{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:38:47Z","timestamp":1770507527661,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.ajo.2007.02.035","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T07:16:56Z","timestamp":1176794216000},"page":"958-969.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Surveillance of the Eye and Vision in Clinical Trials of CP-675,206 for Metastatic Melanoma"],"prefix":"10.1016","volume":"143","author":[{"given":"Bradley R.","family":"Straatsma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Nusinowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn K.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa W.","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Seja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Economou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Glaspy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Bozon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Gomez-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2007.02.035_bib1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1076514","article-title":"Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes","volume":"298","author":"Dudley","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ajo.2007.02.035_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1200\/JCO.1996.14.1.7","article-title":"Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684","volume":"14","author":"Kirkwood","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajo.2007.02.035_bib3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/35077246","article-title":"Progress in human tumor immunology and immunotherapy","volume":"411","author":"Rosenberg","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ajo.2007.02.035_bib4","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1200\/JCO.2005.06.205","article-title":"Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4","volume":"23","author":"Attia","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajo.2007.02.035_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/01.cji.0000178913.41256.06","article-title":"Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer","volume":"28","author":"Blansfield","year":"2005","journal-title":"J Immunother"},{"key":"10.1016\/j.ajo.2007.02.035_bib6","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1073\/pnas.0830997100","article-title":"Biologic activity of cytotoxic T-lymphocyte-associated antigen-4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients","volume":"100","author":"Hodi","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajo.2007.02.035_bib7","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.1200\/JCO.2005.01.109","article-title":"Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody CP-675,206","volume":"23","author":"Ribas","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajo.2007.02.035_bib8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1200\/JCO.2005.01.128","article-title":"Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma","volume":"23","author":"Sanderson","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajo.2007.02.035_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00002371-200411000-00008","article-title":"Cytotoxic T- lymphocyte-associated antigen-4 blockade in patients with metastatic melanoma: a new cause of uveitis","volume":"27","author":"Robinson","year":"2004","journal-title":"J Immunother"},{"key":"10.1016\/j.ajo.2007.02.035_bib10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cct.2004.06.002","article-title":"Surveillance of the eye and vision in a clinical trial of MART1-transformed dendritic cells for metastatic melanoma","volume":"25","author":"Gordon","year":"2004","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.ajo.2007.02.035_bib11","unstructured":"US National Institutes of Health. Common Toxicity Criteria, Version 2.0. Available at: http:\/\/ctep.cancer.gov\/forms\/CTCv20_4-30-992.pdf. Accessed Date: September 26, 2006."},{"key":"10.1016\/j.ajo.2007.02.035_bib12","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2006.24.18_suppl.8033","article-title":"Antigen-specific T cell responses in patients with melanoma treated with the CTLA4 blocking mAb CP-675,206","volume":"24","author":"Ribas","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajo.2007.02.035_bib13","series-title":"COMS manual of procedures","year":"1995"},{"key":"10.1016\/j.ajo.2007.02.035_bib14","unstructured":"US National Institutes of Health. The National Eye Institute 25-item Visual Function Questionnaire (VFQ-25), Version 2000. Available at: http:\/\/www.nei.nih.gov\/index.html. Accessed Date: September 26, 2006."},{"key":"10.1016\/j.ajo.2007.02.035_bib15","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1484::AID-CNCR29>3.0.CO;2-D","article-title":"A new American Joint Committee on Cancer staging system for cutaneous melanoma","volume":"88","author":"Balch","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ajo.2007.02.035_bib16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa053007","article-title":"Prognostic significance of autoimmunity during treatment of melanoma with interferon","volume":"354","author":"Gogas","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajo.2007.02.035_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors","volume":"92","author":"Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajo.2007.02.035_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0002-9394(01)00915-1","article-title":"Retinal findings in melanoma-associated retinopathy","volume":"132","author":"Borkowski","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2007.02.035_bib19","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1001\/archderm.138.6.799","article-title":"Hypopigmentation associated with an adenovirus-mediated gp100\/MART-1-transduced dendritic cell vaccine for metastatic melanoma","volume":"138","author":"Tsao","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ajo.2007.02.035_bib20","first-page":"S55","article-title":"Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma","volume":"6","author":"Fisher","year":"2000","journal-title":"Cancer J Sci Am"},{"key":"10.1016\/j.ajo.2007.02.035_bib21","first-page":"1","article-title":"Normal macula","volume":"Volume 1","author":"Gass","year":"1997"},{"key":"10.1016\/j.ajo.2007.02.035_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0039-6257(02)00416-2","article-title":"Paraneoplastic retinopathies and optic neuropathies","volume":"48","author":"Chan","year":"2003","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajo.2007.02.035_bib23","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1136\/bjo.79.8.746","article-title":"Severe course of cutaneous melanoma associated paraneoplastic retinopathy","volume":"79","author":"Kellner","year":"1995","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2007.02.035_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00041327-200109000-00004","article-title":"Clinical and immunologic characteristics of melanoma-associated retinopathy syndrome: eleven new cases and a review of 51 previously published cases","volume":"21","author":"Keltner","year":"2001","journal-title":"J Neuro-ophthalmol"},{"key":"10.1016\/j.ajo.2007.02.035_bib25","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0002-9394(01)01086-8","article-title":"Melanoma-associated retinopathy and recurrent exudative retinal detachments in a patient with choroidal melanoma","volume":"132","author":"Zacks","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2007.02.035_bib26","first-page":"1189","article-title":"Nature of the cone ON-pathway dysfunction in melanoma-associated retinopathy","volume":"43","author":"Alexander","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2007.02.035_bib27","first-page":"262","article-title":"Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo","volume":"41","author":"Lei","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2007.02.035_bib28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0002-9394(02)01431-9","article-title":"Autoantibodies to transducin in a patient with melanoma-associated retinopathy","volume":"134","author":"Potter","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2007.02.035_bib29","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1365-2133.2005.06480.x","article-title":"Incidence of antiretinal antibodies in melanoma: screening of 77 serum samples from 51 patients with American Joint Committee on Cancer stage I-IV","volume":"152","author":"Ladewig","year":"2005","journal-title":"Br J Dermatol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939407002012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939407002012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T12:54:07Z","timestamp":1757595247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939407002012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0002939407002012"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2007.02.035","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surveillance of the Eye and Vision in Clinical Trials of CP-675,206 for Metastatic Melanoma","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2007.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}