{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:27:23Z","timestamp":1765279643431,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.ajo.2008.03.024","type":"journal-article","created":{"date-parts":[[2008,5,24]],"date-time":"2008-05-24T04:36:30Z","timestamp":1211603790000},"page":"228-234.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Clinical Course and Treatment Outcomes of Sorsby Fundus Dystrophy"],"prefix":"10.1016","volume":"146","author":[{"given":"Sobha","family":"Sivaprasad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Tufail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2008.03.024_bib1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng1294-352","article-title":"Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy","volume":"8","author":"Weber","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajo.2008.03.024_bib2","first-page":"179","article-title":"A novel splice site mutation in the tissue inhibitor of the metalloproteinases-3 gene in Sorsby's fundus dystrophy with unusual clinical features","volume":"103","author":"Tabata","year":"1998","journal-title":"Hum Genet"},{"key":"10.1016\/j.ajo.2008.03.024_bib3","doi-asserted-by":"crossref","first-page":"27027","DOI":"10.1016\/S0021-9258(19)61475-4","article-title":"A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy","volume":"275","author":"Langton","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajo.2008.03.024_bib4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/archopht.123.4.542","article-title":"A novel TIMP3 mutation associated with Sorsby fundus dystrophy","volume":"123","author":"Barbazetto","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1001\/archopht.120.3.376","article-title":"Novel mutation in the TIMP3 gene causes Sorsby fundus dystrophy","volume":"120","author":"Jacobson","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/bjo.84.7.679","article-title":"What is Sorsby's fundus dystrophy?","volume":"84","author":"Gregory-Evans","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/bjo.35.12.751","article-title":"Fundus dystrophy with unusual features; a histological study","volume":"35","author":"Ashton","year":"1951","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/jmg.37.2.83","article-title":"Genetic susceptibility to age-related macular degeneration","volume":"37","author":"Yates","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajo.2008.03.024_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.6.2.92","article-title":"Sorsby's fundus dystrophy in the British Isles: demonstration of a striking founder effect by microsatellite-generated haplotypes","volume":"6","author":"Wijesuriya","year":"1996","journal-title":"Genome Res"},{"key":"10.1016\/j.ajo.2008.03.024_bib10","first-page":"515","article-title":"Color vision defect","volume":"90","author":"Berninger","year":"1993","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.ajo.2008.03.024_bib11","first-page":"1633","article-title":"Abnormal dark adaptation and rhodopsin kinetics in Sorsby's fundus dystrophy","volume":"33","author":"Steinmetz","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2008.03.024_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0002-9394(14)75989-6","article-title":"Choroidal perfusion abnormality with age-related Bruch's membrane change","volume":"109","author":"Pauleikhoff","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib13","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0161-6420(89)32654-6","article-title":"Sorsby's fundus dystrophy: a clinical study","volume":"96","author":"Polkinghorne","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2008.03.024_bib14","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0161-6420(89)32664-9","article-title":"Sorsby's fundus dystrophy: a light and electron microscopic study","volume":"96","author":"Capon","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2008.03.024_bib15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/eye.1988.23","article-title":"Sorsby's pseudoinflammatory macula dystrophy\u2014Sorsby's fundus dystrophies","volume":"2","author":"Capon","year":"1988","journal-title":"Eye"},{"key":"10.1016\/j.ajo.2008.03.024_bib16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/bjo.65.12.859","article-title":"Sorsby's pseudoinflammatory macular dystrophy","volume":"65","author":"Hoskin","year":"1981","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/jmg.32.3.240","article-title":"Linkage refinement localises Sorsby fundus dystrophy between markers D22S275 and D22S278","volume":"32","author":"Gregory","year":"1995","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajo.2008.03.024_bib18","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0002-9394(03)00482-3","article-title":"TIMP-3 mRNA is not overexpressed in Sorsby fundus dystrophy","volume":"136","author":"Chong","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib19","first-page":"1054","article-title":"Evaluation of the gene encoding the tissue inhibitor of metalloproteinases-3 in various maculopathies","volume":"38","author":"Felbor","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2008.03.024_bib20","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1001\/archopht.117.10.1329","article-title":"Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials\u2014TAP report","volume":"117","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archopht.118.1.85","article-title":"Autosomal dominant hemorrhagic macular dystrophy not associated with the TIMP3 gene","volume":"118","author":"Ayyagari","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib22","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0161-6420(89)32647-9","article-title":"Sorsby's fundus dystrophy","volume":"96","author":"Hamilton","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2008.03.024_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jcp.10361","article-title":"Sorsby fundus dystrophy mutation TIMP3(S156C) affects the morphological and biochemical phenotype but not metalloproteinase homeostasis","volume":"197","author":"Soboleva","year":"2003","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajo.2008.03.024_bib24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1136\/bjo.82.11.1329","article-title":"Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa","volume":"82","author":"Fariss","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4615-0067-4_13","article-title":"Tissue inhibitor of metalloproteinases-3 and Sorsby fundus dystrophy","volume":"533","author":"Qi","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajo.2008.03.024_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nm846","article-title":"A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2","volume":"9","author":"Qi","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.ajo.2008.03.024_bib27","first-page":"817","article-title":"Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3","volume":"38","author":"Anand-Apte","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2008.03.024_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0945-053X(01)00180-9","article-title":"Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix","volume":"21","author":"Yeow","year":"2002","journal-title":"Matrix Biol"},{"key":"10.1016\/j.ajo.2008.03.024_bib29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00006982-199414040-00006","article-title":"Recurrent choroidal neovascularization after laser photocoagulation in Sorsby's fundus dystrophy","volume":"14","author":"Holz","year":"1994","journal-title":"Retina"},{"key":"10.1016\/j.ajo.2008.03.024_bib30","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/bjo.87.6.796","article-title":"Successful photodynamic therapy for subretinal neovascularisation due to Sorsby's fundus dystrophy: 1 year follow-up","volume":"87","author":"Wong","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2008.03.024_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00006982-200504000-00024","article-title":"Choroidal neovascularization in Sorsby fundus dystrophy treated with photodynamic therapy and intravitreal triamcinolone acetonide","volume":"25","author":"Peiretti","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.ajo.2008.03.024_bib32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/bjo.2003.020438","article-title":"Sorsby fundus dystrophy presenting with choroidal neovascularisation showing good response to steroid treatment","volume":"88","author":"Atan","year":"2004","journal-title":"Br J Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939408002535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939408002535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T12:56:39Z","timestamp":1757595399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939408002535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0002939408002535"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2008.03.024","relation":{},"ISSN":["0002-9394"],"issn-type":[{"type":"print","value":"0002-9394"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Course and Treatment Outcomes of Sorsby Fundus Dystrophy","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2008.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}