{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:23:31Z","timestamp":1790663011478,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Medicine Open"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ajmo.2026.100126","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:41:06Z","timestamp":1770050466000},"page":"100126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Systemic Nickel Allergy Syndrome"],"prefix":"10.1016","volume":"15","author":[{"given":"Allison","family":"Freeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Letterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Boos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0882-8483","authenticated-orcid":false,"given":"Scott","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ajmo.2026.100126_bib0001","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2500\/aap.2009.30.3275","article-title":"Serum levels of protein oxidation products in patients with nickel allergy","volume":"30","author":"Gangemi","year":"2009","journal-title":"Allergy Asthma Proc"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0002","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/nu9020103","article-title":"Contact dermatitis due to nickel allergy in patients suffering from non-celiac wheat sensitivity","volume":"9","author":"D'Alcamo","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0003","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/039463201002300117","article-title":"Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome","volume":"23","author":"Minelli","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0004","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/cod.12426","article-title":"Short and frequent skin contact with nickel","volume":"73","author":"Erfani","year":"2015","journal-title":"Contact Dermatitis"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/cod.13136","article-title":"Nickel deposition and penetration into the stratum corneum after short metallic nickel contact: an experimental study","volume":"80","author":"Ahlstr\u00f6m","year":"2019","journal-title":"Contact Dermatitis"},{"issue":"3","key":"10.1016\/j.ajmo.2026.100126_bib0006","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jaad.2018.09.058","article-title":"Epidemiology of nickel sensitivity: retrospective cross-sectional analysis of North American Contact Dermatitis Group data 1994-2014","volume":"80","author":"Warshaw","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0007","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1089\/derm.2022.29017.jdk","article-title":"North American contact dermatitis group patch test results: 2019-2020","volume":"34","author":"DeKoven","year":"2023","journal-title":"Dermatitis"},{"issue":"5","key":"10.1016\/j.ajmo.2026.100126_bib0008","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/DER.0000000000000812","article-title":"Prevalence of contact allergy to nickel: a retrospective chart review","volume":"33","author":"Mukovozov","year":"2022","journal-title":"Dermatitis"},{"issue":"6","key":"10.1016\/j.ajmo.2026.100126_bib0009","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/DER.0000000000000701","article-title":"Contact allergy in Canada versus United States: analysis of the North American Contact Dermatitis Group data 2005-2016","volume":"32","author":"Atwater","year":"2021","journal-title":"Dermatitis"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/cod.13327","article-title":"Nickel allergy and allergic contact dermatitis: a clinical review of immunology, epidemiology, exposure, and treatment","volume":"81","author":"Ahlstr\u00f6m","year":"2019","journal-title":"Contact Dermatitis"},{"issue":"6","key":"10.1016\/j.ajmo.2026.100126_bib0011","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/DER.0000000000000935","article-title":"Patch testing with nickel sulfate 5.0% traces significantly more contact allergy than 2.5%: a prospective study within the International Contact Dermatitis Research Group","volume":"33","author":"Svedman","year":"2022","journal-title":"Dermatitis"},{"key":"10.1016\/j.ajmo.2026.100126_bib0012","first-page":"225","article-title":"Systemic nickel allergy syndrome (SNAS): taking stock of medical nutrition therapy SNAS and nutrition","volume":"5","author":"Conti","year":"2021","journal-title":"J Community Med Public Health"},{"issue":"5","key":"10.1016\/j.ajmo.2026.100126_bib0013","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-0536.2010.01702.x","article-title":"Validity of self-reported nickel allergy","volume":"62","author":"Josefson","year":"2010","journal-title":"Contact Dermatitis"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0014","first-page":"176","article-title":"Refractory systemic nickel allergy syndrome management: 5 cases and chart review survey from an integrative medical practice","volume":"29","author":"Chung","year":"2023","journal-title":"Integ Comple Therap"},{"issue":"21","key":"10.1016\/j.ajmo.2026.100126_bib0015","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1136\/heartjnl-2021-319940","article-title":"Nickel hypersensitivity and endovascular devices: a systematic review and meta-analysis","volume":"108","author":"Gu\u00e9roult","year":"2022","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0016","doi-asserted-by":"crossref","first-page":"631","DOI":"10.5606\/tgkdc.dergisi.2022.23893","article-title":"Surgical removal of atrial septal defect closure device due to systemic allergic reaction to nickel: a case report","volume":"30","author":"Kocayi\u011fit","year":"2022","journal-title":"Turk Gogus Kalp Damar Cerrahisi Derg"},{"issue":"5","key":"10.1016\/j.ajmo.2026.100126_bib0017","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0536.2008.01434.x","article-title":"Nickel-induced systemic allergic dermatitis from a sacral neurostimulator","volume":"59","author":"Nosbaum","year":"2008","journal-title":"Contact Dermatitis"},{"issue":"6","key":"10.1016\/j.ajmo.2026.100126_bib0018","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/cod.14295","article-title":"Allergic contact dermatitis from nickel and coronary aneurysm","volume":"88","author":"Giraldo-Tugores","year":"2023","journal-title":"Contact Dermatitis"},{"issue":"6","key":"10.1016\/j.ajmo.2026.100126_bib0019","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.athoracsur.2010.04.076","article-title":"Metal allergy, atrial septal occluder devices and the risk of Kounis syndrome","volume":"90","author":"Kounis","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0020","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.125.015228","article-title":"Patent foramen ovale closure in patients with and without nickel hypersensitivity: a randomized trial","volume":"18","author":"Apostolos","year":"2025","journal-title":"Circ Cardiovasc Interven"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0021","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1097\/IOP.0000000000000819","article-title":"Systemic allergic response in the setting of a metallic intraorbital foreign body with intraoperative magnet-assisted retrieval","volume":"33","author":"Cole","year":"2017","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0022","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1525-1470.2010.01367.x","article-title":"Acute onset of generalized pruritic rash in a toddler. Diagnosis: systemic allergic (contact) dermatitis to nickel from ingestion of metal coins","volume":"28","author":"McLean","year":"2011","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0023","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/039463201402700118","article-title":"Systemic nickel allergy syndrome: epidemiological data from four Italian allergy units","volume":"27","author":"Ricciardi","year":"2014","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jand.2025.09.010","article-title":"Nickel allergy masquerading as irritable bowel syndrome: case report","volume":"126","author":"de Waal","year":"2026","journal-title":"J Acad Nutr Diet"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1177\/039463201102400230","article-title":"Lactose intolerance in systemic nickel allergy syndrome","volume":"24","author":"Cazzato","year":"2011","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0026","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/2050640615595917","article-title":"Nickel sensitization in patients with gastro-esophageal reflux disease","volume":"4","author":"Stanghellini","year":"2015","journal-title":"United Eur Gastroenterol J"},{"issue":"6","key":"10.1016\/j.ajmo.2026.100126_bib0027","first-page":"39","article-title":"Dietary nickel as a cause of systemic contact dermatitis","volume":"2","author":"Zirwas","year":"2009","journal-title":"J Clin Aesthet Dermatol"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0028","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2310\/6620.2011.10062","article-title":"Pruritus ani as a manifestation of systemic contact dermatitis: resolution with dietary nickel restriction","volume":"22","author":"Silvestri","year":"2011","journal-title":"Dermatitis"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0029","first-page":"29","article-title":"The baboon syndrome due to nickel","volume":"11","author":"Kolodziej","year":"2003","journal-title":"Acta Dermatovenerol Croat"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1034\/j.1600-0536.2002.460415.x","article-title":"Eyelid dermatitis and conjunctivitis as sole manifestations of allergy to nickel in an orthodontic appliance","volume":"46","author":"Mancuso","year":"2002","journal-title":"Contact Dermatitis"},{"issue":"3","key":"10.1016\/j.ajmo.2026.100126_bib0031","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1177\/039463201302600314","article-title":"Systemic nickel allergy syndrome: nosologic framework and usefulness of diet regimen for diagnosis","volume":"26","author":"Braga","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"3","key":"10.1016\/j.ajmo.2026.100126_bib0032","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/j.athoracsur.2019.01.034","article-title":"Severe migraine associated with nickel allergy requiring surgical removal of atrial septal device","volume":"108","author":"Fernandes","year":"2019","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0033","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s13317-012-0044-1","article-title":"Autoimmunity in connection with a metal implant: a case of autoimmune\/autoinflammatory syndrome induced by adjuvants","volume":"4","author":"Loyo","year":"2012","journal-title":"Auto Immun Highlights"},{"key":"10.1016\/j.ajmo.2026.100126_bib0034","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jtemb.2015.01.001","article-title":"Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease","volume":"31","author":"Stejskal","year":"2015","journal-title":"J Trace Elem Med Biol"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0035","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3390\/nu12041040","article-title":"The effects of low-nickel diet combined with oral administration of selected probiotics on patients with systemic nickel allergy syndrome (SNAS) and gut dysbiosis","volume":"12","author":"Lombardi","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0036","doi-asserted-by":"crossref","first-page":"00178","DOI":"10.1183\/23120541.00178-2019","article-title":"Nickel allergy is associated with wheezing and asthma in a cohort of young German adults: results from the SOLAR study","volume":"6","author":"Kolberg","year":"2020","journal-title":"ERJ Open Res"},{"issue":"8","key":"10.1016\/j.ajmo.2026.100126_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202683","article-title":"Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals","volume":"13","author":"Watanabe","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ajmo.2026.100126_bib0038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123265","article-title":"High prevalence of nickel allergy in an overweight female population: a pilot observational analysis","volume":"10","author":"Lusi","year":"2015","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.ajmo.2026.100126_bib0039","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.3390\/ijms21249733","article-title":"Nickel sensitivity is associated with GH-IGF1 axis impairment and pituitary abnormalities on MRI in overweight and obese subjects","volume":"21","author":"Risi","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.ajmo.2026.100126_bib0040","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s12020-015-0581-2","article-title":"Systemic nickel allergic syndrome as an immune-mediated disease with an increased risk for thyroid autoimmunity","volume":"50","author":"Andrioli","year":"2015","journal-title":"Endocrine"},{"issue":"10","key":"10.1016\/j.ajmo.2026.100126_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139388","article-title":"Nickel allergy is a risk factor for endometriosis: an 11-year population-based nested case-control study","volume":"10","author":"Yuk","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0042","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/039463201002300117","article-title":"Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome","volume":"23","author":"Minelli","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0043","article-title":"Dietary exposure assessment to nickel through the consumption of poultry, beef, and pork meat for different age groups in the Italian population","volume":"14","author":"Manfredi","year":"2025","journal-title":"Ital J Food Saf"},{"issue":"Suppl 1","key":"10.1016\/j.ajmo.2026.100126_bib0044","doi-asserted-by":"crossref","first-page":"A89","DOI":"10.1186\/1939-4551-8-S1-A89","article-title":"Systemic nickel allergy syndrome","volume":"8","author":"Da Mata Perez","year":"2015","journal-title":"World Allergy Organ J"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5056\/jnm16027","article-title":"Irritable bowel syndrome and nickel allergy: what is the role of the low nickel diet?","volume":"23","author":"Rizzi","year":"2017","journal-title":"J Neurogastroenterol Motil"},{"issue":"8","key":"10.1016\/j.ajmo.2026.100126_bib0046","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.3390\/nu13082897","article-title":"Diet intervention study through telemedicine assistance for systemic nickel allergy syndrome patients during the COVID-19 pandemic","volume":"13","author":"Nucera","year":"2021","journal-title":"Nutrients"},{"issue":"18","key":"10.1016\/j.ajmo.2026.100126_bib0047","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.3390\/jcm11185459","article-title":"Datterino trial: a double blind, randomized, controlled, crossover, clinical trial on the use of hydroponic cultivated tomato sauce in systemic nickel allergy syndrome","volume":"11","author":"Rizzi","year":"2022","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0048","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/07853890.2013.861158","article-title":"Nickel oral hyposensitization in patients with systemic nickel allergy syndrome","volume":"46","author":"Di Gioacchino","year":"2014","journal-title":"Ann Med"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0049","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0378-6323.25635","article-title":"Disulfiram and low nickel diet in the management of hand eczema: a clinical study","volume":"72","author":"Sharma","year":"2006","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"2","key":"10.1016\/j.ajmo.2026.100126_bib0050","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/DER.0000000000000446","article-title":"Dupilumab for systemic allergy syndrome with dermatitis","volume":"30","author":"Jacob","year":"2019","journal-title":"Dermatitis"},{"issue":"5","key":"10.1016\/j.ajmo.2026.100126_bib0051","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/DER.0000000000000409","article-title":"Effective use of Dupilumab in managing systemic allergic contact dermatitis","volume":"29","author":"Joshi","year":"2018","journal-title":"Dermatitis"},{"issue":"1","key":"10.1016\/j.ajmo.2026.100126_bib0052","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/jam.12685","article-title":"Probiotic supplementation in systemic nickel allergy syndrome patients: study of its effects on lactic acid bacteria population and on clinical symptoms","volume":"118","author":"Randazzo","year":"2015","journal-title":"J Appl Microbiol"},{"issue":"4","key":"10.1016\/j.ajmo.2026.100126_bib0053","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.alit.2021.03.004","article-title":"A case of systemic nickel allergy with diarrhea-predominant irritable bowel syndrome in which nickel intake restriction and administration of a probiotic formulation were effective","volume":"70","author":"Mori","year":"2021","journal-title":"Allergol Int"}],"container-title":["American Journal of Medicine Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667036426000038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667036426000038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:47:14Z","timestamp":1780404434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667036426000038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":53,"alternative-id":["S2667036426000038"],"URL":"https:\/\/doi.org\/10.1016\/j.ajmo.2026.100126","relation":{},"ISSN":["2667-0364"],"issn-type":[{"value":"2667-0364","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Nickel Allergy Syndrome","name":"articletitle","label":"Article Title"},{"value":"American Journal of Medicine Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajmo.2026.100126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100126"}}