{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:30:35Z","timestamp":1787002235552,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,6]],"date-time":"2027-02-06T00:00:00Z","timestamp":1801872000000},"content-version":"am","delay-in-days":189,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011172"],"award-info":[{"award-number":["U01HG011172"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG006379"],"award-info":[{"award-number":["U01HG006379"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG008657"],"award-info":[{"award-number":["U01HG008657"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011167"],"award-info":[{"award-number":["U01HG011167"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011166"],"award-info":[{"award-number":["U01HG011166"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011175"],"award-info":[{"award-number":["U01HG011175"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG008680"],"award-info":[{"award-number":["U01HG008680"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011181"],"award-info":[{"award-number":["U01HG011181"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG008685"],"award-info":[{"award-number":["U01HG008685"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011176"],"award-info":[{"award-number":["U01HG011176"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG011169"],"award-info":[{"award-number":["U01HG011169"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajhg.2026.06.014","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:42:59Z","timestamp":1784040179000},"page":"1618-1629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts"],"prefix":"10.1016","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-3173","authenticated-orcid":false,"given":"Mohammadreza","family":"Naderian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Dikilitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan E.","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura S.","family":"Abul-Husn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh B.","family":"Cortopassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Hanks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Irvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P.","family":"Jarvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimear E.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atlas","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah C.","family":"Kottyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita A.","family":"Limdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"McNally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Namjou-Khales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Roy-Puckelwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robb","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant K.","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Qi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri A.","family":"Manolio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6524-3471","authenticated-orcid":false,"given":"Iftikhar J.","family":"Kullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajhg.2026.06.014_bib1","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/S0140-6736(24)00685-8","article-title":"Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ajhg.2026.06.014_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41576-025-00900-8","article-title":"Clinical use of polygenic risk scores: current status, barriers and future directions","volume":"27","author":"Kullo","year":"2026","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ajhg.2026.06.014_bib3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41576-022-00470-z","article-title":"Polygenic scores in biomedical research","volume":"23","author":"Kullo","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ajhg.2026.06.014_bib4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2019.22241","article-title":"Predictive accuracy of a polygenic risk score-enhanced prediction model vs a clinical risk score for coronary artery disease","volume":"323","author":"Elliott","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ajhg.2026.06.014_bib5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1001\/jama.2019.21782","article-title":"Predictive accuracy of a polygenic risk score compared with a clinical risk score for incident coronary heart disease","volume":"323","author":"Mosley","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ajhg.2026.06.014_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2023.100567","article-title":"Polygenic risk, rare variants, and family history: Independent and additive effects on coronary heart disease","volume":"2","author":"Saadatagah","year":"2023","journal-title":"JACC. Adv."},{"key":"10.1016\/j.ajhg.2026.06.014_bib7","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1001\/jama.291.18.2204","article-title":"Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adultsa prospective study of parents and offspring","volume":"291","author":"Lloyd-Jones","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ajhg.2026.06.014_bib8","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.mayocp.2018.01.014","article-title":"Basic vs more complex definitions of family history in the prediction of coronary heart disease: The multi-ethnic study of atherosclerosis","volume":"93","author":"Patel","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ajhg.2026.06.014_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012364","article-title":"Prevalence and cardiovascular health impact of family history of premature heart disease in the United States: Analysis of the National Health and Nutrition Examination Survey, 2007-2014","volume":"8","author":"Moonesinghe","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ajhg.2026.06.014_bib10","doi-asserted-by":"crossref","first-page":"e1154","DOI":"10.1161\/CIR.0000000000001457","article-title":"2026 ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"153","author":"Blumenthal","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.ajhg.2026.06.014_bib11","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41588-018-0183-z","article-title":"Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations","volume":"50","author":"Khera","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ajhg.2026.06.014_bib12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ajhg.2020.04.002","article-title":"Predictive utility of polygenic risk scores for coronary heart disease in three major racial and ethnic groups","volume":"106","author":"Dikilitas","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.014_bib13","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/s41436-020-0810-9","article-title":"Frequency of genomic secondary findings among 21,915 eMERGE network participants","volume":"22","year":"2020","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-8794-4-13","article-title":"The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies","volume":"4","author":"McCarty","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.ajhg.2026.06.014_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2023.100006","article-title":"Returning integrated genomic risk and clinical recommendations: the eMERGE study","volume":"25","author":"Linder","year":"2023","journal-title":"Genet. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib16","series-title":"Return of Genome-Informed Risk-Assessment Results for Common Conditions to 23,840 Adults and Children: An eMERGE Network Study","first-page":"678","volume":"113","author":"Lawson","year":"2026"},{"key":"10.1016\/j.ajhg.2026.06.014_bib17","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ajhg.2026.02.018","article-title":"The Electronic Medical Records and Genomics study: Design and analytic framework for assessing the impact of genome-informed risk assessments","volume":"113","author":"Limdi","year":"2026","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.014_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.ajhg.2026.06.014_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u201cAll of Us\u201d Research Program","volume":"381","author":"Denny","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/EDE.0000000000001028","article-title":"Development of the initial surveys for the All of Us Research Program","volume":"30","author":"Cronin","year":"2019","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajhg.2026.06.014_bib21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41591-024-02796-z","article-title":"Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations","volume":"30","author":"Lennon","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib22","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41586-023-06957-x","article-title":"Genomic data in the All of Us Research Program","volume":"627","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2026.06.014_bib23","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/humu.23634","article-title":"ClinVar database of global familial hypercholesterolemia-associated DNA variants","volume":"39","author":"Iacocca","year":"2018","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ajhg.2026.06.014_bib24","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: An Ensemble Method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ajhg.2026.06.014_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg7492","article-title":"Accurate proteome-wide missense variant effect prediction with AlphaMissense","volume":"381","author":"Cheng","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ajhg.2026.06.014_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41586-023-06045-0","article-title":"A genomic mutational constraint map using variation in 76,156 human genomes","volume":"625","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ajhg.2026.06.014_bib27","doi-asserted-by":"crossref","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","article-title":"ClinVar: public archive of relationships among sequence variation and human phenotype","volume":"42","author":"Landrum","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ajhg.2026.06.014_bib28","first-page":"287","article-title":"Development and validation of a primary care-based family health history and decision support program (MeTree)","volume":"74","author":"Orlando","year":"2013","journal-title":"N. C. Med. J."},{"key":"10.1016\/j.ajhg.2026.06.014_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2296-15-31","article-title":"Quality of family history collection with use of a patient facing family history assessment tool","volume":"15","author":"Wu","year":"2014","journal-title":"BMC Fam. Pract."},{"key":"10.1016\/j.ajhg.2026.06.014_bib30","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1161\/01.cir.0000437741.48606.98","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Goff","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ajhg.2026.06.014_bib31","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ajhg.2026.06.014_bib32","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1056\/NEJMoa1011893","article-title":"Effect of direct-to-consumer genomewide profiling to assess disease risk","volume":"364","author":"Bloss","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7326\/0003-4819-157-4-201208210-00014","article-title":"Beyond the usual prediction accuracy metrics: reporting results for clinical decision making","volume":"157","author":"Localio","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib34","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0272989X06295361","article-title":"Decision curve analysis: A novel method for evaluating prediction models","volume":"26","author":"Vickers","year":"2006","journal-title":"Med. Decis. Mak."},{"key":"10.1016\/j.ajhg.2026.06.014_bib44","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1161\/CIRCULATIONAHA.108.816694","article-title":"Predicting the 30-year risk of cardiovascular disease: the framingham heart study","volume":"119","author":"Pencina","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ajhg.2026.06.014_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-72185-2","article-title":"Integrating common and rare variants improves polygenic risk prediction across diverse populations","volume":"17","author":"Williams","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2026.06.014_bib37","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1038\/s41591-023-02429-x","article-title":"A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease","volume":"29","author":"Patel","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/CIRCULATIONAHA.122.059162","article-title":"Race and ethnicity stratification for polygenic risk score analyses may mask disparities in Hispanics","volume":"146","author":"Clarke","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ajhg.2026.06.014_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125896","article-title":"A detailed family history of myocardial infarction and risk of myocardial infarction--a nationwide cohort study","volume":"10","author":"Ranthe","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ajhg.2026.06.014_bib40","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/CIRCULATIONAHA.111.065490","article-title":"Association between family history and coronary heart disease death across long-term follow-up in men","volume":"125","author":"Bachmann","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ajhg.2026.06.014_bib41","first-page":"3","article-title":"Family history assessment significantly enhances delivery of precision medicine in the genomics era","volume":"13","author":"Bylstra","year":"2021","journal-title":"Gen. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib42","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018410","article-title":"Performance of the pooled cohort equations in Hispanic individuals across the United States: Insights from the Multi-Ethnic Study of Atherosclerosis and the Dallas Heart Study","volume":"10","author":"Flores Rosario","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ajhg.2026.06.014_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/ANNALS-24-00716","article-title":"Development and evaluation of a comprehensive prediction model for incident coronary heart disease using genetic, social, and lifestyle-psychological factors: A prospective analysis of the UK Biobank","volume":"178","author":"Naderian","year":"2025","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ajhg.2026.06.014_bib35","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1038\/s41467-021-26114-0","article-title":"Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories","volume":"12","author":"Lali","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ajhg.2026.06.014_bib45","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/CIRCULATIONAHA.123.067626","article-title":"Development and validation of the American Heart Association\u2019s PREVENT equations","volume":"149","author":"Khan","year":"2024","journal-title":"Circulation"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929726002405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929726002405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:28:44Z","timestamp":1786998524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929726002405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0002929726002405"],"URL":"https:\/\/doi.org\/10.1016\/j.ajhg.2026.06.014","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajhg.2026.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Human Genetics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}