{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:43:55Z","timestamp":1787805835076,"version":"build-2784847793"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ajo.2012.06.026","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T01:18:09Z","timestamp":1347931089000},"page":"127-133.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Intravitreal Triamcinolone Versus Intravitreal Bevacizumab in the Treatment of Exudative Retinal Detachment Secondary to Posterior Uveal Melanoma"],"prefix":"10.1016","volume":"155","author":[{"given":"Raffaele","family":"Parrozzani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pilotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Dario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Miglionico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Midena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ajo.2012.06.026_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/1740774511419684","article-title":"Collaborative Ocular Melanoma Study randomized trial of I-125 brachytherapy","volume":"8","author":"Hawkins","year":"2011","journal-title":"Clin Trials"},{"issue":"9","key":"10.1016\/j.ajo.2012.06.026_bib2","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1001\/archopht.118.9.1219","article-title":"Plaque radiotherapy for uveal melanoma: long-term visual outcome in 1106 consecutive patients","volume":"118","author":"Shields","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2012.06.026_bib3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1442-9071.2009.02127.x","article-title":"Management of exudative retinal detachment in choroidal melanoma","volume":"37","author":"Gibran","year":"2009","journal-title":"Clin Experiment Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2012.06.026_bib4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.preteyeres.2008.09.003","article-title":"Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management","volume":"27","author":"Kaur","year":"2008","journal-title":"Prog Retin Eye Res"},{"issue":"9","key":"10.1016\/j.ajo.2012.06.026_bib5","first-page":"2085","article-title":"Exudative retinal detachment from malignant uveal melanoma: predictors and prognostic significance","volume":"42","author":"Kivel\u00e4","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.ajo.2012.06.026_bib6","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.1167\/iovs.10-5526","article-title":"Inflammatory cytokines in eyes with uveal melanoma and relation with macrophage infiltration","volume":"51","author":"Ly","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2012.06.026_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/bjo.79.4.354","article-title":"Study of the blood-aqueous barrier in choroidal melanoma","volume":"79","author":"Castella","year":"1995","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2012.06.026_bib8","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1136\/bjo.85.11.1305","article-title":"Intraocular inflammation after proton beam irradiation for uveal melanoma","volume":"85","author":"Lumbroso","year":"2001","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2012.06.026_bib9","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1001\/archopht.124.10.1428","article-title":"Vascular endothelial growth factor A in eyes with uveal melanoma","volume":"124","author":"Missotten","year":"2006","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.06.026_bib10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0360-3016(03)00006-3","article-title":"The American Brachytherapy Society recommendations for brachytherapy of uveal melanomas","volume":"56","author":"Nag","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ajo.2012.06.026_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1167\/iovs.08-2625","article-title":"Predictive value of a topical dexamethasone provocative test before intravitreal triamcinolone acetonide injection","volume":"50","author":"Breusegem","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ajo.2012.06.026_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000317909","article-title":"Intravitreal triamcinolone","volume":"225","author":"Tao","year":"2011","journal-title":"Ophthalmologica"},{"issue":"3","key":"10.1016\/j.ajo.2012.06.026_bib13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.survophthal.2009.02.004","article-title":"Bevacizumab (Avastin) for the treatment of ocular disease","volume":"54","author":"Gunther","year":"2009","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2012.06.026_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13277-010-0042-8","article-title":"Radiation-induced cell death mechanisms","volume":"31","author":"Eriksson","year":"2010","journal-title":"Tumour Biol"},{"issue":"8","key":"10.1016\/j.ajo.2012.06.026_bib15","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bcp.2008.06.024","article-title":"Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation","volume":"76","author":"Gewirtz","year":"2008","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"10.1016\/j.ajo.2012.06.026_bib16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/09553000500168549","article-title":"P53-dependent accelerated senescence induced by ionizing radiation in breast tumour cells","volume":"81","author":"Jones","year":"2005","journal-title":"Int J Radiat Biol"},{"issue":"5","key":"10.1016\/j.ajo.2012.06.026_bib17","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4161\/cc.6.5.3901","article-title":"A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells","volume":"6","author":"Lehmann","year":"2007","journal-title":"Cell Cycle"},{"issue":"16","key":"10.1016\/j.ajo.2012.06.026_bib18","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/sj.onc.1207518","article-title":"Hallmarks of senescence in carcinogenesis and cancer therapy","volume":"23","author":"Shay","year":"2004","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ajo.2012.06.026_bib19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajo.2012.06.026_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu Rev Pathol"},{"issue":"2","key":"10.1016\/j.ajo.2012.06.026_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/onc.2009.318","article-title":"Cytokine expression and signaling in drug-induced cellular senescence","volume":"29","author":"Novakova","year":"2010","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.ajo.2012.06.026_bib22","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ophtha.2009.10.018","article-title":"Tumor-related lipid exudation after plaque radiotherapy of choroidal melanoma: the role of Bruch's membrane rupture","volume":"117","author":"Mashayekhi","year":"2010","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.ajo.2012.06.026_bib23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1001\/archopht.120.11.1463","article-title":"Rate of resolution of exudative retinal detachment after plaque radiotherapy for uveal melanoma","volume":"120","author":"Harbour","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.06.026_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00001813-199502000-00002","article-title":"Use of corticosteroids in neuro-oncology","volume":"6","author":"Koehler","year":"1995","journal-title":"Anticancer Drugs"},{"issue":"9","key":"10.1016\/j.ajo.2012.06.026_bib25","first-page":"1041","article-title":"The use and toxicity of steroids in the management of patients with brain metastases","volume":"16","author":"Sturdza","year":"2008","journal-title":"Support Care Cancer"},{"issue":"4","key":"10.1016\/j.ajo.2012.06.026_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/1534735405282557","article-title":"Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in tumor angiogenesis and malignancies","volume":"4","author":"Pradeep","year":"2005","journal-title":"Integr Canc Ther"},{"key":"10.1016\/j.ajo.2012.06.026_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000320015","article-title":"Angiogenesis and vascular endothelial growth factors in intraocular tumors","volume":"46","author":"Missotten","year":"2010","journal-title":"Dev Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2012.06.026_bib28","doi-asserted-by":"crossref","first-page":"796","DOI":"10.5301\/EJO.2011.6477","article-title":"Systemic bevacizumab (Avastin) for exudative retinal detachment secondary to choroidal melanoma","volume":"21","author":"Newman","year":"2011","journal-title":"Eur J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2012.06.026_bib29","first-page":"434","article-title":"Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor trap-eye)","volume":"32","author":"Stewart","year":"2012","journal-title":"Retina"},{"issue":"5","key":"10.1016\/j.ajo.2012.06.026_bib30","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ajo.2008.12.006","article-title":"Effect of triamcinolone acetonide on vascular endothelial growth factor and occludin levels in branch retinal vein occlusion","volume":"147","author":"McAllister","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.06.026_bib31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0002-9394(02)02292-4","article-title":"Laser and proton radiation to reduce uveal melanoma-associated exudative retinal detachments","volume":"136","author":"Char","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2012.06.026_bib32","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1442-9071.2009.02127.x","article-title":"Management of exudative retinal detachment in choroidal melanoma","volume":"37","author":"Gibran","year":"2009","journal-title":"Clin Experiment Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2012.06.026_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/0974-9233.65494","article-title":"Exoresection and endoresection for uveal melanoma","volume":"17","author":"G\u00fcnd\u00fcz","year":"2010","journal-title":"Middle East Afr J Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939412004813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939412004813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:07:07Z","timestamp":1757596027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939412004813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0002939412004813"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2012.06.026","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravitreal Triamcinolone Versus Intravitreal Bevacizumab in the Treatment of Exudative Retinal Detachment Secondary to Posterior Uveal Melanoma","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2012.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}