the Lens of Genomics","volume":"182","author":"Liggett","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib64","article-title":"Genetic associations with ratios between protein levels detect new pQTLs and reveal protein-protein interactions","volume":"4","author":"Suhre","year":"2024","journal-title":"Cell Genom."},{"key":"10.1016\/j.ajhg.2026.06.008_bib65","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2567.2006.02428.x","article-title":"Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes","volume":"119","author":"Macchia","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.ajhg.2026.06.008_bib66","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173602","article-title":"Induced CD8alpha identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation","volume":"134","author":"Cubitt","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ajhg.2026.06.008_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103757","article-title":"CD4(+)CD8(+) double-positive T cells in immune disorders and cancer: Prospects and hurdles in immunotherapy","volume":"24","author":"Alam","year":"2025","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ajhg.2026.06.008_bib68","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2026.06.008_bib69","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1203\/pdr.0b013e3180332d02","article-title":"Maternal tobacco smoking and decreased leukocytes, including dendritic cells, in neonates","volume":"61","author":"Pachlopnik Schmid","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ajhg.2026.06.008_bib70","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2334-11-38","article-title":"The impact of maternal HIV infection on cord blood lymphocyte subsets and cytokine profile in exposed non-infected newborns","volume":"11","author":"Borges-Almeida","year":"2011","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.ajhg.2026.06.008_bib71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clim.2012.08.006","article-title":"The developing human preterm neonatal immune system: a case for more research in this area","volume":"145","author":"Sharma","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib72","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41586-019-1560-1","article-title":"Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth","volume":"574","author":"Shao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2026.06.008_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002230","article-title":"Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age","volume":"21","author":"Mallott","year":"2023","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib74","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1016\/j.cell.2021.04.039","article-title":"Microbial exposure during early human development primes fetal immune cells","volume":"184","author":"Mishra","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ajhg.2026.06.008_bib75","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ajog.2012.08.009","article-title":"Cesarean section and development of the immune system in the offspring","volume":"208","author":"Cho","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib76","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1038\/s41598-025-86015-w","article-title":"Development and validation of a risk prediction model for caesarean delivery among multiparous women","volume":"15","author":"Yimer","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ajhg.2026.06.008_bib77","doi-asserted-by":"crossref","first-page":"598.e1","DOI":"10.1016\/j.ajog.2017.02.017","article-title":"Prediction of cesarean delivery in the term nulliparous woman: results from the prospective, multicenter Genesis study","volume":"216","author":"Burke","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ajhg.2026.06.008_bib78","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12916-022-02632-6","article-title":"Maternal factors during pregnancy influencing maternal, fetal, and childhood outcomes","volume":"20","author":"Muglia","year":"2022","journal-title":"BMC Med."}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292972600234X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292972600234X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:28:55Z","timestamp":1786998535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292972600234X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":78,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S000292972600234X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2026.06.008","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2026.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Human Genetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}