{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:29:47Z","timestamp":1791930587654,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ajo.2012.07.003","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T01:16:45Z","timestamp":1349140605000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Laser Clearance of Drusen Deposit in Patients With Autosomal Dominant Drusen (p.Arg345Trp in EFEMP1)"],"prefix":"10.1016","volume":"155","author":[{"given":"Eva","family":"Lenassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Troeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Tufail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Hawlina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Jeffery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2012.07.003_bib1","first-page":"71","article-title":"A peculiar condition of choroiditis occurring in several members of the same family","volume":"19","author":"Doyne","year":"1899","journal-title":"Trans Ophthalmol Soc UK"},{"key":"10.1016\/j.ajo.2012.07.003_bib2","series-title":"Handbuch der gesamten Augenheilkunde Untersuchungsmethoden","first-page":"1","article-title":"Die Ophthalmoskopie im rotfreien Licht","author":"Vogt","year":"1925"},{"issue":"3","key":"10.1016\/j.ajo.2012.07.003_bib3","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1167\/iovs.09-4497","article-title":"A novel haplotype with the R345W mutation in the EFEMP1 gene associated with autosomal dominant drusen in a Japanese family","volume":"51","author":"Takeuchi","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.ajo.2012.07.003_bib4","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1167\/iovs.05-1600","article-title":"Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction","volume":"47","author":"Michaelides","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ajo.2012.07.003_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/9722","article-title":"A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy","volume":"22","author":"Stone","year":"1999","journal-title":"Nat Genet"},{"issue":"20","key":"10.1016\/j.ajo.2012.07.003_bib6","doi-asserted-by":"crossref","first-page":"13067","DOI":"10.1073\/pnas.202491599","article-title":"Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration","volume":"99","author":"Marmorstein","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajo.2012.07.003_bib7","first-page":"141","article-title":"Prophylactic photocoagulation of the fellow eye in exudative senile maculopathy. A preliminary report","volume":"20","author":"Cleasby","year":"1979","journal-title":"Mod Probl Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2012.07.003_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archopht.1973.01000050208006","article-title":"Drusen and disciform macular detachment and degeneration","volume":"90","author":"Gass","year":"1973","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.07.003_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0002-9394(98)00061-0","article-title":"Prophylactic laser treatment to fellow eyes of unilateral retinal pigment epithelial tears","volume":"126","author":"Gross-Jendroska","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2012.07.003_bib10","first-page":"299","article-title":"Photocoagulation of drusen-related macular degeneration: a long-term outcome","volume":"92","author":"Wetzig","year":"1994","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ajo.2012.07.003_bib11","first-page":"CD006537","article-title":"Laser treatment of drusen to prevent progression to advanced age-related macular degeneration","author":"Parodi","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.ajo.2012.07.003_bib12","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1167\/iovs.09-4372","article-title":"Normal central retinal function and structure preserved in retinitis pigmentosa","volume":"51","author":"Jacobson","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.ajo.2012.07.003_bib13","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1167\/iovs.09-4945","article-title":"A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa","volume":"51","author":"Rangaswamy","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.ajo.2012.07.003_bib14","doi-asserted-by":"crossref","first-page":"7141","DOI":"10.1167\/iovs.11-7509","article-title":"Rod sensitivity, cone sensitivity, and photoreceptor layer thickness in retinal degenerative diseases","volume":"52","author":"Birch","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"10.1016\/j.ajo.2012.07.003_bib15","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1001\/archophthalmol.2009.326","article-title":"Outer retinal tubulation: a novel optical coherence tomography finding","volume":"127","author":"Zweifel","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2012.07.003_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrg2717","article-title":"Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait","volume":"11","author":"Wright","year":"2010","journal-title":"Nat Rev Genet"},{"issue":"20","key":"10.1016\/j.ajo.2012.07.003_bib17","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1056\/NEJMra1012354","article-title":"Genomics and the eye","volume":"364","author":"Sheffield","year":"2011","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ajo.2012.07.003_bib18","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1167\/iovs.09-4497","article-title":"A novel haplotype with the R345W mutation in the EFEMP1 gene associated with autosomal dominant drusen in a Japanese family","volume":"51","author":"Takeuchi","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.ajo.2012.07.003_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1055\/s-2005-857972","article-title":"[Optical coherence tomography in Malattia Leventinese]","volume":"222","author":"Gaillard","year":"2005","journal-title":"Klin Monbl Augenheilkd"},{"issue":"2","key":"10.1016\/j.ajo.2012.07.003_bib20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ajo.2005.09.001","article-title":"Optical coherent tomography features of Malattia Leventinese","volume":"141","author":"Souied","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2012.07.003_bib21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/eye.2008.251","article-title":"Retinal microstructure in patients with EFEMP1 retinal dystrophy evaluated by Fourier domain OCT","volume":"23","author":"Gerth","year":"2009","journal-title":"Eye (Lond)"},{"issue":"7","key":"10.1016\/j.ajo.2012.07.003_bib22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1001\/archopht.1997.01100160074012","article-title":"Assessment of the phenotypic range seen in Doyne honeycomb retinal dystrophy","volume":"115","author":"Evans","year":"1997","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2012.07.003_bib23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1001\/archopht.1985.01050050086024","article-title":"Cellular mechanisms of resolution of drusen after laser coagulation. An experimental study","volume":"103","author":"Duvall","year":"1985","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"10.1016\/j.ajo.2012.07.003_bib24","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1167\/iovs.07-1322","article-title":"In\u00a0vivo visualization of dendritic cells, macrophages, and microglial cells responding to\u00a0laser-induced damage in the fundus of the eye","volume":"49","author":"Eter","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ajo.2012.07.003_bib25","first-page":"890","article-title":"Repair of retinal pigment epithelium and its relationship with capillary endothelium after krypton laser photocoagulation","volume":"31","author":"Pollack","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.ajo.2012.07.003_bib26","first-page":"1644","article-title":"The role of retinal pigment epithelium in the involution of subretinal neovascularization","volume":"27","author":"Miller","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2012.07.003_bib27","first-page":"570","article-title":"Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery","volume":"16","author":"von Leithner","year":"2010","journal-title":"Mol Vis"},{"issue":"10","key":"10.1016\/j.ajo.2012.07.003_bib28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/bjo.82.10.1169","article-title":"Prophylactic laser treatment in early age related maculopathy reduced the incidence of exudative complications","volume":"82","author":"Frennesson","year":"1998","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2012.07.003_bib29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.exer.2010.02.013","article-title":"Macromolecular diffusion characteristics of ageing human Bruch\u2019s membrane: implications for age-related macular degeneration (AMD)","volume":"90","author":"Hussain","year":"2010","journal-title":"Exp Eye Res"},{"issue":"1","key":"10.1016\/j.ajo.2012.07.003_bib30","first-page":"35","article-title":"Peroxidase diffusion in the normal and laser-coagulated primate retina","volume":"11","author":"Peyman","year":"1972","journal-title":"Invest Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.07.003_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/bjo.85.1.40","article-title":"Influence of laser photocoagulation on choroidal capillary cytoarchitecture","volume":"85","author":"Guymer","year":"2001","journal-title":"Br J\u00a0Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939412004990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939412004990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:06:44Z","timestamp":1757596004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939412004990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0002939412004990"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2012.07.003","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Laser Clearance of Drusen Deposit in Patients With Autosomal Dominant Drusen (p.Arg345Trp in EFEMP1)","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2012.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}