{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:23:06Z","timestamp":1773458586844,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01MD009162"],"award-info":[{"award-number":["1R01MD009162"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Medicine Open"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ajmo.2023.100045","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T12:19:26Z","timestamp":1686572366000},"page":"100045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Clinical and Laboratory Correlates of QTc Duration in Adult and Pediatric Sickle Cell Disease"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-3241","authenticated-orcid":false,"given":"Xue","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvankar","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Daryl","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-9199","authenticated-orcid":false,"given":"Erin","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarrod","family":"Knudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3446-8002","authenticated-orcid":false,"given":"Douglas","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-3217","authenticated-orcid":false,"given":"Gregory J.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2515-9600","authenticated-orcid":false,"given":"Joseph F.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajmo.2023.100045_bib0001","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/S0140-6736(16)00647-4","article-title":"Cardiovascular complications and risk of death in sickle-cell disease","volume":"387","author":"Gladwin","year":"2016","journal-title":"Lancet."},{"key":"10.1016\/j.ajmo.2023.100045_bib0002","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tcm.2020.02.002","article-title":"Cardiovascular complications of sickle cell disease","volume":"31","author":"Sachdev","year":"2021","journal-title":"Trends Cardiovasc Med."},{"key":"10.1016\/j.ajmo.2023.100045_bib0003","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/ejh.12127","article-title":"Prolongation of QTc intervals and risk of death among patients with sickle cell disease","volume":"91","author":"Upadhya","year":"2013","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0004","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMcp0706513","article-title":"Clinical practice, long-QT syndrome","volume":"358","author":"Roden","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajmo.2023.100045_bib0005","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jacc.2010.01.001","article-title":"Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation","volume":"55","author":"Drew","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0006","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/pbc.20539","article-title":"Prolonged QT interval in pediatric sickle cell disease","volume":"47","author":"Mueller","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ajmo.2023.100045_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000100929","article-title":"Increased QT dispersion in sickle cell disease: effect of pulmonary hypertension","volume":"118","author":"Akg\u00fcl","year":"2007","journal-title":"Acta Haematol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0008","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/pbc.21973","article-title":"Prolonged QTc interval in children and young adults with sickle cell disease at steady state","volume":"52","author":"Liem","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ajmo.2023.100045_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164526","article-title":"Associations of prolonged QTc in sickle cell disease","volume":"11","author":"Indik","year":"2016","journal-title":"PLoS ONE."},{"key":"10.1016\/j.ajmo.2023.100045_bib0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5830\/CVJA-2015-059","article-title":"Electrocardiographic abnormalities and dyslipidaemic syndrome in children with sickle cell anaemia","volume":"27","author":"Adegoke","year":"2016","journal-title":"Cardiovasc J Afr"},{"key":"10.1016\/j.ajmo.2023.100045_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.117.001724","article-title":"Validation of polygenic scores for QT interval in clinical populations","volume":"10","author":"Rosenberg","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.ajmo.2023.100045_bib0012","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1056\/NEJMra032426","article-title":"Drug-induced prolongation of the QT interval","volume":"350","author":"Roden","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajmo.2023.100045_bib0013","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0002-9343(96)00407-X","article-title":"Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia","volume":"102","author":"Pegelow","year":"1997","journal-title":"Am J Med"},{"key":"10.1016\/j.ajmo.2023.100045_bib0014","article-title":"Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study","volume":"15","author":"Taylor","year":"2005","journal-title":"Ethn Dis"},{"key":"10.1016\/j.ajmo.2023.100045_bib0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCEP.109.858894","article-title":"Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study","volume":"2","author":"Akylbekova","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0016","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0002-9149(92)91399-O","article-title":"Reduction of QT-interval imprecision and variance by measuring the JT interval","volume":"70","author":"Spodick","year":"1992","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0017","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/01.CIR.0000095027.28753.9D","article-title":"Prognostic significance of corrected QT and corrected JT interval for incident coronary heart disease in a general population sample stratified by presence or absence of wide QRS complex: the ARIC Study with 13 years of follow-up","volume":"108","author":"Crow","year":"2003","journal-title":"Circulation."},{"key":"10.1016\/j.ajmo.2023.100045_bib0018","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ahj.2013.10.009","article-title":"Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: the Jackson Heart Study","volume":"167","author":"Akylbekova","year":"2014","journal-title":"Am Heart J"},{"key":"10.1016\/j.ajmo.2023.100045_bib0019","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.CIR.88.2.782","article-title":"Diagnostic criteria for the long QT syndrome. An update","volume":"88","author":"Schwartz","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ajmo.2023.100045_bib0020","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jacc.2008.12.014","volume":"53","author":"Rautaharju","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0021","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/apa.13784","article-title":"Glomerular hyperfiltration is strongly correlated with age in Congolese children with sickle cell anaemia","volume":"106","author":"Aloni","year":"2017","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ajmo.2023.100045_bib0022","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ajh.25390","article-title":"Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy","volume":"94","author":"Lebensburger","year":"2019","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0023","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1093\/eurheartj\/ehy284","article-title":"For neonatal ECG screening there is no reason to relinquish old Bazett's correction","volume":"39","author":"Stramba-Badiale","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajmo.2023.100045_bib0024","doi-asserted-by":"crossref","first-page":"e12804","DOI":"10.1111\/anec.12804","article-title":"QT correction using Bazett's formula remains preferable in long QT syndrome type 1 and 2","volume":"26","author":"Dahlberg","year":"2021","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1161\/01.CIR.103.1.89","article-title":"Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias","volume":"103","author":"Schwartz","year":"2001","journal-title":"Circulation."},{"key":"10.1016\/j.ajmo.2023.100045_bib0026","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2147\/VHRM.S259766","article-title":"Assessment of ventricular repolarization in sickle cell anemia patients: the role of QTc interval, Tp-e interval and Tp-e\/QTc ratio and its gender implication","volume":"16","author":"Ajibare","year":"2020","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.ajmo.2023.100045_bib0027","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijcard.2017.09.005","article-title":"Tpeak-Tend as a predictor of ventricular arrhythmogenesis","volume":"249","author":"Antzelevitch","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0028","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/CCM.0b013e318232db4a","article-title":"High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality: results of the QT in Practice (QTIP) Study","volume":"40","author":"Pickham","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajmo.2023.100045_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.756213","article-title":"Association between dynamic change of QT interval and long-term cardiovascular outcomes: a prospective cohort study","volume":"8","author":"Ye","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ajmo.2023.100045_bib0030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ajh.20304","article-title":"Methadone-related Torsades de Pointes in a sickle cell patient treated for chronic pain","volume":"78","author":"Porter","year":"2005","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0031","unstructured":"E14 and S7B Clinical and Nonclinical Evaluation of QT\/QTc Interval Prolongation and Proarrhythmic Potential\u2014Questions and Answers\u2014Guidance for Industry\/US. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER). August 2022; page 7."},{"key":"10.1016\/j.ajmo.2023.100045_bib0032","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005808","article-title":"Pediatric Heart Network Investigators. Electrocardiograms in healthy North American children in the digital age","volume":"11","author":"Saarel","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ajmo.2023.100045_bib0033","series-title":"GeneReviews\u00ae [Internet]","article-title":"Long QT syndrome","author":"Alders","year":"2018"}],"container-title":["American Journal of Medicine Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667036423000158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667036423000158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T08:18:57Z","timestamp":1763021937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667036423000158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":33,"alternative-id":["S2667036423000158"],"URL":"https:\/\/doi.org\/10.1016\/j.ajmo.2023.100045","relation":{},"ISSN":["2667-0364"],"issn-type":[{"value":"2667-0364","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Laboratory Correlates of QTc Duration in Adult and Pediatric Sickle Cell Disease","name":"articletitle","label":"Article Title"},{"value":"American Journal of Medicine Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajmo.2023.100045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100045"}}