{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:11Z","timestamp":1791353471069,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Higher Education and Scientific Research"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.ajo.2010.11.013","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T04:27:26Z","timestamp":1298089646000},"page":"840-849.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Corneal Nerve Aberrations in Bullous Keratopathy"],"prefix":"10.1016","volume":"151","author":[{"given":"Mouhamed","family":"Al-Aqaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaer","family":"Alomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harminder S.","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6 Suppl","key":"10.1016\/j.ajo.2010.11.013_bib1","first-page":"61","article-title":"[Bullous keratopathy: etiopathogenesis and treatment]","volume":"71","author":"Goncalves","year":"2008","journal-title":"Arq Bras Oftalmol"},{"issue":"11","key":"10.1016\/j.ajo.2010.11.013_bib2","first-page":"1563","article-title":"Analysis of the cause of bullous keratopathy","volume":"16","author":"Biji","year":"1999","journal-title":"Journal of the Eye"},{"issue":"4","key":"10.1016\/j.ajo.2010.11.013_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0161-6420(00)00003-8","article-title":"Indications for and outcomes of repeat penetrating keratoplasty, 1989\u20131995","volume":"107","author":"Patel","year":"2000","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2010.11.013_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00003226-200001000-00002","article-title":"Three decades of corneal transplantation: indications and patient characteristics","volume":"19","author":"Maeno","year":"2000","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.ajo.2010.11.013_bib5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0002-9394(14)72437-7","article-title":"Indications for and outcomes of repeat penetrating keratoplasty","volume":"109","author":"Rapuano","year":"1990","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2010.11.013_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0896-1549(01)00016-5","article-title":"Mechanisms of disease: Fuchs' endothelial dystrophy","volume":"15","author":"Borboli","year":"2002","journal-title":"Ophthalmol Clin North Am"},{"issue":"3","key":"10.1016\/j.ajo.2010.11.013_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.1475-1313.1999.00408.x","article-title":"Fuchs' endothelial dystrophy: a fresh look at an aging disease","volume":"19","author":"Bergmanson","year":"1999","journal-title":"Ophthalmic Physiol Opt"},{"issue":"3","key":"10.1016\/j.ajo.2010.11.013_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/01.ico.0000148288.53323.b2","article-title":"A morphologic study of Fuchs dystrophy and bullous keratopathy","volume":"24","author":"Yuen","year":"2005","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.ajo.2010.11.013_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1442-9071.2009.02020.x","article-title":"Quantitative evaluation of corneal epithelial oedema by confocal microscopy","volume":"37","author":"Morishige","year":"2009","journal-title":"Clin Experiment Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2010.11.013_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00003226-199809000-00006","article-title":"In vivo confocal microscopy of Fuchs' endothelial dystrophy","volume":"17","author":"Mustonen","year":"1998","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.ajo.2010.11.013_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/bjo.83.2.185","article-title":"Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy","volume":"83","author":"Chiou","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2010.11.013_bib12","first-page":"631","article-title":"Confocal microscopy of cystic disorders of the corneal epithelium","volume":"105","author":"Hernandez-Quintela","year":"1998","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ajo.2010.11.013_bib13","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1136\/bjo.2009.178244","article-title":"Ex vivo confocal microscopy of human corneal nerves","volume":"94","author":"Al-Aqaba","year":"2010","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2010.11.013_bib14","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/bjo.2008.150615","article-title":"In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review","volume":"93","author":"Patel","year":"2009","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2010.11.013_bib15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/00003226-200105000-00008","article-title":"Morphology of corneal nerves using confocal microscopy","volume":"20","author":"Oliveira-Soto","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2010.11.013_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/12.3.219","article-title":"A \u201cdirect-coloring\u201d thiocholine method for cholinesterases","volume":"12","author":"Karnovsky","year":"1964","journal-title":"J Histochem Cytochem"},{"issue":"6","key":"10.1016\/j.ajo.2010.11.013_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/bjo.2009.173799","article-title":"Architecture and distribution of human corneal nerves","volume":"94","author":"Al-Aqaba","year":"2010","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2010.11.013_bib18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/01.ico.0000154387.51355.39","article-title":"The effect of age on the corneal subbasal nerve plexus","volume":"24","author":"Erie","year":"2005","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.ajo.2010.11.013_bib19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/bjo.85.6.720","article-title":"Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy","volume":"85","author":"Akhtar","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2010.11.013_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0002-9394(64)90588-4","article-title":"Hyper-regeneration of corneal nerves in bullous keratopathy","volume":"58","author":"Wolter","year":"1964","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2010.11.013_bib21","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/bjo.2008.150599","article-title":"Laser-scanning in vivo confocal microscopy reveals two morphologically distinct populations of stromal nerves in normal human corneas","volume":"93","author":"Visser","year":"2009","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2010.11.013_bib22","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/S0886-3350(00)00840-3","article-title":"Morphological evaluation of Schnyder's central crystalline dystrophy by confocal microscopy before and after phototherapeutic keratectomy","volume":"27","author":"Ciancaglini","year":"2001","journal-title":"J Cataract Refract Surg"},{"issue":"7","key":"10.1016\/j.ajo.2010.11.013_bib23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/01.ico.0000224640.58848.54","article-title":"Morphologic alterations of both the stromal and subbasal nerves in the corneas of patients with diabetes","volume":"25","author":"Mocan","year":"2006","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.ajo.2010.11.013_bib24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/00003226-200310000-00014","article-title":"Aberrant corneal nerve regeneration after PRK","volume":"22","author":"Erie","year":"2003","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.ajo.2010.11.013_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0886-3350(02)01382-2","article-title":"Aberrant regeneration of corneal nerves after laser in situ keratomileusis","volume":"29","author":"Patel","year":"2003","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"10.1016\/j.ajo.2010.11.013_bib26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.exer.2009.12.010","article-title":"Anatomy of the human corneal innervation","volume":"90","author":"Marfurt","year":"2010","journal-title":"Exp Eye Res"},{"issue":"6","key":"10.1016\/j.ajo.2010.11.013_bib27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/00003226-200308000-00005","article-title":"Comparison of confocal biomicroscopy and noncontact specular microscopy for evaluation of the corneal endothelium","volume":"22","author":"Hara","year":"2003","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.ajo.2010.11.013_bib28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/01.ico.0000154384.05614.8f","article-title":"Epithelial innervation of human cornea: a three-dimensional study using confocal laser scanning fluorescence microscopy","volume":"24","author":"Guthoff","year":"2005","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.ajo.2010.11.013_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1442-9071.2001.00393.x","article-title":"Differential diagnosis of corneal oedema assisted by in vivo confocal microscopy","volume":"29","author":"Grupcheva","year":"2001","journal-title":"Clin Experiment Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2010.11.013_bib30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0039-6257(93)90099-S","article-title":"Fuchs' endothelial dystrophy of the cornea","volume":"38","author":"Adamis","year":"1993","journal-title":"Surv Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2010.11.013_bib31","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/ICO.0b013e3181aea0e3","article-title":"Change in corneal sensitivity and corneal nerve after cataract surgery","volume":"28","author":"Kim","year":"2009","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.ajo.2010.11.013_bib32","first-page":"101","article-title":"Corneal sensitivity in aphakic and pseudophakic eyes","volume":"14","author":"John","year":"1988","journal-title":"CLAO J"},{"issue":"14","key":"10.1016\/j.ajo.2010.11.013_bib33","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1073\/pnas.96.14.7693","article-title":"Neurotrophins and hyperalgesia","volume":"96","author":"Shu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.ajo.2010.11.013_bib34","first-page":"97","article-title":"Coordinate expression of NGF and alpha-smooth muscle actin mRNA and protein in cutaneous wound tissue of developing and adult rats","volume":"300","author":"Hasan","year":"2000","journal-title":"Cell Tissue Res"},{"issue":"3","key":"10.1016\/j.ajo.2010.11.013_bib35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.0022-202x.2001.01679.x","article-title":"Nerve growth factor, neuropeptides, and mast cells in ultraviolet-B-induced systemic suppression of contact hypersensitivity responses in mice","volume":"118","author":"Townley","year":"2002","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.1016\/j.ajo.2010.11.013_bib36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0896-6273(00)81003-X","article-title":"Tackling pain at the source: new ideas about nociceptors","volume":"20","author":"Snider","year":"1998","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.ajo.2010.11.013_bib37","first-page":"692","article-title":"Neurotrophic factors in the human cornea","volume":"41","author":"You","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939410009086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939410009086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:02:46Z","timestamp":1757595766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939410009086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0002939410009086"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2010.11.013","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corneal Nerve Aberrations in Bullous Keratopathy","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2010.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}