{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:34:34Z","timestamp":1792114474050,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.ajo.2005.09.017","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T10:29:26Z","timestamp":1139048966000},"page":"313-318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":232,"title":["Polymerase Chain Reaction and Goldmann-Witmer Coefficient Analysis Are Complimentary for the Diagnosis of Infectious Uveitis"],"prefix":"10.1016","volume":"141","author":[{"given":"Jolanda D.F.","family":"De Groot-Mijnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniki","family":"Rothova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton M.","family":"Van Loon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margje","family":"Schuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninette H.","family":"Ten Dam-Van Loon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke H.","family":"De Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Schuurman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie J.L.","family":"Weersink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2005.09.017_bib1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0002-9394(14)70631-2","article-title":"Serologic and polymerase chain reaction analysis of intraocular fluids in the diagnosis of infectious uveitis","volume":"121","author":"De Boer","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib2","series-title":"Diagnosis and treatment of uveitis","first-page":"17","article-title":"Definition, classification, etiology, and epidemiology","author":"Shafik","year":"2002"},{"key":"10.1016\/j.ajo.2005.09.017_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000309752","article-title":"New approaches to the detection of locally produced antiviral antibodies in the aqueous of patients with endogenous uveitis","volume":"194","author":"Dussaix","year":"1987","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.ajo.2005.09.017_bib4","series-title":"Herpetische Augenerkrankungen","first-page":"147","article-title":"Coefficient of antibody activity in the aqueous humor to that in the serum in ocular herpes simplex","author":"Denis","year":"1981"},{"key":"10.1016\/j.ajo.2005.09.017_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000301976","article-title":"Antik\u00f6rper im Kammerwasser","volume":"127","author":"Goldmann","year":"1954","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.ajo.2005.09.017_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0002-9394(78)90012-0","article-title":"Clinical implications of aqueous humor studies in uveitis","volume":"86","author":"Witmer","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF02306485","article-title":"Aqueous humor analysis as a diagnostic tool in Toxoplasma uveitis","volume":"13","author":"Kijlstra","year":"1989","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/bjo.77.2.107","article-title":"Detection of Toxoplasma gondii in aqueous humour by the polymerase chain reaction","volume":"77","author":"Aouizerate","year":"1993","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM199103073241016","article-title":"Analysis of aqueous humor in ocular toxoplasmosis","volume":"324","author":"Brezin","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajo.2005.09.017_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1001\/archopht.1991.01080020112054","article-title":"Detection of herpesvirus DNA in vitreous and aqueous specimens by the polymerase chain reaction","volume":"109","author":"Fox","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0002-9394(02)01500-3","article-title":"Diagnosis of toxoplasmic retinochoroiditis with atypical clinical features","volume":"134","author":"Fardeau","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/bjo.87.1.79","article-title":"Polymerase chain reaction analysis of aqueous humour samples in necrotising retinitis","volume":"87","author":"Tran","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib13","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1128\/JCM.41.8.3537-3541.2003","article-title":"Comparison of enzyme-linked immunosorbent assay, immunoblotting, and PCR for diagnosis of toxoplasmic chorioretinitis","volume":"41","author":"Villard","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajo.2005.09.017_bib14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0896-1549(02)00037-8","article-title":"Testing ocular fluids in uveitis","volume":"15","author":"Bodaghi","year":"2002","journal-title":"Ophthalmol Clin North Am"},{"key":"10.1016\/j.ajo.2005.09.017_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ajo.2005.07.078","article-title":"Rubella virus is associated with Fuchs heterochromic iridocyclitis","volume":"141","author":"de Groot-Mijnes","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0002-9394(14)73077-6","article-title":"Detection of intraocular antibody production to herpesviruses in acute retinal necrosis syndrome","volume":"117","author":"de Boer","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1586\/14737159.1.2.129","article-title":"Standardization and quality control in molecular diagnostics","volume":"1","author":"Niesters","year":"2001","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.ajo.2005.09.017_bib18","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1128\/JCM.41.2.576-580.2003","article-title":"Diagnosing herpesvirus infections by real-time amplification and rapid culture","volume":"41","author":"van Doornum","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajo.2005.09.017_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jcv.2003.08.006","article-title":"Routine use of a highly automated and internally controlled real-time PCR assay for the diagnosis of herpes simplex and varicella-zoster virus infections","volume":"30","author":"Stranska","year":"2004","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajo.2005.09.017_bib20","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JCM.37.6.1941-1947.1999","article-title":"Development of a high-throughput quantitative assay for detecting herpes simplex virus DNA in clinical samples","volume":"37","author":"Ryncarz","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajo.2005.09.017_bib21","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/JCM.38.11.4121-4125.2000","article-title":"Real-time PCR for quantitative detection of Toxoplasma gondii","volume":"38","author":"Lin","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajo.2005.09.017_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0166-0934(98)00176-1","article-title":"Development of a fluorogenic polymerase chain reaction assay (TaqMan) for the detection and quantitation of varicella zoster virus","volume":"79","author":"Hawrami","year":"1999","journal-title":"J Virol Methods"},{"key":"10.1016\/j.ajo.2005.09.017_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1386-6532(03)00003-9","article-title":"An international external quality assessment of nucleic acid amplification of herpes simplex virus","volume":"28","author":"Schloss","year":"2003","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajo.2005.09.017_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/0002-9394(88)90712-X","article-title":"Acute unilateral toxoplasmic iridocyclitis in an AIDS patient","volume":"106","author":"Rehder","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1076\/0927-3948(200009)831-KFT189","article-title":"Use of PCR in endophthalmitis","volume":"8","author":"Okhravi","year":"2000","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.ajo.2005.09.017_bib26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0002-9394(99)00316-5","article-title":"Viral causes of the acute retinal necrosis syndrome","volume":"129","author":"Ganatra","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ophtha.2003.07.004","article-title":"Diagnostic approaches to severe, atypical toxoplasmosis mimicking acute retinal necrosis","volume":"111","author":"Moshfeghi","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2005.09.017_bib28","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000267740","article-title":"Detection of varicella-zoster virus genome having a PstI site in the ocular sample from a patient with acute retinal necrosis","volume":"27","author":"Kumano","year":"1995","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.ajo.2005.09.017_bib29","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-9394(98)00337-7","article-title":"Intraocular anti-Toxoplasma gondii IgA antibody production in patients with ocular toxoplasmosis","volume":"127","author":"Ronday","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1442-9071.2005.00992.x","article-title":"Use of PCR to diagnose Toxoplasma gondii chorioretinitis in eyes with severe vitritis","volume":"33","author":"Okhravi","year":"2005","journal-title":"Clin Experiment Ophthalmol"},{"key":"10.1016\/j.ajo.2005.09.017_bib31","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/S0161-6420(99)90453-0","article-title":"Use of the polymerase chain reaction for diagnosis of ocular toxoplasmosis","volume":"106","author":"Montoya","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2005.09.017_bib32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1086\/322800","article-title":"Unusual abundance of atypical strains associated with human ocular toxoplasmosis","volume":"184","author":"Grigg","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajo.2005.09.017_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0140-6736(91)92155-U","article-title":"Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid","volume":"337","author":"Aurelius","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ajo.2005.09.017_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0928-0197(97)10006-X","article-title":"Routine diagnosis of herpes simplex virus (HSV) encephalitis by an internal DNA controlled HSV PCR and an IgG-capture assay for intrathecal synthesis of HSV antibodies","volume":"9","author":"Fomsgaard","year":"1998","journal-title":"Clin Diagn Virol"},{"key":"10.1016\/j.ajo.2005.09.017_bib35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-5728(98)00160-X","article-title":"Advanced laboratory techniques for diagnosing Toxoplasma gondii encephalitis in AIDS patients","volume":"92","author":"Contini","year":"1998","journal-title":"J Neuroimmunol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293940501024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293940501024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T12:50:39Z","timestamp":1757595039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293940501024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S000293940501024X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2005.09.017","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymerase Chain Reaction and Goldmann-Witmer Coefficient Analysis Are Complimentary for the Diagnosis of Infectious Uveitis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2005.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}