{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:50:26Z","timestamp":1781891426281,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.ajo.2010.03.012","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T04:30:55Z","timestamp":1276057855000},"page":"254-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Similar Effects of Selective Laser Trabeculoplasty and Prostaglandin Analogs on the Permeability of Cultured Schlemm Canal Cells"],"prefix":"10.1016","volume":"150","author":[{"given":"Jorge A.","family":"Alvarado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumiko","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amde Selassie","family":"Shifera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2010.03.012_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/tcrm.2006.2.2.193","article-title":"The management of glaucoma and intraocular hypertension: current approaches and recent advances","volume":"2","author":"Noecker","year":"2006","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.ajo.2010.03.012_bib2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ohc.2005.05.005","article-title":"Selective laser trabeculoplasty","volume":"18","author":"Latina","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"key":"10.1016\/j.ajo.2010.03.012_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/01.ijg.0000176939.43681.c2","article-title":"High failure rate associated with 180 degrees selective laser trabeculoplasty","volume":"14","author":"Song","year":"2005","journal-title":"J Glaucoma"},{"issue":"Supp 11","key":"10.1016\/j.ajo.2010.03.012_bib4","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/j.survophthal.2008.08.010","article-title":"Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction","volume":"53","author":"Toris","year":"2008","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajo.2010.03.012_bib5","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ophtha.2007.07.002","article-title":"Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects","volume":"115","author":"Lim","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2010.03.012_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ajo.2007.09.001","article-title":"Prostaglandins increase trabecular meshwork outflow facility in cultured human anterior segments","volume":"145","author":"Bahler","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2010.03.012_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/bjo.2009.176024","article-title":"Effect of primary selective laser trabeculoplasty on tonographic outflow facility-a randomized clinical trial","author":"Goyal","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2010.03.012_bib8","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00108.2003","article-title":"Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features","volume":"286","author":"Alvarado","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajo.2010.03.012_bib9","first-page":"267","article-title":"Epinephrine effects on major cell types of the aqueous outflow pathway: in vitro studies\/clinical implications","volume":"88","author":"Alvarado","year":"1990","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ajo.2010.03.012_bib10","first-page":"1813","article-title":"Effect of beta-adrenergic agonists on paracellular width and fluid flow across outflow pathway cells","volume":"39","author":"Alvarado","year":"1998","journal-title":"Invest OphthalmolVis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib11","first-page":"148","article-title":"Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eye","volume":"103","author":"Alvarado","year":"2005","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ajo.2010.03.012_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00418-002-0398-y","article-title":"A Z01-GFP fusion protein to study the dynamics of tight junctions in living cells","volume":"117","author":"Riesen","year":"2002","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ajo.2010.03.012_bib13","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1096\/fj.02-0121fje","article-title":"Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1","volume":"16","author":"Fanning","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.ajo.2010.03.012_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/107632702753725003","article-title":"Efficient transfection method for primary cells","volume":"8","author":"Hamm","year":"2002","journal-title":"Tissue Eng"},{"key":"10.1016\/j.ajo.2010.03.012_bib15","first-page":"167","article-title":"From the bedside to the bench and back again: predicting and improving the outcomes of SLT glaucoma therapy","volume":"107","author":"Alvarado","year":"2009","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ajo.2010.03.012_bib16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bjo.2006.110155","article-title":"Levels of bimatoprost acid in the aqueous humour after bimatoprost treatment of patients with cataract","volume":"91","author":"Cantor","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.ajo.2010.03.012_bib17","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S0039-6257(02)00302-8","article-title":"Ocular and systemic pharmacokinetics of latanoprost in humans","volume":"47","author":"Sjoquist","year":"2002","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajo.2010.03.012_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2165\/00002512-200219060-00005","article-title":"Travoprost","volume":"19","author":"Waugh","year":"2002","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ajo.2010.03.012_bib19","first-page":"1621","article-title":"Population pharmacokinetics of 2% topical dorzolamide in the aqueous humor of humans","volume":"40","author":"Schmitz","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/108076802317373888","article-title":"Bioavailability in the human eye of a fixed combination of latanoprost and timolol compared to monotherapy","volume":"18","author":"Calissendorff","year":"2002","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.ajo.2010.03.012_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/IJG.0b013e318162257f","article-title":"Absorption of brimonidine 0.1% and 0.15% ophthalmic solutions in the aqueous humor of cataract patients","volume":"17","author":"Cantor","year":"2008","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ajo.2010.03.012_bib22","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1136\/bjo.2005.081307","article-title":"A new insight into the cellular regulation of aqueous outflow: how trabecular meshwork endothelial cells drive a mechanism that regulates the permeability of Schlemm's canal endothelial cells","volume":"89","author":"Alvarado","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2010.03.012_bib23","doi-asserted-by":"crossref","first-page":"C330","DOI":"10.1152\/ajpcell.1999.277.2.C330","article-title":"Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions","volume":"277","author":"Underwood","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajo.2010.03.012_bib24","first-page":"1836","article-title":"Trabecular meshwork cells grown on filters","volume":"29","author":"Perkins","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.exer.2004.08.029","article-title":"Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility","volume":"80","author":"Rao","year":"2005","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajo.2010.03.012_bib26","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1167\/iovs.06-1089","article-title":"Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells","volume":"48","author":"Sanka","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib27","first-page":"2631","article-title":"Ethacrynic acid induces reversible shape and cytoskeletal changes in cultured cells","volume":"33","author":"Erickson-Lamy","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib28","first-page":"619","article-title":"Cytoskeletal involvement in the regulation of aqueous humor outflow","volume":"41","author":"Tian","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib29","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1681\/ASN.V1061337","article-title":"Transmembrane proteins in the tight junction barrier","volume":"10","author":"Fanning","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajo.2010.03.012_bib30","first-page":"160","article-title":"Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye","volume":"32","author":"Epstein","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib31","first-page":"1795","article-title":"Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not","volume":"42","author":"Ethier","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2010.03.012_bib32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/108076801753266802","article-title":"Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist","volume":"17","author":"Hellberg","year":"2001","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.ajo.2010.03.012_bib33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/10807680260218489","article-title":"Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor","volume":"18","author":"Sharif","year":"2002","journal-title":"J Ocul Pharmacol Ther"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939410002266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939410002266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:39:46Z","timestamp":1762079986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939410002266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0002939410002266"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2010.03.012","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Similar Effects of Selective Laser Trabeculoplasty and Prostaglandin Analogs on the Permeability of Cultured Schlemm Canal Cells","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2010.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}