{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:31:45Z","timestamp":1786984305472,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.ajo.2012.12.007","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T15:00:55Z","timestamp":1360162855000},"page":"843-851.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Association of Open-angle Glaucoma With Perfusion Pressure Status in the Thessaloniki Eye Study"],"prefix":"10.1016","volume":"155","author":[{"given":"Fotis","family":"Topouzis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Roy","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiota","family":"Founti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Anastasopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theofanis","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archimidis","family":"Koskosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Salonikiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ajo.2012.12.007_bib1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1136\/bjo.2008.149047","article-title":"Blood pressure and glaucoma","volume":"93","author":"Costa","year":"2009","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2012.12.007_bib2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1001\/archopht.125.6.805","article-title":"Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam study","volume":"125","author":"Hulsman","year":"2007","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2012.12.007_bib3","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0161-6420(00)00138-X","article-title":"Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study","volume":"107","author":"Bonomi","year":"2000","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajo.2012.12.007_bib4","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/archopht.1995.01100070092031","article-title":"Risk factors for open-angle glaucoma. The Barbados Eye Study","volume":"113","author":"Leske","year":"1995","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2012.12.007_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/archopht.1995.01100020100038","article-title":"Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment","volume":"113","author":"Tielsch","year":"1995","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2012.12.007_bib6","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1001\/archopht.119.12.1819","article-title":"The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VER","volume":"119","author":"Quigley","year":"2001","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2012.12.007_bib7","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1167\/iovs.08-2956","article-title":"Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study","volume":"51","author":"Memarzadeh","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.ajo.2012.12.007_bib8","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1167\/iovs.09-4867","article-title":"Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the Singapore Malay Eye Study","volume":"51","author":"Zheng","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.ajo.2012.12.007_bib9","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1001\/archopht.120.7.954","article-title":"Incident open-angle glaucoma and blood pressure","volume":"120","author":"Leske","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.12.007_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ophtha.2007.03.017","article-title":"Risk factors for incident open-angle glaucoma: the Barbados Eye Studies","volume":"115","author":"Leske","year":"2008","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ajo.2012.12.007_bib11","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1167\/iovs.11-7376","article-title":"Ocular perfusion pressure and the incidence of glaucoma: real effect or artifact? - The Rotterdam Study","volume":"52","author":"Ramdas","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.ajo.2012.12.007_bib12","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","article-title":"Predictors of long-term progression in the Early Manifest Glaucoma Trial","volume":"114","author":"Leske","year":"2007","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2012.12.007_bib13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajo.2010.01.018","article-title":"Blood pressure, perfusion pressure, and glaucoma","volume":"149","author":"Caprioli","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2012.12.007_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1874364100903010043","article-title":"Weighing in ocular perfusion pressure in managing glaucoma","volume":"3","author":"Topouzis","year":"2009","journal-title":"Open Ophthalmol J"},{"issue":"1","key":"10.1016\/j.ajo.2012.12.007_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ajo.2006.02.055","article-title":"Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki eye study","volume":"142","author":"Topouzis","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2012.12.007_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajo.2011.01.032","article-title":"Risk factors for primary open-angle glaucoma and pseudoexfoliative glaucoma in the Thessaloniki Eye Study","volume":"152","author":"Topouzis","year":"2011","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2012.12.007_bib17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ajo.2007.06.029","article-title":"Prevalence of open-angle glaucoma in Greece: the Thessaloniki Eye Study","volume":"144","author":"Topouzis","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2012.12.007_bib18","first-page":"709","article-title":"The normal development of the human anterior chamber angle: a new system of descriptive grading","volume":"91","author":"Spaeth","year":"1971","journal-title":"Trans Ophthalmol Soc UK"},{"issue":"3","key":"10.1016\/j.ajo.2012.12.007_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/IJG.0b013e3181d9d8bd","article-title":"Characteristics of pseudoexfoliation in the Thessaloniki Eye Study","volume":"20","author":"Anastasopoulos","year":"2011","journal-title":"J Glaucoma"},{"issue":"2","key":"10.1016\/j.ajo.2012.12.007_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/ICU.0b013e32831eef82","article-title":"Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings","volume":"20","author":"Leske","year":"2009","journal-title":"Curr Opin Ophthalmol"},{"issue":"19","key":"10.1016\/j.ajo.2012.12.007_bib21","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.ajo.2012.12.007_bib22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00061198-200408000-00010","article-title":"Open-angle glaucoma and systemic hypertension: the Blue Mountains Eye Study","volume":"13","author":"Mitchell","year":"2004","journal-title":"J Glaucoma"},{"issue":"5","key":"10.1016\/j.ajo.2012.12.007_bib23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0002-9394(14)70067-4","article-title":"Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders","volume":"117","author":"Hayreh","year":"1994","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2012.12.007_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1350-9462(01)00005-2","article-title":"Blood flow in the optic nerve head and factors\u00a0that may influence it","volume":"20","author":"Hayreh","year":"2001","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"10.1016\/j.ajo.2012.12.007_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0161-6420(95)31053-6","article-title":"Ambulatory blood pressure monitoring in glaucoma. The nocturnal dip","volume":"102","author":"Graham","year":"1995","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2012.12.007_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/112067219600600309","article-title":"Simultaneous 24-hour monitoring of intraocular pressure and arterial blood pressure in patients with progressive and non-progressive primary open-angle glaucoma","volume":"6","author":"Detry","year":"1996","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2012.12.007_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1167\/iovs.06-0615","article-title":"Circadian fluctuation of mean ocular perfusion pressure is a consistent risk factor for normal-tension glaucoma","volume":"48","author":"Choi","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8121","key":"10.1016\/j.ajo.2012.12.007_bib28","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(79)91274-1","article-title":"Relation of reduction in pressure to first myocardial infraction in patients receiving treatment for severe hypertension","volume":"1","author":"Stewart","year":"1979","journal-title":"Lancet"},{"issue":"8533","key":"10.1016\/j.ajo.2012.12.007_bib29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(87)90231-5","article-title":"Benefits and potential harm of lowering high blood pressure","volume":"1","author":"Cruickshank","year":"1987","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ajo.2012.12.007_bib30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.1991.03460040065031","article-title":"The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous?","volume":"265","author":"Farnett","year":"1991","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.ajo.2012.12.007_bib31","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1097\/HJH.0b013e32834b62a3","article-title":"J-curve and cardiovascular mortality in coronary artery disease patients: myth or reality","volume":"29","author":"Kotsis","year":"2011","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.ajo.2012.12.007_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.amjhyper.2005.07.011","article-title":"Prevalence, awareness, treatment and control of hypertension in Hellas, Greece: the Hypertension Study in General Practice in Hellas (HYPERTENSHELL) national study","volume":"19","author":"Efstratopoulos","year":"2006","journal-title":"Am J Hypertens"},{"issue":"4","key":"10.1016\/j.ajo.2012.12.007_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/09286580701501931","article-title":"Open-angle glaucoma\u2014an epidemiologic overview","volume":"14","author":"Leske","year":"2007","journal-title":"Ophthalmic Epidemiol"},{"issue":"9349","key":"10.1016\/j.ajo.2012.12.007_bib34","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939412008616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939412008616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:07:20Z","timestamp":1757596040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939412008616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0002939412008616"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2012.12.007","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Open-angle Glaucoma With Perfusion Pressure Status in the Thessaloniki Eye Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2012.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}