{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:03:33Z","timestamp":1787612613926,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024075","name":"Region of Southern Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013814","name":"University of Southern Denmark Department of Clinical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajicjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Infection Control"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ajic.2026.01.020","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:48:35Z","timestamp":1769705315000},"page":"575-581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Flavonifractor plautii: A rare pathogen in sepsis and critical care---A systematic narrative review of literature"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1350-4497","authenticated-orcid":false,"given":"Joachim","family":"Kvernberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Rehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isik Somuncu","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-647X","authenticated-orcid":false,"given":"Paul","family":"Peterslund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Martin","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajic.2026.01.020_bib1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.ajic.2026.01.020_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib4","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Fleischmann-Struzek","year":"2020","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib5","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to treatment and mortality during mandated emergency care for sepsis","volume":"376","author":"Seymour","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/CCM.0000000000002235","article-title":"Early goal-directed therapy for sepsis: a novel solution for discordant survival outcomes in clinical trials","volume":"45","author":"Kalil","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1128\/jcm.33.3.755-758.1995","article-title":"Techniques for controlling variability in gram staining of obligate anaerobes","volume":"33","author":"Johnson","year":"1995","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/CIRCRESAHA.122.322354","article-title":"Finding needles in the gut microbiota\u2019s haystack","volume":"132","author":"Aljadah","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.ajic.2026.01.020_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst Rev"},{"key":"10.1016\/j.ajic.2026.01.020_bib10","doi-asserted-by":"crossref","unstructured":"Covidence - better systematic review management. Accessed December 22, 2025. \u3008https:\/\/www.covidence.org\/\u3009.","DOI":"10.1080\/15424065.2025.2547027"},{"key":"10.1016\/j.ajic.2026.01.020_bib11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0140-6736(91)90518-T","article-title":"Fulminant Eubacterium plautii infection following dog bite in asplenic man","volume":"338","author":"Garre","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ajic.2026.01.020_bib12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1399-0012.2008.00805.x","article-title":"Eubacterium plautii infection in a kidney transplant recipient: a noteworthy case of pleural effusion and fever","volume":"22","author":"Orlando","year":"2008","journal-title":"Clin Transplant"},{"key":"10.1016\/j.ajic.2026.01.020_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2018.e00461","article-title":"Flavonifractor (Eubacterium) plautii bloodstream infection following acute cholecystitis","volume":"14","author":"Berger","year":"2018","journal-title":"IDCases"},{"key":"10.1016\/j.ajic.2026.01.020_bib14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00508-021-01877-0","article-title":"Flavonifractor plautii bloodstream infection in an asplenic patient with infectious colitis","volume":"133","author":"Karpat","year":"2021","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.ajic.2026.01.020_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/17843286.2021.1944584","article-title":"A case of Flavonifractor plautii blood stream infection in a severe burn patient and a review of the literature","volume":"77","author":"Costescu Strachinaru","year":"2022","journal-title":"Acta Clin Belg"},{"key":"10.1016\/j.ajic.2026.01.020_bib16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5371\/hp.2022.34.4.255","article-title":"Periprosthetic hip joint infection with Flavonifractor plautii: a literature review and case report","volume":"34","author":"Wilton","year":"2022","journal-title":"Hip Pelvis"},{"key":"10.1016\/j.ajic.2026.01.020_bib17","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.943920","article-title":"Genome sequencing analysis of a rare case of blood infection caused by Flavonifractor plautii","volume":"25","author":"Chen","year":"2024","journal-title":"Am J Case Rep"},{"key":"10.1016\/j.ajic.2026.01.020_bib18","article-title":"Flavonifractor plautii bacteremia with generalized peritonitis: a case report and literature review","volume":"16","author":"Saito","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ajic.2026.01.020_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiac.2024.12.021","article-title":"Flavonifractor plautii bacteremia following bacterial translocation from the gut: a case report and literature review","volume":"31","author":"Osada","year":"2025","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.ajic.2026.01.020_bib20","first-page":"1","article-title":"Rare multiorgan failure sepsis with Flavonifractor plautii","volume":"187","author":"Kvernberg","year":"2025","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.ajic.2026.01.020_bib21","article-title":"Flavonifractor plautii: a rare cause of anaerobic bacteremia","volume":"17","author":"Zamora Diaz","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.ajic.2026.01.020_bib22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/0255-0857.118870","article-title":"Translocation of gut flora and its role in sepsis","volume":"31","author":"Vaishnavi","year":"2013","journal-title":"Indian J Med Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3181\/00379727-71-17114","article-title":"Transmural migration of intestinal bacteria during peritoneal irrigation in uremic dogs","volume":"71","author":"Schweinburg","year":"1949","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.904758","article-title":"Different fecal microbiota in Hirschsprung\u2019s patients with and without associated enterocolitis","volume":"13","author":"Arnaud","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12866-021-02201-6","article-title":"Ecological and network analyses identify four microbial species with potential significance for the diagnosis\/treatment of ulcerative colitis (UC)","volume":"21","author":"Li","year":"2021","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00438-19","article-title":"Association of Flavonifractor plautii, a flavonoid-degrading bacterium, with the gut microbiome of colorectal cancer patients in India","volume":"4","author":"Gupta","year":"2019","journal-title":"mSystems"},{"key":"10.1016\/j.ajic.2026.01.020_bib27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jmoldx.2019.01.006","article-title":"Leveraging human microbiome features to diagnose and stratify children with irritable bowel syndrome","volume":"21","author":"Hollister","year":"2019","journal-title":"J Mol Diagn"},{"issue":"5 Suppl","key":"10.1016\/j.ajic.2026.01.020_bib28","article-title":"The surgically induced stress response","volume":"37","author":"Finnerty","year":"2013","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.ajic.2026.01.020_bib29","doi-asserted-by":"crossref","first-page":"e432","DOI":"10.1016\/j.jemermed.2023.12.005","article-title":"Evaluating clinical prediction rules for bacteremia detection in the emergency department: a retrospective review","volume":"66","author":"McNab","year":"2024","journal-title":"J Emerg Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1473-3099(09)70110-0","article-title":"Bite-related and septic syndromes caused by cats and dogs","volume":"9","author":"Oehler","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ajic.2026.01.020_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1556\/1886.2020.00009","article-title":"Relevance of anaerobic bacteremia in adult patients: a never-ending story?","volume":"10","author":"Gajd\u00e1cs","year":"2020","journal-title":"Eur J Microbiol Immunol"},{"key":"10.1016\/j.ajic.2026.01.020_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.anaerobe.2009.12.001","article-title":"The role of anaerobic bacteria in bacteremia","volume":"16","author":"Brook","year":"2010","journal-title":"Anaerobe"},{"key":"10.1016\/j.ajic.2026.01.020_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/jacamr\/dlae112","article-title":"Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source","volume":"6","author":"Freeman","year":"2024","journal-title":"JAC-Antimicrob Resist"},{"key":"10.1016\/j.ajic.2026.01.020_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3201\/eid3106.250182","article-title":"Characterization of adult and pediatric healthcare-associated and community-associated Clostridioides difficile infections, Canada, 2015\u20132022","volume":"31","author":"Du","year":"2025","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ajic.2026.01.020_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/srep37865","article-title":"The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis","volume":"6","author":"Tang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajic.2026.01.020_bib36","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1099\/ijs.0.016725-0","volume":"60","author":"Carlier","year":"2010","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib37","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1093\/infdis\/jiaa221","article-title":"Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance","volume":"222","author":"Strich","year":"2021","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajic.2026.01.020_bib38","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/s12879-022-07653-3","article-title":"The 2021 Dutch Working Party on Antibiotic Policy (SWAB) guidelines for empirical antibacterial therapy of sepsis in adults","volume":"22","author":"Sieswerda","year":"2022","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ajic.2026.01.020_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1469-0691.2007.01933.x","article-title":"New antimicrobial agents for the treatment of gram-positive bacterial infections","volume":"14","author":"Aksoy","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ajic.2026.01.020_bib40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/microorganisms12020322","article-title":"MALDI-TOF MS: a reliable tool in the real life of the clinical microbiology laboratory","volume":"12","author":"Calderaro","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.ajic.2026.01.020_bib41","article-title":"The clinical utility of Nanopore 16S rRNA gene sequencing for direct bacterial identification in normally sterile body fluids","volume":"14","author":"Lao","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib42","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.3201\/eid3113.241101","article-title":"16S ribosomal RNA gene PCR and sequencing for pediatric infection diagnosis, United States, 2020-2023","volume":"31","author":"Li","year":"2025","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ajic.2026.01.020_bib43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1089\/hs.2023.0100","article-title":"Literature review of pathogen agnostic molecular testing of clinical specimens from difficult-to-diagnose patients: implications for public health","volume":"22","author":"Downie","year":"2024","journal-title":"Health Secur"},{"key":"10.1016\/j.ajic.2026.01.020_bib44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1126\/science.ade2503","article-title":"Wastewater surveillance for public health","volume":"379","author":"Levy","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ajic.2026.01.020_bib45","article-title":"Advancing pathogen genomics in resource-limited settings","volume":"3","author":"Pronyk","year":"2023","journal-title":"Cell Genom"},{"key":"10.1016\/j.ajic.2026.01.020_bib46","series-title":"Encyclopedia of Genetics, Genomics, Proteomics and Informatics","first-page":"1893","article-title":"Study bias","author":"Popovic","year":"2023"},{"key":"10.1016\/j.ajic.2026.01.020_bib47","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1213\/ANE.0000000000001596","article-title":"Publication bias: the elephant in the review","volume":"123","author":"Dalton","year":"2016","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ajic.2026.01.020_bib48","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s00134-018-5175-z","article-title":"Surviving sepsis campaign: research priorities for sepsis and septic shock","volume":"44","author":"Coopersmith","year":"2018","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.ajic.2026.01.020_bib49","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1128\/JCM.00492-13","article-title":"Identification of rare pathogenic bacteria in a clinical microbiology laboratory: impact of matrix-assisted laser desorption ionization\u2013time of flight mass spectrometry","volume":"51","author":"Seng","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajic.2026.01.020_bib50","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.csbj.2021.01.007","article-title":"Evolution of bacteria in the human gut in response to changing environments: an invisible player in the game of health","volume":"19","author":"Venkatakrishnan","year":"2021","journal-title":"Comput Struct Biotechnol J"}],"container-title":["American Journal of Infection Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196655326000507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196655326000507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T19:32:12Z","timestamp":1775849532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196655326000507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0196655326000507"],"URL":"https:\/\/doi.org\/10.1016\/j.ajic.2026.01.020","relation":{},"ISSN":["0196-6553"],"issn-type":[{"value":"0196-6553","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavonifractor plautii: A rare pathogen in sepsis and critical care---A systematic narrative review of literature","name":"articletitle","label":"Article Title"},{"value":"American Journal of Infection Control","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajic.2026.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.","name":"copyright","label":"Copyright"}]}}