{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:18:36Z","timestamp":1783793916660,"version":"3.55.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100024655","name":"Teleflex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajicjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Infection Control"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajic.2025.03.002","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:39:06Z","timestamp":1741239546000},"page":"862-868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicenter, multinational, prospective cohort study of the impact of chlorhexidine impregnated versus plain central lines on central line-associated bloodstream infections"],"prefix":"10.1016","volume":"53","author":[{"given":"Victor Daniel","family":"Rosenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-2929","authenticated-orcid":false,"given":"Ruijie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-6155","authenticated-orcid":false,"given":"Zhilin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat Nor Mohd","family":"Basri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Yin","family":"Hoong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah","family":"Mohamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-7664","authenticated-orcid":false,"given":"Amani","family":"El-Kholy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Bayani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Hatem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-163X","authenticated-orcid":false,"given":"Sheila Nainan","family":"Myatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Castro","family":"P\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-1909","authenticated-orcid":false,"given":"Mohit","family":"Kharbanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikas","family":"Nag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2860-2831","authenticated-orcid":false,"given":"Ertugrul","family":"Guclu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra Olmez","family":"Gazioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nellie","family":"Tumu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1S suppl 1","key":"10.1016\/j.ajic.2025.03.002_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/NAN.0000000000000532","article-title":"Infusion therapy standards of practice, 9th edition","volume":"47","author":"Nickel","year":"2024","journal-title":"J Infus Nurs"},{"key":"10.1016\/j.ajic.2025.03.002_bib2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajic.2014.11.014","article-title":"National Healthcare Safety Network report, data summary for 2013, device-associated module","volume":"43","author":"Dudeck","year":"2015","journal-title":"Am J Infect Control"},{"issue":"10","key":"10.1016\/j.ajic.2025.03.002_bib3","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.ajic.2024.04.007","article-title":"International Nosocomial Infection Control Consortium (INICC) report of health care-associated infections, data summary of 25 countries for 2014 to 2023, Surgical Site Infections Module","volume":"52","author":"Rosenthal","year":"2024","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/510812","article-title":"Attributable cost and length of stay for patients with central venous catheter-associated bloodstream infection in Mexico City intensive care units: a prospective, matched analysis","volume":"28","author":"Higuera","year":"2007","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ajic.2025.03.002_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ajic.2023.06.002","article-title":"Etiology and utility of hospital-onset bacteremia as a safety metric for targeted harm reduction","volume":"52","author":"Stack","year":"2024","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1586\/erp.09.53","article-title":"Economic burden of healthcare-associated infections: an American perspective","volume":"9","author":"Stone","year":"2009","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"10.1016\/j.ajic.2025.03.002_bib7","unstructured":"Estimating the Additional Hospital Inpatient Cost and Mortality Associated with Selected Hospital-Acquired Conditions. Agency for Healthcare Research and Quality (AHRQ). Accessed November 26, 2024. https:\/\/www.ahrq.gov\/hai\/pfp\/haccost2017-results.html."},{"key":"10.1016\/j.ajic.2025.03.002_bib8","first-page":"1","article-title":"Multinational prospective study of incidence and risk factors for central-line-associated bloodstream infections in 728 intensive care units of 41 Asian, African, Eastern European, Latin American, and Middle Eastern countries over 24 years","author":"Rosenthal","year":"2023","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"5","key":"10.1016\/j.ajic.2025.03.002_bib9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1017\/ice.2022.87","article-title":"Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 update","volume":"43","author":"Buetti","year":"2022","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ajic.2025.03.002_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00134-003-2045-z","article-title":"The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters","volume":"30","author":"Safdar","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajic.2025.03.002_bib11","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ajic.2024.06.015","article-title":"The antimicrobial effectiveness of chlorhexidine and chlorhexidine-silver sulfadiazine-impregnated central venous catheters against the emerging fungal pathogen Candida auris","volume":"52","author":"Gupta","year":"2024","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib12","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0195-6701(13)60012-2","article-title":"Epic3: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England","volume":"86","author":"Loveday","year":"2014","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.ajic.2025.03.002_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13613-018-0416-4","article-title":"Effectiveness of antimicrobial-coated central venous catheters for preventing catheter-related blood-stream infections with the implementation of bundles: a systematic review and network meta-analysis","volume":"8","author":"Wang","year":"2018","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.ajic.2025.03.002_bib14","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ajic.2023.04.163","article-title":"Efficacy of antimicrobial peripherally inserted central catheters in line-associated bloodstream infections: a systematic review and meta-analysis","volume":"51","author":"Wu","year":"2023","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ajic.2015.11.017","article-title":"A comparative evaluation of antimicrobial coated versus nonantimicrobial coated peripherally inserted central catheters on associated outcomes: a randomized controlled trial","volume":"44","author":"Storey","year":"2016","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib17","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.ajic.2016.01.005","article-title":"International Nosocomial Infection Control Consortium (INICC) resources: INICC multidimensional approach and INICC surveillance online system","volume":"44","author":"Rosenthal","year":"2016","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ajic.2025.03.002_bib18","unstructured":"New World Bank country classifications by income level: 2021\u20132022. Cited on November 1, 2022. Accessed August 23, 2022. https:\/\/blogs.worldbank.org\/opendata\/new-world-bank-country-classifications-income-level-2021-2022."},{"key":"10.1016\/j.ajic.2025.03.002_bib19","unstructured":"World Health Organization. Glossary of Terms. WHO European Primary Health Care Impact Performance and Capacity Tool (PHC-IMPACT). Cited on November 1, 2022. Accessed August 23, 2022. https:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0006\/421944\/Glossary-web-171219.pdf."},{"key":"10.1016\/j.ajic.2025.03.002_bib20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12957-015-0707-2","article-title":"Port type is a possible risk factor for implantable venous access port-related bloodstream infections and no sign of local infection predicts the growth of gram-negative bacilli","volume":"13","author":"Hsu","year":"2015","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.ajic.2025.03.002_bib21","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1017\/ice.2016.203","article-title":"CLABSI risk factors in the NICU: potential for prevention: a PICNIC study","volume":"37","author":"Dahan","year":"2016","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["American Journal of Infection Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196655325001051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196655325001051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T13:32:16Z","timestamp":1762263136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196655325001051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0196655325001051"],"URL":"https:\/\/doi.org\/10.1016\/j.ajic.2025.03.002","relation":{},"ISSN":["0196-6553"],"issn-type":[{"value":"0196-6553","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multicenter, multinational, prospective cohort study of the impact of chlorhexidine impregnated versus plain central lines on central line-associated bloodstream infections","name":"articletitle","label":"Article Title"},{"value":"American Journal of Infection Control","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajic.2025.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.","name":"copyright","label":"Copyright"}]}}