{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:31:13Z","timestamp":1759365073427,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajicjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Infection Control"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.ajic.2009.02.006","type":"journal-article","created":{"date-parts":[[2009,6,10]],"date-time":"2009-06-10T08:00:30Z","timestamp":1244620830000},"page":"723-728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epidemiology of an outbreak of antibiotic-resistant Klebsiella pneumoniae at a tertiary care medical center"],"prefix":"10.1016","volume":"37","author":[{"given":"Alina","family":"Filozov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Visintainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Carbonaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Aguero-Rosenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa A.","family":"Montecalvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajic.2009.02.006_bib1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJMra041359","article-title":"The new \u03b2-lactamases","volume":"352","author":"Jacoby","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajic.2009.02.006_bib2","first-page":"315","volume":"11","author":"Knothe","year":"1983","journal-title":"Transferable resistance to cefotaxime, cefoxitin, cefamandole, and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcenscens. Infection"},{"key":"10.1016\/j.ajic.2009.02.006_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.7326\/0003-4819-140-1-200401060-00008","article-title":"International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum \u03b2-lactamase production in nosocomial infections","volume":"140","author":"Paterson","year":"2004","journal-title":"Ann Intern Med"},{"issue":"Suppl 2","key":"10.1016\/j.ajic.2009.02.006_bib4","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1086\/320182","article-title":"Variations in the prevalence of strains expressing an extended-spectrum \u03b2-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific Region","volume":"32","author":"Winokur","year":"2001","journal-title":"Clin Infect Dis"},{"issue":"Suppl 4","key":"10.1016\/j.ajic.2009.02.006_bib5","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1086\/500664","article-title":"Hospital-based strategies for combating resistance","volume":"42","author":"Owens","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib6","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.280.14.1233","article-title":"Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella","volume":"280","author":"Rahal","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.ajic.2009.02.006_bib7","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1001\/archinte.165.12.1430","article-title":"Rapid spread of carbapenem resistance in New York City: a threat to our antibiotic armamentarium","volume":"165","author":"Bratu","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ajic.2009.02.006_bib8","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajic.2009.02.006_bib9","unstructured":"Clinical and Laboratory Standards Institute\/NCCLS. 2005. Performance Standards for Antimicrobial Susceptibility Testing; Fifteenth Informational Supplement. M100-S15, Vol.25 No. 1. Clinical and Laboratory Standards Institute, Wayne, Pa."},{"key":"10.1016\/j.ajic.2009.02.006_bib10","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/jcm.33.9.2233-2239.1995","article-title":"Interpreting chromosomal DNA restriction patterns produced by pulse-field gel electrophoresis: criteria for bacterial strain typing","volume":"33","author":"Tenover","year":"1995","journal-title":"J Clin Microbiol"},{"issue":"8554","key":"10.1016\/j.ajic.2009.02.006_bib11","first-page":"302","volume":"2","author":"Brun-Buisson","year":"1987","journal-title":"Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae. Lancet"},{"key":"10.1016\/j.ajic.2009.02.006_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0195-6701(91)90088-P","article-title":"A case-control study of an outbreak of infections caused by Klebsiella pnumoniae strains producing CTX-1 (TEM-3) \u03b2-lactamase","volume":"18","author":"De Champs","year":"1991","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.ajic.2009.02.006_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0195-6701(96)90011-0","article-title":"An outbreak of multiple-resistant Klebsiella pnumoniae in the Grampian region of Scotland","volume":"33","author":"Hobson","year":"1996","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.ajic.2009.02.006_bib14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/clinids\/22.3.430","article-title":"Outbreak of multiple-resistant Enterobacteriaceae in an intensive care unit: epidemiology and risk factors for acquisition","volume":"22","author":"Lucet","year":"1996","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0195-6701(97)90163-8","article-title":"Risk factors for faecal carriage of Klebsiella pneumoniae producing extended-spectrum \u03b2-lactamase (ESBL-KP) in the intensive care unit","volume":"35","author":"Pe\u0148a","year":"1997","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.ajic.2009.02.006_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.7326\/0003-4819-119-5-199309010-00001","article-title":"Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins","volume":"119","author":"Meyer","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajic.2009.02.006_bib17","first-page":"279","article-title":"The molecular and clinical epidemiology of enterobacteriaceae-producing extended-spectrum \u03b2-lactamase in a tertiary care hospital","volume":"36","author":"D'Agata","year":"1998","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.ajic.2009.02.006_bib18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1086\/502045","article-title":"Extended-spectrum \u03b2-lactamase-producing Escherichia Coli and Klebsiella species: risk factors for colonization and impact of antimicrobial formulary interventions on colonization prevalence","volume":"23","author":"Bisson","year":"2002","journal-title":"Infect Control Hosp Epidimiol"},{"key":"10.1016\/j.ajic.2009.02.006_bib19","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/AAC.46.5.1481-1491.2002","article-title":"Bloodstream infections by extended-spectrum \u03b2-lactamase-producing Escherichia Coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome","volume":"46","author":"Kim","year":"2002","journal-title":"Antmicrob Agents Chemother"},{"key":"10.1016\/j.ajic.2009.02.006_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/514643","article-title":"Spread of extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae: are \u03b2-lactamase inhibitors of therapeutic value?","volume":"27","author":"Piroth","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1086\/502310","article-title":"Risk factors for and clinical outcomes of bloodstream infections caused by extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae","volume":"25","author":"Kang","year":"2004","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ajic.2009.02.006_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1128\/AAC.42.1.53","article-title":"Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended-spectrum \u03b2-lactamases","volume":"42","author":"Pe\u0148a","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajic.2009.02.006_bib23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/infdis\/174.3.529","article-title":"Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: a case-control and molecular epidemiologic investigation","volume":"174","author":"Schiappa","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib24","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/319757","article-title":"Extended-spectrum \u03b2-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes","volume":"32","author":"Lautenbach","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib25","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1128\/AAC.34.11.2193","article-title":"Outbreak of ceftazidime resistance caused by extended-spectrum \u03b2-lactamases at a Massachusetts chronic care facility","volume":"34","author":"Rice","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajic.2009.02.006_bib26","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1128\/AAC.36.9.1991","article-title":"Outbreak of ceftazidime resistance dueto novel extended-spectrum \u03b2-lactamase in isolates from cancer patients","volume":"36","author":"Naumovski","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajic.2009.02.006_bib27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1086\/342577","article-title":"Molecular epidemiology of a citywide outbreak of extended spectrum \u03b2-lactamase producing Klebsiella pneumoniae infection","volume":"35","author":"Quale","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1086\/313590","article-title":"Outbreak of a multiresistant Klebsiella pneumoniae strain in an intensive care unit: antibiotic use as risk factor for colonization and infection","volume":"30","author":"Asensio","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib29","first-page":"832","volume":"25","author":"Lee","year":"2004","journal-title":"Reduced use of third-generation cephalosporins decreases the acquisition of extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae. Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ajic.2009.02.006_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/jhin.2002.1331","article-title":"Risk factors in the acquisition of extended-spectrum \u03b2-lactamase Klebsiella pneumoniae: a case-control study in a district teaching hospital in Taiwan","volume":"53","author":"Lin","year":"2003","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.ajic.2009.02.006_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/clinids\/23.1.118","article-title":"Ceftazidime-resistant Klebsiella pneumoniae at the Cleveland Department of Veterans Affairs Medical Center","volume":"23","author":"Rice","year":"1996","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/503016","article-title":"Limiting the emergence of extended-spectrum \u03b2-lactamase-producing enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventions","volume":"27","author":"Lipworth","year":"2006","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ajic.2009.02.006_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/jama.281.6.517","article-title":"Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes","volume":"281","author":"Wiener","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.ajic.2009.02.006_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/420816","article-title":"Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum \u03b2-lactamases","volume":"39","author":"Paterson","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajic.2009.02.006_bib35","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1086\/313511","article-title":"Control of a prolonged outbreak of extended-spectrum \u03b2-lactamase-producing enterobacteriaceae in a university hospital","volume":"29","author":"Lucet","year":"1999","journal-title":"Clin Infect Dis"}],"container-title":["American Journal of Infection Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196655309004258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196655309004258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:33:07Z","timestamp":1759296787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196655309004258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0196655309004258"],"URL":"https:\/\/doi.org\/10.1016\/j.ajic.2009.02.006","relation":{},"ISSN":["0196-6553"],"issn-type":[{"type":"print","value":"0196-6553"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiology of an outbreak of antibiotic-resistant Klebsiella pneumoniae at a tertiary care medical center","name":"articletitle","label":"Article Title"},{"value":"American Journal of Infection Control","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajic.2009.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}